Salvatore Vincent Pizzo
Distinguished Professor of Pathology, in the School of Medicine

RESEARCH ABSTRACT
Studies from this laboratory identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies.  Cell surface GRP78 functions as a signaling receptor promoting tumor proliferation and suppressing apoptosis.  Patients with a number of malignancies mount an autoimmune response to GRP78 and these antibodies, which bind to the NH2 terminal domains of GRP78, are receptor agonists whose appearance is a marker of poor prognosis.  More recently, we have shown that antibodies directed against the COOH-terminal domain of GRP78 are receptor antagonists which may have therapeutic potential for treating patients whose tumors express GRP78 on the cell surface.

Current Appointments & Affiliations

Contact Information

  • Rm 3059 Duke South Hospital, Durham, NC 27710
  • Rm 3059 Duke South Hospital, Duke Box 3712, Durham, NC 27710

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.