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Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone.

Publication ,  Journal Article
Misra, UK; Gawdi, G; Lewis, JG; Pizzo, SV
Published in: Toxicol Appl Pharmacol
July 1998

Exposure of murine peritoneal macrophages to very low concentrations of 1,4-benzoquinone (BQ) induced immediate increases in intracellular Ca2+ concentrations ([Ca2+]i). Increases in [Ca2+]i were induced by concentrations as low as 5 nM and the response was dose dependent and linear up to 1 microM. The sources of Ca2+ were from both internal inositol triphosphate (IP3)-sensitive and -insensitive sites and from the external medium. BQ did not induce IP3 formation and did not affect binding to its receptors. 1, 4-Hydroquinone had no effect on [Ca2+]i. Catechol did elicit some increases in [Ca2+]i, but did so only at much higher concentrations (5 microM). The action of BQ was almost identical to that of the established Ca2+-ATPase inhibitor thapsigargin except that there were some intracellular stores of Ca2+ released by thapsigargin that were not released by BQ. BQ also was mitogenic for macrophages in conjunction with phorbol myristate acetate. These data suggest that BQ raises [Ca2+]i by inhibition of Ca2+-ATPases, is a comitogen, and does so at concentrations that could be achieved in vivo in the general urban population.

Duke Scholars

Published In

Toxicol Appl Pharmacol

DOI

ISSN

0041-008X

Publication Date

July 1998

Volume

151

Issue

1

Start / End Page

1 / 8

Location

United States

Related Subject Headings

  • Toxicology
  • Thapsigargin
  • Tetradecanoylphorbol Acetate
  • Sulfhydryl Reagents
  • Receptors, Cytoplasmic and Nuclear
  • Mutagens
  • Mice, Inbred C57BL
  • Mice
  • Macrophages, Peritoneal
  • Inositol 1,4,5-Trisphosphate Receptors
 

Citation

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Misra, U. K., Gawdi, G., Lewis, J. G., & Pizzo, S. V. (1998). Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. Toxicol Appl Pharmacol, 151(1), 1–8. https://doi.org/10.1006/taap.1998.8415
Misra, U. K., G. Gawdi, J. G. Lewis, and S. V. Pizzo. “Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone.Toxicol Appl Pharmacol 151, no. 1 (July 1998): 1–8. https://doi.org/10.1006/taap.1998.8415.
Misra UK, Gawdi G, Lewis JG, Pizzo SV. Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. Toxicol Appl Pharmacol. 1998 Jul;151(1):1–8.
Misra, U. K., et al. “Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone.Toxicol Appl Pharmacol, vol. 151, no. 1, July 1998, pp. 1–8. Pubmed, doi:10.1006/taap.1998.8415.
Misra UK, Gawdi G, Lewis JG, Pizzo SV. Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. Toxicol Appl Pharmacol. 1998 Jul;151(1):1–8.
Journal cover image

Published In

Toxicol Appl Pharmacol

DOI

ISSN

0041-008X

Publication Date

July 1998

Volume

151

Issue

1

Start / End Page

1 / 8

Location

United States

Related Subject Headings

  • Toxicology
  • Thapsigargin
  • Tetradecanoylphorbol Acetate
  • Sulfhydryl Reagents
  • Receptors, Cytoplasmic and Nuclear
  • Mutagens
  • Mice, Inbred C57BL
  • Mice
  • Macrophages, Peritoneal
  • Inositol 1,4,5-Trisphosphate Receptors