Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats.

Journal Article (Journal Article)

The effect of fly ash inhalation on xenobiotic metabolizing enzymes and heme metabolism in lung and liver has been studied in rats. Fly ash inhalation induced pulmonary and hepatic cytochrome P-450 content, aryl hydrocarbon hydroxylase and glutathione S-transferase activity. Induction of cytochrome P-450 was accompanied by induction of delta-amino levulinic acid synthetase in lung and inhibition of heme oxygenase in both lung and liver. Fly ash inhalation induced those species of cytochrome P-450 which closely resembled cytochrome P-448 in spectral properties and electrophoretic mobility.

Full Text

Duke Authors

Cited Authors

  • Chauhan, SS; Singh, SK; Misra, UK

Published Date

  • May 31, 1989

Published In

Volume / Issue

  • 56 / 1

Start / End Page

  • 95 - 105

PubMed ID

  • 2728010

International Standard Serial Number (ISSN)

  • 0300-483X

Digital Object Identifier (DOI)

  • 10.1016/0300-483x(89)90215-1


  • eng

Conference Location

  • Ireland