Pulmonary and hepatic glutathione levels, glutathione shuttle enzymes and lipid peroxidation in rats exposed intratracheally to coal fly ash.

Published

Journal Article

Fly ash and fly ash residue increased the formation of conjugated dienes and the levels of oxidized glutathione (GSSG) and reduced the levels of reduced glutathione (GSH) in lung and liver whereas fly ash extract administration had no effect on the formation of conjugated dienes and glutathione levels in lung and liver. Fly ash and fly ash residue reduced the activity of glutathione reductase both in lung and liver but did not alter the activity of glutathione peroxidase. Fly ash and fly ash extract significantly increased glucose-6-phosphate dehydrogenase activity in lung whereas in liver, fly ash and fly ash residue reduced the activity of glucose-6-phosphate dehydrogenase. Fly ash residue did not alter the activity of glucose-6-phosphate dehydrogenase in lung whereas fly ash extract was not effective in liver.

Full Text

Duke Authors

Cited Authors

  • Srivastava, PK; Singh, Y; Misra, UK

Published Date

  • September 1988

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 509 - 516

PubMed ID

  • 3202885

Pubmed Central ID

  • 3202885

International Standard Serial Number (ISSN)

  • 0158-5231

Language

  • eng