Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats.
Publication
, Journal Article
Chauhan, SS; Singh, SK; Misra, UK
Published in: Toxicology
May 31, 1989
The effect of fly ash inhalation on xenobiotic metabolizing enzymes and heme metabolism in lung and liver has been studied in rats. Fly ash inhalation induced pulmonary and hepatic cytochrome P-450 content, aryl hydrocarbon hydroxylase and glutathione S-transferase activity. Induction of cytochrome P-450 was accompanied by induction of delta-amino levulinic acid synthetase in lung and inhibition of heme oxygenase in both lung and liver. Fly ash inhalation induced those species of cytochrome P-450 which closely resembled cytochrome P-448 in spectral properties and electrophoretic mobility.
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Published In
Toxicology
DOI
ISSN
0300-483X
Publication Date
May 31, 1989
Volume
56
Issue
1
Start / End Page
95 / 105
Location
Ireland
Related Subject Headings
- Toxicology
- Rats, Inbred Strains
- Rats
- Random Allocation
- Mixed Function Oxygenases
- Male
- Lung
- Liver
- Isoenzymes
- Heme Oxygenase (Decyclizing)
Citation
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ICMJE
MLA
NLM
Chauhan, S. S., Singh, S. K., & Misra, U. K. (1989). Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats. Toxicology, 56(1), 95–105. https://doi.org/10.1016/0300-483x(89)90215-1
Chauhan, S. S., S. K. Singh, and U. K. Misra. “Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats.” Toxicology 56, no. 1 (May 31, 1989): 95–105. https://doi.org/10.1016/0300-483x(89)90215-1.
Chauhan SS, Singh SK, Misra UK. Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats. Toxicology. 1989 May 31;56(1):95–105.
Chauhan, S. S., et al. “Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats.” Toxicology, vol. 56, no. 1, May 1989, pp. 95–105. Pubmed, doi:10.1016/0300-483x(89)90215-1.
Chauhan SS, Singh SK, Misra UK. Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats. Toxicology. 1989 May 31;56(1):95–105.
Published In
Toxicology
DOI
ISSN
0300-483X
Publication Date
May 31, 1989
Volume
56
Issue
1
Start / End Page
95 / 105
Location
Ireland
Related Subject Headings
- Toxicology
- Rats, Inbred Strains
- Rats
- Random Allocation
- Mixed Function Oxygenases
- Male
- Lung
- Liver
- Isoenzymes
- Heme Oxygenase (Decyclizing)