Coal fly ash induces hepatic and pulmonary cytochrome P-450 and sigma-aminolevulinic acid synthetase in rats.
Journal Article (Journal Article)
The effect of intratracheal administration of coal fly ash, its benzene-soluble and benzene-insoluble fractions has been studied on the levels of hepatic and pulmonary cytochrome P-450, cytochrome b5, and the activities of sigma-aminolevulinic acid synthetase and heme oxygenase. Fly ash and both its fractions significantly increased the levels of hepatic and pulmonary cytochrome P-450. Benzene-soluble and benzene-insoluble fractions of coal fly ash significantly increased the levels of cytochrome b5 also in both lung and liver. Fly ash and both its fractions increased the activity of sigma-aminolevulinic acid synthetase and reduced the activity of heme oxygenase in lung and liver. Glass bead particles of similar size did not show any effect on hepatic and pulmonary cytochrome P-450 and cytochrome b5.
Full Text
Duke Authors
Cited Authors
- Srivastava, PK; Misra, UK
Published Date
- 1987
Published In
Volume / Issue
- 21 / 1-2
Start / End Page
- 187 - 192
PubMed ID
- 3573070
International Standard Serial Number (ISSN)
- 0098-4108
Digital Object Identifier (DOI)
- 10.1080/15287398709531011
Language
- eng
Conference Location
- United States