Pulmonary and hepatic glutathione levels, glutathione shuttle enzymes and lipid peroxidation in rats exposed intratracheally to coal fly ash.
Journal Article (Journal Article)
Fly ash and fly ash residue increased the formation of conjugated dienes and the levels of oxidized glutathione (GSSG) and reduced the levels of reduced glutathione (GSH) in lung and liver whereas fly ash extract administration had no effect on the formation of conjugated dienes and glutathione levels in lung and liver. Fly ash and fly ash residue reduced the activity of glutathione reductase both in lung and liver but did not alter the activity of glutathione peroxidase. Fly ash and fly ash extract significantly increased glucose-6-phosphate dehydrogenase activity in lung whereas in liver, fly ash and fly ash residue reduced the activity of glucose-6-phosphate dehydrogenase. Fly ash residue did not alter the activity of glucose-6-phosphate dehydrogenase in lung whereas fly ash extract was not effective in liver.
Full Text
Duke Authors
Cited Authors
- Srivastava, PK; Singh, Y; Misra, UK
Published Date
- September 1988
Published In
Volume / Issue
- 17 / 3
Start / End Page
- 509 - 516
PubMed ID
- 3202885
International Standard Serial Number (ISSN)
- 0158-5231
Language
- eng
Conference Location
- Australia