Salvatore Vincent Pizzo | Scholars@Duke

Salvatore Vincent Pizzo
Distinguished Professor of Pathology, in the School of Medicine

RESEARCH ABSTRACT
Studies from this laboratory identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies. Cell surface GRP78 functions as a signaling receptor promoting tumor proliferation and suppressing apoptosis. Patients with a number of malignancies mount an autoimmune response to GRP78 and these antibodies, which bind to the NH₂ terminal domains of GRP78, are receptor agonists whose appearance is a marker of poor prognosis. More recently, we have shown that antibodies directed against the COOH-terminal domain of GRP78 are receptor antagonists which may have therapeutic potential for treating patients whose tumors express GRP78 on the cell surface.

Current Appointments & Affiliations

Distinguished Professor of Pathology, in the School of Medicine, Pathology, Clinical Science Departments 2007
Professor of Pathology, Pathology, Clinical Science Departments 1985

Contact Information

Rm 3059 Duke South Hospital, Durham, NC 27710
Rm 3059 Duke South Hospital, Duke Box 3712, Durham, NC 27710
pizzo001@mc.duke.edu (919) 684-3528

Background
Education, Training, & Certifications
- Head, Program in Cell Biology and Biochemistry, Cancer Center, Duke University 1988 - 1993
- Resident, Pathology, Duke University 1973 - 1976
- M.D., Duke University 1973
- Ph.D., Duke University 1972
Previous Appointments & Affiliations
- Chair, Department of Pathology, Pathology, Clinical Science Departments 1991 - 2014
- Professor in Surgery, Surgery, Clinical Science Departments 2009 - 2010
- Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 1994 - 1995
- Associate Professor, Pathology, Clinical Science Departments 1980 - 1985
- Assistant Professor, Pathology, Clinical Science Departments 1976 - 1980
Research
Selected Grants
- Development of an Optimized Human Antibody to a Novel Target for the Treatment of Fibrotic Diseases awarded by North Carolina Biotechnology Center 2019 - 2020
- Tension-Stat3-miR-mediated Metastasis awarded by City of Hope 2015 - 2017
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression awarded by National Institutes of Health 2008 - 2014
- Non Muscle Myosin II Contractility Putatively Regulates Scar Contracture awarded by National Institutes of Health 2008 - 2013
- Novel Oral Adjuvant for Dental Vaccines awarded by National Institutes of Health 2004 - 2008
- Cell Receptors In Coagulation And Atherogenesis awarded by National Institutes of Health 1979 - 2008
- Bromelain Proteinase Activity in IBD awarded by National Institutes of Health 2005 - 2008
- Modulation of Angiogenesis Via the Angiostatin Receptor awarded by National Institutes of Health 2001 - 2007
- The Molecular Mechanism of GRP94 Function awarded by National Institutes of Health 1997 - 2007
- Alpha2-Macroglobulin-PA Complexes:Novel Anthrax Vaccines awarded by National Institutes of Health 2002 - 2004
- Macroglobulin in Cancer Angiogenesis awarded by National Institutes of Health 2001 - 2002
- Medical Scientist Training Program awarded by National Institutes of Health 1975 - 2002
- Peptide Immunogens For Mucosal & Systemic Hiv Vaccines awarded by National Institutes of Health 1993 - 1997
- Peptide Immunogens For Mucosal & Systemic Hiv Vaccines Nat awarded by National Institutes of Health 1993 - 1997
- Medical Scientist Training Program awarded by National Institutes of Health 1996 - 1997
- Medical Scientist Training Program awarded by National Institutes of Health 1995 - 1997
- Cell Receptors In Coagulation And Atherogenesis awarded by National Institutes of Health 1979 - 1997
- Medical Scientists Training Program awarded by National Institutes of Health 1975 - 1997
- Macrophage Activation: Development And Regulation awarded by National Institutes of Health 1981 - 1996
- Fibrinolysis In Vitro And In Vivo awarded by National Institutes of Health 1995
- Lipoprotein (A), Coagulation And Fibrinolysis awarded by National Institutes of Health 1993 - 1994
- Lipoprotein(A) Coagulation And Fibrinolysis awarded by National Institutes of Health 1992 - 1994
- Lipoportein(A) Coagulation And Fibrinolysis awarded by National Institutes of Health 1990 - 1994
- Src On Malignant Human Gliomas And Medulloblastomas awarded by National Institutes of Health 1993 - 1994
- Medical Scientist Training Grant awarded by National Institutes of Health 1991 - 1992
Publications & Artistic Works
Selected Publications
- Books
  - Pizzo, S. V. Preface, 2018. https://doi.org/10.1016/B978-0-12-812351-5.00011-8.
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  - Pizzo, S. V. Cell Surface GRP78, a New Paradigm in Signal Transduction Biology, 2018. https://doi.org/10.1016/C2016-0-00712-X.
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  - Pizzo, S. V., R. L. Lundblad, and M. S. Willis. Proteolysis in the interstitial space, 2016. https://doi.org/10.1201/9781315374307.
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- Academic Articles
  - Ferrell, Paul Durham, Kristianne Michelle Oristian, Ishaan Puranam, and Salvatore Vincent Pizzo. “Serum Pro-N-Cadherin Is a Marker of Subclinical Heart Failure in the General Population.” J Am Heart Assoc 12, no. 6 (March 21, 2023): e028234. https://doi.org/10.1161/JAHA.122.028234.
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  - Gonzalez-Gronow, Mario, and Salvatore Vincent Pizzo. “Physiological Roles of the Autoantibodies to the 78-Kilodalton Glucose-Regulated Protein (GRP78) in Cancer and Autoimmune Diseases.” Biomedicines 10, no. 6 (May 24, 2022). https://doi.org/10.3390/biomedicines10061222.
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  - Ferrell, Paul Durham, Kristianne Michelle Oristian, Everett Cockrell, and Salvatore Vincent Pizzo. “Pathologic Proteolytic Processing of N-Cadherin as a Marker of Human Fibrotic Disease.” Cells 11, no. 1 (January 4, 2022). https://doi.org/10.3390/cells11010156.
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  - Trink, Jackie, Renzhong Li, Yaseelan Palarasah, Stéphan Troyanov, Thomas E. Andersen, Johannes J. Sidelmann, Mark D. Inman, Salvatore V. Pizzo, Bo Gao, and Joan C. Krepinsky. “Activated Alpha 2-Macroglobulin Is a Novel Mediator of Mesangial Cell Profibrotic Signaling in Diabetic Kidney Disease.” Biomedicines 9, no. 9 (August 30, 2021). https://doi.org/10.3390/biomedicines9091112.
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  - Gopal, Udhayakumar, and Salvatore V. Pizzo. “Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer.” J Cell Physiol 236, no. 4 (April 2021): 2352–63. https://doi.org/10.1002/jcp.30030.
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  - Gopal, Udhayakumar, Yvonne Mowery, Kenneth Young, and Salvatore Vincent Pizzo. “Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling.” J Biol Chem 294, no. 38 (September 20, 2019): 13939–52. https://doi.org/10.1074/jbc.RA119.009091.
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  - Lyes, Matthew A., Sturgis Payne, Paul Ferrell, Salvatore V. Pizzo, Scott T. Hollenbeck, and Robin E. Bachelder. “Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence.” Breast Cancer Res Treat 174, no. 2 (April 2019): 413–22. https://doi.org/10.1007/s10549-018-05103-w.
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  - Allott, Emma H., Elizabeth M. Masko, Alexis R. Freedland, Everardo Macias, Kristine Pelton, Keith R. Solomon, Elahe A. Mostaghel, et al. “Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer.” Prostate Cancer Prostatic Dis 21, no. 2 (June 2018): 196–203. https://doi.org/10.1038/s41391-018-0045-x.
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  - Al-Hashimi, Ali A., Paul Lebeau, Fadwa Majeed, Enio Polena, Šárka Lhotak, Celeste A. F. Collins, Jehonathan H. Pinthus, et al. “Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.” J Biol Chem 292, no. 51 (December 22, 2017): 21180–92. https://doi.org/10.1074/jbc.M117.799908.
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  - Gopal, Udhayakumar, and Salvatore V. Pizzo. “Cell surface GRP78 promotes tumor cell histone acetylation through metabolic reprogramming: a mechanism which modulates the Warburg effect.” Oncotarget 8, no. 64 (December 8, 2017): 107947–63. https://doi.org/10.18632/oncotarget.22431.
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  - Bellezza, Ilaria, Paolo Scarpelli, Salvatore V. Pizzo, Silvia Grottelli, Egidia Costanzi, and Alba Minelli. “ROS-independent Nrf2 activation in prostate cancer.” Oncotarget 8, no. 40 (September 15, 2017): 67506–18. https://doi.org/10.18632/oncotarget.18724.
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  - Gonzalez-Gronow, Mario, Jenny L. Fiedler, Cristian Farias Gomez, Fang Wang, Rupa Ray, Paul D. Ferrell, and Salvatore V. Pizzo. “Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains.” Biochem Biophys Res Commun 490, no. 3 (August 26, 2017): 855–60. https://doi.org/10.1016/j.bbrc.2017.06.131.
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  - Bellezza, Ilaria, Paolo Scarpelli, Salvatore V. Pizzo, Silvia Grottelli, Egidia Costanzi, and Alba Minelli. “ROS-independent Nrf2 activation in prostate cancer.” Oncotarget, June 28, 2017. https://doi.org/10.18632/oncotarget.18724.
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  - Masko, Elizabeth M., Mahmoud A. Alfaqih, Keith R. Solomon, William T. Barry, Christopher B. Newgard, Michael J. Muehlbauer, Nikolaos A. Valilis, et al. “Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model.” Prostate 77, no. 5 (April 2017): 446–57. https://doi.org/10.1002/pros.23282.
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  - Jensen, Brian C., Scott J. Bultman, Darcy Holley, Wei Tang, Gustaaf de Ridder, Salvatore Pizzo, Dawn Bowles, and Monte S. Willis. “Upregulation of autophagy genes and the unfolded protein response in human heart failure.” Int J Clin Exp Med 10, no. 1 (2017): 1051–58.
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  - Nelson, Erik R., Shenduo Li, Margaret Kennedy, Sturgis Payne, Kelly Kilibarda, Jeffrey Groth, Michelle Bowie, et al. “Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface.” Oncotarget 7, no. 51 (December 20, 2016): 84030–42. https://doi.org/10.18632/oncotarget.12767.
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  - Gopal, Udhayakumar, Mario Gonzalez-Gronow, and Salvatore Vincent Pizzo. “Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein.” J Biol Chem 291, no. 20 (May 13, 2016): 10904–15. https://doi.org/10.1074/jbc.M115.708131.
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  - Bultman, Scott J., Darcy Wood Holley, Gustaaf G de Ridder, Salvatore V. Pizzo, Tatiana N. Sidorova, Katherine T. Murray, Brian C. Jensen, et al. “BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.” Cardiovasc Pathol 25, no. 3 (2016): 258–69. https://doi.org/10.1016/j.carpath.2016.02.004.
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  - Ridder, G. G. de, R. L. Lundblad, and S. V. Pizzo. “Actions of thrombin in the interstitium.” J Thromb Haemost 14, no. 1 (January 2016): 40–47. https://doi.org/10.1111/jth.13191.
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  - Al-Hashimi, Ali A., Jennifer Caldwell, Mario Gonzalez-Gronow, Salvatore V. Pizzo, Danya Aboumrad, Lindsay Pozza, Hiam Al-Bayati, et al. “Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.” J Biol Chem 290, no. 48 (November 27, 2015): 28725. https://doi.org/10.1074/jbc.A110.119107.
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  - Gonzalez-Gronow, Mario, Miguel Cuchacovich, Rina Francos, Stephanie Cuchacovich, Angel Blanco, Rodrigo Sandoval, Cristian Farias Gomez, Javier A. Valenzuela, Rupa Ray, and Salvatore V. Pizzo. “Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus.” J Neuroimmunol 287 (October 15, 2015): 1–8. https://doi.org/10.1016/j.jneuroim.2015.07.006.
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  - Li, Shenduo, Sturgis Payne, Fang Wang, Peter Claus, Zuowei Su, Jeffrey Groth, Joseph Geradts, et al. “Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance.” Breast Cancer Res 17, no. 1 (July 4, 2015): 91. https://doi.org/10.1186/s13058-015-0590-3.
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  - Misra, Uma Kant, and Salvatore Vincent Pizzo. “Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses.” J Biol Chem 290, no. 15 (April 10, 2015): 9571–87. https://doi.org/10.1074/jbc.M114.617837.
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  - Mo, Lihong, Robin E. Bachelder, Margaret Kennedy, Po-Han Chen, Jen-Tsan Chi, Andrew Berchuck, George Cianciolo, and Salvatore V. Pizzo. “Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78.” Mol Cancer Ther 14, no. 3 (March 2015): 747–56. https://doi.org/10.1158/1535-7163.MCT-14-0579.
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  - Li, S., S. Payne, F. Wang, P. Claus, Z. Su, J. Groth, J. Geradts, et al. “Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance.” Breast Cancer Research, 2015. https://doi.org/10.1186/s13058-015-0590-3.
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  - Mo, Lihong, Vendula Pospichalova, Zhiqing Huang, Susan K. Murphy, Sturgis Payne, Fang Wang, Margaret Kennedy, et al. “Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells.” Plos One 10, no. 7 (2015): e0131579. https://doi.org/10.1371/journal.pone.0131579.
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  - Gonzalez-Gronow, Mario, Cristian Farias Gomez, Gustaaf G. de Ridder, Rupa Ray, and Salvatore V. Pizzo. “Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro.” J Biol Chem 289, no. 36 (September 5, 2014): 25166–76. https://doi.org/10.1074/jbc.M114.589341.
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  - Li, Shenduo, Margaret Kennedy, Sturgis Payne, Kelly Kennedy, Victoria L. Seewaldt, Salvatore V. Pizzo, and Robin E. Bachelder. “Model of tumor dormancy/recurrence after short-term chemotherapy.” Plos One 9, no. 5 (2014): e98021. https://doi.org/10.1371/journal.pone.0098021.
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  - Misra, Uma Kant, and Salvatore Vincent Pizzo. “Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.” Plos One 9, no. 2 (2014): e88373. https://doi.org/10.1371/journal.pone.0088373.
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  - Misra, Uma Kant, Sturgis Payne, and Salvatore Vincent Pizzo. “The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.” Biochemistry 52, no. 23 (June 11, 2013): 4014–25. https://doi.org/10.1021/bi400376s.
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  - Klink, Joseph C., Alok K. Tewari, Elizabeth M. Masko, Jodi Antonelli, Phillip G. Febbo, Pinchas Cohen, Mark W. Dewhirst, Salvatore V. Pizzo, and Stephen J. Freedland. “Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways.” Prostate 73, no. 7 (May 2013): 754–62. https://doi.org/10.1002/pros.22619.
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  - Caso, Jorge, Elizabeth M. Masko, Jean A Thomas Ii, Susan H. Poulton, Mark Dewhirst, Salvatore V. Pizzo, and Stephen J. Freedland. “The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model.” Prostate 73, no. 5 (April 2013): 449–54. https://doi.org/10.1002/pros.22586.
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  - Gonzalez-Gronow, Mario, Rupa Ray, Fang Wang, and Salvatore V. Pizzo. “The voltage-dependent anion channel (VDAC) binds tissue-type plasminogen activator and promotes activation of plasminogen on the cell surface.” J Biol Chem 288, no. 1 (January 4, 2013): 498–509. https://doi.org/10.1074/jbc.M112.412502.
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  - Misra, Uma Kant, and Salvatore Vincent Pizzo. “Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.” Plos One 8, no. 4 (2013): e63150. https://doi.org/10.1371/journal.pone.0063150.
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  - Osmond, Gregory W., Elizabeth M. Masko, Douglas S. Tyler, Stephen J. Freedland, and Salvatore Pizzo. “In vitro and in vivo evaluation of resveratrol and 3,5-dihydroxy-4'-acetoxy-trans-stilbene in the treatment of human prostate carcinoma and melanoma.” J Surg Res 179, no. 1 (January 2013): e141–48. https://doi.org/10.1016/j.jss.2012.02.057.
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  - Kennedy, Kelly M., Peter M. Scarbrough, Anthony Ribeiro, Rachel Richardson, Hong Yuan, Pierre Sonveaux, Chelsea D. Landon, et al. “Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.” Plos One 8, no. 9 (2013): e75154. https://doi.org/10.1371/journal.pone.0075154.
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  - Kim, Howard S., Elizabeth M. Masko, Susan L. Poulton, Kelly M. Kennedy, Salvatore V. Pizzo, Mark W. Dewhirst, and Stephen J. Freedland. “Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer.” Bju Int 110, no. 7 (October 2012): 1062–69. https://doi.org/10.1111/j.1464-410X.2012.10971.x.
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  - Ray, Rupa, Gustaaf G. de Ridder, Jerry P. Eu, Adrienne W. Paton, James C. Paton, and Salvatore V. Pizzo. “The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling.” J Biol Chem 287, no. 39 (September 21, 2012): 32755–69. https://doi.org/10.1074/jbc.M112.399808.
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  - Ridder, Gustaaf G. de, Rupa Ray, and Salvatore V. Pizzo. “A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.” Melanoma Res 22, no. 3 (June 2012): 225–35. https://doi.org/10.1097/CMR.0b013e32835312fd.
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  - Misra, Uma K., and Salvatore V. Pizzo. “Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.” J Cell Biochem 113, no. 5 (May 2012): 1488–1500. https://doi.org/10.1002/jcb.24018.
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  - Masko, Elizabeth M., Keith R. Solomon, Nikolaos A. Valilis, Alexis R. Gaines, Michael J. Muehlbauer, Christopher B. Newgard, Mark W. Dewhirst, Salvatore V. Pizzo, and Stephen J. Freedland. “Abstract 3220: The effects of cholesterol treatment drugs alone and in combination on prostate tumor xenograft growth.” Cancer Research 72, no. 8_Supplement (April 15, 2012): 3220–3220. https://doi.org/10.1158/1538-7445.am2012-3220.
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  - Cianciolo, George J., and Salvatore V. Pizzo. “Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects.” Plos One 7, no. 12 (2012): e52693. https://doi.org/10.1371/journal.pone.0052693.
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  - Misra, Uma K., and Salvatore V. Pizzo. “Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.” Plos One 7, no. 12 (2012): e51735. https://doi.org/10.1371/journal.pone.0051735.
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  - Selim, Maria A., James L. Burchette, Edith V. Bowers, Gustaaf G. de Ridder, Lihong Mo, Salvatore V. Pizzo, and Mario Gonzalez-Gronow. “Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival.” Melanoma Res 21, no. 4 (August 2011): 323–34. https://doi.org/10.1097/CMR.0b013e3283471042.
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  - Misra, U. K., Y. M. Mowery, G. Gawdi, and S. V. Pizzo. “Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated α₂ -macroglobulin.” J Cell Biochem 112, no. 6 (June 2011): 1685–95. https://doi.org/10.1002/jcb.23083.
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  - Chu, David I., Elizabeth M. Masko, Susan H. Poulton, Salvatore V. Pizzo, and Stephen J. Freedland. “Abstract 4602: Cholesterol and ezetimibe: Effects on tumor growth and survival outcomes: An interim analysis.” Cancer Research 71, no. 8_Supplement (April 15, 2011): 4602–4602. https://doi.org/10.1158/1538-7445.am2011-4602.
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  - Ridder, Gustaaf G. de, Mario Gonzalez-Gronow, Rupa Ray, and Salvatore V. Pizzo. “Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma.” Melanoma Res 21, no. 1 (February 2011): 35–43. https://doi.org/10.1097/CMR.0b013e3283426805.
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  - Misra, Uma K., Sturgis Payne, and Salvatore V. Pizzo. “Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.” J Biol Chem 286, no. 2 (January 14, 2011): 1248–59. https://doi.org/10.1074/jbc.M110.129767.
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  - Fearmonti, Regina M., Jennifer E. Bond, Detlev Erdmann, L Scott Levin, Salvatore V. Pizzo, and Howard Levinson. “The modified Patient and Observer Scar Assessment Scale: a novel approach to defining pathologic and nonpathologic scarring.” Plast Reconstr Surg 127, no. 1 (January 2011): 242–47. https://doi.org/10.1097/PRS.0b013e3181f959e8.
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  - Ridder, Gustaaf de, Rupa Ray, Uma K. Misra, and Salvatore V. Pizzo. “Modulation of the unfolded protein response by GRP78 in prostate cancer.” Methods Enzymol 489 (2011): 245–57. https://doi.org/10.1016/B978-0-12-385116-1.00014-5.
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  - Jockheck-Clark, Angela R., Edith V. Bowers, Mariam B. Totonchy, Julie Neubauer, Salvatore V. Pizzo, and Christopher V. Nicchitta. “Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation.” J Immunol 185, no. 11 (December 1, 2010): 6819–30. https://doi.org/10.4049/jimmunol.1000448.
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  - Mowery, Y. M., and S. V. Pizzo. “Cell surface ATP synthase: A potential target for anti-angiogenic therapy,” December 1, 2010, 139–59. https://doi.org/10.1007/978-90-481-3435-9_9.
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  - Gonzalez-Gronow, Mario, Miguel Cuchacovich, Rina Francos, Stephanie Cuchacovich, Maria del Pilar Fernandez, Angel Blanco, Edith V. Bowers, Steven Kaczowka, and Salvatore V. Pizzo. “Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism.” J Neuroimmunol 227, no. 1–2 (October 8, 2010): 153–61. https://doi.org/10.1016/j.jneuroim.2010.06.001.
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  - Al-Hashimi, Ali A., Jennifer Caldwell, Mario Gonzalez-Gronow, Salvatore V. Pizzo, Danya Aboumrad, Lindsay Pozza, Hiam Al-Bayati, et al. “Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.” J Biol Chem 285, no. 37 (September 10, 2010): 28912–23. https://doi.org/10.1074/jbc.M110.119107.
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  - Masko, Elizabeth M., Jean A. Thomas, Jodi A. Antonelli, Jessica C. Lloyd, Tameika E. Phillips, Susan H. Poulton, Mark W. Dewhirst, Salvatore V. Pizzo, and Stephen J. Freedland. “Low-carbohydrate diets and prostate cancer: how low is "low enough"?” Cancer Prev Res (Phila) 3, no. 9 (September 2010): 1124–31. https://doi.org/10.1158/1940-6207.CAPR-10-0071.
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  - Mowery, Y. M., J. B. Weinberg, M. N. Kennedy, K. M. Bond, J. O. Moore, M. C. Lanasa, J. P. Gockerman, et al. “LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells.” Leukemia 24, no. 9 (September 2010): 1580–87. https://doi.org/10.1038/leu.2010.150.
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  - Misra, U. K., S. Kaczowka, and S. V. Pizzo. “Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation.” Biochem Biophys Res Commun 392, no. 4 (February 19, 2010): 538–42. https://doi.org/10.1016/j.bbrc.2010.01.058.
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  - Misra, U. K., and S. V. Pizzo. “Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.” Apoptosis 15, no. 2 (February 2010): 173–82. https://doi.org/10.1007/s10495-009-0430-y.
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  - Misra, U. K., and S. V. Pizzo. “PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells.” Biochem Biophys Res Commun 391, no. 1 (January 1, 2010): 272–76. https://doi.org/10.1016/j.bbrc.2009.11.048.
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  - Misra, Uma K., and Salvatore V. Pizzo. “Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.” Cancer Biol Ther 9, no. 2 (January 2010): 142–52. https://doi.org/10.4161/cbt.9.2.10422.
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  - Papalas, John A., Robin T. Vollmer, Mario Gonzalez-Gronow, Salvatore V. Pizzo, James Burchette, Kenneth E. Youens, Krystal B. Johnson, and Maria A. Selim. “Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma.” Mod Pathol 23, no. 1 (January 2010): 134–43. https://doi.org/10.1038/modpathol.2009.152.
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  - Bowers, Edith V., Jeffrey J. Horvath, Jennifer E. Bond, George J. Cianciolo, and Salvatore V. Pizzo. “Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response.” J Leukoc Biol 86, no. 5 (November 2009): 1259–68. https://doi.org/10.1189/jlb.1008653.
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  - Misra, Uma Kant, and Salvatore Vincent Pizzo. “Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.” J Cell Biochem 108, no. 4 (November 1, 2009): 998–1011. https://doi.org/10.1002/jcb.22333.
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  - Gonzalez-Gronow, Mario, Maria Angelica Selim, John Papalas, and Salvatore V. Pizzo. “GRP78: a multifunctional receptor on the cell surface.” Antioxid Redox Signal 11, no. 9 (September 2009): 2299–2306. https://doi.org/10.1089/ARS.2009.2568.
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  - Mowery, Yvonne M., and Salvatore V. Pizzo. “The antitumorigenic trifecta.” Blood 114, no. 9 (August 27, 2009): 1727–28. https://doi.org/10.1182/blood-2009-06-226233.
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  - Benvegnù, Stefano, Diego Franciotta, Josh Sussman, Angela Bachi, Elisabetta Zardini, Paola Torreri, Cedric Govaerts, Salvatore Pizzo, and Giuseppe Legname. “Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration.” Plos One 4, no. 6 (June 18, 2009): e5968. https://doi.org/10.1371/journal.pone.0005968.
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  - Mavropoulos, John C., W Cooper Buschemeyer, Alok K. Tewari, Dmitriy Rokhfeld, Michael Pollak, Yunhua Zhao, Phillip G. Febbo, et al. “The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model.” Cancer Prev Res (Phila) 2, no. 6 (June 2009): 557–65. https://doi.org/10.1158/1940-6207.CAPR-08-0188.
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  - Misra, Uma Kant, Yvonne Mowery, Steven Kaczowka, and Salvatore Vincent Pizzo. “Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis.” Mol Cancer Ther 8, no. 5 (May 2009): 1350–62. https://doi.org/10.1158/1535-7163.MCT-08-0990.
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  - Freedland, Stephen J., John C. Mavropoulos, W Cooper Buschemeyer, Alok K. Tewari, Dmitriy Rokhfeld, Michael Pollak, Yunhua Zhao, et al. “A NO CARBOHYDRATE DIET SIGNIFICANTLY PROLONGS SURVIVAL IN A PROSTATE CANCER XENOGRAFT MODEL VIA IGF-1 AND GLOBAL GENE EXPRESSION CHANGES.” Journal of Urology 181, no. 4S (April 2009): 47–47. https://doi.org/10.1016/s0022-5347(09)60144-0.
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  - Klink, Joseph C., Susan Poulton, Jodi Antonelli, Michael Q. Potter, Jayakrishnan Jayachandran, Alok K. Tewari, Phillip G. Febbo, Salvatore V. Pizzo, and Stephen J. Freedland. “RESVERATROL ALTERS PROSTATE CANCER XENOGRAFT GROWTH.” Journal of Urology 181, no. 4S (April 2009): 259–259. https://doi.org/10.1016/s0022-5347(09)60738-2.
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  - Misra, U. K., F. Wang, and S. V. Pizzo. “Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells.” J Cell Biochem 106, no. 3 (February 15, 2009): 381–89. https://doi.org/10.1002/jcb.22016.
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  - Mowery, Y. M., and S. V. Pizzo. “Targeting cell surface F1F0 ATP synthase in cancer therapy.” Cancer Biology and Therapy 7, no. 11 (November 1, 2008): 1837–39.
  - Mowery, Yvonne M., and Salvatore V. Pizzo. “Targeting cell surface F1F0 ATP synthase in cancer therapy.” Cancer Biol Ther 7, no. 11 (November 2008): 1836–38. https://doi.org/10.4161/cbt.7.11.7155.
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  - Yüksel, Sahru, and Nesrin Ozören. “Can you tBID on it?” Cancer Biol Ther 7, no. 11 (November 2008): 1723–25. https://doi.org/10.4161/cbt.7.11.7281.
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  - Quinones, Quintin J., Gustaaf G. de Ridder, and Salvatore V. Pizzo. “GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum.” Histol Histopathol 23, no. 11 (November 2008): 1409–16. https://doi.org/10.14670/HH-23.1409.
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  - Schmidt, C., E. Lepsverdize, S. L. Chi, A. M. Das, S. V. Pizzo, A. Dityatev, and M. Schachner. “Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells.” Mol Psychiatry 13, no. 10 (October 2008): 953–69. https://doi.org/10.1038/sj.mp.4002077.
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  - Misra, Uma K., Steven Kaczowka, and Salvatore V. Pizzo. “The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.” Cell Signal 20, no. 8 (August 2008): 1459–70. https://doi.org/10.1016/j.cellsig.2008.04.002.
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  - Lillis, Anna P., Mallary C. Greenlee, Irina Mikhailenko, Salvatore V. Pizzo, Andrea J. Tenner, Dudley K. Strickland, and Suzanne S. Bohlson. “Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis.” J Immunol 181, no. 1 (July 1, 2008): 364–73. https://doi.org/10.4049/jimmunol.181.1.364.
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  - McLachlan, James B., Christopher P. Shelburne, Justin P. Hart, Salvatore V. Pizzo, Rajen Goyal, Rhea Brooking-Dixon, Herman F. Staats, and Soman N. Abraham. “Mast cell activators: a new class of highly effective vaccine adjuvants.” Nat Med 14, no. 5 (May 2008): 536–41. https://doi.org/10.1038/nm1757.
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  - Misra, Uma Kant, and Salvatore Vincent Pizzo. “Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.” J Cell Biochem 104, no. 1 (May 1, 2008): 96–104. https://doi.org/10.1002/jcb.21607.
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  - Pizzo, Salvatore V. “Annexin 2/factor xa-mediated signal transduction.” Circ Res 102, no. 4 (February 29, 2008): 389–91. https://doi.org/10.1161/CIRCRESAHA.108.172080.
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  - Anderson, Ryan B., George J. Cianciolo, Margaret N. Kennedy, and Salvatore V. Pizzo. “Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism.” J Leukoc Biol 83, no. 2 (February 2008): 381–92. https://doi.org/10.1189/jlb.0407236.
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  - Freedland, Stephen J., John Mavropoulos, Amy Wang, Medha Darshan, Wendy Demark-Wahnefried, William J. Aronson, Pinchas Cohen, et al. “Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis.” Prostate 68, no. 1 (January 1, 2008): 11–19. https://doi.org/10.1002/pros.20683.
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  - Gonzalez-Gronow, Mario, Steven Kaczowka, Govind Gawdi, and Salvatore V. Pizzo. “Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor.” Front Biosci 13 (January 1, 2008): 1610–18. https://doi.org/10.2741/2785.
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  - Mowery, Y. M., and S. V. Pizzo. “Targeting cell surface F₁F₀ ATP synthase in cancer therapy.” Cancer Biology and Therapy 7, no. 11 (2008): 1837–39.
  - Kaczowka, Steven J., Lara S. Madding, Kevin L. Epting, Robert M. Kelly, George J. Cianciolo, and Salvatore V. Pizzo. “Probing the stability of native and activated forms of alpha2-macroglobulin.” Int J Biol Macromol 42, no. 1 (January 1, 2008): 62–67. https://doi.org/10.1016/j.ijbiomac.2007.09.019.
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  - Misra, Uma K., Steven J. Kaczowka, and Salvatore V. Pizzo. “Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.” Cell Signal 20, no. 1 (January 2008): 130–38. https://doi.org/10.1016/j.cellsig.2007.10.008.
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  - Gonzalez-Gronow, Mario, Steven J. Kaczowka, Sturgis Payne, Fang Wang, Govind Gawdi, and Salvatore V. Pizzo. “Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel.” J Biol Chem 282, no. 45 (November 9, 2007): 32811–20. https://doi.org/10.1074/jbc.M703342200.
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  - Bond, Jennifer E., George J. Cianciolo, and Salvatore V. Pizzo. “Incorporation of low molecular weight molecules into alpha(2)-macroglobulin by nucleophilic exchange.” Biochem Biophys Res Commun 357, no. 2 (June 1, 2007): 433–38. https://doi.org/10.1016/j.bbrc.2007.03.151.
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  - Chi, Sulene L., Miriam L. Wahl, Yvonne M. Mowery, Siqing Shan, Somnath Mukhopadhyay, Susana C. Hilderbrand, Daniel J. Kenan, et al. “Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.” Cancer Res 67, no. 10 (May 15, 2007): 4716–24. https://doi.org/10.1158/0008-5472.CAN-06-1094.
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  - McGowen, Afton, Nicole A. Paraggio, Ashley E. Sobel, Shaun M. Kirwan, Chris P. Shelburne, Salvatore V. Pizzo, Soman N. Abraham, and Herman F. Staats. “The mast cell activator Compound 48/80 is a potent adjuvant for intradermally-administered anthrax protective antigen.” Journal of Immunology 178 (April 1, 2007).
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  - Misra, Uma Kant, and Salvatore Vincent Pizzo. “Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter.” J Cell Biochem 100, no. 4 (March 1, 2007): 1022–33. https://doi.org/10.1002/jcb.21086.
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  - Gonzalez-Gronow, Mario, Miguel Cuchacovich, Carolina Llanos, Cristian Urzua, Govind Gawdi, and Salvatore V. Pizzo. “Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum.” Cancer Res 66, no. 23 (December 1, 2006): 11424–31. https://doi.org/10.1158/0008-5472.CAN-06-1721.
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  - Mavropoulos, John C., William B. Isaacs, Salvatore V. Pizzo, and Stephen J. Freedland. “Is there a role for a low-carbohydrate ketogenic diet in the management of prostate cancer?” Urology 68, no. 1 (July 2006): 15–18. https://doi.org/10.1016/j.urology.2006.03.073.
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  - Misra, Uma Kant, Rohit Deedwania, and Salvatore Vincent Pizzo. “Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.” J Biol Chem 281, no. 19 (May 12, 2006): 13694–707. https://doi.org/10.1074/jbc.M511694200.
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  - Haraguchi, Soichi, Noorbibi K. Day, Wasu Kamchaisatian, Macarena Beigier-Pompadre, Steffen Stenger, Nutthapong Tangsinmankong, John W. Sleasman, Salvatore V. Pizzo, and George J. Cianciolo. “LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells.” Aids Res Ther 3 (March 31, 2006): 8. https://doi.org/10.1186/1742-6405-3-8.
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  - Chi, Sulene L., and Salvatore V. Pizzo. “Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase.” Cancer Res 66, no. 2 (January 15, 2006): 875–82. https://doi.org/10.1158/0008-5472.CAN-05-2806.
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  - Chi, Sulene L., and Salvatore V. Pizzo. “Cell surface F1Fo ATP synthase: a new paradigm?” Ann Med 38, no. 6 (2006): 429–38. https://doi.org/10.1080/07853890600928698.
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  - Mavropoulos, John C., Timothy A. Fields, and Salvatore V. Pizzo. “Chaperones and disease.” N Engl J Med 353, no. 26 (December 29, 2005): 2821–22.
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  - Hart, Justin P., Gloria Broadwater, Zahid Rabbani, Benjamin J. Moeller, Robert Clough, Dale Huang, Gregory A. Sempowski, et al. “Cytokine profiling for prediction of symptomatic radiation-induced lung injury.” Int J Radiat Oncol Biol Phys 63, no. 5 (December 1, 2005): 1448–54. https://doi.org/10.1016/j.ijrobp.2005.05.032.
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  - Misra, Uma K., and Salvatore V. Pizzo. “Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.” J Biol Chem 280, no. 46 (November 18, 2005): 38276–89. https://doi.org/10.1074/jbc.M507332200.
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  - Banbula, Agnieszka, Lara S. Chang, Wayne F. Beyer, Charu L. Bohra, George J. Cianciolo, and Salvatore V. Pizzo. “The properties of rabbit alpha1-macroglobulin upon activation are distinct from those of rabbit and human alpha2-macroglobulins.” J Biochem 138, no. 5 (November 2005): 527–37. https://doi.org/10.1093/jb/mvi162.
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  - Mavropoulos, John C., Miguel Cuchacovich, Carolina Llanos, Juan C. Aguillón, Hector Gatica, Salvatore V. Pizzo, and Mario Gonzalez-Gronow. “Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis.” J Rheumatol 32, no. 11 (November 2005): 2116–24.
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  - Wahl, Miriam L., Daniel J. Kenan, Mario Gonzalez-Gronow, and Salvatore V. Pizzo. “Angiostatin's molecular mechanism: aspects of specificity and regulation elucidated.” J Cell Biochem 96, no. 2 (October 1, 2005): 242–61. https://doi.org/10.1002/jcb.20480.
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  - Misra, Uma Kant, Tushar Sharma, and Salvatore Vincent Pizzo. “Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages.” J Immunol 175, no. 4 (August 15, 2005): 2525–33. https://doi.org/10.4049/jimmunol.175.4.2525.
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  - Gonzalez-Gronow, Mario, Uma K. Misra, Govind Gawdi, and Salvatore V. Pizzo. “Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells.” J Biol Chem 280, no. 29 (July 22, 2005): 27173–78. https://doi.org/10.1074/jbc.M500383200.
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  - Misra, Uma Kant, Rohit Deedwania, and Salvatore Vincent Pizzo. “Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.” J Biol Chem 280, no. 28 (July 15, 2005): 26278–86. https://doi.org/10.1074/jbc.M414467200.
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  - Misra, Uma Kant, and Salvatore Vincent Pizzo. “Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin.” J Leukoc Biol 78, no. 1 (July 2005): 187–94. https://doi.org/10.1189/jlb.1104685.
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  - Williams, Eric A., Richard J. Ing, Justin P. Hart, James Jaggers, Frank H. Kern, Damian M. Craig, and Salvatore V. Pizzo. “Soluble alpha2-macroglobulin receptor is increased in endotracheal aspirates from infants and children after cardiopulmonary bypass.” J Thorac Cardiovasc Surg 129, no. 5 (May 2005): 1098–1103. https://doi.org/10.1016/j.jtcvs.2004.08.020.
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  - Misra, Uma Kant, Mario Gonzalez-Gronow, Govind Gawdi, and Salvatore Vincent Pizzo. “The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling.” J Immunol 174, no. 4 (February 15, 2005): 2092–97. https://doi.org/10.4049/jimmunol.174.4.2092.
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  - Gonzalez-Gronow, Mario, Hernan E. Grenett, Govind Gawdi, and Salvatore V. Pizzo. “Angiostatin directly inhibits human prostate tumor cell invasion by blocking plasminogen binding to its cellular receptor, CD26.” Exp Cell Res 303, no. 1 (February 1, 2005): 22–31. https://doi.org/10.1016/j.yexcr.2004.09.008.
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  - Burwick, Nick R., Miriam L. Wahl, Jun Fang, Zhaoxi Zhong, Tammy L. Moser, Bo Li, Roderick A. Capaldi, Daniel J. Kenan, and Salvatore V. Pizzo. “An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface.” J Biol Chem 280, no. 3 (January 21, 2005): 1740–45. https://doi.org/10.1074/jbc.M405947200.
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  - Cuchacovich, M., G. Merino, J. H. Yamamoto, F. Villarroel, T. Saavedra, S. Jofre, H. Gatica, V. Velasquez, S. V. Pizzo, and M. Gonzalez-Gronow. “Behçet's disease patients present high levels of deglycosylated anti-lipoteichoic acid IgG and high IL-8 production after lipoteichoic acid stimulation.” Clin Exp Rheumatol 23, no. 4 Suppl 38 (2005): S27–34.
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  - Berwin, Brent, Yves Delneste, Rachel V. Lovingood, Steven R. Post, and Salvatore V. Pizzo. “SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin.” J Biol Chem 279, no. 49 (December 3, 2004): 51250–57. https://doi.org/10.1074/jbc.M406202200.
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  - Misra, U. K., and Salvatore V. Pizzo. “Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.” J Cell Biochem 93, no. 5 (November 15, 2004): 1020–32. https://doi.org/10.1002/jcb.20233.
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  - Misra, Uma Kant, Mario Gonzalez-Gronow, Govind Gawdi, Fang Wang, and Salvatore Vincent Pizzo. “A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling.” Cell Signal 16, no. 8 (August 2004): 929–38. https://doi.org/10.1016/j.cellsig.2004.01.003.
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  - Veitonmäki, Niina, Renhai Cao, Lin-Hua Wu, Tammy L. Moser, Bo Li, Salvatore V. Pizzo, Boris Zhivotovsky, and Yihai Cao. “Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis.” Cancer Res 64, no. 10 (May 15, 2004): 3679–86. https://doi.org/10.1158/0008-5472.CAN-03-1754.
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  - Gonzalez-Gronow, Mario, Michael S. Hershfield, Francisco X. Arredondo-Vega, and Salvatore V. Pizzo. “Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.” J Biol Chem 279, no. 20 (May 14, 2004): 20993–98. https://doi.org/10.1074/jbc.M401023200.
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  - Misra, U. K., and S. V. Pizzo. “Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells.” Cell Signal 16, no. 4 (April 2004): 487–96. https://doi.org/10.1016/j.cellsig.2003.09.010.
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  - Hart, Justin P., Michael D. Gunn, and Salvatore V. Pizzo. “A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens.” J Immunol 172, no. 1 (January 1, 2004): 70–78. https://doi.org/10.4049/jimmunol.172.1.70.
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  - Wahl, Miriam L., Tammy L. Moser, and Salvatore V. Pizzo. “Angiostatin and anti-angiogenic therapy in human disease.” Recent Prog Horm Res 59 (2004): 73–104. https://doi.org/10.1210/rp.59.1.73.
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  - McLachlan, James B., Justin P. Hart, Salvatore V. Pizzo, Christopher P. Shelburne, Herman F. Staats, Michael D. Gunn, and Soman N. Abraham. “Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.” Nat Immunol 4, no. 12 (December 2003): 1199–1205. https://doi.org/10.1038/ni1005.
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  - Berwin, Brent, Justin P. Hart, Stuart Rice, Cecilia Gass, Salvatore V. Pizzo, Steven R. Post, and Christopher V. Nicchitta. “Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells.” Embo J 22, no. 22 (November 17, 2003): 6127–36. https://doi.org/10.1093/emboj/cdg572.
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  - Misra, Uma Kant, Govind Gawdi, and Salvatore Vincent Pizzo. “Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+.” Cell Signal 15, no. 11 (November 2003): 1059–70. https://doi.org/10.1016/s0898-6568(03)00117-7.
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  - Mathew, Smitha, Sanja Arandjelovic, Wayne F. Beyer, Steven L. Gonias, and Salvatore V. Pizzo. “Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions.” Biochem J 374, no. Pt 1 (August 15, 2003): 123–29. https://doi.org/10.1042/BJ20021655.
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  - Gonzalez-Gronow, Mario, Theodosia Kalfa, Carrie E. Johnson, Govind Gawdi, and Salvatore V. Pizzo. “The voltage-dependent anion channel is a receptor for plasminogen kringle 5 on human endothelial cells.” J Biol Chem 278, no. 29 (July 18, 2003): 27312–18. https://doi.org/10.1074/jbc.M303172200.
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  - Fields, Ryan C., Jonathan G. Schoenecker, Justin P. Hart, Maureane R. Hoffman, Salvatore V. Pizzo, and Jeffrey H. Lawson. “Protease-activated receptor-2 signaling triggers dendritic cell development.” Am J Pathol 162, no. 6 (June 2003): 1817–22. https://doi.org/10.1016/S0002-9440(10)64316-7.
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  - Cuchacovich, Miguel, Héctor Gatica, Paula Vial, Jorge Yovanovich, Salvatore V. Pizzo, and Mario Gonzalez-Gronow. “Streptokinase promotes development of dipeptidyl peptidase IV (CD26) autoantibodies after fibrinolytic therapy in myocardial infarction patients.” Clin Diagn Lab Immunol 9, no. 6 (November 2002): 1253–59. https://doi.org/10.1128/cdli.9.6.1253-1259.2002.
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  - Misra, Uma K., Mario Gonzalez-Gronow, Govind Gawdi, Justin P. Hart, Carrie E. Johnson, and Salvatore V. Pizzo. “The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction.” J Biol Chem 277, no. 44 (November 1, 2002): 42082–87. https://doi.org/10.1074/jbc.M206174200.
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  - Misra, Uma Kant, Gamal Akabani, and Salvatore Vincent Pizzo. “The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.” J Biol Chem 277, no. 39 (September 27, 2002): 36509–20. https://doi.org/10.1074/jbc.M203543200.
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  - Thøgersen, Ida B., Stephen R. Hammes, David S. Rubenstein, Salvatore V. Pizzo, Zuzana Valnickova, and Jan J. Enghild. “New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor.” Biochim Biophys Acta 1598, no. 1–2 (July 29, 2002): 131–39. https://doi.org/10.1016/s0167-4838(02)00360-6.
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  - Gonzalez-Gronow, Mario, Govind Gawdi, and Salvatore V. Pizzo. “Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells.” Blood 99, no. 12 (June 15, 2002): 4562–67. https://doi.org/10.1182/blood.v99.12.4562.
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  - Liao, Hua Xin, George J. Cianciolo, Herman F. Staats, Richard M. Scearce, Dana M. Lapple, Stephen H. Stauffer, James R. Thomasch, et al. “Increased immunogenicity of HIV envelope subunit complexed with alpha2-macroglobulin when combined with monophosphoryl lipid A and GM-CSF.” Vaccine 20, no. 17–18 (May 22, 2002): 2396–2403. https://doi.org/10.1016/s0264-410x(02)00090-7.
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  - Berwin, Brent, Justin P. Hart, Salvatore V. Pizzo, and Christopher V. Nicchitta. “Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides.” J Immunol 168, no. 9 (May 1, 2002): 4282–86. https://doi.org/10.4049/jimmunol.168.9.4282.
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  - Misra, Uma Kant, Govind Gawdi, Gomal Akabani, and Salvatore Vincent Pizzo. “Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms.” Cell Signal 14, no. 4 (April 2002): 327–40. https://doi.org/10.1016/s0898-6568(01)00268-6.
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  - Moser, Tammy L., M Sharon Stack, Miriam L. Wahl, and Salvatore V. Pizzo. “The mechanism of action of angiostatin: can you teach an old dog new tricks?” Thromb Haemost 87, no. 3 (March 2002): 394–401.
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  - Misra, Uma Kant, Govind Gawdi, and Salvatore Vincent Pizzo. “Beryllium fluoride-induced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation.” J Leukoc Biol 71, no. 3 (March 2002): 487–94.
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  - Misra, Uma Kant, and Salvatore Vincent Pizzo. “Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation.” J Biol Chem 277, no. 6 (February 8, 2002): 4069–78. https://doi.org/10.1074/jbc.M109764200.
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  - Misra, U. K., and S. V. Pizzo. “Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein.” Arch Biochem Biophys 396, no. 1 (December 1, 2001): 106–10. https://doi.org/10.1006/abbi.2001.2597.
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  - Cianciolo, G. J., J. J. Enghild, and S. V. Pizzo. “Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity.” Vaccine 20, no. 3–4 (November 12, 2001): 554–62. https://doi.org/10.1016/s0264-410x(01)00361-9.
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  - Adlakha, C. L., J. P. Hart, and S. V. Pizzo. “Kinetics of nonproteolytic incorporation of a protein ligand into thermally activated alpha 2-macroglobulin: evidence for a novel nascent state.” J Biol Chem 276, no. 45 (November 9, 2001): 41547–52. https://doi.org/10.1074/jbc.M106357200.
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  - Misra, U. K., and S. V. Pizzo. “Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor.” Cell Signal 13, no. 11 (November 2001): 801–8. https://doi.org/10.1016/s0898-6568(01)00202-9.
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  - Misra, U. K., C. L. Adlakha, G. Gawdi, M. K. McMillian, S. V. Pizzo, and D. T. Laskowitz. “Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages.” J Leukoc Biol 70, no. 4 (October 2001): 677–83.
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  - Wu, S. M., and S. V. Pizzo. “alpha(2)-Macroglobulin from rheumatoid arthritis synovial fluid: functional analysis defines a role for oxidation in inflammation.” Arch Biochem Biophys 391, no. 1 (July 1, 2001): 119–26. https://doi.org/10.1006/abbi.2001.2408.
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  - Moser, T. L., D. J. Kenan, T. A. Ashley, J. A. Roy, M. D. Goodman, U. K. Misra, D. J. Cheek, and S. V. Pizzo. “Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin.” Proc Natl Acad Sci U S A 98, no. 12 (June 5, 2001): 6656–61. https://doi.org/10.1073/pnas.131067798.
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  - Asplin, I. R., S. M. Wu, S. Mathew, G. Bhattacharjee, and S. V. Pizzo. “Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis.” Blood 97, no. 11 (June 1, 2001): 3450–57. https://doi.org/10.1182/blood.v97.11.3450.
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  - Gonzalez-Gronow, M., H. E. Grenett, M. R. Weber, G. Gawdi, and S. V. Pizzo. “Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells.” Biochem J 355, no. Pt 2 (April 15, 2001): 397–407. https://doi.org/10.1042/0264-6021:3550397.
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  - Misra, U. K., and S. V. Pizzo. “Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.” Arch Biochem Biophys 386, no. 2 (February 15, 2001): 227–32. https://doi.org/10.1006/abbi.2000.2199.
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  - Bhattacharjee, G., U. K. Misra, G. Gawdi, G. Cianciolo, and S. V. Pizzo. “Inducible expression of the alpha2-macroglobulin signaling receptor in response to antigenic stimulation: a study of second messenger generation.” J Cell Biochem 82, no. 2 (2001): 260–70. https://doi.org/10.1002/jcb.1152.
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  - Cuchacovich, M., H. Gatica, S. V. Pizzo, and M. Gonzalez-Gronow. “Characterization of human serum dipeptidyl peptidase IV (CD26) and analysis of its autoantibodies in patients with rheumatoid arthritis and other autoimmune diseases.” Clin Exp Rheumatol 19, no. 6 (2001): 673–80.
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  - Laskowitz, D. T., A. D. Thekdi, S. D. Thekdi, S. K. Han, J. K. Myers, S. V. Pizzo, and E. R. Bennett. “Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.” Exp Neurol 167, no. 1 (January 2001): 74–85. https://doi.org/10.1006/exnr.2001.7541.
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  - Asplin, I. R., U. K. Misra, G. Gawdi, M. Gonzalez-Gronow, and S. V. Pizzo. “Selective upregulated expression of the alpha2-macroglobulin signaling receptor in highly metastatic 1-LN prostate carcinoma cells.” Arch Biochem Biophys 383, no. 1 (November 1, 2000): 135–41. https://doi.org/10.1006/abbi.2000.2052.
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  - Bhattacharjee, G., I. R. Asplin, S. M. Wu, G. Gawdi, and S. V. Pizzo. “The conformation-dependent interaction of alpha 2-macroglobulin with vascular endothelial growth factor. A novel mechanism of alpha 2-macroglobulin/growth factor binding.” J Biol Chem 275, no. 35 (September 1, 2000): 26806–11. https://doi.org/10.1074/jbc.M000156200.
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  - Misra, U. K., and S. V. Pizzo. “Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin.” Arch Biochem Biophys 379, no. 1 (July 1, 2000): 153–60. https://doi.org/10.1006/abbi.2000.1878.
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  - Misra, U. K., G. Gawdi, and S. V. Pizzo. “Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin.” Cell Signal 12, no. 2 (February 2000): 99–104. https://doi.org/10.1016/s0898-6568(99)00070-4.
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  - Misra, U. K., G. Gawdi, and S. V. Pizzo. “Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages.” Arch Biochem Biophys 372, no. 2 (December 15, 1999): 238–47. https://doi.org/10.1006/abbi.1999.1521.
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  - Wu, S. M., and S. V. Pizzo. “Mechanism of hypochlorite-mediated inactivation of proteinase inhibition by alpha 2-macroglobulin.” Biochemistry 38, no. 42 (October 19, 1999): 13983–90. https://doi.org/10.1021/bi991438i.
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  - Misra, U. K., G. Gawdi, M. Gonzalez-Gronow, and S. V. Pizzo. “Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin.” J Biol Chem 274, no. 36 (September 3, 1999): 25785–91. https://doi.org/10.1074/jbc.274.36.25785.
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  - Bhattacharjee, G., H. Grøn, and S. V. Pizzo. “Incorporation of non-proteolytic proteins by murine alpha2-macroglobulin.” Biochim Biophys Acta 1432, no. 1 (June 15, 1999): 49–56. https://doi.org/10.1016/s0167-4838(99)00072-2.
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  - Misra, U. K., G. Gawdi, S. V. Pizzo, and J. G. Lewis. “Exposure of cultured murine peritoneal macrophages to low concentrations of beryllium induces increases in intracellular calcium concentrations and stimulates DNA synthesis.” J Leukoc Biol 65, no. 6 (June 1999): 786–91. https://doi.org/10.1002/jlb.65.6.786.
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  - Moser, T. L., M. S. Stack, I. Asplin, J. J. Enghild, P. Højrup, L. Everitt, S. Hubchak, H. W. Schnaper, and S. V. Pizzo. “Angiostatin binds ATP synthase on the surface of human endothelial cells.” Proc Natl Acad Sci U S A 96, no. 6 (March 16, 1999): 2811–16. https://doi.org/10.1073/pnas.96.6.2811.
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  - Misra, U. K., and S. V. Pizzo. “Upregulation of macrophage plasma membrane and nuclear phospholipase D activity on ligation of the alpha2-macroglobulin signaling receptor: involvement of heterotrimeric and monomeric G proteins.” Arch Biochem Biophys 363, no. 1 (March 1, 1999): 68–80. https://doi.org/10.1006/abbi.1998.1074.
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  - Gonzalez-Gronow, M., M. R. Weber, and S. V. Pizzo. “Secretion of MMP-9 by 1-LN human prostate tumor cells is modulated via a signaling mechanism initiated by interaction between plasminogen carbohydrate chains and DPP IV (CD26) on the cell surface.” Faseb Journal 12, no. 8 (December 1, 1998).
  - Misra, U. K., G. Gawdi, and S. V. Pizzo. “Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages.” J Immunol 161, no. 11 (December 1, 1998): 6122–27.
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  - Misra, U., D. Laskowitz, N. L. McMillian, G. Gawdi, and S. Pizzo. “APOE3 and APOE4 binding to macrophages triggers inositol (1,4,5-) triphosphate-mediated increases in intracellular calcium.” Faseb Journal 12, no. 8 (December 1, 1998).
  - Pizzo, S. V., U. K. Misra, M. Gonzalez-Gronow, and G. Gawdi. “Upregulation of a2m signalling receptor by insulin in macrophages.” Faseb Journal 12, no. 8 (December 1, 1998).
  - Wu, S. M., D. D. Patel, and S. V. Pizzo. “Oxidized alpha2-macroglobulin (alpha2M) differentially regulates receptor binding by cytokines/growth factors: implications for tissue injury and repair mechanisms in inflammation.” J Immunol 161, no. 8 (October 15, 1998): 4356–65.
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  - Misra, U. K., G. Gawdi, J. G. Lewis, and S. V. Pizzo. “Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone.” Toxicol Appl Pharmacol 151, no. 1 (July 1998): 1–8. https://doi.org/10.1006/taap.1998.8415.
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  - Misra, U. K., and S. V. Pizzo. “Ligation of the alpha2M signalling receptor elevates the levels of p21Ras-GTP in macrophages.” Cell Signal 10, no. 6 (June 1998): 441–45. https://doi.org/10.1016/s0898-6568(97)00171-x.
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  - Misra, U. K., and S. V. Pizzo. “Binding of receptor-recognized forms of alpha2-macroglobulin to the alpha2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase.” J Biol Chem 273, no. 22 (May 29, 1998): 13399–402. https://doi.org/10.1074/jbc.273.22.13399.
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  - Grøn, H., and S. V. Pizzo. “Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of alpha 2-macroglobulin.” Biochemistry 37, no. 17 (April 28, 1998): 6009–14. https://doi.org/10.1021/bi973027c.
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  - Misra, U. K., and S. V. Pizzo. “Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium.” Biochim Biophys Acta 1401, no. 1 (January 2, 1998): 121–28. https://doi.org/10.1016/s0167-4889(97)00123-7.
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  - Gonzalez-Gronow, M., M. R. Weber, G. Gawdi, and S. V. Pizzo. “Dipeptidyl peptidase IV (CD26) is a receptor for streptokinase on rheumatoid synovial fibroblasts.” Fibrinolysis and Proteolysis 12, no. 3 (January 1, 1998): 129–35. https://doi.org/10.1016/S0268-9499(98)80294-4.
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  - Gonzalez-Gronow, M., M. R. Weber, T. V. Shearin, G. Gawdi, S. R. Pirie-Shepherd, and S. V. Pizzo. “Plasmin(ogen) carbohydrate chains mediate binding to dipeptidyl peptidase IV (CD 26) in rheumatoid arthritis human synovial fibroblasts.” Fibrinolysis and Proteolysis 12, no. 6 (January 1, 1998): 366–74. https://doi.org/10.1016/S0268-9499(98)80395-0.
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  - Wu, S. M., and S. V. Pizzo. “Oxidized α₂-macroglobulin differentially regulates receptor binding by cytokines/growth factors.” Faseb Journal 12, no. 4 (1998): A485.
  - Misra, U. K., G. Gowal, and S. V. Pizzo. “Cyclosporin a inhibits ip,-mediated release of calcium from intracellu lar stores in macrophages.” Faseb Journal 11, no. 9 (December 1, 1997).
  - Moser, T. L., S. V. Pizzo, J. J. Enghild, S. Hubchak, and M. Sharon Stack. “Isolation of an angiostatin receptor from the membranes of human umbilical vein endothehal cells.” Fibrinolysis and Proteolysis 11, no. SUPPL. 3 (December 1, 1997): 39.
  - Pizzo, S. V., and U. K. Misra. “Activation of ARF- But not RHO-dependent nuclear phospholipase D in murine peritoneal macrophages on ligation of cvM signaling receptor.” Faseb Journal 11, no. 9 (December 1, 1997).
  - Odom, A. R., U. K. Misra, and S. V. Pizzo. “Nickel inhibits binding of alpha2-macroglobulin-methylamine to the low-density lipoprotein receptor-related protein/alpha2-macroglobulin receptor but not the alpha2-macroglobulin signaling receptor.” Biochemistry 36, no. 41 (October 14, 1997): 12395–99. https://doi.org/10.1021/bi970806k.
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  - Shackelford, R. E., P. B. Alford, Y. Xue, S. F. Thai, D. O. Adams, and S. Pizzo. “Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages.” Mol Pharmacol 52, no. 3 (September 1997): 421–29. https://doi.org/10.1124/mol.52.3.421.
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  - Wu, S. M., C. M. Boyer, and S. V. Pizzo. “The binding of receptor-recognized alpha2-macroglobulin to the low density lipoprotein receptor-related protein and the alpha2M signaling receptor is decoupled by oxidation.” J Biol Chem 272, no. 33 (August 15, 1997): 20627–35. https://doi.org/10.1074/jbc.272.33.20627.
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  - Shearin, T. V., S. V. Pizzo, and M. Gonzalez-Gronow. “Molecular abnormalities of human plasminogen isolated from synovial fluid of rheumatoid arthritis patients.” J Mol Med (Berl) 75, no. 5 (May 1997): 378–85.
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  - Pirie-Shepherd, S. R., R. D. Stevens, N. L. Andon, J. J. Enghild, and S. V. Pizzo. “Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2.” J Biol Chem 272, no. 11 (March 14, 1997): 7408–11. https://doi.org/10.1074/jbc.272.11.7408.
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  - Misra, U. K., G. Gawdi, and S. V. Pizzo. “Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor.” J Cell Biochem 64, no. 2 (February 1997): 225–32. https://doi.org/10.1002/(sici)1097-4644(199702)64:2<225::aid-jcb6>3.0.co;2-z.
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  - Misra, U. K., M. Gonzalez-Gronow, G. Gawdi, and S. V. Pizzo. “Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts.” J Biol Chem 272, no. 1 (January 3, 1997): 497–502. https://doi.org/10.1074/jbc.272.1.497.
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  - Grøn, H., R. Pike, J. Potempa, J. Travis, I. B. Thøgersen, J. J. Enghild, and S. V. Pizzo. “The potential role of alpha 2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis.” J Periodontal Res 32, no. 1 Pt 1 (January 1997): 61–68. https://doi.org/10.1111/j.1600-0765.1997.tb01383.x.
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  - Misra, U. K., R. E. Shackelford, K. Florine-Casteel, S. F. Thai, P. B. Alford, S. V. Pizzo, and D. O. Adams. “Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages.” J Leukoc Biol 60, no. 6 (December 1996): 784–92. https://doi.org/10.1002/jlb.60.6.784.
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  - Howard, G. C., D. L. DeCamp, U. K. Misra, and S. V. Pizzo. “Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor.” Biochim Biophys Acta 1297, no. 2 (October 17, 1996): 111–14. https://doi.org/10.1016/s0167-4838(96)00135-5.
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  - Moser, T. L., S. V. Pizzo, L. M. Bafetti, D. A. Fishman, and M. S. Stack. “Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin.” Int J Cancer 67, no. 5 (September 4, 1996): 695–701. https://doi.org/10.1002/(SICI)1097-0215(19960904)67:5<695::AID-IJC18>3.0.CO;2-4.
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  - Howard, G. C., B. C. Roberts, D. L. Epstein, and S. V. Pizzo. “Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor.” Arch Biochem Biophys 333, no. 1 (September 1, 1996): 19–26. https://doi.org/10.1006/abbi.1996.0359.
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  - Grøn, H., I. B. Thøgersen, J. J. Enghild, and S. V. Pizzo. “Structural and functional analysis of the spontaneous re-formation of the thiol ester bond in human alpha 2-macroglobulin, rat alpha 1-inhibitor-3 and chemically modified derivatives.” Biochem J 318 ( Pt 2), no. Pt 2 (September 1, 1996): 539–45. https://doi.org/10.1042/bj3180539.
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  - Gonzalez-Gronow, M., M. Cuchacovich, D. M. Grigg, and S. V. Pizzo. “Analysis of autoantibodies to plasminogen in the serum of patients with rheumatoid arthritis.” J Mol Med (Berl) 74, no. 8 (August 1996): 463–69. https://doi.org/10.1007/BF00217522.
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  - Young, T. N., G. C. Rodriguez, A. R. Rinehart, R. C. Bast, S. V. Pizzo, and M. S. Stack. “Characterization of gelatinases linked to extracellular matrix invasion in ovarian adenocarcinoma: purification of matrix metalloproteinase 2.” Gynecol Oncol 62, no. 1 (July 1996): 89–99. https://doi.org/10.1006/gyno.1996.0195.
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  - Howard, G. C., Y. Yamaguchi, U. K. Misra, G. Gawdi, A. Nelsen, D. L. DeCamp, and S. V. Pizzo. “Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor.” J Biol Chem 271, no. 24 (June 14, 1996): 14105–11. https://doi.org/10.1074/jbc.271.24.14105.
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  - Valnickova, Z., I. B. Thogersen, S. Christensen, C. T. Chu, S. V. Pizzo, and J. J. Enghild. “Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein.” J Biol Chem 271, no. 22 (May 31, 1996): 12937–43. https://doi.org/10.1074/jbc.271.22.12937.
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  - Bradford, W. D., D. Anthony, C. T. Chu, and S. V. Pizzo. “Career characteristics of graduates of a Medical Scientist Training Program, 1970-1990.” Acad Med 71, no. 5 (May 1996): 484–87. https://doi.org/10.1097/00001888-199605000-00019.
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  - Misra, U. K., G. Gawdi, and S. V. Pizzo. “Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers.” J Cell Biochem 61, no. 1 (April 1996): 61–71. https://doi.org/10.1002/(SICI)1097-4644(19960401)61:1%3C61::AID-JCB8%3E3.0.CO;2-0.
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  - Misra, U. K., and S. V. Pizzo. “Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor.” J Cell Biochem 61, no. 1 (April 1996): 39–47. https://doi.org/10.1002/(SICI)1097-4644(19960401)61:1%3C39::AID-JCB6%3E3.0.CO;2-3.
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  - Howard, G. C., U. K. Misra, D. L. DeCamp, and S. V. Pizzo. “Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor.” J Clin Invest 97, no. 5 (March 1, 1996): 1193–1203. https://doi.org/10.1172/JCI118533.
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  - Howard, G. C., B. C. Roberts, D. L. Epstein, and S. V. Pizzo. “Human trabecular meshwork cells possess two distinct receptors for receptor-recognized forms of α2macroglobulin.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
  - Wu, S. M., and S. V. Pizzo. “Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor on murine peritoneal macrophages mediates the binding and catabolism of low-density lipoprotein.” Arch Biochem Biophys 326, no. 1 (February 1, 1996): 39–47. https://doi.org/10.1006/abbi.1996.0044.
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  - Gonzalez-Gronow, M., G. Gawdi, T. V. Shearin, S. R. Pirie-Shepherd, and S. V. Pizzo. “Plasmin(ogen) carbohydrate chains mediate binding to dipeptidyl peptidase iv (cd 26) on rheumatoid artrhitis human synovial fibroblasts.” Fibrinolysis 10, no. SUPPL. 3 (January 1, 1996): 25. https://doi.org/10.1016/s0268-9499(96)80163-9.
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  - Gonzalez-Gronow, M., T. V. Shearin, and S. V. Pizzo. “Dipeptidyl Peptidase IV(CD 26) is a Receptor for Streptokinase and Fibronectin on Rheumatoid Arthritis Human Synovial Fibroblasts.” Fibrinolysis 10, no. SUPPL. 3 (January 1, 1996): 32. https://doi.org/10.1016/s0268-9499(96)80184-6.
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  - Moser, T. L., M. S. Stack, M. Gonzalez-Gronow, and S. V. Pizzo. “Interaction of human plasminogen kringles 1-3 (angiostatin) with human umbilical vein endothelial cells (huvec): binding properties and effects on cell proliferation.” Fibrinolysis 10, no. SUPPL. 3 (January 1, 1996): 73. https://doi.org/10.1016/s0268-9499(96)80336-5.
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  - Pirie-Shepherd, S. R., R. L. Serrano, N. L. Andon, M. Gonzalez-Gronow, and S. V. Pizzo. “The role of carbohydrate in the activation of plasminogen 2 glycoforms by streptokinase.” Fibrinolysis 10, no. 1 (January 1, 1996): 49–53. https://doi.org/10.1016/S0268-9499(05)80076-1.
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  - Stack, M. S., T. L. Moser, L. M. Bafetti, S. V. Pizzo, and D. A. Fishman. “Role of adhesion and proteolysis in epithelial ovarian carcinoma dissemination.” Fibrinolysis 10, no. SUPPL. 3 (January 1, 1996): 26. https://doi.org/10.1016/s0268-9499(96)80165-2.
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  - Cuchacovich, M., H. Gatica, D. M. Grigg, S. V. Pizzo, and M. Gonzalez-Gronow. “Potential pathogenicity of deglycosylated IgG cross reactive with streptokinase and fibronectin in the serum of patients with rheumatoid arthritis.” J Rheumatol 23, no. 1 (January 1996): 44–51.
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  - Serrano, R. L., P. Rodriguez, S. V. Pizzo, and M. Gonzalez-Gronow. “ATP-regulated activity of the plasmin-streptokinase complex: a novel mechanism involving phosphorylation of streptokinase.” Biochem J 313 ( Pt 1), no. Pt 1 (January 1, 1996): 171–77. https://doi.org/10.1042/bj3130171.
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  - Webb, D. J., I. M. Hussaini, A. M. Weaver, T. L. Atkins, C. T. Chu, S. V. Pizzo, G. K. Owens, and S. L. Gonias. “Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.” Eur J Biochem 234, no. 3 (December 15, 1995): 714–22. https://doi.org/10.1111/j.1432-1033.1995.714_a.x.
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  - Misra, U. K., G. Gawdi, and S. V. Pizzo. “Ligation of the alpha 2-macroglobulin signalling receptor on macrophages induces protein phosphorylation and an increase in cytosolic pH.” Biochem J 309 ( Pt 1), no. Pt 1 (July 1, 1995): 151–58. https://doi.org/10.1042/bj3090151.
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  - Christensen, S., Z. Valnickova, I. B. Thøgersen, S. V. Pizzo, H. R. Nielsen, P. Roepstorff, and J. J. Enghild. “Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop.” J Biol Chem 270, no. 25 (June 23, 1995): 14859–62. https://doi.org/10.1074/jbc.270.25.14859.
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  - Moser, T. L., J. J. Enghild, S. V. Pizzo, and M. S. Stack. “Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells.” Biochem J 307 ( Pt 3), no. Pt 3 (May 1, 1995): 867–73. https://doi.org/10.1042/bj3070867.
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  - Pirie-Shepherd, S. R., E. A. Jett, N. L. Andon, and S. V. Pizzo. “Sialic acid content of plasminogen 2 glycoforms as a regulator of fibrinolytic activity. Isolation, carbohydrate analysis, and kinetic characterization of six glycoforms of plasminogen.” J Biol Chem 270, no. 11 (March 17, 1995): 5877–81. https://doi.org/10.1074/jbc.270.11.5877.
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  - Falkenberg, C., M. Allhorn, I. B. Thøgersen, Z. Valnickova, S. V. Pizzo, G. Salvesen, B. Akerström, and J. J. Enghild. “alpha 1-Microglobulin destroys the proteinase inhibitory activity of alpha 1-inhibitor-3 by complex formation.” J Biol Chem 270, no. 9 (March 3, 1995): 4478–83. https://doi.org/10.1074/jbc.270.9.4478.
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  - Schackelford, R. E., U. K. Misra, K. Florine-Casteel, S. F. Thai, S. V. Pizzo, and D. O. Adams. “Oxidized low density lipoprotein suppresses activation of NF kappa B in macrophages via a pertussis toxin-sensitive signaling mechanism.” J Biol Chem 270, no. 8 (February 24, 1995): 3475–78. https://doi.org/10.1074/jbc.270.8.3475.
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  - Young, T. N., S. V. Pizzo, and M. S. Stack. “A plasma membrane-associated component of ovarian adenocarcinoma cells enhances the catalytic efficiency of matrix metalloproteinase-2.” J Biol Chem 270, no. 3 (January 20, 1995): 999–1002. https://doi.org/10.1074/jbc.270.3.999.
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  - Edelberg, J. M., and S. V. Pizzo. “Lipoprotein (a) in the regulation of fibrinolysis.” J Atheroscler Thromb 2 Suppl 1 (1995): S5–7. https://doi.org/10.5551/jat1994.2.supplement1_s5.
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  - Falkenberg, C., M. Allhorn, I. B. Thøgersen, Z. Valnickova, S. V. Pizzo, G. Salvesen, B. Åkerström, and J. J. Enghild. “α₁-Microglobulin destroys the proteinase inhibitory activity of α₁-inhibitor-3 by complex formation.” Journal of Biological Chemistry 270, no. 9 (1995): 4478–83.
  - Stack, M. S., A. R. Rinehart, and S. V. Pizzo. “Comparison of plasminogen binding and activation on extracellular matrices produced by vascular smooth muscle and endothelial cells.” Eur J Biochem 226, no. 3 (December 15, 1994): 937–43. https://doi.org/10.1111/j.1432-1033.1994.00937.x.
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  - Chu, C. T., and S. V. Pizzo. “α2-Macroglobulin, complement, and biologic defense: Antigens, growth factors, microbial proteases, and receptor ligation.” Laboratory Investigation 71, no. 6 (December 1, 1994): 792–812.
  - Chu, C. T., and S. V. Pizzo. “alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation.” Lab Invest 71, no. 6 (December 1994): 792–812.
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  - Humphries, J. E., S. L. Gonias, S. V. Pizzo, and M. E. Williams. “Life-long bleeding diathesis: effect of orthotopic liver transplantation.” Am J Clin Pathol 102, no. 6 (December 1994): 816–20. https://doi.org/10.1093/ajcp/102.6.816.
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  - Chu, C. T., G. C. Howard, U. K. Misra, and S. V. Pizzo. “Alpha 2-macroglobulin: a sensor for proteolysis.” Ann N Y Acad Sci 737 (September 10, 1994): 291–307. https://doi.org/10.1111/j.1749-6632.1994.tb44319.x.
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  - Misra, U. K., and S. V. Pizzo. “Ligation of alpha 2M receptors with alpha 2M-methylamine stimulates the activities of phospholipase C, phospholipase A2, and protein kinase C in murine peritoneal macrophages.” Ann N Y Acad Sci 737 (September 10, 1994): 486–89. https://doi.org/10.1111/j.1749-6632.1994.tb44347.x.
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  - Enghild, J. J., Z. Valnickova, I. B. Thøgersen, and S. V. Pizzo. “Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors.” J Biol Chem 269, no. 31 (August 5, 1994): 20159–66.
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  - Misra, U. K., C. T. Chu, G. Gawdi, and S. V. Pizzo. “The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.” J Biol Chem 269, no. 28 (July 15, 1994): 18303–6.
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  - Young, T. N., G. C. Rodriguez, T. L. Moser, R. C. Bast, S. V. Pizzo, and M. S. Stack. “Coordinate expression of urinary-type plasminogen activator and its receptor accompanies malignant transformation of the ovarian surface epithelium.” Am J Obstet Gynecol 170, no. 5 Pt 1 (May 1994): 1285–96. https://doi.org/10.1016/s0002-9378(94)70143-1.
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  - Misra, U. K., C. T. Chu, G. Gawdi, and S. V. Pizzo. “Evidence for a second alpha 2-macroglobulin receptor.” J Biol Chem 269, no. 17 (April 29, 1994): 12541–47.
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  - Chu, C. T., T. D. Oury, J. J. Enghild, and S. V. Pizzo. “Adjuvant-free in vivo targeting. Antigen delivery by alpha 2-macroglobulin enhances antibody formation.” J Immunol 152, no. 4 (February 15, 1994): 1538–45.
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  - Stack, M. S., and S. V. Pizzo. “The effect of substituted laminin A chain-derived peptides on the conformation and activation kinetics of plasminogen.” Arch Biochem Biophys 309, no. 1 (February 15, 1994): 117–22. https://doi.org/10.1006/abbi.1994.1093.
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  - Moser, T. L., T. N. Young, G. C. Rodriguez, S. V. Pizzo, R. C. Bast, and M. S. Stack. “Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma.” Int J Cancer 56, no. 4 (February 15, 1994): 552–59. https://doi.org/10.1002/ijc.2910560415.
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  - Gonzalez-Gronow, M., G. Gawdi, and S. V. Pizzo. “Characterization of the plasminogen receptors of normal and rheumatoid arthritis human synovial fibroblasts.” J Biol Chem 269, no. 6 (February 11, 1994): 4360–66.
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  - Reddy, V. Y., P. E. Desorchers, S. V. Pizzo, S. L. Gonias, J. A. Sahakian, R. L. Levine, and S. J. Weiss. “Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers.” J Biol Chem 269, no. 6 (February 11, 1994): 4683–91.
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  - Chu, C. T., and S. V. Pizzo. “α₂-Macroglobulin, complement, and biologic defense: Antigens, growth factors, microbial proteases, and receptor ligation.” Laboratory Investigation 71, no. 6 (1994): 792–812.
  - Pirie-Shepherd, S. R., E. Blasco, and S. V. Pizzo. “Heparin as an hyperbolic modulator of plasminogen activation by t-PA.” Fibrinolysis and Proteolysis 8, no. 3 (January 1, 1994): 182–88. https://doi.org/10.1016/S0268-9499(05)80017-7.
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  - Pizzo, S. V., D. B. Cines, D. B. Fareed, D. B. Blajchman, D. B. Alvarez, D. B. Yo, and D. B. Rustagi. “The physiologic role of antithrombin III as an anticoagulant.” Seminars in Hematology 31, no. 2 SUPPL. 1 (January 1, 1994): 4–9.
  - Edelberg, J. M., D. C. Sane, and S. V. Pizzo. “Vascular regulation of plasminogen activator inhibitor-1 activity.” Semin Thromb Hemost 20, no. 4 (1994): 319–23. https://doi.org/10.1055/s-2007-1001920.
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  - Edelberg, J., and S. V. Pizzo. “Lipoprotein (a) regulates plasmin generation and inhibition.” Chem Phys Lipids 67–68 (January 1994): 363–68. https://doi.org/10.1016/0009-3084(94)90158-9.
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  - Gonzalez-Gronow, M., G. Gawdi, and S. V. Pizzo. “Plasminogen activation stimulates an increase in intracellular calcium in human synovial fibroblasts.” J Biol Chem 268, no. 28 (October 5, 1993): 20791–95.
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  - Howard, G. C., and S. V. Pizzo. “Lipoprotein(a) and its role in atherothrombotic disease.” Lab Invest 69, no. 4 (October 1993): 373–86.
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  - Moser, T. L., J. J. Enghild, S. V. Pizzo, and M. S. Stack. “The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator.” J Biol Chem 268, no. 25 (September 5, 1993): 18917–23.
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  - Stack, M. S., and S. V. Pizzo. “Modulation of tissue plasminogen activator-catalyzed plasminogen activation by synthetic peptides derived from the amino-terminal heparin binding domain of fibronectin.” J Biol Chem 268, no. 25 (September 5, 1993): 18924–28.
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  - Stack, M. S., R. D. Gray, and S. V. Pizzo. “Modulation of murine B16F10 melanoma plasminogen activator production by a synthetic peptide derived from the laminin A chain.” Cancer Res 53, no. 9 (May 1, 1993): 1998–2004.
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  - Enghild, J. J., Z. Valnickova, I. B. Thøgersen, S. V. Pizzo, and G. Salvesen. “An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with alpha 2-antiplasmin.” Biochem J 291 ( Pt 3), no. Pt 3 (May 1, 1993): 933–38. https://doi.org/10.1042/bj2910933.
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  - Enghild, J. J., G. Salvesen, I. B. Thøgersen, Z. Valnickova, S. V. Pizzo, and S. A. Hefta. “Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin.” J Biol Chem 268, no. 12 (April 25, 1993): 8711–16.
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  - Gonias, S. L., L. B. Marshall, N. L. Figler, I. M. Hussaini, M. D. Moncino, and S. V. Pizzo. “Electron microscopy studies of alpha 2-macroglobulin subunit association after limited reduction with dithiothreitol.” Arch Biochem Biophys 302, no. 1 (April 1993): 42–48. https://doi.org/10.1006/abbi.1993.1178.
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  - Misra, U. K., C. T. Chu, D. S. Rubenstein, G. Gawdi, and S. V. Pizzo. “Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages.” Biochem J 290 ( Pt 3), no. Pt 3 (March 15, 1993): 885–91. https://doi.org/10.1042/bj2900885.
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  - Rubenstein, D. S., I. B. Thøgersen, S. V. Pizzo, and J. J. Enghild. “Identification of monomeric alpha-macroglobulin proteinase inhibitors in birds, reptiles, amphibians and mammals, and purification and characterization of a monomeric alpha-macroglobulin proteinase inhibitor from the American bullfrog Rana catesbeiana.” Biochem J 290 ( Pt 1), no. Pt 1 (February 15, 1993): 85–95. https://doi.org/10.1042/bj2900085.
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  - Gonzalez-Gronow, M., J. J. Enghild, and S. V. Pizzo. “Streptokinase and human fibronectin share a common epitope: implications for regulation of fibrinolysis and rheumatoid arthritis.” Biochim Biophys Acta 1180, no. 3 (January 22, 1993): 283–88. https://doi.org/10.1016/0925-4439(93)90051-2.
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  - Chu, C. T., and S. V. Pizzo. “Receptor-mediated antigen delivery into macrophages. Complexing antigen to alpha 2-macroglobulin enhances presentation to T cells.” J Immunol 150, no. 1 (January 1, 1993): 48–58.
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  - Enghild, J. J., G. Salvesen, L. Theagerson, Z. Valanickova, S. V. Pizzo, and S. A. Hefta. “Protein-glycosaminoglycan-protein Covalent Cross-link in Heavy Chain 2-Bikunin.” Trends in Glycoscience and Glycotechnology 5, no. 25 (January 1, 1993): 401–4. https://doi.org/10.4052/tigg.5.401.
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  - Edelberg, J. M., Y. J. Lee, T. N. Young, and S. V. Pizzo. “Lipoprotein (a): purification and kinetic analysis.” Methods Enzymol 223 (1993): 272–88. https://doi.org/10.1016/0076-6879(93)23051-n.
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  - Salvesen, G., L. T. Quan, J. J. Enghild, S. Snipas, G. H. Fey, and S. V. Pizzo. “Expression of a functional alpha-macroglobulin receptor binding domain in Escherichia coli.” Febs Lett 313, no. 2 (November 23, 1992): 198–202. https://doi.org/10.1016/0014-5793(92)81443-p.
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  - Edelberg, J., and S. V. Pizzo. “Why is lipoprotein(a) relevant to thrombosis?” Am J Clin Nutr 56, no. 4 Suppl (October 1992): 791S-792S. https://doi.org/10.1093/ajcn/56.4.791s.
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  - Edelberg, J. M., and S. V. Pizzo. “Lipoprotein (a) promotes plasmin inhibition by alpha 2-antiplasmin.” Biochem J 286 ( Pt 1), no. Pt 1 (August 15, 1992): 79–84. https://doi.org/10.1042/bj2860079.
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  - Young, T. N., J. M. Edelberg, S. Stack, and S. V. Pizzo. “Ionic modulation of the effects of heparin on plasminogen activation by tissue plasminogen activator: the effects of ionic strength, divalent cations, and chloride.” Arch Biochem Biophys 296, no. 2 (August 1, 1992): 530–38. https://doi.org/10.1016/0003-9861(92)90607-x.
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  - Thøgersen, I. B., G. Salvesen, F. H. Brucato, S. V. Pizzo, and J. J. Enghild. “Purification and characterization of an alpha-macroglobulin proteinase inhibitor from the mollusc Octopus vulgaris.” Biochem J 285 ( Pt 2), no. Pt 2 (July 15, 1992): 521–27. https://doi.org/10.1042/bj2850521.
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  - Stack, M. S., S. V. Pizzo, and M. Gonzalez-Gronow. “Effect of desialylation on the biological properties of human plasminogen.” Biochem J 284 ( Pt 1), no. Pt 1 (May 15, 1992): 81–86. https://doi.org/10.1042/bj2840081.
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  - Stack, M. S., T. L. Moser, and S. V. Pizzo. “Binding of human plasminogen to basement-membrane (type IV) collagen.” Biochem J 284 ( Pt 1), no. Pt 1 (May 15, 1992): 103–8. https://doi.org/10.1042/bj2840103.
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  - Edelberg, J. M., and S. V. Pizzo. “Lipoprotein(a) inhibits plasminogen activation in a template-dependent manner.” Blood Coagul Fibrinolysis 2, no. 6 (December 1991): 759–64. https://doi.org/10.1097/00001721-199112000-00010.
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  - Edelberg, J. M., H. E. Conrad, and S. V. Pizzo. “Heparin oligosaccharides enhance tissue-type plasminogen activator: a correlation between oligosaccharide length and stimulation of plasminogen activation.” Biochemistry 30, no. 45 (November 12, 1991): 10999–3. https://doi.org/10.1021/bi00109a027.
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  - Stack, S., R. D. Gray, and S. V. Pizzo. “Erratum: Modulation of plasminogen activation and type IV collagenase activity by a synthetic peptide derived from the laminin A chain (Biochemistry, Volume 30, Number 8, February 26, 1991, pages 2073-2077).” Biochemistry 30, no. 34 (October 28, 1991): 8500.
  - Mast, A. E., J. J. Enghild, H. Nagase, K. Suzuki, S. V. Pizzo, and G. Salvesen. “Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin).” J Biol Chem 266, no. 24 (August 25, 1991): 15810–16.
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  - Uhing, R. J., C. H. Martenson, D. S. Rubenstein, P. W. Hollenbach, and S. V. Pizzo. “The exposure of murine macrophages to alpha 2-macroglobulin 'fast' forms results in the rapid secretion of eicosanoids.” Biochim Biophys Acta 1093, no. 2–3 (July 10, 1991): 115–20. https://doi.org/10.1016/0167-4889(91)90111-a.
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  - Chu, C. T., and S. V. Pizzo. “Interactions between cytokines and alpha 2-macroglobulin.” Immunol Today 12, no. 7 (July 1991): 249. https://doi.org/10.1016/0167-5699(91)90043-s.
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  - Rubenstein, D. S., J. J. Enghild, and S. V. Pizzo. “Limited proteolysis of the alpha-macroglobulin rat alpha 1-inhibitor-3. Implications for a domain structure.” J Biol Chem 266, no. 17 (June 15, 1991): 11252–61.
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  - Edelberg, J. M., M. Weissler, and S. V. Pizzo. “Kinetic analysis of the effects of glycosaminoglycans and lipoproteins on urokinase-mediated plasminogen activation.” Biochem J 276 ( Pt 3), no. Pt 3 (June 15, 1991): 785–91. https://doi.org/10.1042/bj2760785.
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  - Gonzalez-Gronow, M., S. Stack, and S. V. Pizzo. “Plasmin binding to the plasminogen receptor enhances catalytic efficiency and activates the receptor for subsequent ligand binding.” Arch Biochem Biophys 286, no. 2 (May 1, 1991): 625–28. https://doi.org/10.1016/0003-9861(91)90090-6.
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  - Edelberg, J. M., C. F. Reilly, and S. V. Pizzo. “The inhibition of tissue type plasminogen activator by plasminogen activator inhibitor-1. The effects of fibrinogen, heparin, vitronectin, and lipoprotein(a).” J Biol Chem 266, no. 12 (April 25, 1991): 7488–93.
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  - Edelberg, J. M., and S. V. Pizzo. “Appendices. Kinetic models for the analysis of modulation and suppression of irreversible enzymatic inhibition.” J Biol Chem 266, no. 12 (April 25, 1991): 7494–95.
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  - Stack, S., R. D. Gray, and S. V. Pizzo. “Modulation of plasminogen activation and type IV collagenase activity by a synthetic peptide derived from the laminin A chain.” Biochemistry 30, no. 8 (February 26, 1991): 2073–77. https://doi.org/10.1021/bi00222a011.
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  - Chu, C. T., D. S. Rubenstein, J. J. Enghild, and S. V. Pizzo. “Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding.” Biochemistry 30, no. 6 (February 12, 1991): 1551–60. https://doi.org/10.1021/bi00220a016.
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  - Mast, A. E., J. J. Enghild, S. V. Pizzo, and G. Salvesen. “Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin.” Biochemistry 30, no. 6 (February 12, 1991): 1723–30. https://doi.org/10.1021/bi00220a039.
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  - Moncino, M. D., P. A. Roche, and S. V. Pizzo. “Characterization of human alpha 2-macroglobulin monomers obtained by reduction with dithiothreitol.” Biochemistry 30, no. 6 (February 12, 1991): 1545–51. https://doi.org/10.1021/bi00220a015.
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  - Enghild, J. J., G. Salvesen, S. A. Hefta, I. B. Thøgersen, S. Rutherfurd, and S. V. Pizzo. “Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor.” J Biol Chem 266, no. 2 (January 15, 1991): 747–51.
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  - Edelberg, J. M., and S. V. Pizzo. “Lipoprotein (a): The link between impaired fibrinolysis and atherosclerosis.” Fibrinolysis and Proteolysis 5, no. 3 (January 1, 1991): 135–43. https://doi.org/10.1016/0268-9499(91)90015-V.
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  - Pizzo, S. V. “Preparation, in vivo properties and proposed clinical use of polyoxyethylene-modified tissue plasminogen activator and streptokinase.” Advanced Drug Delivery Reviews 6, no. 2 (January 1, 1991): 153–66. https://doi.org/10.1016/0169-409X(91)90038-E.
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  - Tabbaa, M. A., M. Ramirez-Lassepas, B. D. Snyder, S. V. Pizzo, S. Taylor, and K. L. Johnston. “Releasable tissue plasminogen activators in ischemic stroke.” J Stroke Cerebrovasc Dis 1, no. 4 (1991): 203–8. https://doi.org/10.1016/S1052-3057(10)80018-7.
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  - Stack, S., M. Gonzalez-Gronow, and S. V. Pizzo. “The effect of divalent cations on the conformation and function of human plasminogen.” Arch Biochem Biophys 284, no. 1 (January 1991): 58–62. https://doi.org/10.1016/0003-9861(91)90263-i.
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  - Phillips, G., J. Hartman, V. A. Keller, M. A. Santiago, and S. Pizzo. “Regulation of tissue plasminogen activator in sickle cell anemia.” Am J Hematol 35, no. 3 (November 1990): 167–70. https://doi.org/10.1002/ajh.2830350305.
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  - Enghild, J. J., I. B. Thøgersen, G. Salvesen, G. H. Fey, N. L. Figler, S. L. Gonias, and S. V. Pizzo. “Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system.” Biochemistry 29, no. 43 (October 30, 1990): 10070–80. https://doi.org/10.1021/bi00495a009.
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  - Gonzalez-Gronow, M., H. E. Grenett, G. M. Fuller, and S. V. Pizzo. “The role of carbohydrate in the function of human plasminogen: comparison of the protein obtained from molecular cloning and expression in Escherichia coli and COS cells.” Biochim Biophys Acta 1039, no. 3 (July 6, 1990): 269–76. https://doi.org/10.1016/0167-4838(90)90259-i.
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  - Brucato, F. H., and S. V. Pizzo. “Catabolism of streptokinase and polyethylene glycol-streptokinase: evidence for transport of intact forms through the biliary system in the mouse.” Blood 76, no. 1 (July 1, 1990): 73–79.
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  - Edelberg, J. M., J. J. Enghild, S. V. Pizzo, and M. Gonzalez-Gronow. “Neonatal plasminogen displays altered cell surface binding and activation kinetics. Correlation with increased glycosylation of the protein.” J Clin Invest 86, no. 1 (July 1990): 107–12. https://doi.org/10.1172/JCI114671.
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  - Mast, A. E., G. Salvesen, H. P. Schnebli, and S. V. Pizzo. “Evaluation of the rapid plasma elimination of recombinant alpha 1-proteinase inhibitor: synthesis of polyethylene glycol conjugates with improved therapeutic potential.” J Lab Clin Med 116, no. 1 (July 1990): 58–65.
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  - Edelberg, J. M., and S. V. Pizzo. “Kinetic analysis of the effects of heparin and lipoproteins on tissue plasminogen activator mediated plasminogen activation.” Biochemistry 29, no. 25 (June 26, 1990): 5906–11. https://doi.org/10.1021/bi00477a004.
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  - Stack, S., M. Gonzalez-Gronow, and S. V. Pizzo. “Regulation of plasminogen activation by components of the extracellular matrix.” Biochemistry 29, no. 20 (May 22, 1990): 4966–70. https://doi.org/10.1021/bi00472a029.
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  - Gebhard, W., K. Hochstrasser, H. Fritz, J. J. Enghild, S. V. Pizzo, and G. Salvesen. “Structure of inter-alpha-inhibitor (inter-alpha-trypsin inhibitor) and pre-alpha-inhibitor: current state and proposition of a new terminology.” Biol Chem Hoppe Seyler 371 Suppl (May 1990): 13–22.
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  - Mast, A. E., G. Salvesen, F. H. Brucato, H. P. Schnebli, and S. V. Pizzo. “Polyethylene glycol modification of serpins improves therapeutic potential.” Biol Chem Hoppe Seyler 371 Suppl (May 1990): 101–9.
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  - Pizzo, S. V., R. C. Friedberg, P. Sze, R. Winant, D. Hudson, J. M. Lazar, and P. H. Johnson. “Recombinant hirudin displaces human factor Xa from its endothelial binding sites.” Thromb Res 57, no. 5 (March 1, 1990): 803–6. https://doi.org/10.1016/0049-3848(90)90037-d.
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  - Roche, P. A., M. R. Hoffman, and S. V. Pizzo. “Effect of interferon-gamma and human alpha 2-macroglobulin on peritoneal macrophage morphology and Ia antigen expression.” Biochim Biophys Acta 1051, no. 2 (February 19, 1990): 166–73. https://doi.org/10.1016/0167-4889(90)90189-k.
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  - Edelberg, J. M., M. Gonzalez-Gronow, and S. V. Pizzo. “Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator.” Thromb Res 57, no. 1 (January 1, 1990): 155–62. https://doi.org/10.1016/0049-3848(90)90203-o.
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  - Moncino, M. D., H. S. Friedman, J. Kurtzberg, and S. V. Pizzo. “Papillary adenocarcinoma of the renal pelvis in a child: case report and brief review of the literature.” Med Pediatr Oncol 18, no. 1 (1990): 81–86. https://doi.org/10.1002/mpo.2950180118.
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  - Enghild, J. J., I. B. Thøgersen, S. V. Pizzo, and G. Salvesen. “Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.” J Biol Chem 264, no. 27 (September 25, 1989): 15975–81.
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  - Roche, P. A., M. D. Moncino, and S. V. Pizzo. “Independent analysis of bait region cleavage dependent and thiolester bond cleavage dependent conformational changes by cross-linking of alpha 2-macroglobulin with cis-dichlorodiammineplatinum(II) and dithiobis(succinimidyl propionate).” Biochemistry 28, no. 19 (September 19, 1989): 7629–36. https://doi.org/10.1021/bi00445a019.
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  - Pizzo, S. V. “Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes.” Am J Med 87, no. 3B (September 11, 1989): 10S-14S. https://doi.org/10.1016/0002-9343(89)80524-8.
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  - Reddy, V. Y., S. V. Pizzo, and S. J. Weiss. “Functional inactivation and structural disruption of human alpha 2-macroglobulin by neutrophils and eosinophils.” J Biol Chem 264, no. 23 (August 15, 1989): 13801–9.
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  - Enghild, J. J., G. Salvesen, I. B. Thøgersen, and S. V. Pizzo. “Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3.” J Biol Chem 264, no. 19 (July 5, 1989): 11428–35.
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  - Sane, D. C., S. V. Pizzo, and C. S. Greenberg. “Elevated urokinase-type plasminogen activator level and bleeding in amyloidosis: case report and literature review.” Am J Hematol 31, no. 1 (May 1989): 53–57. https://doi.org/10.1002/ajh.2830310111.
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  - Edelberg, J. M., M. Gonzalez-Gronow, and S. V. Pizzo. “Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen.” Biochemistry 28, no. 6 (March 21, 1989): 2370–74. https://doi.org/10.1021/bi00432a004.
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  - Gonzalez-Gronow, M., J. M. Edelberg, and S. V. Pizzo. “Further characterization of the cellular plasminogen binding site: evidence that plasminogen 2 and lipoprotein a compete for the same site.” Biochemistry 28, no. 6 (March 21, 1989): 2374–77. https://doi.org/10.1021/bi00432a005.
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  - Enghild, J. J., I. B. Thøgersen, P. A. Roche, and S. V. Pizzo. “A conserved region in alpha-macroglobulins participates in binding to the mammalian alpha-macroglobulin receptor.” Biochemistry 28, no. 3 (February 7, 1989): 1406–12. https://doi.org/10.1021/bi00429a069.
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  - Jensen, P. E. H., and S. V. Pizzo. “Comparison of α2-macroglobulin receptors from human, baboon, rat and mouse liver.” Biochemical Archives 5, no. 2 (January 1, 1989): 171–76.
  - Pratt, C. W., M. W. Swaim, and S. V. Pizzo. “Inflammatory cells degrade inter-alpha inhibitor to liberate urinary proteinase inhibitors.” J Leukoc Biol 45, no. 1 (January 1989): 1–9. https://doi.org/10.1002/jlb.45.1.1.
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  - Hoffman, M., S. V. Pizzo, and J. B. Weinberg. “Alpha 2 macroglobulin-proteinase complexes stimulate prostaglandin E2 synthesis by peritoneal macrophages.” Agents Actions 25, no. 3–4 (December 1988): 360–67. https://doi.org/10.1007/BF01965043.
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  - Pizzo, S. V., A. E. Mast, S. R. Feldman, and G. Salvesen. “In vivo catabolism of alpha 1-antichymotrypsin is mediated by the Serpin receptor which binds alpha 1-proteinase inhibitor, antithrombin III and heparin cofactor II.” Biochim Biophys Acta 967, no. 2 (November 17, 1988): 158–62. https://doi.org/10.1016/0304-4165(88)90005-0.
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  - Roche, P. A., and S. V. Pizzo. “Analysis of thiolester bond cleavage-dependent conformational changes in binary alpha 2-macroglobulin-proteinase complexes.” Arch Biochem Biophys 267, no. 1 (November 15, 1988): 285–93. https://doi.org/10.1016/0003-9861(88)90034-3.
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  - Herzberg, A. J., and S. V. Pizzo. “Primary undifferentiated sarcoma of the thoracic aorta.” Histopathology 13, no. 5 (November 1988): 571–74. https://doi.org/10.1111/j.1365-2559.1988.tb02082.x.
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  - Roche, P. A., G. S. Salvesen, and S. V. Pizzo. “Symmetry of the inhibitory unit of human alpha 2-macroglobulin.” Biochemistry 27, no. 20 (October 4, 1988): 7876–81. https://doi.org/10.1021/bi00420a044.
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  - Phillips, G., L. B. Mitchell, and S. V. Pizzo. “Defective release of tissue plasminogen activator in patients with sickle cell anemia.” Am J Hematol 29, no. 1 (September 1988): 52–53. https://doi.org/10.1002/ajh.2830290113.
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  - Swaim, M. W., and S. V. Pizzo. “Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II).” Biochem J 254, no. 1 (August 15, 1988): 171–78. https://doi.org/10.1042/bj2540171.
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  - Gonias, S. L., M. M. Allietta, S. V. Pizzo, F. J. Castellino, and T. W. Tillack. “Electron microscopic identification of exposed plasmin epitopes in alpha 2-macroglobulin-plasmin complex using monoclonal antibody-colloidal gold adducts.” J Biol Chem 263, no. 22 (August 5, 1988): 10903–6.
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  - Friedberg, R. C., and S. V. Pizzo. “The effect of phosphatidylserine on the inhibition of human factor Xa by the plasma proteinase inhibitors.” Thromb Res 50, no. 6 (June 15, 1988): 901–6. https://doi.org/10.1016/0049-3848(88)90350-7.
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  - Berger, H., and S. V. Pizzo. “Preparation of polyethylene glycol-tissue plasminogen activator adducts that retain functional activity: characteristics and behavior in three animal species.” Blood 71, no. 6 (June 1988): 1641–47.
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  - Isaacs, I. J., J. P. Steiner, P. A. Roche, S. V. Pizzo, and D. K. Strickland. “Use of anti-idiotypic antibodies to establish that monoclonal antibody 7H11D6 binds to the alpha 2-macroglobulin receptor recognition site.” J Biol Chem 263, no. 14 (May 15, 1988): 6709–14.
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  - Roche, P. A., D. K. Strickland, J. J. Enghild, and S. V. Pizzo. “Evidence that the platinum-reactive methionyl residue of the alpha 2-macroglobulin receptor recognition site is not in the carboxyl-terminal receptor binding domain.” J Biol Chem 263, no. 14 (May 15, 1988): 6715–21.
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  - Friedberg, R. C., P. O. Hagen, and S. V. Pizzo. “The role of endothelium in factor Xa regulation: the effect of plasma proteinase inhibitors and hirudin.” Blood 71, no. 5 (May 1988): 1321–28.
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  - Pizzo, S. V., M. W. Swaim, P. A. Roche, and S. L. Gonias. “Selectivity and stereospecificity of the reactions of dichlorodiammineplatinum(II) with three purified plasma proteins.” J Inorg Biochem 33, no. 1 (May 1988): 67–76. https://doi.org/10.1016/0162-0134(88)80035-7.
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  - Gonias, S. L., S. V. Pizzo, and M. Hoffman. “Clearance and distribution of recombinant murine gamma-interferon in mice.” Cancer Res 48, no. 8 (April 15, 1988): 2021–24.
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  - Greenberg, C. S., K. E. Achyuthan, S. Rajagopalan, and S. V. Pizzo. “Characterization of the fibrin polymer structure that accelerates thrombin cleavage of plasma factor XIII.” Arch Biochem Biophys 262, no. 1 (April 1988): 142–48. https://doi.org/10.1016/0003-9861(88)90176-2.
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  - Pratt, C. W., F. C. Church, and S. V. Pizzo. “In vivo catabolism of heparin cofactor II and its complex with thrombin: evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors.” Arch Biochem Biophys 262, no. 1 (April 1988): 111–17. https://doi.org/10.1016/0003-9861(88)90173-7.
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  - Swaim, M. W., and S. V. Pizzo. “Methionine sulfoxide and the oxidative regulation of plasma proteinase inhibitors.” J Leukoc Biol 43, no. 4 (April 1988): 365–79. https://doi.org/10.1002/jlb.43.4.365.
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  - Roche, P. A., P. E. Jensen, and S. V. Pizzo. “Intersubunit cross-linking by cis-dichlorodiammineplatinum(II) stabilizes an alpha 2-macroglobulin "nascent" state: evidence that thiol ester bond cleavage correlates with receptor recognition site exposure.” Biochemistry 27, no. 2 (January 26, 1988): 759–64. https://doi.org/10.1021/bi00402a040.
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  - Gonias, S. L., M. W. Swaim, M. F. Massey, and S. V. Pizzo. “cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin.” J Biol Chem 263, no. 1 (January 5, 1988): 393–97.
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  - Friedberg, R. C., and S. V. Pizzo. “Large scale purification of factor X by hydrophobic chromatography.” Prep Biochem 18, no. 3 (1988): 303–20. https://doi.org/10.1080/00327488808062531.
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  - Turner, A. D., S. V. Pizzo, N. A. Porter, and G. Rozakis. “Photoreactivation of Irreversibly Inhibited Serine Proteinases.” Journal of the American Chemical Society 110, no. 1 (January 1, 1988): 244–50. https://doi.org/10.1021/ja00209a040.
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  - Pizzo, S. V., and S. R. Feldman. “Carbohydrate recognition systems in amphibians: primitive alpha 2-macroglobulin receptors.” Biochem Int 15, no. 6 (December 1987): 1197–1204.
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  - Pratt, C. W., P. A. Roche, and S. V. Pizzo. “The role of inter-alpha-trypsin inhibitor and other proteinase inhibitors in the plasma clearance of neutrophil elastase and plasmin.” Arch Biochem Biophys 258, no. 2 (November 1, 1987): 591–99. https://doi.org/10.1016/0003-9861(87)90381-x.
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  - Hoffman, M. R., S. V. Pizzo, and J. B. Weinberg. “Modulation of mouse peritoneal macrophage Ia and human peritoneal macrophage HLA-DR expression by alpha 2-macroglobulin "fast" forms.” J Immunol 139, no. 6 (September 15, 1987): 1885–90.
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  - Prpic, V., J. E. Weiel, S. D. Somers, J. DiGuiseppi, S. L. Gonias, S. V. Pizzo, T. A. Hamilton, B. Herman, and D. O. Adams. “Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages.” J Immunol 139, no. 2 (July 15, 1987): 526–33.
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  - Roche, P. A., and S. V. Pizzo. “The role of histidyl residues in zinc-induced precipitation of alpha 2-macroglobulin-proteinase complexes.” Arch Biochem Biophys 256, no. 1 (July 1987): 265–72. https://doi.org/10.1016/0003-9861(87)90445-0.
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  - Pratt, C. W., and S. V. Pizzo. “Mechanism of action of inter-alpha-trypsin inhibitor.” Biochemistry 26, no. 10 (May 19, 1987): 2855–63. https://doi.org/10.1021/bi00384a029.
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  - Rajagopalan, S., S. L. Gonias, and S. V. Pizzo. “The temperature-dependent reaction between alpha 2-macroglobulin and streptokinase-plasmin(ogen) complex.” J Biol Chem 262, no. 8 (March 15, 1987): 3660–64.
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  - Gore, M., S. Eldon, K. F. Trofatter, S. J. Soong, and S. V. Pizzo. “Pregnancy-induced changes in the fibrinolytic balance: evidence for defective release of tissue plasminogen activator and increased levels of the fast-acting tissue plasminogen activator inhibitor.” Am J Obstet Gynecol 156, no. 3 (March 1987): 674–80. https://doi.org/10.1016/0002-9378(87)90076-7.
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  - Jordan, J. M., N. B. Allen, and S. V. Pizzo. “Defective release of tissue plasminogen activator in systemic and cutaneous vasculitis.” Am J Med 82, no. 3 (March 1987): 397–400. https://doi.org/10.1016/0002-9343(87)90436-0.
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  - Turner, A. D., S. V. Pizzo, G. W. Rozakis, and N. A. Porter. “Photochemical Activation of Acylated α-Thrombin.” Journal of the American Chemical Society 109, no. 4 (February 1, 1987): 1274–75. https://doi.org/10.1021/ja00238a062.
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  - Roche, P. A., and S. V. Pizzo. “Characterization of alpha 2-macroglobulin-plasmin complexes: complete subunit cleavage alters receptor recognition in vivo and in vitro.” Biochemistry 26, no. 2 (January 27, 1987): 486–91. https://doi.org/10.1021/bi00376a021.
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  - Pizzo, S. V., A. D. Turner, N. A. Porter, and S. L. Gonias. “Evaluation of p-amidinophenyl esters as potential antithrombotic agents.” Thromb Haemost 56, no. 3 (December 15, 1986): 387–90.
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  - Lee, Y. S., T. J. Matthews, S. Pizzo, J. L. Abernethy, and D. D. Bigner. “Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies.” J Neuroimmunol 13, no. 2 (December 1986): 203–16. https://doi.org/10.1016/0165-5728(86)90065-2.
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  - Bradford, W. D., S. Pizzo, and A. C. Christakos. “Careers and professional activities of graduates of a Medical Scientist Training Program.” J Med Educ 61, no. 11 (November 1986): 915–18. https://doi.org/10.1097/00001888-198611000-00010.
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  - Pizzo, S. V., S. Rajagopalan, P. A. Roche, H. E. Fuchs, S. R. Feldman, and S. L. Gonias. “Specificity of alpha 2-macroglobulin covalent cross-linking for the active domain of proteinases.” Biol Chem Hoppe Seyler 367, no. 11 (November 1986): 1177–82. https://doi.org/10.1515/bchm3.1986.367.2.1177.
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  - Pizzo, S. V. “Oral contraceptives and thromboembolic disease.” West J Med 145, no. 3 (September 1986): 381–82.
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  - Turner, A. D., D. M. Monroe, H. R. Roberts, N. A. Porter, and S. V. Pizzo. “p-Amidino esters as irreversible inhibitors of factors IXa and Xa and thrombin.” Biochemistry 25, no. 17 (August 26, 1986): 4929–35. https://doi.org/10.1021/bi00365a031.
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  - Pizzo, S. V., P. A. Roche, S. R. Feldman, and S. L. Gonias. “Further characterization of the platinum-reactive component of the alpha 2-macroglobulin-receptor recognition site.” Biochem J 238, no. 1 (August 15, 1986): 217–25. https://doi.org/10.1042/bj2380217.
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  - Pratt, C. W., and S. V. Pizzo. “In vivo metabolism of inter-alpha-trypsin inhibitor and its proteinase complexes: evidence for proteinase transfer to alpha 2-macroglobulin and alpha 1-proteinase inhibitor.” Arch Biochem Biophys 248, no. 2 (August 1, 1986): 587–96. https://doi.org/10.1016/0003-9861(86)90512-6.
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  - Feldman, S. R., and S. V. Pizzo. “A three-dimensional model of a unique proteinase inhibitor: alpha 2-macroglobulin.” Semin Thromb Hemost 12, no. 3 (July 1986): 223–25. https://doi.org/10.1055/s-2007-1003556.
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  - Lehrman, M. A., S. V. Pizzo, M. J. Imber, and R. L. Hill. “The binding of fucose-containing glycoproteins by hepatic lectins. Re-examination of the clearance from blood and the binding to membrane receptors and pure lectins.” J Biol Chem 261, no. 16 (June 5, 1986): 7412–18.
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  - Pizzo, S. V., J. C. Murray, and S. L. Gonias. “Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator.” Arch Pathol Lab Med 110, no. 6 (June 1986): 517–19.
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  - Rajagopalan, S., and S. V. Pizzo. “Characterization of murine peritoneal macrophage receptors for fibrin(ogen) degradation products.” Blood 67, no. 5 (May 1986): 1224–28.
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  - Gonias, S. L., P. A. Roche, and S. V. Pizzo. “Purification and characterization of human alpha 2-macroglobulin conformational variants by non-ideal high performance size-exclusion chromatography.” Biochem J 235, no. 2 (April 15, 1986): 559–67. https://doi.org/10.1042/bj2350559.
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  - Hoffman, M., H. E. Fuchs, and S. V. Pizzo. “The macrophage-mediated regulation of hepatocyte synthesis of antithrombin III and alpha 1-proteinase inhibitor.” Thromb Res 41, no. 5 (March 1, 1986): 707–15. https://doi.org/10.1016/0049-3848(86)90368-3.
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  - Feldman, S. R., and S. V. Pizzo. “Purification and characterization of a "half-molecule" alpha 2-macroglobulin from the southern grass frog: absence of binding to the mammalian alpha 2-macroglobulin receptor.” Biochemistry 25, no. 3 (February 11, 1986): 721–27. https://doi.org/10.1021/bi00351a032.
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  - Doman, K. A., M. Gore, K. E. Miller, S. J. Soong, D. L. Clarke-Pearson, and S. V. Pizzo. “Defective release of vascular plasminogen activator in patients with gynecologic malignancies.” Gynecol Oncol 23, no. 2 (February 1986): 141–48. https://doi.org/10.1016/0090-8258(86)90217-9.
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  - Gonias, S. L., and S. V. Pizzo. “The biochemistry of haemostasis.” Clin Lab Haematol 8, no. 4 (1986): 281–306. https://doi.org/10.1111/j.1365-2257.1986.tb00116.x.
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  - Pizzo, S. V., A. D. Turner, S. L. Gonias, D. M. Monroe, H. R. Roberts, and N. A. Porter. “Nontoxic irreversible inhibitors of factors IXa, Xa, and thrombin: potential therapeutic agents for the in vivo regulation of thrombin generation and activity.” Ann N Y Acad Sci 485 (1986): 199–203. https://doi.org/10.1111/j.1749-6632.1986.tb34581.x.
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  - Pizzo, S. V., H. E. Fuchs, K. A. Doman, D. B. Petruska, and H. Berger. “Release of tissue plasminogen activator and its fast-acting inhibitor in defective fibrinolysis.” Arch Intern Med 146, no. 1 (January 1986): 188–91.
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  - Pizzo, S. V., D. B. Petruska, K. A. Doman, S. J. Soong, and H. E. Fuchs. “Releasable vascular plasminogen activator and thrombotic strokes.” Am J Med 79, no. 4 (October 1985): 407–11. https://doi.org/10.1016/0002-9343(85)90026-9.
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  - Feldman, S. R., S. L. Gonias, and S. V. Pizzo. “Model of alpha 2-macroglobulin structure and function.” Proc Natl Acad Sci U S A 82, no. 17 (September 1985): 5700–5704. https://doi.org/10.1073/pnas.82.17.5700.
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  - Ney, K. A., S. Gidwitz, and S. V. Pizzo. “Binding and endocytosis of alpha 2-macroglobulin-plasmin complexes.” Biochemistry 24, no. 17 (August 13, 1985): 4586–92. https://doi.org/10.1021/bi00338a016.
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  - Gonias, S. L., J. J. Pasqua, C. Greenberg, and S. V. Pizzo. “Precipitation of fibrinogen, fibrinogen degradation products and fibrin monomer by histone H3.” Thromb Res 39, no. 1 (July 1, 1985): 97–116. https://doi.org/10.1016/0049-3848(85)90125-2.
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  - Feldman, S. R., and S. V. Pizzo. “Purification and characterization of frog alpha-macroglobulin: receptor recognition of an amphibian glycoprotein.” Biochemistry 24, no. 10 (May 7, 1985): 2569–75. https://doi.org/10.1021/bi00331a026.
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  - Ney, K. A., J. J. Pasqua, K. J. Colley, C. E. Guthrow, and S. V. Pizzo. “In vitro preparation of nonenzymatically glucosylated human transferrin, alpha 2-macroglobulin, and fibrinogen with preservation of function.” Diabetes 34, no. 5 (May 1985): 462–70. https://doi.org/10.2337/diab.34.5.462.
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  - Feldman, S. R., M. R. Rosenberg, K. A. Ney, G. Michalopoulos, and S. V. Pizzo. “Binding of alpha 2-macroglobulin to hepatocytes: mechanism of in vivo clearance.” Biochem Biophys Res Commun 128, no. 2 (April 30, 1985): 795–802. https://doi.org/10.1016/0006-291x(85)90117-2.
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  - Shorr, R. I., K. J. Kao, S. V. Pizzo, E. J. Rauckman, and G. M. Rosen. “In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis.” Thromb Res 38, no. 1 (April 1, 1985): 33–43. https://doi.org/10.1016/0049-3848(85)90005-2.
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  - Fuchs, H. E., H. Berger, and S. V. Pizzo. “Catabolism of human tissue plasminogen activator in mice.” Blood 65, no. 3 (March 1985): 539–44.
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  - Rajagopalan, S., S. L. Gonias, and S. V. Pizzo. “A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function.” J Clin Invest 75, no. 2 (February 1985): 413–19. https://doi.org/10.1172/JCI111715.
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  - Balber, A. E., S. L. Gonias, and S. V. Pizzo. “Trypanosoma brucei gambiense: growth in vitro of bloodstream forms inhibited by dichlorodiammineplatinum (II) compounds and hypolipidemic drugs.” Exp Parasitol 59, no. 1 (February 1985): 74–80. https://doi.org/10.1016/0014-4894(85)90059-1.
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  - Bourdon, M. A., T. J. Matthews, S. V. Pizzo, and D. D. Bigner. “Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein.” J Cell Biochem 28, no. 3 (1985): 183–95. https://doi.org/10.1002/jcb.240280302.
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  - Weinberg, J. B., M. M. Hobbs, and S. V. Pizzo. “Microassay for the photometric quantitation of cell-associated plasminogen activator using a chromogenic tripeptide substrate.” J Immunol Methods 75, no. 2 (December 31, 1984): 289–94. https://doi.org/10.1016/0022-1759(84)90112-1.
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  - Strickland, D. K., J. P. Steiner, S. R. Feldman, and S. V. Pizzo. “Fluorescent probes as a measure of conformational alterations induced by nucleophilic modification and proteolysis of bovine alpha 2-macroglobulin.” Biochemistry 23, no. 26 (December 18, 1984): 6679–85. https://doi.org/10.1021/bi00321a061.
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  - Pratt, C. W., and S. V. Pizzo. “The effect of zinc and other divalent cations on the structure and function of human alpha 2-macroglobulin.” Biochim Biophys Acta 791, no. 2 (December 7, 1984): 123–30. https://doi.org/10.1016/0167-4838(84)90002-5.
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  - Gonias, S. L., A. C. Oakley, P. J. Walther, and S. V. Pizzo. “Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum(II).” Cancer Res 44, no. 12 Pt 1 (December 1984): 5764–70.
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  - Gonias, S. L., A. C. Oakley, S. V. Pizzo, and P. J. Walther. “Effects of Diethyldithiocarbamate and Nine Other Nucleophiles on the Intersubunit Protein Cross-Linking and Inactivation of Purified Human α2-Macroglobulin by cis-Diamminedichloroplatinum(ll).” Cancer Research 44 (December 1, 1984): 5764–70.
  - Feldman, S. R., and S. V. Pizzo. “Comparison of the binding of chicken alpha-macroglobulin and ovomacroglobulin to the mammalian alpha 2-macroglobulin receptor.” Arch Biochem Biophys 235, no. 1 (November 15, 1984): 267–75. https://doi.org/10.1016/0003-9861(84)90275-3.
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  - Key, K. A., A. C. Oakley, and S. V. Pizzo. “Effects of pimozide and penfluridol on the binding and endocytosis of alpha 2-macroglobulin-CH3NH2 by mouse peritoneal macrophages.” Biochem Pharmacol 33, no. 22 (November 15, 1984): 3712–14. https://doi.org/10.1016/0006-2952(84)90162-x.
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  - Feldman, S. R., and S. V. Pizzo. “Circular dichroic spectroscopy of non-human alpha-macroglobulins.” Biochem Biophys Res Commun 123, no. 2 (September 17, 1984): 771–77. https://doi.org/10.1016/0006-291x(84)90296-1.
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  - Gonias, S. L., S. R. Feldman, C. W. Pratt, and S. V. Pizzo. “Conformation-specific precipitation of human alpha 2-macroglobulin by divalent zinc or calf thymus histone H3.” Arch Biochem Biophys 233, no. 2 (September 1984): 462–68. https://doi.org/10.1016/0003-9861(84)90468-5.
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  - Walther, P. J., M. Gore, and S. V. Pizzo. “Increased releasable vascular plasminogen activator and a bleeding diathesis.” Am J Med 77, no. 3 (September 1984): 566–68. https://doi.org/10.1016/0002-9343(84)90123-2.
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  - Gore, M., K. E. Miller, S. J. Soong, D. L. Clarke-Pearson, and S. V. Pizzo. “Vascular plasminogen activator levels and thromboembolic disease in patients with gynecologic malignancies.” Am J Obstet Gynecol 149, no. 8 (August 15, 1984): 830–34. https://doi.org/10.1016/0002-9378(84)90599-4.
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  - Ney, K. A., S. Gidwitz, and S. V. Pizzo. “Changes in the binding of "fast"-form alpha 2-macroglobulin to 3T3-L1 cells after differentiation to adipocytes.” Biochemistry 23, no. 15 (July 17, 1984): 3395–3403. https://doi.org/10.1021/bi00310a003.
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  - Fuchs, H. E., H. G. Trapp, M. J. Griffith, H. R. Roberts, and S. V. Pizzo. “Regulation of factor IXa in vitro in human and mouse plasma and in vivo in the mouse. Role of the endothelium and the plasma proteinase inhibitors.” J Clin Invest 73, no. 6 (June 1984): 1696–1703. https://doi.org/10.1172/JCI111377.
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  - Feldman, S. R., S. L. Gonias, K. A. Ney, C. W. Pratt, and S. V. Pizzo. “Identification of "embryonin" as bovine alpha 2-macroglobulin.” J Biol Chem 259, no. 7 (April 10, 1984): 4458–62.
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  - Cummings, H. S., S. V. Pizzo, D. K. Strickland, and F. J. Castellino. “Effect of methylamine and plasmin on the conformation of human alpha 2-macroglobulin as revealed by differential scanning calorimetric analysis.” Biophys J 45, no. 4 (April 1984): 721–24. https://doi.org/10.1016/S0006-3495(84)84214-9.
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  - Fuchs, H. E., G. K. Michalopoulos, and S. V. Pizzo. “Hepatocyte uptake of alpha 1-proteinase inhibitor-trypsin complexes in vitro: evidence for a shared uptake mechanism for proteinase complexes of alpha 1-proteinase inhibitor and antithrombin III.” J Cell Biochem 25, no. 4 (1984): 231–43. https://doi.org/10.1002/jcb.240250405.
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  - Fuchs, H. E., M. A. Shifman, G. Michalopoulos, and S. V. Pizzo. “Hepatocyte receptors for antithrombin III-proteinase complexes.” J Cell Biochem 24, no. 3 (1984): 197–206. https://doi.org/10.1002/jcb.240240302.
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  - Gonias, S. L., and S. V. Pizzo. “Conformation and protease binding activity of binary and ternary human alpha 2-macroglobulin-protease complexes.” J Biol Chem 258, no. 23 (December 10, 1983): 14682–85.
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  - Fuchs, H. E., and S. V. Pizzo. “Regulation of factor Xa in vitro in human and mouse plasma and in vivo in mouse. Role of the endothelium and plasma proteinase inhibitors.” J Clin Invest 72, no. 6 (December 1983): 2041–49. https://doi.org/10.1172/JCI111169.
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  - Hoffman, M., S. R. Feldman, and S. V. Pizzo. “Alpha 2-macroglobulin 'fast' forms inhibit superoxide production by activated macrophages.” Biochim Biophys Acta 760, no. 3 (November 8, 1983): 421–23. https://doi.org/10.1016/0304-4165(83)90384-7.
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  - Gonias, S. L., and S. V. Pizzo. “Reaction of human alpha 2-macroglobulin half-molecules with plasmin as a probe of protease binding site structure.” Biochemistry 22, no. 21 (October 11, 1983): 4933–40. https://doi.org/10.1021/bi00290a009.
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  - Boyko, O. B., and S. V. Pizzo. “Mesenteric vein thrombosis and vascular plasminogen activator.” Arch Pathol Lab Med 107, no. 10 (October 1983): 541–42.
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  - Weiel, J. E., and S. V. Pizzo. “Down regulation of macrophage mannose/N-acetylglucosamine receptors by elevated glucose concentrations.” Biochim Biophys Acta 759, no. 3 (September 13, 1983): 170–75. https://doi.org/10.1016/0304-4165(83)90309-4.
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  - Feldman, S. R., K. A. Ney, S. L. Gonias, and S. V. Pizzo. “In vitro binding and in vivo clearance of human alpha 2-macroglobulin after reaction with endoproteases from four different classes.” Biochem Biophys Res Commun 114, no. 2 (July 29, 1983): 757–62. https://doi.org/10.1016/0006-291x(83)90845-8.
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  - Pasqua, J. J., and S. V. Pizzo. “The role of ligand-ligand interactions in competition by fibrinogen and fibrin degradation products for fibrinogen binding to human platelets.” Biochim Biophys Acta 757, no. 3 (June 9, 1983): 282–87. https://doi.org/10.1016/0304-4165(83)90052-1.
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  - Imber, M. J., and S. V. Pizzo. “Clearance and binding of native and defucosylated lactoferrin.” Biochem J 212, no. 2 (May 15, 1983): 249–57. https://doi.org/10.1042/bj2120249.
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  - Gonias, S. L., and S. V. Pizzo. “Complexes of serum albumin and cis-dichlorodiammineplatinum (II). The role of cysteine 34 as a nucleophilic entering group and evidence for reaction between bound platinum and a second macromolecule.” J Biol Chem 258, no. 9 (May 10, 1983): 5764–69.
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  - Kao, K. J., B. S. Tsai, P. A. McKee, R. J. Lefkowitz, and S. V. Pizzo. “Inhibitory effect of ristocetin and factor VIII/von Willebrand factor protein on human platelet adenylate cyclase activity.” Thromb Res 30, no. 3 (May 1, 1983): 301–8. https://doi.org/10.1016/0049-3848(83)90084-1.
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  - Beauchamp, C. O., S. L. Gonias, D. P. Menapace, and S. V. Pizzo. “A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin.” Anal Biochem 131, no. 1 (May 1983): 25–33. https://doi.org/10.1016/0003-2697(83)90131-8.
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  - Pasqua, J. J., and S. V. Pizzo. “The clearance of human fibrinogen fragments X and Y in mice: a process mediated by the fragment D receptor.” Thromb Haemost 49, no. 2 (April 28, 1983): 78–80.
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  - Shifman, M. A., and S. V. Pizzo. “In vivo metabolism of reversibly inhibited alpha-thrombin.” Biochem Pharmacol 32, no. 4 (February 15, 1983): 739–41. https://doi.org/10.1016/0006-2952(83)90507-5.
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  - Gonias, S. L., and S. V. Pizzo. “Characterization of functional human alpha 2-macroglobulin half-molecules isolated by limited reduction with dithiothreitol.” Biochemistry 22, no. 3 (February 1, 1983): 536–46. https://doi.org/10.1021/bi00272a003.
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  - Gonias, S. L., and S. V. Pizzo. “Chemical and structural modifications of alpha 2-macroglobulin: effects on receptor binding and endocytosis studied in an in vivo model.” Ann N Y Acad Sci 421 (1983): 457–71. https://doi.org/10.1111/j.1749-6632.1983.tb18139.x.
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  - Hoffman, M., S. R. Feldman, and S. V. Pizzo. “α₂-macroglobulin 'fast' forms inhibit superoxide production by activated macrophages.” Bba General Subjects 760, no. 3 (1983): 421–23.
  - Gonias, S. L., A. E. Balber, W. J. Hubbard, and S. V. Pizzo. “Ligand binding, conformational change and plasma elimination of human, mouse and rat alpha-macroglobulin proteinase inhibitors.” Biochem J 209, no. 1 (January 1, 1983): 99–105. https://doi.org/10.1042/bj2090099.
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  - Ralston, M. D., S. Pizzo, S. Woodfield, and W. M. Thompson. “Evaluation of embolization distal to arterial occlusion by transcatheter electrocoagulation (TCEC) and Gianturco coils.” Invest Radiol 18, no. 2 (1983): 171–76. https://doi.org/10.1097/00004424-198303000-00014.
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  - Stead, N. W., K. A. Bauer, T. R. Kinney, J. G. Lewis, E. E. Campbell, M. A. Shifman, R. D. Rosenberg, and S. V. Pizzo. “Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor.” Am J Med 74, no. 1 (January 1983): 33–39. https://doi.org/10.1016/0002-9343(83)91115-4.
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  - Miller, K. E., and S. V. Pizzo. “Venous and arterial thromboembolic disease in women using oral contraceptives.” Am J Obstet Gynecol 144, no. 7 (December 1, 1982): 824–27. https://doi.org/10.1016/0002-9378(82)90359-3.
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  - Ney, K. A., and S. V. Pizzo. “Fibrinolysis and fibrinogenolysis by Val442-plasmin.” Biochim Biophys Acta 708, no. 2 (November 9, 1982): 218–24. https://doi.org/10.1016/0167-4838(82)90223-0.
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  - Johnson, W. J., S. V. Pizzo, M. J. Imber, and D. O. Adams. “Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages.” Science 218, no. 4572 (November 5, 1982): 574–76. https://doi.org/10.1126/science.6289443.
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  - Sanfilippo, F., S. V. Pizzo, and B. P. Croker. “Immunohistochemical studies of cell differentiation in a juxtaglomerular tumor.” Arch Pathol Lab Med 106, no. 12 (November 1982): 604–7.
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  - Gonias, S. L., H. E. Fuchs, and S. V. Pizzo. “A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice.” Thromb Haemost 48, no. 2 (October 29, 1982): 208–10.
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  - Pizzo, S. V., and J. J. Pasqua. “The clearance of human fibrinogen fragments D1, D2, D3 and fibrin fragment D1 dimer in mice.” Biochim Biophys Acta 718, no. 2 (October 8, 1982): 177–84. https://doi.org/10.1016/0304-4165(82)90217-3.
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  - McComb, R. D., T. R. Jones, S. V. Pizzo, and D. D. Bigner. “Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma.” J Neuropathol Exp Neurol 41, no. 5 (September 1982): 479–89.
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  - Gonias, S. L., J. A. Reynolds, and S. V. Pizzo. “Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin.” Biochim Biophys Acta 705, no. 3 (August 10, 1982): 306–14. https://doi.org/10.1016/0167-4838(82)90252-7.
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  - Gonias, S. L., M. Einarsson, and S. V. Pizzo. “Catabolic pathways for streptokinase, plasmin, and streptokinase activator complex in mice. In vivo reaction of plasminogen activator with alpha 2-macroglobulin.” J Clin Invest 70, no. 2 (August 1982): 412–23. https://doi.org/10.1172/jci110631.
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  - Imber, M. J., L. R. Glasgow, and S. V. Pizzo. “Purification of an almond emulsin fucosidase on Cibacron blue-sepharose and demonstration of its activity toward fucose-containing glycoproteins.” J Biol Chem 257, no. 14 (July 25, 1982): 8205–10.
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  - Fuchs, H. E., M. A. Shifman, and S. V. Pizzo. “In vivo catabolism of alpha 1-proteinase inhibitor-trypsin, antithrombin III-thrombin and alpha 2-macroglobulin-methylamine.” Biochim Biophys Acta 716, no. 2 (May 27, 1982): 151–57. https://doi.org/10.1016/0304-4165(82)90263-x.
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  - Imber, M. J., S. V. Pizzo, W. J. Johnson, and D. O. Adams. “Selective diminution of the binding of mannose by murine macrophages in the late stages of activation.” J Biol Chem 257, no. 9 (May 10, 1982): 5129–35.
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  - Campbell, E. E., M. A. Shifman, J. G. Lewis, J. J. Pasqua, and S. V. Pizzo. “A colorimetric assay for releasable plasminogen activator.” Clin Chem 28, no. 5 (May 1982): 1125–28.
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  - McComb, R. D., T. R. Jones, S. V. Pizzo, and D. D. Bigner. “Specificity and sensitivity of immunohistochemical detection of factor VIII/von Willebrand factor antigen in formalin-fixed paraffin-embedded tissue.” J Histochem Cytochem 30, no. 4 (April 1982): 371–77. https://doi.org/10.1177/30.4.6801111.
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  - Shifman, M. A., and S. V. Pizzo. “The in vivo metabolism of antithrombin III and antithrombin III complexes.” J Biol Chem 257, no. 6 (March 25, 1982): 3243–48.
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  - Pizzo, S. V., and J. J. Pasqua. “The clearance of human fibrinogen fragments D₁, D₂, D₃ and fibrin fragment D₁ dimer in mice.” Bba General Subjects 718, no. 2 (1982): 177–84.
  - Lourie, G. L., S. V. Pizzo, C. Ravin, C. Putnam, and W. M. Thompson. “Experimental pulmonary infarction in dogs: a comparison of chest radiography and computed tomography.” Invest Radiol 17, no. 3 (1982): 224–32.
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  - McComb, R. D., T. R. Jones, S. V. Pizzo, and D. D. Bigner. “Localization of factor VIII/von Willebrand factor and glial fibrillary acidic protein in the hemangioblastoma: implications for stromal cell histogenesis.” Acta Neuropathol 56, no. 3 (1982): 207–13. https://doi.org/10.1007/BF00690637.
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  - Ralston, M. D., S. Woodfield, R. Halvorsen, S. V. Pizzo, and W. M. Thompson. “Effect of increasing current and decreasing blood flow for transcatheter electrocoagulation (TCEC).” Invest Radiol 17, no. 2 (1982): 171–77. https://doi.org/10.1097/00004424-198203000-00011.
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  - Gonias, S. L., and S. V. Pizzo. “Inactivation of the plasma protease inhibitor alpha 2-macroglobulin by the antitumor drug cis-dichlorodiamineplatinum(II).” J Biol Chem 256, no. 23 (December 10, 1981): 12478–84.
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  - Gonias, S. L., and S. V. Pizzo. “Altered clearance of human alpha 2-macroglobulin complexes following reaction with cis-dichlorodiamineplatinum(II).” Biochim Biophys Acta 678, no. 2 (December 4, 1981): 268–74. https://doi.org/10.1016/0304-4165(81)90216-6.
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  - Ney, K. A., K. J. Colley, and S. V. Pizzo. “The standardization of the thiobarbituric acid assay for nonenzymatic glucosylation of human serum albumin.” Anal Biochem 118, no. 2 (December 1981): 294–300. https://doi.org/10.1016/0003-2697(81)90585-6.
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  - Kao, K. J., and S. V. Pizzo. “Lack of thromboxane A2 synthesis in platelet aggregation induced by factor VIII/von Willebrand factor.” Thromb Res 24, no. 3 (November 1, 1981): 245–51. https://doi.org/10.1016/0049-3848(81)90094-3.
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  - Lewis, J. G., S. V. Pizzo, and D. O. Adams. “Simple and sensitive assay employing stable reagents for quantification of plasminogen activator.” Am J Clin Pathol 76, no. 4 (October 1981): 403–9. https://doi.org/10.1093/ajcp/76.4.403.
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  - Pizzo, S. V. “Reducing the risk of oral contraceptive-induced thrombosis.” Drug Ther (Ny) 11, no. 9 (September 1981): 101–8.
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  - Imber, M. J., and S. V. Pizzo. “Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin.” J Biol Chem 256, no. 15 (August 10, 1981): 8134–39.
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  - Pizzo, S. V., M. A. Lehrman, M. J. Imber, and C. E. Guthrow. “The clearance of glycoproteins in diabetic mice.” Biochem Biophys Res Commun 101, no. 2 (July 30, 1981): 704–8. https://doi.org/10.1016/0006-291x(81)91315-2.
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  - Kao, K. J., J. R. Sommer, and S. V. Pizzo. “Modulation of platelet shape and membrane receptor binding by Ca2+-calmodulin complex.” Nature 292, no. 5818 (July 2, 1981): 82–84. https://doi.org/10.1038/292082a0.
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  - Jones, T. R., K. J. Kao, S. V. Pizzo, and D. D. Bigner. “Endothelial cell surface expression and binding of factor VIII/von Willebrand factor.” Am J Pathol 103, no. 2 (May 1981): 304–8.
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  - Kao, K. J., S. V. Pizzo, and P. A. McKee. “A radioreceptor assay for quantitating plasma factor VIII/von Willebrand's protein.” Blood 57, no. 3 (March 1981): 579–85.
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  - Pizzo, S. V., J. G. Lewis, E. E. Campbell, and N. A. Dreyer. “Fibrinolytic response and oral contraceptive associated thromboembolism.” Contraception 23, no. 2 (February 1981): 181–86. https://doi.org/10.1016/0010-7824(81)90103-7.
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  - Hill, R. L., S. V. Pizzo, and M. Imber. “Receptors on hepatocytes that bind ligands containing fucosyl α1,3 N-acetylglucosamine linkages.” Birth Defects: Original Article Series 17, no. 1 (January 1, 1981): 85–91.
  - Hirschfeld, B., D. S. McAlister, S. Pizzo, and W. M. Thompson. “Evaluation of the anode and cathode for transcatheter electrocoagulation.” Acta Radiol Diagn (Stockh) 22, no. 2 (1981): 133–39. https://doi.org/10.1177/028418518102200205.
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  - McAlister, D. S., S. Pizzo, C. E. Putman, and W. M. Thompson. “Transcatheter electrocoagulation of the pulmonary artery: an experimental model in dogs for studying pulmonary thrombosis.” Invest Radiol 16, no. 4 (1981): 289–97. https://doi.org/10.1097/00004424-198107000-00009.
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  - Kao, K. J., P. O. Hagen, and S. V. Pizzo. “Membrane protein mediation of thromboxane A2-induced platelet aggregation.” Biochem Biophys Res Commun 97, no. 1 (November 17, 1980): 87–93. https://doi.org/10.1016/s0006-291x(80)80138-0.
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  - Kao, K. J., S. V. Pizzo, and P. A. McKee. “Factor VIII/von Willebrand protein. Modification of its carbohydrate causes reduced binding to platelets.” J Biol Chem 255, no. 21 (November 10, 1980): 10134–39.
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  - Herbert, V. “Physical conditioning and fibrinolysis.” N Engl J Med 303, no. 13 (September 25, 1980): 757. https://doi.org/10.1056/NEJM198009253031317.
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  - Dreyer, N. A., and S. V. Pizzo. “Blood coagulation and idiopathic thromboembolism among fertile women.” Contraception 22, no. 2 (August 1980): 123–35. https://doi.org/10.1016/0010-7824(80)90057-8.
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  - Kao, K. J., R. A. Coleman, and S. V. Pizzo. “The bleeding diathesis in human glycogen storage disease type I: in vitro identification of a naturally occurring inhibitor of ristocetin-induced platelet aggregation.” Thromb Res 18, no. 5 (June 1, 1980): 683–92. https://doi.org/10.1016/0049-3848(80)90223-6.
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  - Cecil, B., B. Woodard, D. D. Mickey, and S. Pizzo. “Renal carcinosarcoma. Ultrastructure and transplantation into athymic mice.” Arch Pathol Lab Med 104, no. 5 (May 1980): 276–79.
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  - Williams, R. S., E. E. Logue, J. G. Lewis, T. Barton, N. W. Stead, A. G. Wallace, and S. V. Pizzo. “Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults.” N Engl J Med 302, no. 18 (May 1, 1980): 987–91. https://doi.org/10.1056/NEJM198005013021802.
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  - Sanfilippo, F., K. J. Kao, S. V. Pizzo, and J. J. Collins. “Immunotherapy of murine leukemia. II. Effect of passive serum therapy on Friend murine leukemia virus-induced hematologic and coagulation parameters.” J Natl Cancer Inst 64, no. 3 (March 1980): 547–53.
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  - Adams, D. O., K. J. Kao, R. Farb, and S. V. Pizzo. “Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases.” J Immunol 124, no. 1 (January 1980): 293–300.
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  - Hill, R. L., S. V. Pizzo, M. Imber, M. Lehrman, J. P. Prieels, L. R. Glasgow, C. E. Guthrow, and J. C. Paulson. “Receptors on hepatocytes that bind ligands containing fucosyl alpha 1,3 N-acetylglucosamine linkages.” Birth Defects Orig Artic Ser 16, no. 1 (1980): 85–91.
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  - Thompson, W. M., I. S. Johnsrude, D. C. Jackson, S. McAlister, M. D. Miller, and S. V. Pizzo. “Vessel occlusion with transcatheter electrocoagulation: initial clinical experience.” Radiology 133, no. 2 (November 1979): 335–40. https://doi.org/10.1148/133.2.335.
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  - Kao, K. J., S. V. Pizzo, and P. A. McKee. “Platelet receptors for human Factor VIII/von Willebrand protein: functional correlation of receptor occupancy and ristocetin-induced platelet aggregation.” Proc Natl Acad Sci U S A 76, no. 10 (October 1979): 5317–20. https://doi.org/10.1073/pnas.76.10.5317.
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  - Switzer, M. E., S. V. Pizzo, and P. A. McKee. “Is there a precursive, relatively procoagulant-inactive form of normal antihemophilic factor (factor VIII)?” Blood 54, no. 4 (October 1979): 916–27.
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  - Kao, K. J., S. V. Pizzo, and P. A. McKee. “Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets.” J Clin Invest 63, no. 4 (April 1979): 656–64. https://doi.org/10.1172/JCI109348.
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  - Thompson, W. M., D. S. McAlister, M. Miller, S. V. Pizzo, D. C. Jackson, and I. S. Johnsrude. “Transcatheter electrocoagulation: experimental evaluation of the anode.” Invest Radiol 14, no. 1 (1979): 41–47. https://doi.org/10.1097/00004424-197901000-00008.
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  - Sodetz, J. M., J. C. Paulson, S. V. Pizzo, and P. A. McKee. “Carbohydrate on human factor VIII/von Willebrand factor. Impairment of function by removal of specific galactose residues.” J Biol Chem 253, no. 20 (October 25, 1978): 7202–6.
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  - Blum, J., J. C. Reed, S. V. Pizzo, and W. M. Thompson. “Miliary aspergillosis associated with alcoholism.” Ajr Am J Roentgenol 131, no. 4 (October 1978): 707–9. https://doi.org/10.2214/ajr.131.4.707.
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  - Miller, M. D., I. S. Johnsrude, A. J. Limberakis, D. C. Jackson, S. Pizzo, and W. M. Thompson. “Clinical use of transcatheter electrocoagulation.” Radiology 129, no. 1 (October 1978): 211–14. https://doi.org/10.1148/129.1.211.
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  - Prieels, J. P., S. V. Pizzo, L. R. Glasgow, J. C. Paulson, and R. L. Hill. “Hepatic receptor that specifically binds oligosaccharides containing fucosyl alpha1 leads to 3 N-acetylglucosamine linkages.” Proc Natl Acad Sci U S A 75, no. 5 (May 1978): 2215–19. https://doi.org/10.1073/pnas.75.5.2215.
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  - Thompson, W. M., S. V. Pizzo, F. M. Kelvin, and R. P. Rice. “Necrosis of the colon secondary to pancreatitis.” The American Journal of Digestive Diseases 23, no. 5 (January 1, 1978). https://doi.org/10.1007/BF01072498.
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  - Thompson, W. M., S. Pizzo, D. C. Jackson, and I. S. Johnsrude. “The effect of drug-induced thrombocytopenia on direct-current transcatheter electrocoagulation.” Radiology 124, no. 3 (September 1977): 831–33. https://doi.org/10.1148/124.3.831.
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  - Sodetz, J. M., S. V. Pizzo, and P. A. McKee. “Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein.” J Biol Chem 252, no. 15 (August 10, 1977): 5538–46.
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  - Thompson, W. M., S. V. Pizzo, D. C. Jackson, and I. S. Johnsrude. “Transcatheter electrocoagulation: a therapeutic angiographic technique for vessel occlusion.” Invest Radiol 12, no. 2 (1977): 146–53. https://doi.org/10.1097/00004424-197703000-00008.
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  - Ownby, D. R., S. Pizzo, L. Blackmon, S. A. Gall, and R. H. Buckley. “Severe combined immunodeficiency with leukopenia (reticular dysgenesis) in siblings: immunologic and histopathologic findings.” J Pediatr 89, no. 3 (September 1976): 382–87. https://doi.org/10.1016/s0022-3476(76)80532-x.
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  - Daniel, T. M., S. V. Pizzo, and P. A. Mckee. “Comparison of ancrod and heparin as anticoagulants following endarterectomy in the dog.” Ann Surg 184, no. 2 (August 1976): 223–28. https://doi.org/10.1097/00000658-197608000-00015.
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  - Slade, C. L., S. V. Pizzo, L. M. Taylor, H. M. Steinman, and P. A. McKee. “Characterization of fragment E from fibrinogen and cross-linked fibrin.” J Biol Chem 251, no. 6 (March 25, 1976): 1591–96.
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  - Shapiro, G. A., J. C. Andersen, S. V. Pizzo, and P. A. McKee. “The subunit structure of normal and hemophilic factor VIII.” J Clin Invest 52, no. 9 (September 1973): 2198–2210. https://doi.org/10.1172/JCI107405.
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  - Pizzo, S. V., L. M. Taylor, M. L. Schwartz, R. L. Hill, and P. A. McKee. “Subunit structure of fragment D from fibrinogen and cross-linked fibrin.” J Biol Chem 248, no. 13 (July 10, 1973): 4584–90.
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  - Pizzo, S. V., M. L. Schwartz, R. L. Hill, and P. A. McKee. “The effect of plasmin on the subunit structure of human fibrin.” J Biol Chem 248, no. 13 (July 10, 1973): 4574–83.
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  - Schwartz, M. L., S. V. Pizzo, J. B. Sullivan, R. L. Hill, and P. A. McKee. “A comparative study of crosslinked and noncrosslinked fibrin from the major classes of vertebrates.” Thromb Diath Haemorrh 29, no. 2 (May 10, 1973): 313–38.
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  - Schwartz, M. L., S. V. Pizzo, R. L. Hill, and P. A. McKee. “Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin.” J Biol Chem 248, no. 4 (February 25, 1973): 1395–1407.
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  - McKee, P. A., M. L. Schwartz, S. V. Pizzo, and R. L. Hill. “Cross-linking of fibrin by fibrin=stabilizing factor.” Ann N Y Acad Sci 202 (December 8, 1972): 127–48. https://doi.org/10.1111/j.1749-6632.1972.tb16326.x.
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  - Pizzo, S. V., M. L. Schwartz, R. L. Hill, and P. A. McKee. “Mechanism of ancrod anticoagulation. A direct proteolytic effect on fibrin.” J Clin Invest 51, no. 11 (November 1972): 2841–50. https://doi.org/10.1172/JCI107107.
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  - Pizzo, S. V., M. L. Schwartz, R. L. Hill, and P. A. McKee. “The effect of plasmin on the subunit structure of human fibrinogen.” J Biol Chem 247, no. 3 (February 10, 1972): 636–45.
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  - Schwartz, M. L., S. V. Pizzo, R. L. Hill, P. A. McKee, and R. M. Bird. “Purification and subunit structure of human plasma and platelet fibrin-stabilizing factor.” J Lab Clin Med 78, no. 5 (November 1971): 848.
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  - Schwartz, M. L., S. V. Pizzo, R. L. Hill, and P. A. McKee. “The subunit structures of human plasma and platelet factor XIII (fibrin-stabilizing factor).” J Biol Chem 246, no. 18 (September 25, 1971): 5851–54.
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  - Schwartz, M. L., S. V. Pizzo, and P. A. McKee. “Minimal brain dysfunction and methylphenidate.” N Engl J Med 285, no. 5 (July 29, 1971): 293.
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  - Schwartz, M. L., S. V. Pizzo, R. L. Hill, and P. A. McKee. “The effect of fibrin-stabilizing factor on the subunit structure of human fibrin.” J Clin Invest 50, no. 7 (July 1971): 1506–13. https://doi.org/10.1172/JCI106636.
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- Book Sections
  - Gonzalez-Gronow, M., and S. V. Pizzo. “Novel Cell Surface Targets for the Plasminogen Activating System in the Brain: Implications for Human Disease.” In Cell Surface GRP78, a New Paradigm in Signal Transduction Biology, 87–98, 2018. https://doi.org/10.1016/B978-0-12-812351-5.00005-2.
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  - Gopal, U., and S. V. Pizzo. “The Endoplasmic Reticulum Chaperone GRP78 Also Functions as a Cell Surface Signaling Receptor.” In Cell Surface GRP78, a New Paradigm in Signal Transduction Biology, 9–40, 2018. https://doi.org/10.1016/B978-0-12-812351-5.00002-7.
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  - Pizzo, S. V. “An Historical Perspective: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology.” In Cell Surface GRP78, a New Paradigm in Signal Transduction Biology, 1–7, 2018. https://doi.org/10.1016/B978-0-12-812351-5.00001-5.
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- Other Articles
  - Fuchs, H. E., and S. V. Pizzo. “Catabolism of antithrombin III-protease complexes.” Thromb Res, October 15, 1983. https://doi.org/10.1016/0049-3848(83)90037-3.
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- Conference Papers
  - Ridder, Gustaaf de, Ayako Suzuki, Liyan Xu, Diana Cardona, Jeff Groth, Rupa Ray, Manal F. Abdelmalek, Salvatore V. Pizzo, and Cynthia Guy. “GRP78 Immunohistochemistry Outperforms HSP70 for the Diagnosis of Cirrhotic- and Noncirrhotic-HCC.” In Modern Pathology, 31:632–632. NATURE PUBLISHING GROUP, 2018.
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  - Ridder, Gustaaf de, Ayako Suzuki, Liyan Xu, Diana Cardona, Jeff Groth, Rupa Ray, Manal F. Abdelmalek, Salvatore V. Pizzo, and Cynthia Guy. “GRP78 Immunohistochemistry Outperforms HSP70 for the Diagnosis of Cirrhotic- and Noncirrhotic-HCC.” In Laboratory Investigation, 98:632–632. NATURE PUBLISHING GROUP, 2018.
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  - Mo, Lihong, Margaret Kennedy, Andrew Berchuck, George Cianciolo, Robin E. Bachelder, and Salvatore V. Pizzo. “Abstract POSTER-THER-1420: Ascites drives ovarian cancer stem-like cell growth: therapeutic opportunities.” In Clinical Cancer Research, Vol. 21. American Association for Cancer Research (AACR), 2015. https://doi.org/10.1158/1557-3265.ovcasymp14-poster-ther-1420.
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  - Allott, Emma H., Elizabeth M. Masko, Alexa Choy, Alexis R. Gaines, Keith R. Solomon, Salvatore V. Pizzo, and Stephen J. Freedland. “Abstract 3698: Inhibition of cholesterol uptake with ezetimibe reduces intra-tumoral testosterone levels and slows tumor growth in transgenic mouse models of prostate cancer.” In Cancer Research, 73:3698–3698. American Association for Cancer Research (AACR), 2013. https://doi.org/10.1158/1538-7445.am2013-3698.
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  - Masko, Elizabeth M., Keith R. Solomon, Nikolaos A. Valilis, Alexis R. Gaines, Michael J. Muehlbauer, Christopher B. Newgard, Mark W. Dewhirst, Salvatore V. Pizzo, and Stephen J. Freedland. “225 THE EFFECTS OF CHOLESTEROL TREATMENT DRUGS ALONE AND IN COMBINATION ON PROSTATE TUMOR XENOGRAFT GROWTH.” In Journal of Urology, Vol. 187. Ovid Technologies (Wolters Kluwer Health), 2012. https://doi.org/10.1016/j.juro.2012.02.279.
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  - Masko, Elizabeth, Lionel L. Banez, Nikolaos A. Valilis, Tameika E. Phillips, Susan H. M. Poulton, Keith R. Solomon, Salvatore V. Pizzo, and Stephen J. Freedland. “THE USE OF SIMVASTATIN AND EZETIMIBE AS NOVEL THERAPEUTICS FOR PROSTATE CANCER IN A XENOGRAFT MODEL.” In Journal of Urology, 183:E553–E553. ELSEVIER SCIENCE INC, 2010.
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  - Masko, Elizabeth, Lionel L. Banez, Salvatore V. Pizzo, and Stephen J. Freedland. “SIMVASTATIN INHIBITS THE GROWTH OF ANDROGEN-SENSITIVE AND ANDROGEN-INDEPENDENT CELLS IN VITRO.” In Journal of Urology, 183:E553–54. ELSEVIER SCIENCE INC, 2010.
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  - Masko, Elizabeth, Jean-Alfred Thomas, Jodi A. Antonelli, Jessica C. Lloyd, Tameika E. Phillips, Susan H. M. Poulton, Salvatore V. Pizzo, and Stephen J. Freedland. “1437 LOW-CARBOHYDRATE DIETS AND PROSTATE CANCER GROWTH: HOW LOW IS “LOW ENOUGH”?” In Journal of Urology, Vol. 183. Ovid Technologies (Wolters Kluwer Health), 2010. https://doi.org/10.1016/j.juro.2010.02.1130.
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