Radioprotection of lipogenesis from glucose (U-14C) and activities of pyridine nucleotide dehydrogenases in liver of gamma-irradiated female rats by cystamine.

Published

Journal Article

Whole-body gamma-irradiation (1200 R) of female rats significantly increased liver glycogen and incorporation of glucose (U-14C) into liver fatty acids. Administration of cystamine before irradiation protected the enhanced lipogenesis from glucose (U-14C), but afforded only a partial protection of liver glycogen levels. Irradiation significantly decreased the activities of liver pyruvate kinase and isocitrate dehydrogenase, and this decrease was not prevented by the administration of cystamine before irradiation. A significant increase in the activity of liver malate dehydrogenase (dehydrogenating) was noted in irradiated rats, which was not prevented by the administration of cystamine before irradiation. Irradiation did not affect the activities of combined hexose monophosphate pathway dehydrogenases and of malate dehydrogenase (decarboxylating).

Full Text

Duke Authors

Cited Authors

  • Ramanathan, R; Misra, UK

Published Date

  • July 1, 1975

Published In

Volume / Issue

  • 28 / 1

Start / End Page

  • 35 - 43

PubMed ID

  • 1081089

Pubmed Central ID

  • 1081089

International Standard Serial Number (ISSN)

  • 0020-7616

Digital Object Identifier (DOI)

  • 10.1080/09553007514550731

Language

  • eng