Coal fly ash induces hepatic and pulmonary cytochrome P-450 and sigma-aminolevulinic acid synthetase in rats.

Published

Journal Article

The effect of intratracheal administration of coal fly ash, its benzene-soluble and benzene-insoluble fractions has been studied on the levels of hepatic and pulmonary cytochrome P-450, cytochrome b5, and the activities of sigma-aminolevulinic acid synthetase and heme oxygenase. Fly ash and both its fractions significantly increased the levels of hepatic and pulmonary cytochrome P-450. Benzene-soluble and benzene-insoluble fractions of coal fly ash significantly increased the levels of cytochrome b5 also in both lung and liver. Fly ash and both its fractions increased the activity of sigma-aminolevulinic acid synthetase and reduced the activity of heme oxygenase in lung and liver. Glass bead particles of similar size did not show any effect on hepatic and pulmonary cytochrome P-450 and cytochrome b5.

Full Text

Duke Authors

Cited Authors

  • Srivastava, PK; Misra, UK

Published Date

  • January 1987

Published In

Volume / Issue

  • 21 / 1-2

Start / End Page

  • 187 - 192

PubMed ID

  • 3573070

Pubmed Central ID

  • 3573070

International Standard Serial Number (ISSN)

  • 0098-4108

Digital Object Identifier (DOI)

  • 10.1080/15287398709531011

Language

  • eng