Developmental pattern of DNA and proteins in brain, liver, lung and heart of rats given excess vitamin A postnatally.
The effect of an excessive dose of vitamin A (1,000 IU) to rat pups on 4, 6, 8 and 10 days of age was studied on growth and organ weights. The effects on the amounts of DNA and proteins and incorporation of 3H-thymidine into DNA and 3H-leucine into proteins of brain, liver, lung and heart was studied on 11, 17 and 23 days of age. Excess vitamin A administration affected the postnatal development of DNA and protein metabolism of these organs differently.
Shukla, RR; Joshi, HC; Misra, UK
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