Uma Kant Misra

Journal Article J Biol Chem · April 10, 2015 Ligation of cell surface GRP78 by activated α2-macroglobulin (α2M*) promotes cell proliferation and suppresses apoptosis. α2M*-treated human prostate cancer cells exhibit a 2-3-fold increase in glucose uptake and lactate secretion, an effect similar to ins ... Full text Link to item Cite

Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.

Journal Article PLoS One · 2014 PDK1 phosphorylates multiple substrates including Akt by PIP3-dependent mechanisms. In this report we provide evidence that in prostate cancer cells stimulated with activated α2-macroglobulin (α2M*) PDK1 phosphorylates Akt in the T-loop at Thr(308) by usin ... Full text Link to item Cite

The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.

Journal Article Biochemistry · June 11, 2013 α2-Macroglobulin (α2M) is a broad spectrum proteinase inhibitor that when activated by proteinases (α2M*) undergoes a major conformational change exposing receptor recognition sites in each of its four subunits. These complexes bind to two distinct recepto ... Full text Link to item Cite

Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.

Journal Article PLoS One · 2013 OBJECTIVE: In human prostate cancer cells, a selective Epac agonist, 8-CPT-2Me-cAMP, upregulates cell proliferation and survival via activation of Ras-MAPK and PI- 3-kinase-Akt-mTOR signaling cascades. Here we examine the role of inflammatory mediators in ... Full text Link to item Cite

Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.

Journal Article J Cell Biochem · May 2012 Ligation of cell surface-associated GRP78 by activated α(2) -macroglobulin triggers pro-proliferative cellular responses. In part, this results from activation of adenylyl cyclase leading to an increase in cAMP. We have previously employed the cAMP analog ... Full text Link to item Cite

Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.

Journal Article PLoS One · 2012 OBJECTIVE: Tetrameric α(2)-macroglobulin (α(2)M), a plasma panproteinase inhibitor, is activated upon interaction with a proteinase, and undergoes a major conformational change exposing a receptor recognition site in each of its subunits. Activated α(2)M ( ... Full text Link to item Cite

Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin.

Journal Article J Cell Biochem · June 2011 Receptor-recognized forms of α₂ -macroglobulin (α₂ M) bind to cell surface-associated GRP78 and initiate pro-proliferative and anti-apoptotic signaling. Ligation of GRP78 with α₂ M also upregulates TFII-I, which binds to the GRP78 promoter and enhances GRP ... Full text Link to item Cite

Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.

Journal Article J Biol Chem · January 14, 2011 GRP78, a well characterized chaperone in the endoplasmic reticulum, is critical to the unfolded protein response. More recently, it has been identified on the cell surface, where it has many roles. On cancer cells, it functions as a signaling receptor coup ... Full text Link to item Cite

Modulation of the unfolded protein response by GRP78 in prostate cancer.

Journal Article Methods Enzymol · 2011 The unfolded protein response (UPR) is an adaptive survival mechanism through which cells can weather the stress of misfolded protein accumulation induced by a wide variety of pathophysiologic and pharmacologic insults. The ER chaperone GRP78 is a central ... Full text Link to item Cite

Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation.

Journal Article Biochem Biophys Res Commun · February 19, 2010 Ligation of cancer cell surface GRP78 by activated alpha2-macroglobulin (alpha2M*) triggers pro-proliferative and anti-apoptotic signaling pathways. Cancer patients who develop autoantibodies to the alpha2M* binding site in GRP78 have a poor prognosis sinc ... Full text Link to item Cite

Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.

Journal Article Apoptosis · February 2010 Receptor-recognized forms of alpha(2)-macroglobulin (alpha(2)M*) bind to cancer cell surface GRP78, which functions as a signaling receptor promoting proliferation and survival. Patients with prostate, ovary, and skin cancer may develop auto-antibodies to ... Full text Link to item Cite

PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells.

Journal Article Biochem Biophys Res Commun · January 1, 2010 Antibodies against the COOH-terminal domain of cell surface GRP78 induce apoptosis in cancer cell lines via activation of p53 signaling. We now have studied the effects of PFT-alpha, an inhibitor of p53-mediated apoptotic pathways, on anti-GRP78 antibody-i ... Full text Link to item Cite

Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.

Journal Article Cancer Biol Ther · January 2010 We have previously shown that treatment of prostate cancer and melanoma cells expressing GRP78 on their cell surface with antibody directed against the COOH-terminal domain of GRP78 upregulates and activates p53 causing decreased cell proliferation and upr ... Full text Open Access Link to item Cite

Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.

Journal Article J Cell Biochem · November 1, 2009 cAMP-dependent, PKA-independent effects on cell proliferation are mediated by cAMP binding to EPAC and activation of Rap signaling. In this report, we employed the analogue 8-CPT-2-O-Me-cAMP to study binding to EPAC and subsequent activation of B-Raf/ERK a ... Full text Link to item Cite

Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis.

Journal Article Mol Cancer Ther · May 2009 Binding of activated α(2)-macroglobulin to GRP78 on the surface of human prostate cancer cells promotes proliferation by activating signaling cascades. Autoantibodies directed against the activated α(2)-macroglobulin binding site in the NH(2)-terminal doma ... Full text Link to item Cite

The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.

Journal Article Cell Signal · August 2008 cAMP regulates a wide range of processes through its downstream effectors including PKA, and the family of guanine nucleotide exchange factors. Depending on the cell type, cAMP inhibits or stimulates growth and proliferation in a PKA-dependent or independe ... Full text Link to item Cite

Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.

Journal Article J Cell Biochem · May 1, 2008 We have previously shown that a fraction of newly expressed GRP78 is translocated to the cell surface in association with the co-chaperone MTJ-1. Proteinase and methylamine-activated alpha(2)M (alpha(2)M*) bind to cell surface-associated GRP78 activating p ... Full text Link to item Cite

Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.

Journal Article Cell Signal · January 2008 Epac1 is a cAMP-stimulated guanine exchange factor that activates Rap1. The protein product of the T cell leukemia 1 (TCL1) proto-oncogene binds to Akt enhancing its kinase activity. TCL1 and Epac promote cellular proliferation because of their activating ... Full text Link to item Cite

Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter.

Journal Article J Cell Biochem · March 1, 2007 Recently, we reported that silencing CREB gene expression by RNAi significantly attenuates forskolin-induced activation of Akt1. We now provide evidence that forskolin-treatment causes transcriptional and translational upregulation of Akt1 in macrophages. ... Full text Link to item Cite

Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.

Journal Article J Biol Chem · May 12, 2006 Binding of activated forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M*) to cell surface-associated GRP78 on 1-LN human prostate cancer cells causes their proliferation. We have now examined the interplay between Akt activation, regulation of ... Full text Link to item Cite

Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.

Journal Article J Biol Chem · November 18, 2005 In this study, we have examined the role of two cAMP downstream effectors protein kinase A (PKA) and Epac, in forskolin-induced macrophage proliferation. Treatment of macrophages with forskolin enhanced [(3)H]thymidine uptake and increased cell number, and ... Full text Link to item Cite

Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages.

Journal Article J Immunol · August 15, 2005 Previous studies of the plasma proteinase inhibitor alpha2-macroglobulin (alpha2M) demonstrated that alpha2M-proteinase complexes (alpha2M*) modulate immune responses and promotes macrophage locomotion and chemotaxis. Alpha2M* binds to cell surface-associa ... Full text Link to item Cite

Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells.

Journal Article J Biol Chem · July 22, 2005 Binding of plasminogen type II (Pg 2) to dipeptidyl peptidase IV (DPP IV) on the surface of the highly invasive 1-LN human prostate tumor cell line induces an intracellular Ca2+ ([Ca2+]i) signaling cascade accompanied by a rise in intracellular pH (pHi). I ... Full text Link to item Cite

Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.

Journal Article J Biol Chem · July 15, 2005 Two characteristics of highly malignant cells are their increased motility and secretion of proteinases allowing these cells to penetrate surrounding basement membranes and metastasize. Activation of 21-kDa activated kinases (PAKs) is an important mechanis ... Full text Link to item Cite

Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin.

Journal Article J Leukoc Biol · July 2005 The unfolded protein response pathway (UPR) compensates for excessive protein accumulation in the endoplasmic reticulum (ER). As insulin induces global protein synthesis, it may cause accumulation of unfolded proteins in the ER, thus triggering UPR. We ass ... Full text Link to item Cite

The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling.

Journal Article J Immunol · February 15, 2005 MTJ-1 associates with a glucose-regulated protein of Mr approximately 78,000(GRP78) in the endoplasmic reticulum and modulates GRP78 activity as a chaperone. GRP78 also exists on the cell surface membrane, where it is associated with a number of functions. ... Full text Link to item Cite

Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.

Journal Article J Cell Biochem · November 15, 2004 Macrophage binding of receptor-recognized forms of alpha2-macrogobulin (alpha2M*) significantly increases cAMP, CREB, and activated CREB. We have now examined the participation of the PI 3-kinase/PDK/Akt/p70s6k signaling cascade in alpha2M*-induced cellula ... Full text Link to item Cite

A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling.

Journal Article Cell Signal · August 2004 The activated proteinase inhibitor alpha2-macroglobulin (alpha2M*) binds to two receptors, the low density lipoprotein receptor-related protein (LRP-1) and the alpha2M* signalling receptor (alpha2MSR). Silencing LRP-1 gene expression in macrophages by RNA ... Full text Link to item Cite

Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.

Journal Article Invest Ophthalmol Vis Sci · July 2004 PURPOSE: To investigate the role of lysophospholipid growth factors in the regulation of aqueous humor outflow in the trabecular meshwork (TM). METHODS: The expression profile of the endothelial differentiation gene (Edg) family of G-protein coupled recept ... Full text Link to item Cite

Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells.

Journal Article Cell Signal · April 2004 The alpha2-macroglobulin signalling receptor is upregulated in highly metastatic 1-LN prostate cancer cells. Stimulation of 1-LN cells with activated alpha2-macroglobulin (alpha2M*) caused a two- to threefold increase in [3H]thymidine uptake and cell numbe ... Full text Link to item Cite

Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+.

Journal Article Cell Signal · November 2003 Cadmium exposure increases the risk of prostate cancer. We now describe the effects of Cd2+ on signalling and proliferation in 1LN prostate cells. Cd2+ increased [3H]thymidine uptake and cell number twofold. Cd2+ elevated intracellular IP3, cytosolic-free ... Full text Link to item Cite

The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction.

Journal Article J Biol Chem · November 1, 2002 The low density lipoprotein receptor-related protein (LRP) is a scavenger receptor that binds to many proteins, some of which trigger signal transduction. Receptor-recognized forms of alpha(2)-Macroglobulin (alpha(2)M*) bind to LRP, but the pattern of sign ... Full text Link to item Cite

The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.

Journal Article J Biol Chem · September 27, 2002 Ligation of alpha(2)-macroglobulin receptors by receptor-recognized forms of alpha(2)-macroglobulin (alpha(2)M*) activates various signaling cascades and promotes cell proliferation. It also elevates cAMP in murine peritoneal macrophages. We now report tha ... Full text Link to item Cite

Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms.

Journal Article Cell Signal · April 2002 Cd(2+) exposure increases the risk of cancer in humans and animals. In this report, we have studied the effect of Cd(2+) on signal transduction and Ca(2+) mobilization in murine macrophages. At micromolar concentrations, Cd(2+) significantly increased cell ... Full text Link to item Cite

Beryllium fluoride-induced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation.

Journal Article J Leukoc Biol · March 2002 We studied the effect of beryllium fluoride on murine peritoneal macrophages and determined its effects on signal transduction and genetic regulation. At low concentration (1-5 nM), BeF(2) caused an approximate twofold increase in [(3)H]thymidine uptake an ... Link to item Cite

Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation.

Journal Article J Biol Chem · February 8, 2002 Macrophages exposed to receptor-recognized forms of alpha(2)-macroglobulin (alpha(2)M*) demonstrate increased DNA synthesis and cell division. In the current study, we have probed the role of cytosolic phospholipase A(2) (cPLA(2)) activity in the cellular ... Full text Link to item Cite

Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein.

Journal Article Arch Biochem Biophys · December 1, 2001 The low density lipoprotein receptor-related protein (LRP) consists of two subunits, M(r) approximately 515,000 and 85,000. LRP is a receptor for activated alpha2-macrogobulin (alpha2M*), Pseudomonas exotoxin A, and many other proteins. We now report that ... Full text Link to item Cite

Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor.

Journal Article Cell Signal · November 2001 We have studied the induction of cyclooxygenase-2 (COX-2) in macrophages consequent to ligating the alpha(2)-macroglobulin (alpha(2)M) signalling receptor (alpha(2)MSR) with receptor-recognized forms of alpha(2)M (alpha(2)M*). Macrophage stimulation with a ... Full text Link to item Cite

Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages.

Journal Article J Leukoc Biol · October 2001 Apolipoprotein E (ApoE) is a 34-kDa cholesterol transport protein that also possesses immunomodulatory properties. In this study, we demonstrate that ApoE initiates a signaling cascade in murine peritoneal macrophages that leads to increased production of ... Link to item Cite

Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin.

Journal Article Proc Natl Acad Sci U S A · June 5, 2001 Angiostatin blocks tumor angiogenesis in vivo, almost certainly through its demonstrated ability to block endothelial cell migration and proliferation. Although the mechanism of angiostatin action remains unknown, identification of F(1)-F(O) ATP synthase a ... Full text Link to item Cite

Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.

Journal Article Arch Biochem Biophys · February 15, 2001 We have studied the regulation of cytosolic phospholipase A2 (cPLA2) synthesis in macrophages stimulated with receptor-recognized forms of alpha2-macroglobulin (alpha2M*). [35S]methionine-labeled cells were stimulated with alpha2M* and [35S]cPLA2 was immun ... Full text Link to item Cite

Inducible expression of the alpha2-macroglobulin signaling receptor in response to antigenic stimulation: a study of second messenger generation.

Journal Article J Cell Biochem · 2001 Thioglycollate (TG)-elicited murine, peritoneal macrophages express two receptors for activated forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M*)--namely, the low density lipoprotein receptor-related protein (LRP) and the alpha2M signaling ... Full text Link to item Cite

Selective upregulated expression of the alpha2-macroglobulin signaling receptor in highly metastatic 1-LN prostate carcinoma cells.

Journal Article Arch Biochem Biophys · November 1, 2000 Cellular binding of receptor-recognized forms of alpha2-macroglobulin (alpha2M*) is mediated by the low-density lipoprotein receptor related protein (LRP) and the alpha2M signaling receptor (alpha2MSR). In nonmalignant cells, ligation of alpha2MSR promotes ... Full text Link to item Cite

Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin.

Journal Article Arch Biochem Biophys · July 1, 2000 We have studied the translocation of cytosolic phospholipase A(2) (cPLA(2)) to nuclei in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin (alpha(2)M*). Translocation of phosphorylated cPLA(2) to nuclei was determined by immun ... Full text Link to item Cite

Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin.

Journal Article Cell Signal · February 2000 Ligation of macrophage alpha(2)-macroglobulin signalling receptors (alpha(2)MSR) with activated alpha(2)-macroglobulin (alpha(2)M*) increases intracellular Ca(2+), and cytosolic phospholipase A(2) (cPLA(2)) and phospholipase D activities. In view of the re ... Full text Link to item Cite

Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages.

Journal Article Arch Biochem Biophys · December 15, 1999 We have probed the signaling characteristics of the macrophage low-density lipoprotein receptor-related protein (LRP) with monoclonal antibody 8G1, its Fab and F(ab')(2) fragments directed against the ligand binding heavy chain, and monoclonal antibody 5A6 ... Full text Link to item Cite

Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin.

Journal Article J Biol Chem · September 3, 1999 We have studied insulin-dependent regulation of macrophage alpha(2)-macroglobulin signaling receptors (alpha(2)MSR) and low density lipoprotein receptor-related protein/alpha(2)M receptors (LRP/alpha(2)MR) employing cell binding of (125)I-alpha(2)M*, inhib ... Full text Link to item Cite

Exposure of cultured murine peritoneal macrophages to low concentrations of beryllium induces increases in intracellular calcium concentrations and stimulates DNA synthesis.

Journal Article J Leukoc Biol · June 1999 Exposure of humans to beryllium dusts can induce a specific form of chronic pneumonitis that consists mainly of noncaseating granulomas in the lungs. Multiple studies have documented both genetic and immune components of chronic berylliosis. Much work has ... Full text Link to item Cite

Upregulation of macrophage plasma membrane and nuclear phospholipase D activity on ligation of the alpha2-macroglobulin signaling receptor: involvement of heterotrimeric and monomeric G proteins.

Journal Article Arch Biochem Biophys · March 1, 1999 The effect of ligating the alpha2-macroglobulin signaling receptor (alpha2MSR) with receptor-recognized forms of alpha2M (alpha2M*) was studied with respect to phospholipase D (PLD) activity in murine macrophages, their plasma membranes, and nuclei. PLD ac ... Full text Link to item Cite

Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages.

Journal Article J Immunol · December 1, 1998 We have studied the effects of the immunosuppressive drug cyclosporin A (CsA) on the generation of inositol 1,4,5-trisphosphate (IP3) and intracellular Ca2+ levels elicited upon ligation of murine macrophage receptors for alpha2-macroglobulin, bradykinin, ... Link to item Cite

APOE3 and APOE4 binding to macrophages triggers inositol (1,4,5-) triphosphate-mediated increases in intracellular calcium

Journal Article FASEB Journal · December 1, 1998 Apolipoprotein E (apoE) is a 34 kDa protein that mediates binding of lipopro teins to the LDL and LRP receptors- Apart from maintaining plasma cholesterol homeostasis, apoE may participate in mobilization and redistribution of lipids during normal developm ... Cite

Upregulation of a2m signalling receptor by insulin in macrophages

Journal Article FASEB Journal · December 1, 1998 In 1984 this laboratory showed that the treatment of adipocytes and fibrob lasts with insulin enhanced the binding of 125I-a2M-methylamine by about 2-3 fold and its slowed receptor-mediated degradation. We have recently reported the presence of a novel ojM ... Cite

Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone.

Journal Article Toxicol Appl Pharmacol · July 1998 Exposure of murine peritoneal macrophages to very low concentrations of 1,4-benzoquinone (BQ) induced immediate increases in intracellular Ca2+ concentrations ([Ca2+]i). Increases in [Ca2+]i were induced by concentrations as low as 5 nM and the response wa ... Full text Link to item Cite

Ligation of the alpha2M signalling receptor elevates the levels of p21Ras-GTP in macrophages.

Journal Article Cell Signal · June 1998 Ligation of the alpha2-macroglobulin signalling receptor (alpha2MSR) with alpha2-macroglobulin (alpha2M)-methylamine or a cloned and expressed receptor binding fragment (RBF) stimulates DNA synthesis. To examine the possible role of the Ras pathway in the ... Full text Link to item Cite

Binding of receptor-recognized forms of alpha2-macroglobulin to the alpha2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase.

Journal Article J Biol Chem · May 29, 1998 Ligation of the alpha2-macroglobulin (alpha2M) signaling receptor by receptor-recognized forms of alpha2M (alpha2M*) initiates mitogenesis secondary to increased intracellular Ca2+. We report here that ligation of the alpha2M signaling receptor also causes ... Full text Link to item Cite

Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium.

Journal Article Biochim Biophys Acta · January 2, 1998 We have previously reported that receptor-recognized forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M) bind to a distinct receptor (alpha2MSR), Kd approximately 50-100 pM, activating a signaling cascade, triggering tyrosine phosphorylation o ... Full text Link to item Cite

Cyclosporin a inhibits ip,-mediated release of calcium from intracellu lar stores in macrophages

Journal Article FASEB Journal · December 1, 1997 Cycloporin A (CsA) and FKöOfi interteie wiHi Ca2+ -nnsimc T-cell sigtial l raii-duct ion pathways, preventing 'he activation of specific transcription fulors involved in lymphokine gene expression. CsA find FK">Oli act by interaction witii (orna ... Cite

Activation of ARF- But not RHO-dependent nuclear phospholipase D in murine peritoneal macrophages on ligation of cvM signaling receptor

Journal Article FASEB Journal · December 1, 1997 Activation of phospholipase D (PLD) is a receptor-mediated event revolved m signal transduction, ntembrane trafficking, cell proliferation, and phagocytosis Phosphatidic acid (PA). the prmary lipid product of PLD, possesses growth factors-like properties a ... Cite

Nickel inhibits binding of alpha2-macroglobulin-methylamine to the low-density lipoprotein receptor-related protein/alpha2-macroglobulin receptor but not the alpha2-macroglobulin signaling receptor.

Journal Article Biochemistry · October 14, 1997 A previous study demonstrated that activated alpha2-macroglobulin (alpha2M*) binding to the low-density receptor-related protein/alpha2-macroglobulin receptor (LRP/alpha2MR) is blocked by Ni2+ [Hussain, M. M., et al. (1995) Biochemistry 34, 16074-16081]. W ... Full text Link to item Cite

Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor.

Journal Article J Cell Biochem · February 1997 The binding of many ligands to cellular receptors induces a signaling cascade which generates inositol 1,4,5-trisphosphate (IP3). IP3 binding to its receptors in various internal compartments causes a rapid Ca2+ efflux into the cytosol. We now demonstrate ... Full text Link to item Cite

Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts.

Journal Article J Biol Chem · January 3, 1997 In the present study, we demonstrate that the alpha2-macroglobulin (alpha2M) signaling receptor is up-regulated on rheumatoid synovial fibroblasts. In rheumatoid cells, 125I-alpha2M-methylamine bound to two sites; namely, one of high affinity (Kd approxima ... Full text Link to item Cite

Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages.

Journal Article J Leukoc Biol · December 1996 The interaction of altered lipids or proteins with the several scavenger receptors (SR) on macrophages can lead to disparate results in both gene expression and cell function. However, the molecular bases of signaling induced by SR ligation have remained o ... Full text Link to item Cite

Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor.

Journal Article Biochim Biophys Acta · October 17, 1996 Site-directed mutagenesis of residues in the receptor binding fragment of rat alpha 1-macroglobulin identify residues 1377 and 1378 (human numbering) as crucial for interaction with the alpha 2M signaling receptor on murine macrophages. Secondary structure ... Full text Link to item Cite

Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor.

Journal Article J Biol Chem · June 14, 1996 alpha2-Macroglobulin (alpha2M) activated with methylamine binds to two distinct cell-surface receptors: low density-lipoprotein receptor-related protein/alpha2M receptors and alpha2M signaling receptors. Binding to lipoprotein receptor-related protein/alph ... Full text Link to item Cite

Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor.

Journal Article J Cell Biochem · April 1996 The binding of receptor-recognized forms of alpha 2-macroglobulin (alpha 2M) to macrophage alpha 2M signaling receptors increases inositol-1,4,5-triphosphate synthesis and induces Ca2+ mobilization. In this report, we demonstrate that ligation of the macro ... Full text Link to item Cite

Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers.

Journal Article J Cell Biochem · April 1996 Binding of receptor-recognized forms of tetrameric human alpha 2-macroglobulin (alpha 2M*) to a macrophage signaling receptor induces cAMP synthesis, increases in inositol 1,4,5-triphosphate (IP3) synthesis, and a concomitant rise in cytosolic free calcium ... Full text Link to item Cite

Differential activity of protein kinase C in alveolar and peritoneal macrophages.

Journal Article Indian J Biochem Biophys · April 1996 The characteristics of protein kinase C activity present in guinea pig alveolar and peritoneal macrophages have been compared and examined. The activity is predominantly cytosolic with preference for phosphatidyl serine as cofactor over other phospholipids ... Link to item Cite

Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor.

Journal Article J Clin Invest · March 1, 1996 Receptor-recognized forms of alpha 2-macroglobulin (alpha 2M*) bind to two macrophage receptors: an endocytic receptor, the low density lipoprotein receptor-related protein/alpha 2M receptor (LRP/alpha 2MR), and a G protein-coupled receptor, the alpha 2M s ... Full text Link to item Cite

Effect of dietary protein manipulation on translocation of protein kinase C activity in various tissues of rats.

Journal Article Indian J Exp Biol · March 1996 Ingestion of protein deficient diet is known to decrease the enzyme load, particularly drug metabolising enzymes in liver. It also leads to decrease in polyphosphoinositide pool in brain and kidney. Therefore, changes in protein kinase C activity and its t ... Link to item Cite

Ligation of the alpha 2-macroglobulin signalling receptor on macrophages induces protein phosphorylation and an increase in cytosolic pH.

Journal Article Biochem J · July 1, 1995 We have recently described an alpha 2-macroglobulin (alpha 2M) signalling receptor which is distinct from the low-density lipoprotein-related protein/alpha 2M receptor (LRP/alpha 2MR). Ligation of the macrophage signalling receptor by alpha 2M-methylamine ... Full text Link to item Cite

Oxidized low density lipoprotein suppresses activation of NF kappa B in macrophages via a pertussis toxin-sensitive signaling mechanism.

Journal Article J Biol Chem · February 24, 1995 The interaction of oxidized low density lipoprotein (ox-LDL) and macrophages is generally believed to be a significant inductive step in atherogenesis. Endocytosis of ox-LDL by scavenger receptors (SR) on macrophages is one result of this interaction, as i ... Full text Link to item Cite

Ligation of alpha 2M receptors with alpha 2M-methylamine stimulates the activities of phospholipase C, phospholipase A2, and protein kinase C in murine peritoneal macrophages.

Journal Article Ann N Y Acad Sci · September 10, 1994 Full text Link to item Cite

Alpha 2-macroglobulin: a sensor for proteolysis.

Journal Article Ann N Y Acad Sci · September 10, 1994 Full text Link to item Cite

The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.

Journal Article J Biol Chem · July 15, 1994 alpha 2-Macroglobulin (alpha 2M)-methylamine binding to macrophages appears to involve two receptors. Binding of alpha 2M-methylamine to low density lipoprotein-related protein (LRP) results in cellular uptake and degradation, while binding to a newly desc ... Link to item Cite

Evidence for a second alpha 2-macroglobulin receptor.

Journal Article J Biol Chem · April 29, 1994 alpha 2-Macroglobulin (alpha 2M)-methylamine binds to purified low density lipoprotein receptor-related protein (LRP), and it is assumed that LRP functions as the alpha 2M receptor in vivo. Binding of alpha 2M-methylamine to macrophage receptors elevates i ... Link to item Cite

Clinical aspects of neurolathyrism in Unnao, India.

Journal Article Paraplegia · April 1993 To study the clinical picture of lathyrism in Unnao, India and compare it with that reported from other endemic areas, 41 patients from Unnao were studied. Their mean age was 42.9 years (range 22-85) and the mean duration of the illness was 17.1 years (ran ... Full text Link to item Cite

Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages.

Journal Article Biochem J · March 15, 1993 Human plasma alpha 2-macroglobulin (alpha 2M) is a tetrameric proteinase inhibitor, which undergoes a conformational change upon reaction with either a proteinase or methylamine. As a result, a receptor recognition site is exposed on each subunit of the mo ... Full text Link to item Cite

Chronic ethanol treatment induces H2O2 production selectively in pericentral regions of the liver lobule.

Journal Article Alcohol Clin Exp Res · October 1992 Chronic treatment with ethanol damages pericentral regions of the liver selectively, and reactive oxygen species such as H2O2 may be involved in the mechanism of hepatotoxicity. To test this idea, the effect of chronic treatment with ethanol on rates of H2 ... Full text Link to item Cite

Hepatic plasma membrane fluidity and dietary proteins.

Journal Article Indian J Biochem Biophys · August 1991 Effect of protein deficient diet on hepatic plasma membrane fluidity has been studied in rats using (i) steady state fluorescence polarization and anisotropy, (ii) phospholipid and cholesterol contents, (iii) phospholipid fatty acid composition, (iv) turno ... Link to item Cite

Phosphoinositides of sheep platelets plasma membranes.

Journal Article Indian J Biochem Biophys · April 1991 Phospholipid composition of sheep blood platelets and its various plasma membrane fractions have been analyzed. Based on their flotation rates in discontinuous sucrose density gradient centrifugation, three membrane fractions were isolated. 5'-Nucelotidase ... Link to item Cite

Hepatic mitochondrial membrane lipid environment and protein nutrition.

Journal Article Indian J Biochem Biophys · February 1991 Effect of feeding rice diet with and without lysine and threonine supplementation on hepatic mitochondria and its inner and outer membrane proteins, enzymes and phospholipids has been studied. The exchange of phosphatidylcholine and phosphatidylethanolamin ... Link to item Cite

Elevation of rat pulmonary, hepatic and lung surfactant lipids by fly ash inhalation.

Journal Article Biochem Pharmacol · January 15, 1991 Fly ash contains many polycyclic aromatic hydrocarbons and genotoxic trace elements. In rats, fly ash exposure profoundly affects lung and liver histology. In the present study, the effect of fly ash inhalation on lung and liver lipids of rats was examined ... Full text Link to item Cite

Lung subcellular fractions and surfactant lipid metabolism of rats exposed with DDT or endosulfan intratracheally.

Journal Article J Environ Sci Health B · April 1990 The effect of intratracheally administered DDT (5 mg/100 g body weight) or endosulfan (1 mg/100 g body weight) for three consecutive days has been studied on lipid metabolism of rat lung subcellular fractions. Both the insecticides did not affect the lung ... Full text Link to item Cite

Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan.

Journal Article J Environ Sci Health B · April 1990 The effect of intratracheal administration of DDT (5 mg/100 g body weight) or endosulfan (1 mg/100 g body weight) to rats for three consecutive days, has been studied on liver lipid metabolism. The administration of DDT but not endosulfan significantly inc ... Full text Link to item Cite

Maternal vitamin A restriction alters biochemical development of the brain in rats.

Journal Article Experientia · February 15, 1990 The biochemical development of the fetal brain in relation to maternal vitamin A restriction was studied in rats. The vitamin A status of pregnant rats was varied by supplying low, medium and adequate amounts (6, 40, and 100 micrograms retinol/day/kg body ... Full text Link to item Cite

Placental transfer of metals of coal fly ash into various fetal organs of rat.

Journal Article Arch Toxicol · 1990 Fly ash (100 mg/kg body weight) was administered intratracheally to 14-day pregnant rats for 6 consecutive days. On day 20 of gestation the translocation of metals present in the fly ash to various maternal and fetal organs was studied. Fly ash administrat ... Full text Link to item Cite

Interaction of ethanol, cholesterol and vitamin A on phospholipid methylation in hepatic microsomes of rats.

Journal Article Int J Vitam Nutr Res · 1990 Effect of ethanol, cholesterol and vitamin A either alone or in combination has been studied on cyt P450 and phospholipid methylation in hepatic microsomes of rats. Ethanol increased cyt P450 activity and decreased phospholipid methylation. Cholesterol eff ... Link to item Cite

Apparent multiplicity of retinol binding proteins in goat milk

Journal Article Nutrition Reports International · December 1, 1989 Cite

Altered synthesis of phospholipid molecular species in hepatic endoplasmic reticulum on feeding of different proteins

Journal Article Nutrition Reports International · December 1, 1989 Cite

Reduction in pulmonary and hepatic respiratory cytochrome contents by fly ash inhalation in rats.

Journal Article Toxicol Lett · October 1989 Exposure of rats to fly ash for 15 days, 6 hours daily, inhibited pulmonary and hepatic NADH-oxidase activity. The content of cytochrome b and cytochromes a + a3 was significantly lower in the lungs of the fly-ash-exposed group. However, in liver, fly ash ... Full text Link to item Cite

Secretion pattern of retinol-binding protein in blood of goats: effect of vitamin A, provitamin A and their dosing schedule.

Journal Article Z Ernahrungswiss · September 1989 Studies were conducted on the secretion of retinol-binding protein (RBP) in blood of goats given different treatments of preformed vitamin A, beta-carotene and plant carotenoids. Administration of these sources either in a single massive dose or massive do ... Full text Link to item Cite

Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats.

Journal Article Toxicology · May 31, 1989 The effect of fly ash inhalation on xenobiotic metabolizing enzymes and heme metabolism in lung and liver has been studied in rats. Fly ash inhalation induced pulmonary and hepatic cytochrome P-450 content, aryl hydrocarbon hydroxylase and glutathione S-tr ... Full text Link to item Cite

Induction of phosphatidylcholine biosynthesis via CDPcholine pathway in lung and liver of rats following intratracheal administration of DDT and endosulfan.

Journal Article J Biochem Toxicol · 1989 The induction of phosphatidylcholine (PC) biosynthesis via the CDPcholine pathway in lung and liver of rats has been shown following the intratracheal administration of 1,1,1-trichloro-2m2-bis(p-chlorophenyl) ethane (DDT) (5 mg/100 g body weight) and endos ... Full text Link to item Cite

Second messenger and its regulatory enzymes under protein nutrition

Journal Article Nutrition Research · January 1, 1989 In rat pancreatic tissue the levels of cAMP are elevated in protein deficient diet and lowered in the case of protein rich diet. The activity of the enzymes for the synthesis and degradation of this molecule namely adenylate cyclase (AC) and phosphodiester ... Full text Cite

Effect of permethrin and cypermethrin on vitamin A distribution to the various organs of chicks fed vitamin A-deficient diet

Journal Article Nutrition Reports International · January 1, 1989 Cite

Hepatic phosphatidylcholine synthesis in deficiency of lysine and threonine: effect of malathion.

Journal Article Experientia · September 15, 1988 Rats fed on a rice diet deficient in lysine and threonine showed increased activities of CDP-Choline pathway enzymes and incorporation of (methyl-3H)-choline into hepatic microsomal phosphatidylcholine, compared to rats fed on the same diet supplemented wi ... Full text Link to item Cite

Pulmonary and hepatic glutathione levels, glutathione shuttle enzymes and lipid peroxidation in rats exposed intratracheally to coal fly ash.

Journal Article Biochem Int · September 1988 Fly ash and fly ash residue increased the formation of conjugated dienes and the levels of oxidized glutathione (GSSG) and reduced the levels of reduced glutathione (GSH) in lung and liver whereas fly ash extract administration had no effect on the formati ... Link to item Cite

Mixed function oxidases in response to quality and quantity of dietary protein.

Journal Article Biochem Int · July 1988 Feeding of rice diet reduced the food consumption and growth of rats. Hepatic Cytochrome P-450, NADPH Cytochrome c reductase and the activity of cytochrome P-450 dependent enzymes (Aniline hydroxylase, aminopyrine N-demethylase, p-nitroanisole O-demethylas ... Link to item Cite

Vitamin A supply and biochemical development of the rat heart: studies on cellular DNA, RNA and protein.

Journal Article Z Ernahrungswiss · June 1988 The effect of restricted vitamin A supply to the mother on the biochemical development of the heart in rats has been studied. The vitamin A status of female rats was varied by supplying low, medium and adequate amounts (6, 40, 100 micrograms retinol/day/kg ... Full text Link to item Cite

Effect of spermine on membranolytic effect of vitamin A in rats.

Journal Article Int J Vitam Nutr Res · 1988 The effect of spermine on membranolytic effect of vitamin A has been studied on mitochondrial membrane integrity by examining phospholipase A2 activity and membrane phospholipids. Spermine arrest the vitamin A induced activity of mitochondrial phospholipas ... Link to item Cite

Function of microtubules under inadequate protein diet.

Journal Article Int J Vitam Nutr Res · 1988 Microtubules from pancreas have been isolated and estimated. It was found that rats fed with lysine and threonine deficient diet have profoundly lowered levels of microtubules as compared to rats fed either with lysine and threonine supplemented diet or a ... Link to item Cite

Induction of hepatic mixed-function oxidases by permethrin and cypermethrin in chicks fed vitamin A-deficient diet

Journal Article Pesticide Biochemistry and Physiology · January 1, 1988 The effect of permethrin and cypermethrin on the induction of hepatic mixed-function oxidases was studied in chicks fed a vitamin A-deficient diet. Oral administration of permethrin at 10, 50, 100, and 200 mg/kg for 6 consecutive days induced microsomal pr ... Full text Cite

Possible involvement of the cellular retinol binding protein (cRBP) in retinol uptake in vitro

Journal Article Nutrition Reports International · January 1, 1988 The role of cellular retinol binding protein (cRBP) in the uptake of retinol by mammary gland (target tissue) was studied in vitro by using purified cRBP from goat mammary gland. The cRBP mediated retinol uptake process was found to be saturable. The serum ... Cite

Endoplasmic reticulum phospholipid and mixed function oxidase system on proteins feeding

Journal Article Nutrition Research · January 1, 1988 A relationship between phosphatidylcholine metabolism and mixed function oxidases was evaluated in rats fed with different proteins diets. Hepatic rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) phosphatidylcholine (PC) was signifi ... Full text Cite

Induction of hepatic drug metabolizing enzymes by coal fly ash in rats.

Journal Article Environ Res · December 1987 The effect of intratracheal administration of fly ash, its benzene-extracted residue and the benzene extract has been studied on the activities of hepatic mixed-function oxidases in the rat. Fly ash and its fractions significantly increased the levels of c ... Full text Link to item Cite

Cytotoxicity of inhaled coal fly ash in rats.

Journal Article Environ Res · June 1987 The effect of inhalation of coal fly ash for 6 hr daily for 15 days has been studied on the hematology, blood chemistry, and histopathology of lungs and liver of rats up to 4 months from the first day of exposure. Fly ash inhalation significantly reduced W ... Full text Link to item Cite

Biochemical development of the rat lung: studies on cellular DNA, RNA and protein content in relation to maternal vitamin A status.

Journal Article Z Ernahrungswiss · June 1987 The effect of maternal vitamin A restriction on the biochemical development of the lung in rats has been studied. The vitamin A status of dams has been varied by supplying low, medium and adequate amounts of vitamin A (6, 40 and 100 micrograms retinol/day/ ... Full text Link to item Cite

Isolation and purification of cellular retinol binding protein (CRBP) from goat mammary gland.

Journal Article Life Sci · March 2, 1987 The cellular retinol binding protein (CRBP) from goat mammary gland has been isolated in pure form. The molecular weight of CRBP by gel filtration was 15,120 dalton. The 280/350 absorbance ratio of this protein was 1.20 and it gave a single precipitin line ... Full text Link to item Cite

Distribution of vitamin A in various organs of rats in relation to the quality and the quantity of dietary proteins.

Journal Article Z Ernahrungswiss · March 1987 The influence of the quality and the quantity of dietary proteins on the distribution of a single massive dose of vitamin A in various organs of growing Wistar strain rats has been studied by using casein and bengal gram diets at 20% and 10% protein levels ... Full text Link to item Cite

Interaction of ethanol and acute hypoxia (7620 m) on vitamin A distribution in rat organs.

Journal Article Int J Vitam Nutr Res · 1987 The effect of a moderate dose of ethanol (3 g/kg body weight) and acute hypoxia (282 mmHg pressure) for 6 h on vitamin A content of rat tissue has been investigated. In addition, to find the effect of ethanol administration and hypoxic exposure on freshly ... Link to item Cite

Rice diet deficient in lysine and threonine alters normal cholesterol metabolism of rat hepatic Golgi apparatus

Journal Article Nutrition Research · January 1, 1987 The effects of feeding a diet deficient in lysine and threonine on the cholesterol metabolism of rat hepatic Golgi apparatus and microsomes was studied. Rice diet without supplementation of lysine and threonine resulted in decreased cholesterol contents of ... Full text Cite

Coal fly ash induces hepatic and pulmonary cytochrome P-450 and sigma-aminolevulinic acid synthetase in rats.

Journal Article J Toxicol Environ Health · 1987 The effect of intratracheal administration of coal fly ash, its benzene-soluble and benzene-insoluble fractions has been studied on the levels of hepatic and pulmonary cytochrome P-450, cytochrome b5, and the activities of sigma-aminolevulinic acid synthet ... Full text Link to item Cite

Effect of simulated hypoxia (7620 m, 6 h) on hepatic microsomal drug metabolising enzymes activity in rats given ethanol and vitamin A.

Journal Article Int J Vitam Nutr Res · 1987 The hepatic MFO activity has been studied in rats exposed to acute hypoxia given single dose of ethanol (3 g/kg body weight) alone or along with 10,000 I.U. of vitamin A. The cytochrome P-450 was found to be depressed on ethanol administration in rats. Hyp ... Link to item Cite

In vitro secretion and uptake of radioactive vitamin A in rats fed different dietary proteins.

Journal Article Ann Nutr Metab · 1987 Generally, protein energy malnutrition is accompanied with vitamin A deficiency. The present study was undertaken to evaluate the importance of the quality and the quantity of dietary proteins on the in vitro secretion and uptake of vitamin A in growing ra ... Full text Link to item Cite

Changes of fatty acid composition in pancreas of rats fed inadequate dietary protein

Journal Article Nutrition Research · January 1, 1987 Rats fed deficient dients and supplemented with lysine and threonine significantly affected the fatty acid composition of the pancreas as compared to rats fed casein diet. The major fatty acids indentified include C16:0, C16:1, C ... Full text Cite

An improved method for the isolation of human serum retinol binding protein (S-RBP).

Journal Article Indian J Biochem Biophys · August 1986 Link to item Cite

Hepatic microsomal phospholipids in rats exposed intratracheally to coal fly ash.

Journal Article Arch Toxicol · February 1986 The effects of intratracheal administration of fly ash (50 mg/kg body weight, daily for 7 days) on hepatic microsomal phospholipid metabolism has been studied in rats using various phospholipid precursors, viz NaH2(32)PO4, (methyl-14C)-choline, and (methyl ... Full text Link to item Cite

Effect of single massive dose of vitamin A on hepatic and plasma phospholipids of rats fed different dietary proteins

Journal Article Nutrition Reports International · January 1, 1986 Cite

Seasonal variations of metals in coal fly ash

Journal Article Environmental Pollution Series B Chemical and Physical · January 1, 1986 Seasonal variations in fly ash collected from the electrostatic precipitator of a thermal power plant over a period of a year have been studied in parameters of (i) particle size, (ii) per cent silicate, (iii) haemolysis and (iv) contents of Ni, Pb, Mn, Zn ... Full text Cite

Fetal translocation and metabolism of PAH obtained from coal fly ash given intratracheally to pregnant rats.

Journal Article J Toxicol Environ Health · 1986 Polycyclic aromatic hydrocarbons (PAH) were extracted from coal fly ash collected from the electrostatic precipitator of a thermal power plant. The PAH extract was given intratracheally daily to pregnant rats (2 mg/100 g body weight) on d 18 and 19 of gest ... Full text Link to item Cite

Turnover of pancreas phospholipids in rats fed inadequate dietary protein.

Journal Article Int J Vitam Nutr Res · 1986 Effect of feeding rice diets with and without lysine and threonine supplementation has been studied on phospholipid turnover of rat pancreas and compared to rats fed casein diet at 20% protein level. Rice diet without amino acid supplementation significant ... Link to item Cite

Placental transfer and fetal distribution of 3H-retinoic acid in rats.

Journal Article Int J Vitam Nutr Res · 1986 The placental transfer of 3H-retinoic acid in vitamin A deprived and vitamin A supplemented pregnant female rats was studied on 20th day of gestation and compared with 3H-retinyl acetate. Radiolabelled compounds were administered to pregnant mothers orally ... Link to item Cite

Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate.

Journal Article J Toxicol Environ Health · 1986 Administration of benzene-soluble fraction (FAE) and benzene-insoluble fraction (FAR) of fly ash for 3 consecutive days to rats significantly raised cytochrome P-450 levels, aryl hydrocarbon hydroxylase (AHH) activity, and glutathione S-transferase activit ... Full text Link to item Cite

Postnatal distribution of vitamin A in liver, lung, heart and brain of the rat in relation to maternal vitamin A status.

Journal Article Biol Neonate · 1986 The effect of low, medium and adequate vitamin A (6, 40 and 100 micrograms/day/kg body weight) supplementation to the dams was studied on the accumulation of vitamin A in various tissues of the rat during postnatal growth. The restricted supply of vitamin ... Full text Link to item Cite

Phosphatidylcholine metabolism in lung microsomes and lung surfactant of rats exposed intratracheally to coal fly ash.

Journal Article J Toxicol Environ Health · 1986 The effect of intratracheal administration of fly ash has been studied on lung microsomal and lung surfactant phosphatidylcholine (PC) metabolism in rats using [methyl-14C]choline and [methyl-14C]methionine. Fly-ash administration significantly increased t ... Full text Link to item Cite

Induction of cytochrome P-450 and phosphatidylcholine synthesis by endosulfan in liver of rats: effect of quality of dietary proteins.

Journal Article J Environ Sci Health B · December 1985 Administration of endosulfan significantly increased microsomal protein, cytochrome P-450 content and the activity of aminopyrine N-demethylase. Effect of endosulfan and actinomycin D either alone or together on microsomal protein, cytochrome P-450, NADPH ... Full text Link to item Cite

Evidence for colchicine binding protein in Mycobacterium smegmatis.

Journal Article Indian J Biochem Biophys · October 1985 Link to item Cite

Induction of pulmonary drug metabolizing enzymes by coal fly ash in rats.

Journal Article Toxicology · August 1985 The effect of intratracheal administration of fly ash, benzene extracted fly ash residue and benzene extract of fly ash has been studied on the activity of pulmonary mixed function oxidase. Fly ash, its benzene extract and benzene extracted residue signifi ... Full text Link to item Cite

Quality & quantity of dietary protein & acute endosulphan metabolic toxicity in rat liver microsomes.

Journal Article Indian J Med Res · May 1985 Link to item Cite

Polycyclic aromatic hydrocarbons of coal fly ash: analysis by gas-liquid chromatography using nematic liquid crystals.

Journal Article J Toxicol Environ Health · 1985 The seasonal variations over a period of 12 m in the amounts of polycyclic aromatic hydrocarbons (PAH) in fly-ash samples collected from the electrostatic precipitator of a thermal power plant have been studied. PAH generally did not show much seasonal var ... Full text Link to item Cite

Effect of inadequate dietary proteins on pancreatic insulin and cAMP levels in rats

Journal Article Nutrition Reports International · January 1, 1985 Feeding of lysine and threonine deficient and supplemented rice diets for four weeks lowered serum insulin levels and increased pancreatic insulin levels as compared to rats fed a casein diet at 20% protein level. Pancreatic cAMP levels were significantly ... Cite

Cytotoxicity of intratracheally administered coal fly ash: studies on liver and plasma lipids in rats.

Journal Article Arch Environ Contam Toxicol · January 1985 Full text Link to item Cite

Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats.

Journal Article Bull Environ Contam Toxicol · January 1985 Full text Link to item Cite

Cytotoxicity of intratracheally administered coal fly ash: studies on lipids in the lung of rats.

Journal Article Arch Environ Contam Toxicol · January 1985 Full text Link to item Cite

Effect of vitamin A on hepatic microsomal drug metabolising enzymes activity in rats exposed to acute hypoxia.

Journal Article Int J Vitam Nutr Res · 1985 The hepatic drug metabolising enzymes activity has been studied in rats exposed to acute hypoxia alone or along with supplementation of single dose of 10 000 I.U. Vitamin A. Hypoxic stress reduces the activities of cytochrome P-450, cytochrome c-reductase ... Link to item Cite

delta-Aminolevulinic acid synthetase and heme oxygenase activity in lung and liver of rats given DDT and endosulfan intratracheally.

Journal Article Bull Environ Contam Toxicol · January 1985 Full text Link to item Cite

Effect of inhalation of coal fly ash on vitamin A distribution in organs of the rat.

Journal Article J Toxicol Environ Health · 1985 Fly ash contains several polycyclic aromatic hydrocarbons. The effect of inhalation of coal fly ash on vitamin A distribution in various organs of rat has been studied. Inhalation of fly ash for 6 h daily, for 15 d, decreased vitamin A content in liver. Th ... Full text Link to item Cite

Lipid peroxidation in lung and liver of rats given DDT and endosulfan intratracheally.

Journal Article Bull Environ Contam Toxicol · January 1985 Full text Link to item Cite

Developmental pattern of the hepatic DNA, RNA and protein in relation to maternal vitamin A status in rats.

Journal Article Acta Vitaminol Enzymol · 1985 The effect of maternal vitamin A restriction on the biochemical development of fetal liver in rats has been studied. Vitamin A status of the dams has been varied by supplying low, medium and adequate (6.40 and 100 micrograms retinol equivalents/day/kg body ... Link to item Cite

A relationship between dietary protein and vitamin A metabolism: Studies on cellular triglyceride and cholesterol levels of rats

Journal Article Nutrition Reports International · January 1, 1985 The quality and quantity of dietary proteins show their affect on various lipid components (e.g. triglyceride, total cholesterol, free cholesterol, esterified cholesterol) of liver, lung, heart and kidney organs of rats. In relation to dietary proteins, or ... Cite

Effect of intratracheally administered DDT and endosulfan on pulmonary and hepatic respiratory cytochromes.

Journal Article Bull Environ Contam Toxicol · August 1984 Full text Link to item Cite

Distribution of metals of inhaled fly ash in various organs of rats at various periods after exposure

Journal Article Journal of Environmental Science and Health Part A Environmental Science and Engineering · August 1, 1984 Effect of inhalation of coal fly ash for 6 hrs daily for fifteen days has been studied on the distribution of metal ions of fly ash in lung, liver, kidney, heart, small intestine and serum of rata 1, 7, 15 and 30 days after the last inhalation exposure. Th ... Full text Cite

Biochemical and pathological effects of fly ash on lung, liver, and blood of rats.

Journal Article Arch Environ Contam Toxicol · July 1984 Full text Link to item Cite

Induction of hepatic mixed function oxidase system by endosulfan in rats.

Journal Article Bull Environ Contam Toxicol · May 1984 Full text Link to item Cite

Inhibition of hepatic phosphatidylcholine synthesis by malathion in rats.

Journal Article Toxicol Lett · February 1984 Rats maintained on a 20% casein diet were given malathion orally throughout the feeding period (100 mg/kg body weight/day, dissolved in groundnut oil). Hepatic choline kinase (EC 2.7.1.32) and cholinephosphate cytidyltransferase (EC 2.7.7.15) activities we ... Full text Link to item Cite

An improved method for isolation of retinol-binding protein from goat serum.

Journal Article Indian J Biochem Biophys · February 1984 Link to item Cite

Restoration of vitamin A deficiency induced lesions by provitamin A carotenoids in chicks: Studies on tissue DNA, RNA and protein

Journal Article Nutrition Reports International · January 1, 1984 Cite

Efficacy of provitamin A carotenoids in reversing vitamin A deficiency induced lesions in brain lipids of chicks.

Journal Article Acta Vitaminol Enzymol · 1984 Link to item Cite

Vitamin A and biochemical development. II. Effect of postnatal excess vitamin-A administration on the activity of pyridine nucleotide-linked dehydrogenases.

Journal Article Biol Neonate · 1984 The effect of excess vitamin A, (1,000 IU) administration to rat pups on the 4th, 6th, 8th and 10th days of age was studied on the activities of combined HMP dehydrogenases, malic enzyme and isocitrate dehydrogenase on the 11th, 17th and 23rd days of age. ... Full text Link to item Cite

A block in the release of hepatic triglyceride at Golgi to plasma membrane level in rats fed lysine and threonine deficient rice diet

Journal Article Nutrition Reports International · January 1, 1984 Cite

Endosulfan alters the distribution of 3H-retinyl acetate in various organs of rats

Journal Article Nutrition Reports International · January 1, 1984 Cite

Triglycerides of hepatic Golgi rich fraction and plasma membranes of rats fed inadequate dietary proteins

Journal Article Nutrition Reports International · January 1, 1984 Cite

Interaction of endosulfan and dietary vitamin A on rat hepatic drug metabolising enzymes.

Journal Article Acta Vitaminol Enzymol · 1983 The effect of interaction of Endosulfan, a chlorinated insecticide of the cyclodiene group, with dietary vitamin A on the hepatic mixed function oxidase system in rats has been studied. Endosulfan administration (ten days) significantly increased microsoma ... Link to item Cite

Developmental pattern of DNA and proteins in brain, liver, lung and heart of rats given excess vitamin A postnatally.

Journal Article Biol Neonate · 1983 The effect of an excessive dose of vitamin A (1,000 IU) to rat pups on 4, 6, 8 and 10 days of age was studied on growth and organ weights. The effects on the amounts of DNA and proteins and incorporation of 3H-thymidine into DNA and 3H-leucine into protein ... Full text Link to item Cite

Vitamin A and RBP contents of milk of goats given a single massive dose of vitamin A orally

Journal Article Nutrition Reports International · January 1, 1983 Cite

Impaired Myelination in rats given excess vitamin A postnatally.

Journal Article Int J Vitam Nutr Res · 1983 The effect of postnatal administration of 1000 I.U. of Vitamin A on 4th, 6th, 8th, and 10th day of age to rat pups has been studied on brain myelin lipid and sulphatide synthesis from Na235SO4. Administration of vitamin A reduced brain weight, free cholest ... Link to item Cite

Phosphatidyl N-methylethanolamine in rat brain.

Journal Article Indian J Biochem Biophys · February 1982 Link to item Cite

Interaction of putrescine and vitamin A on hepatic mitochondrial lipids of rat.

Journal Article Int J Vitam Nutr Res · 1982 Link to item Cite

Induction of different isozymes of cytochrome P-450 in chicken liver

Journal Article Biochemistry International · January 1, 1982 Treatment of chicks with phenobarbitone (PB, 75 x 4 mg/kg body wt) increased the content of cytochrome P-450 whereas beta-naphthoflavone (BNF, 75 x 4 mg/kg body wt) increased the content of cytochrome P-448. Microsomes obtained from PB treated chicks metab ... Cite

A dose dependent relationship between vitamin A and brain myelin lipids in vitamin A deficient rats.

Journal Article Int J Vitam Nutr Res · 1982 Link to item Cite

Effect of heparin on vitamin A induced hyperlipidemia in rats.

Journal Article Int J Vitam Nutr Res · 1981 Effect of intravenous administration of heparin (5 I.U.) has been studied on vitamin A induced changes in plasma, liver, kidney, heart and adipose tissue of rats. Heparin reversed vitamin A induced hypertriglyceridemia. It reduced plasma TG and PC levels a ... Link to item Cite

Molecular species of phosphatidyl choline and phosphatidyl ethanolamine in heart of rats given excess vitamin A.

Journal Article Acta Vitaminol Enzymol · 1981 The effect of 33 mg of vitamin A for two days on heart phospholipids and on the molecular species of phosphatidyl-choline and phosphatidyl-ethanolamine of rats has been studied. Vitamin A reduced the amounts of heart total phospholipids, phosphatidyl-choli ... Link to item Cite

Effect of endosulfan on liver vitamin A in rats.

Journal Article Int J Vitam Nutr Res · 1981 Link to item Cite

Effect of vitamin A on microtubules of rat brain and liver.

Journal Article Int J Vitam Nutr Res · 1981 Link to item Cite

Glycosylation of serum HDL and LDL in rats given excess retinol.

Journal Article Int J Vitam Nutr Res · 1981 Link to item Cite

Retinol & membrane functions: phospholipid exchange between liver microsomes & mitochondria in rats fed retinol.

Journal Article Indian J Biochem Biophys · August 1980 Link to item Cite

Metabolism of subfractions of phosphatidyl choline & phosphatidyl ethanolamine of liver & plasma of rats given retinol & phenobarbital.

Journal Article Indian J Biochem Biophys · February 1980 Link to item Cite

Effect of cystamine on liver lipids.

Journal Article Indian J Biochem Biophys · February 1980 Link to item Cite

Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. I. Proteins, lipids, triglycerides and cholesterol.

Journal Article Biochem Exp Biol · 1980 Effect of partial hepatectomy on serum and its betalipoprotein protein, lipids, triglycerides, free and esterified cholesterol in dogs has been studied up to 48 hrs after surgery. Effect of actinomycin D has also been studied on the serum and betalipoprote ... Link to item Cite

Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. II - Phospholipids.

Journal Article Biochem Exp Biol · 1980 Effect of partial hepatectomy and administration of actinomycin D to partially hepatectomized dogs was studied on the amounts of serum and betalipoprotein phospholipids and incorporation of NaH2 32PO4 into various phospholipid at various periods after surg ... Link to item Cite

Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. I. Proteins, lipids, triglycerides and cholesterol

Journal Article Journal of Drug Education · January 1, 1980 Cite

Effect of endosulphan on aniline hydroxylase activity of hepatic SER in rats fed lysine, threonine deficient and supplemented rice diets

Journal Article Nutrition Reports International · January 1, 1980 Rats were fed lysine and threonine deficient and supplemented rice diet for 15 days and given endosulphan (5 mg/kg body weight) on terminal two days. Aniline hydroxylase activity, proteins, cholesterol, phospholipids and triglycerides were assayed in hepat ... Cite

Evaluation of biosynthetic pathways of phosphatidyl choline in liver of rats given phenobarbital: a study on molecular species of phosphatidyl choline.

Journal Article Biochem Exp Biol · 1980 Administration of phenobarbital to female rats significantly increased the levels of liver monoenoic, dienoic and tetraenoic PC and in plasma it raised phosphatidyl choline and its monoenoic and dienoic species and decreased triglyceride levels. Significan ... Link to item Cite

Interaction of protein nutrition and endosulphan treatment on aniline hydroxylase activity of liver SER of rats

Journal Article Indian Journal of Biochemistry and Biophysics · January 1, 1980 Cite

Retinol feeding and low and high density lipoproteins of plasma of rats.

Journal Article Int J Vitam Nutr Res · 1980 Effect of feeding 33 mg retinol daily for two days has been studied on lipids of plasma low and high density lipoproteins of rats. Triglycerides, nonesterified fatty acids, phosphatidyl choline and its monoenoic, dienoic and tetraenoic species were increas ... Link to item Cite

Effect of lysine and threonine deficient and supplement rice diets on lipids of hepatic smooth and rough endoplasmic reticulum of rats.

Journal Article Biochem Exp Biol · 1980 Effect of feeding lysine and threonine deficient and supplemented rice diets to rats for fifteen days has been studied on the lipids of hepatic smooth (SER) and rough endoplasmic reticulum. The deficient diet reduced protein and phospholipids of SER where ... Link to item Cite

Interaction of vitamin A and cortisol on liver and plasma lipids of rats.

Journal Article Int J Vitam Nutr Res · 1980 Effect of vitamin A and cortisol administration either alone or together has been studied on liver and plasma lipids of rats. The effects of cortisol administration on liver and plasma lipids of rats and incorporation of palmitate-1-14C into liver and plas ... Link to item Cite

Serum retinol binding protein secretion through microtubules in chicks.

Journal Article Int J Vitam Nutr Res · 1980 Link to item Cite

Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. III - Fatty acid distribution.

Journal Article Biochem Exp Biol · 1980 Effect of administration of actinomycin D to partially hepatectomized dogs has been studied on various neutral and phospholipid components of serum and its beta-lipoprotein fraction. Partial hepatectomy altered distribution of palmitic, stearic, oleic, lin ... Link to item Cite

Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. III. Fatty acid distribution

Journal Article Journal of Drug Education · January 1, 1980 Cite

Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. II. Phospholipids

Journal Article Journal of Drug Education · January 1, 1980 Cite

Lung, heart, kidney and spleen lipids in experimental tuberculosis in chicken.

Journal Article Indian J Chest Dis Allied Sci · 1980 Link to item Cite

Aniline hydroxylase of hepatic SER in rats fed lysine, threonine deficient and supplemented rice diets and given phenobarbital

Journal Article Nutrition Reports International · January 1, 1979 Cite

Effect of gamma irradiation and cystamine on kidney lipids of rats.

Journal Article Biochem Exp Biol · 1979 Effect of whole body gamma irradiation (1200 r) and the effect of administration cystamine prior to irradiation has been studied on kidney total lipids, cholesterol, phospholipids (phosphatidylcholine and phosphatidylethanolamine). Irradiation significantl ... Link to item Cite

Hepatic lysosomal enzymes in young rats fed retinol.

Journal Article Int J Vitam Nutr Res · 1979 Oral administration of one dose of 6.0 and 12.0 mg retinol for one day significantly increased percentage free activities of protease (cathepsins), cathepsin B1 and acid ribonuclease, whereas feeding of one dose of 1.5 mg retinol for one day did not releas ... Link to item Cite

Spleen lipids: effect of whole body gamma irradiation and radioprotective chemicals.

Journal Article Biochem Exp Biol · 1979 Effect of whole body gamma irradiation (1200 r) on spleen lipid metabolism of male and female rats 24 hrs and 48 hrs after irradiation and the effect of radioprotective chemicals vis. AET, serotonin, their mixture and cystamine on radiation induced changes ... Link to item Cite

Effect of retinol on the molecular species of hepatic phosphatidyl choline in young rats.

Journal Article Int J Vitam Nutr Res · 1979 Effect of feeding 1.5 and 12 mg retinol respectively for two days to young rats on the distribution and synthesis of molecular species of PC in liver was studied. A significant decrease was observed in the amounts of trienoic and tetraeonic PC in rats fed ... Link to item Cite

Liver lipids on weanling rats fed lysine threonine deficient rice diets

Journal Article Nutrition Reports International · January 1, 1979 Cite

Kidney lipids of weanling rats fed lysine threonine deficient rice diets

Journal Article Nutrition Reports International · January 1, 1979 Feeding of lysine and threonine dificient rice diets for three days reduced kidney total lipid. Total, free and esterified cholesterol were increased in the deficient group while triglyceride and free fatry acids were decreased. The incorporatin of acetate ... Cite

Early effects of feeding lysine and threonine deficient and supplemented rice diets on adrenal lipids of weanling rats

Journal Article Nutrition Reports International · January 1, 1977 Cite

Effect of whole body gamma irradiation on fatty acid composition of liver lipids of female rats and radioprotection by cystamine.

Journal Article Strahlentherapie · June 1976 Effect of whole body gamma irradiation (1200 R) on the fatty acid composition of liver lipids and its triglycerides (TG), phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC) has been studied in female rats. Radioprotective effect of cystamine on r ... Link to item Cite

Early effects of feeding lysine and threonine deficient and supplemented rice diets on distribution and synthesis of molecular species of phosphatidyl choline in weanling rat liver

Journal Article Nutrition Reports International · January 1, 1976 Effect of feeding lysine and threonine deficient and supplemented rice diets to weanling rats for one day has been studied on the relative distribution and synthesis of molecular species of phosphatidyl choline from choline 1,2- 14C and methioni ... Cite

In vivo acylation of triglycerides and phosphoglycerides of liver subcellular fractions with palmitate-1-14C in rats fed vitamin A.

Journal Article Int J Vitam Nutr Res · 1976 Incorporation of palmitate-1-14C into liver and its mitochondrial, and microsomal triglycerides and phosphoglycerides of rats fed 100000 I.U. of vitamin A for two days has been studied. Feeding of vitamin A significantly increased triglycerides in liver an ... Link to item Cite

Radioprotection of liver lipids of whole-body gamma-irradiated female rats by cystamine.

Journal Article Strahlentherapie · January 1976 The effect of administration of cystamine (5 mg/100 g body weight) before 1200 R whole-body gamma irradiation has been studied on irradiation-induced changes in liver and its subcellular fractions'lipids of fasted female rats. Cystamine prevented the irrad ... Link to item Cite

Vitamin A and liver lipids of suckling rats

Journal Article Biology of the Neonate Foetal and Neonatal Research · January 1, 1976 To 6 day old pups, 1,000 IU of vitamin A were successively fed on the 6th, 8th, 10th and 12th days of age and its effects on liver studied on the 23rd day. Feeding of vitamin A to pups significantly reduced liver DNA, protein, total and free cholesterol an ... Full text Cite

Radioprotection of whole-body gamma irradiation induced alterations in lipid metabolism of liver and plasma by AET (S-2, aminoethyl isothiuronium Br. H. Br.) and serotonin in rats.

Journal Article Strahlentherapie · October 1975 Radioprotective effect of AET, serotonin and their mixture has been studied on liver and plasma lipid metabolism 24 hrs and 48 hrs after irradiation in fasted male rats. AET and serotonin both gave significant radioprotection to certain liver and plasma li ... Link to item Cite

Radioprotection of lipogenesis from glucose (U-14C) and activities of pyridine nucleotide dehydrogenases in liver of gamma-irradiated female rats by cystamine.

Journal Article Int J Radiat Biol Relat Stud Phys Chem Med · July 1975 Whole-body gamma-irradiation (1200 R) of female rats significantly increased liver glycogen and incorporation of glucose (U-14C) into liver fatty acids. Administration of cystamine before irradiation protected the enhanced lipogenesis from glucose (U-14C), ... Full text Link to item Cite

Secretion of Hepatic Triglycerides Into Plasma of Rats Fed Retinol

Journal Article Agricultural and Biological Chemistry · January 1, 1975 The effect of feeding 33 mg of retinol daily for two days on liver and plasma lipids of rats has been studied. The secretion of liver TG into plasma of retinol fed rats has been measured by the use of palmitic acid-1-14C and of Triton WR 1339. Liver and pl ... Full text Cite

Note: Effect of feeding bengal gram (cicer arietinum) at different protein levels on plasma lipids of rats

Journal Article Agricultural and Biological Chemistry · January 1, 1975 Full text Cite

Incorporation of [U ¹⁴C]glucose into liver lipids of rats fed millet (Sorghum vulgarie) at different protein concentrations

Journal Article Biochemistry and Experimental Biology · January 1, 1975 Feeding defatted millet flour at different protein concentrations to rats for 6 wk significantly increased the amount of triglycerides (TG), fatty acids, total phospholipids, phosphatidyl choline (PC) and phosphatidyl ethanolamine (PE) in the liver. Lipoge ... Cite

Upake of plasma lipids by extrahepatic tissues of vitamin A fed rats.

Journal Article Int J Vitam Nutr Res · 1975 The uptake of newly synthesized plasma lipids from intraportally injected palmitate 1(-14)C by heart, kidney and adipose tissues of rats fed 33 mg retinol for 2 days have been studied. The uptake of plasma lipids by adipose tissues and heart was decreased ... Link to item Cite

RNA synthesis in liver nuclei of young rats fed varying amounts of vitamin A.

Journal Article Int J Vitam Nutr Res · 1975 Twenty five days old male rats were feed 5000, 20000 and 40000 I.U. of vitamin A for two days and its effects studied on RNA contents and its synthesis from orotic acid-6(-14)C in liver and its nuclear and mitochondrial fractions. RNA contents and its synt ... Link to item Cite

Inhibition of lipogenesis from glucose U ¹⁴C in liver and adipose tissues of rats fed vitamin A

Journal Article Nutrition Reports International · January 1, 1975 Feeding of 100000 I.U. of vitamin A for two days resulted in reduced utilization of glucose U 14C in liver and adipose tissue of rats for fatty acid synthesis. In liver, the utilization of radioactivity of glucose U 14C for the synthesis of neutral lipids ... Cite

Distribution and synthesis of molecular species of phosphatidyl choline in weanling rat liver

Journal Article Indian Journal of Biochemistry and Biophysics · January 1, 1975 The distribution of monoenoic, dienoic, tetraenoic and hexaenoic species of phosphatidyl choline (PC) in weanling rat liver was 20,40, 29.67, 38.29 and 12.82% respectively whereas that of the species of phosphatidyl ethanolamine (PE) was 2.12, 7.66, 18.80 ... Cite

Secretion of hepatic triglycerides into plasma of rats fed retinol

Studies on mode of action of vitamin A.

Journal Article Int J Vitam Nutr Res · 1975 Effect of feeding 5000,10 000, 20 000, 30 000 and 40 000 I.U. of vitamin A for two days to 25 days old rats has been studied on liver protein, RNA and DNA, liver and plasma lipids and adrenal cholesterol. The incorporation of palmitate- I-14-C into liver a ... Link to item Cite

Effect of Feeding Bengal Gram (Cicer Arietinum) at Different Protein Levels on Plasma Lipids of Rats

Journal Article Agricultural and Biological Chemistry · January 1, 1975 Full text Cite

Effect of gamma irradiation on fatty acid oxidation in rat liver slices.

Journal Article Indian J Biochem Biophys · December 1974 Link to item Cite

Effect of feeding plant proteins on plasma, liver, heart, aorta and brain lipids of rats.

Journal Article Indian J Chest Dis · September 1974 Link to item Cite

Effect of retinol and retinoic acid on liver lipids of rats fed different levels of protein.

Journal Article Res Commun Chem Pathol Pharmacol · June 1974 Link to item Cite

Hepatic Subcellular Fractions Lipids in Rats Fed Millet (Sorghum vulgarie) at Different Protein Levels

Journal Article Agricultural and Biological Chemistry · January 1, 1974 Effect of feeding defatted millet (Sorghum vulgarie) flour at 5, 10 and 14.5% protein levels respectively for six weeks has been studied on rat liver mitochondrial, microsomal and supernatant fractions total lipids, cholesterol, triglycerides, total phosph ... Full text Cite

Effect of Feeding Millet (Sorghum vulgarie) Protein at Various Protein Levels on Adrenal Lipids of Rats

Journal Article Agricultural and Biological Chemistry · January 1, 1974 A significant increase in adrenal weight, total lipids, cholesterol phospholipids and glycerides (mono-and triglycerides) was observed in rats fed millet at 5, 10 and 15% protein levels respectively for a period of six weeks as compared to rats fed casein ... Full text Cite

Hepatic subcellular fractions lipids in rats fed millet (Sorghum vulgarie) at different protein levels

Effect of feeding defatted millet (Sorghum vulgarie) flour at different protein levels on phospholipids of rat liver

Journal Article Agricultural and Biological Chemistry · January 1, 1974 Effect of feeding defatted millet flour at 5, 10 and 14.5 percent protein levels respectively to rats for 6 weeks has been studied on their liver phospholipids. Feeding of millet at these protein levels significantly increased liver total lipids and total ... Full text Cite

Effect of vitamin A on rat brain maturation as measured by lipid composition

Journal Article Nutrition Reports International · January 1, 1974 1000 I.U. of vitamin A was fed to 6 day old rat pups on alternate 4 days and its effects studied on 23rd day of age on brain weight, brain DNA, protein, cholesterol, phospholipids, phosphatidal ethanolamine, sphingomyelin cerebrosides, sulphatides, and the ... Cite

Effect of feeding excess of vitamin A and vitamin C on liver, plasma and adrenal lipids of rats.

Journal Article Int J Vitam Nutr Res · 1974 Link to item Cite

Effect of feeding millet (Sorghum vulgarie) protein at various protein levels on adrenal lipids of rats

Lipogenesis from acetate 1 ¹⁴C in liver of rats fed millet (Sorghum vulgarie) at different protein levels

Journal Article Nutrition Reports International · January 1, 1974 Feeding rats defatted millet flour at various protein levels for 6 wk significantly increased their liver total lipids, glycerides, phospholipids, cholesterol and fatty acids. The increase in liver lipids, triglycerides, cholesterol and phospholipids varie ... Cite

Effect of retinol on liver lipid metabolism of rats

Journal Article Agricultural and Biological Chemistry · January 1, 1974 Effect of feeding 4.23, 16.94 and 27.53 mg of retinol daily for 10 days on the liver lipids of adult rats has been studied. Feeding of different amounts of retinol produced dose dependent toxicity symptoms in rats. Retinol feeding resulted in significant e ... Full text Cite

Hepatic lipogenesis from glucose U ¹⁴C and liver dehydrogenases in rats fed Bengal gram (Cicer arietinum) at different protein levels

Journal Article Nutrition Reports International · January 1, 1974 The effect of feeding defatted Bengal gram (Cicer arietinum) flour at 5, 10 and 20% protein levels respectively to rats for 6 wk was studied on incorporation of glucose U 14C into liver fatty acids and on liver combined hexose monophosphate pathway (HMP) d ... Cite

Incorporation of palmitate-1-14C into liver lipids of rats fed millet (Sorghum vulgarie) at different protein levels.

Journal Article Nutr Metab · 1974 Full text Link to item Cite

Effect of retinol and retinoic acid on leucine l ¹⁴C incorporation into plasma and liver proteins in rats fed different levels of dietary protein

Journal Article Nutrition Reports International · January 1, 1974 The effect of feeding 50,000 I.U. of retinol or 5 mg of retinoic acid for two days to rats fed casein at 20, 5 and 0% levels respectively for 2 wk was studied in liver and plasma protein, and the incorporation of leucine 1 14C in these proteins was determi ... Cite

Effect of retinol and retinoic acid on brain cerebrosides and sulphatides of rats fed different levels of protein

Journal Article Nutrition Reports International · January 1, 1974 Effect of feeding retinol (50000 I.U.) or retinoic acid (5 mg) for two days on brain cerebrosides and sulphatides of rats maintained on 20, 5 and 0 % casein diet for two weeks was studied. The incorporation of 35S sulphate into brain sulphatides of rats ma ... Cite

Effect of feeding millet (Sorghum vulgarie) protein on heart lipids of rats

Journal Article Biochemistry and Experimental Biology · January 1, 1974 In a longitudinal study of 5362 children born in 1946 the prevalence of juvenile onset diabetes at ages 0 to 26 yr was found to be 3.5 per 1000. Although this seems a relatively large figure it accords well with rates found in other investigations where in ... Cite

Stimulation of cholesterogenesis by ascorbic acid in adrenal of rats fed vitamin A.

Journal Article Int J Vitam Nutr Res · 1974 Link to item Cite

Effects of vitamin A and phenobarbital on liver endoplasmic reticulum of rats.

Journal Article Int J Vitam Nutr Res · 1974 Link to item Cite

Lipogenesis in adipose tissue of rats fed millet (Sorghum vulgarie) at different protein levels

Journal Article Nutrition Reports International · January 1, 1974 Feeding of defatted millet (Sorghum vulgarie) flour at 5, 10 and 14.5% protein levels to rats for 6 wk increased adipose tissue cholesterol as compared to the control rats fed casein. The incorporation of acetate 1 14C, palmitate 1 14 ... Cite

Effect of Feeding Defatted Mille(Sorghum vulgarie) Flour at Different Protein Levels on Phospholipids of Rat Liver

Effect of Retinol on Liver Lipid Metabolism of Rats

Hypervitaminosis A and Liver Phospholipids

Journal Article Agricultural and Biological Chemistry · January 1, 1973 Effect of daily oral feeding of 33 mg retinol for nine days on the liver phospholipids of rats has been studied. As early as two days after feeding retinol an increase in the amounts of liver triglycerides, proteins, phospholipids, and cholesterol was note ... Full text Cite

Effect of feeding millet (sorghum vulgarie) protein on growth, nucleic acids and proteins of liver and plasma of rats

Journal Article Agricultural and Biological Chemistry · January 1, 1973 Effect of feeding millet (Sorghum vulgarie) at 5, 10 and 15 per cent protein levels respectively for a period of six weeks to rats on their liver DNA, RNA and proteins of liver, its subcellular fractions and plasma has been studied, and results compared wi ... Full text Cite

Plasma lipids of rats fed millet (sorghum vulgarie) at various protein levels

Journal Article Agricultural and Biological Chemistry · January 1, 1973 Effect of feeding defatted millet (Sorghum vulgarie) flour at 5, 10 and 14.5 per cent protein levels to rats for six weeks on their plasma lipids has been studied. The results have been compared with rats fed casein at 10 per cent level. The plasma lipid m ... Full text Cite

Plasma lipids of rats fed millet (Sorghum vulgarie) at various protein levels

Effect of feeding millet (Sorghum vulgarie) protein on growth, nucleic acids and proteins of liver and plasma of rats

Hypervitaminosis a and liver phospholipids

Dynamics of phospholipid metabolism in the sexual segment and kidney of the indian house lizard, Hemidactylus flaviviridis ruppell

Journal Article Comparative Biochemistry and Physiology Part B Biochemistry and · September 15, 1972 1. 1. The incorporation of radioactive inorganic orthophosphate into the sexual segment and kidney phospholipids was studied at various time intervals in sexually active and regressing lizards and following castration and testosterone administration. 2. 2. ... Full text Cite

Effect of feeding retinoic acid on liver and plasma lipids of rats

Journal Article Biochemistry and Experimental Biology · January 1, 1972 Cite

Seasonal variations in the pattern of lipids in the sexual segment, kidney and liver of the Indian house lizard, Hemidactylus flaviviridis Ruppell.

Journal Article Comp Biochem Physiol A Comp Physiol · January 1, 1972 Full text Link to item Cite

Retinol and adrenal lipids of rats.

Journal Article J Vitaminol (Kyoto) · December 10, 1969 Full text Link to item Cite

Effect of intramuscular administration of retinol on plasma lipids of rats

Journal Article Agricultural and Biological Chemistry · January 1, 1968 The effect of intramuscular administration of 100,000 I. U. of retinol daily for 13 days on plasma lipids of young rats has been studied. Significant elevations in the plasma total lipids, phospholipids and glycerides were noted in retinol treated rats as ... Full text Cite

Differences in the lipid pattern of T-tube and gallbladder puncture bile in surgical patients

Journal Article Clinical Biochemistry · January 1, 1968 Summary1.The lipid composition of human bile obtained by T-tube drainage has been compared to bile obtained by direct sterile needle puncture of the gallbladder during elective surgery. The following lipids were found (mg/100 mg/dry weight) in T-tube and g ... Full text Cite

Effect of intramuscular administration of retinol on plasma lipids of rats

Journal Article Agricultural and Biological Chemistry · January 1, 1968 The effect of intramuscular administration of 100, 000 I. U. of retinol daily for 13 days on plasma lipids of young rats has been studied. Significant elevations in the plasma total lipids, phospholipids and glycerides were noted in retinol treated rats as ... Full text Cite

Effect of whole body gamma irradiation on tissue lipids of rats & the effect of S-beta-aminoethylisothiouronium bromide hydrobromide.

Journal Article Indian J Biochem · December 1966 Link to item Cite

Effect of whole body gamma irradiation on rat plasma phospholipids & the effect of S-beta-aminoethylisothiouronium bromide hydrobromide.

Journal Article Indian J Biochem · December 1966 Link to item Cite

Phospholipids in the androgen stimulated sexual segment of the kidney of the Indian house lizard, Hemidactylus flaviviridis Rüppell.

Journal Article Steroids · April 1966 Full text Link to item Cite