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Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor.

Publication ,  Journal Article
Howard, GC; DeCamp, DL; Misra, UK; Pizzo, SV
Published in: Biochim Biophys Acta
October 17, 1996

Site-directed mutagenesis of residues in the receptor binding fragment of rat alpha 1-macroglobulin identify residues 1377 and 1378 (human numbering) as crucial for interaction with the alpha 2M signaling receptor on murine macrophages. Secondary structure prediction and signaling studies with the mutant proteins suggest the alpha 2M signaling receptor binding site involves part of a loop-helix-loop motif comprised of residues 1372-1378.

Duke Scholars

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

October 17, 1996

Volume

1297

Issue

2

Start / End Page

111 / 114

Location

Netherlands

Related Subject Headings

  • alpha-Macroglobulins
  • Signal Transduction
  • Receptors, Immunologic
  • Rats
  • Protein Structure, Secondary
  • Peptide Fragments
  • Mutation
  • Mutagenesis, Site-Directed
  • Molecular Sequence Data
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Howard, G. C., DeCamp, D. L., Misra, U. K., & Pizzo, S. V. (1996). Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor. Biochim Biophys Acta, 1297(2), 111–114. https://doi.org/10.1016/s0167-4838(96)00135-5
Howard, G. C., D. L. DeCamp, U. K. Misra, and S. V. Pizzo. “Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor.Biochim Biophys Acta 1297, no. 2 (October 17, 1996): 111–14. https://doi.org/10.1016/s0167-4838(96)00135-5.
Howard GC, DeCamp DL, Misra UK, Pizzo SV. Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor. Biochim Biophys Acta. 1996 Oct 17;1297(2):111–4.
Howard, G. C., et al. “Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor.Biochim Biophys Acta, vol. 1297, no. 2, Oct. 1996, pp. 111–14. Pubmed, doi:10.1016/s0167-4838(96)00135-5.
Howard GC, DeCamp DL, Misra UK, Pizzo SV. Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor. Biochim Biophys Acta. 1996 Oct 17;1297(2):111–114.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

October 17, 1996

Volume

1297

Issue

2

Start / End Page

111 / 114

Location

Netherlands

Related Subject Headings

  • alpha-Macroglobulins
  • Signal Transduction
  • Receptors, Immunologic
  • Rats
  • Protein Structure, Secondary
  • Peptide Fragments
  • Mutation
  • Mutagenesis, Site-Directed
  • Molecular Sequence Data
  • Mice