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Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate.

Publication ,  Journal Article
Chauhan, SS; Srivastava, PK; Srivastava, VK; Kumar, V; Misra, UK
Published in: J Toxicol Environ Health
1986

Administration of benzene-soluble fraction (FAE) and benzene-insoluble fraction (FAR) of fly ash for 3 consecutive days to rats significantly raised cytochrome P-450 levels, aryl hydrocarbon hydroxylase (AHH) activity, and glutathione S-transferase activity in liver. This treatment also significantly increased pulmonary AHH and glutathione S-transferase activity. Intratracheal administration of FAR (5 mg/100 g body weight) alone for 6 consecutive days also significantly increased hepatic cytochrome P-450 levels and the activity of glutathione S-transferase. Intragastric administration of retinyl palmitate (5000 IU/100 g body weight), along with intratracheal FAE and FAR administration, significantly reduced P-450 levels, activity of glutathione S-transferase in liver, and activity of AHH and glutathione S-transferase in lung of rats. Intraperitoneal administration of citrate (40 mg/100 g body weight) along with FAR significantly reduced FAR-induced increase in hepatic cytochrome P-450 levels and glutathione S-transferase activity. The activity of AHH was not affected by these treatments.

Duke Scholars

Published In

J Toxicol Environ Health

DOI

ISSN

0098-4108

Publication Date

1986

Volume

17

Issue

4

Start / End Page

357 / 363

Location

United States

Related Subject Headings

  • Vitamin A
  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Particulate Matter
  • Mixed Function Oxygenases
  • Male
  • Lung
  • Liver
  • Hydrocarbons
 

Citation

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ICMJE
MLA
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Chauhan, S. S., Srivastava, P. K., Srivastava, V. K., Kumar, V., & Misra, U. K. (1986). Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate. J Toxicol Environ Health, 17(4), 357–363. https://doi.org/10.1080/15287398609530830
Chauhan, S. S., P. K. Srivastava, V. K. Srivastava, V. Kumar, and U. K. Misra. “Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate.J Toxicol Environ Health 17, no. 4 (1986): 357–63. https://doi.org/10.1080/15287398609530830.
Chauhan SS, Srivastava PK, Srivastava VK, Kumar V, Misra UK. Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate. J Toxicol Environ Health. 1986;17(4):357–63.
Chauhan, S. S., et al. “Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate.J Toxicol Environ Health, vol. 17, no. 4, 1986, pp. 357–63. Pubmed, doi:10.1080/15287398609530830.
Chauhan SS, Srivastava PK, Srivastava VK, Kumar V, Misra UK. Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate. J Toxicol Environ Health. 1986;17(4):357–363.

Published In

J Toxicol Environ Health

DOI

ISSN

0098-4108

Publication Date

1986

Volume

17

Issue

4

Start / End Page

357 / 363

Location

United States

Related Subject Headings

  • Vitamin A
  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Particulate Matter
  • Mixed Function Oxygenases
  • Male
  • Lung
  • Liver
  • Hydrocarbons