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Radioprotection of whole-body gamma irradiation induced alterations in lipid metabolism of liver and plasma by AET (S-2, aminoethyl isothiuronium Br. H. Br.) and serotonin in rats.

Publication ,  Journal Article
Ramanathan, R; Misra, UK
Published in: Strahlentherapie
October 1975

Radioprotective effect of AET, serotonin and their mixture has been studied on liver and plasma lipid metabolism 24 hrs and 48 hrs after irradiation in fasted male rats. AET and serotonin both gave significant radioprotection to certain liver and plasma lipid components, but the mixture of the two afforded a better protection. The non-radioprotection of plasma NEFA, phospholipids and phosphatidyl choline levels by serotonin observed in irradiated rats was because serotonin itself raised the levels of these lipids in control rats. Serotonin alone or in mixture effectively protected the radiation-induced increased incorporation of NaH2(32)PO4 into liver phospholipids. Mixture of AET and serotonin failed to protect the increased incorporation of aceae-1-14-C into liver total fatty acids and cholesterol, but it prevented this increased incorporation into liver triglycerides and phospholipids.

Duke Scholars

Published In

Strahlentherapie

ISSN

0039-2073

Publication Date

October 1975

Volume

150

Issue

4

Start / End Page

433 / 443

Location

Germany

Related Subject Headings

  • beta-Aminoethyl Isothiourea
  • Serotonin
  • Rats
  • Radiation Effects
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Phosphates
  • Male
  • Liver
 

Published In

Strahlentherapie

ISSN

0039-2073

Publication Date

October 1975

Volume

150

Issue

4

Start / End Page

433 / 443

Location

Germany

Related Subject Headings

  • beta-Aminoethyl Isothiourea
  • Serotonin
  • Rats
  • Radiation Effects
  • Phospholipids
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Phosphates
  • Male
  • Liver