Coal fly ash induces hepatic and pulmonary cytochrome P-450 and sigma-aminolevulinic acid synthetase in rats.
The effect of intratracheal administration of coal fly ash, its benzene-soluble and benzene-insoluble fractions has been studied on the levels of hepatic and pulmonary cytochrome P-450, cytochrome b5, and the activities of sigma-aminolevulinic acid synthetase and heme oxygenase. Fly ash and both its fractions significantly increased the levels of hepatic and pulmonary cytochrome P-450. Benzene-soluble and benzene-insoluble fractions of coal fly ash significantly increased the levels of cytochrome b5 also in both lung and liver. Fly ash and both its fractions increased the activity of sigma-aminolevulinic acid synthetase and reduced the activity of heme oxygenase in lung and liver. Glass bead particles of similar size did not show any effect on hepatic and pulmonary cytochrome P-450 and cytochrome b5.
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- Toxicology
- Rats, Inbred Strains
- Rats
- Particulate Matter
- Microsomes, Liver
- Microsomes
- Male
- Lung
- Heme Oxygenase (Decyclizing)
- Enzyme Induction
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Toxicology
- Rats, Inbred Strains
- Rats
- Particulate Matter
- Microsomes, Liver
- Microsomes
- Male
- Lung
- Heme Oxygenase (Decyclizing)
- Enzyme Induction