Induction of cytochrome P-450 and phosphatidylcholine synthesis by endosulfan in liver of rats: effect of quality of dietary proteins.

Journal Article

Administration of endosulfan significantly increased microsomal protein, cytochrome P-450 content and the activity of aminopyrine N-demethylase. Effect of endosulfan and actinomycin D either alone or together on microsomal protein, cytochrome P-450, NADPH cytochrome c reductase, aniline hydroxylase, aminopyrine N-demethylase, phosphatidylcholine content, incorporation of 3H-choline and 14C-methionine were studied in rats given amino acid deficient and supplemented diets. Administration of endosulfan significantly increased the above parameters in both the dietary groups, whereas administration of actinomycin D did not have any effect in rats fed supplemented diets, however, significant decrease in the PC and the incorporation of choline and methionine into PC of rats fed deficient diet were observed. A positive correlation in the effect of endosulfan on hepatic mixed function oxidase activity and hepatic phosphatidylcholine is observed.

Full Text

Duke Authors

Cited Authors

  • Tyagi, SR; Sriram, K; Narayan, S; Misra, UK

Published Date

  • December 1985

Published In

Volume / Issue

  • 20 / 6

Start / End Page

  • 651 - 664

PubMed ID

  • 4093546

Electronic International Standard Serial Number (EISSN)

  • 1532-4109

International Standard Serial Number (ISSN)

  • 0360-1234

Digital Object Identifier (DOI)

  • 10.1080/03601238509372502

Language

  • eng