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Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.

Publication ,  Journal Article
Fox, CS; Hall, JL; Arnett, DK; Ashley, EA; Delles, C; Engler, MB; Freeman, MW; Johnson, JA; Lanfear, DE; Liggett, SB; Lusis, AJ; Loscalzo, J ...
Published in: Circulation
May 12, 2015

The field of genetics and genomics has advanced considerably with the achievement of recent milestones encompassing the identification of many loci for cardiovascular disease and variable drug responses. Despite this achievement, a gap exists in the understanding and advancement to meaningful translation that directly affects disease prevention and clinical care. The purpose of this scientific statement is to address the gap between genetic discoveries and their practical application to cardiovascular clinical care. In brief, this scientific statement assesses the current timeline for effective translation of basic discoveries to clinical advances, highlighting past successes. Current discoveries in the area of genetics and genomics are covered next, followed by future expectations, tools, and competencies for achieving the goal of improving clinical care.

Duke Scholars

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

May 12, 2015

Volume

131

Issue

19

Start / End Page

1715 / 1736

Location

United States

Related Subject Headings

  • United States
  • Translational Research, Biomedical
  • Molecular Targeted Therapy
  • Mice
  • Induced Pluripotent Stem Cells
  • Hyperlipoproteinemia Type II
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Human Genome Project
  • Genomics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fox, C. S., Hall, J. L., Arnett, D. K., Ashley, E. A., Delles, C., Engler, M. B., … American Heart Association Council on Functional Genomics and Translational Biology, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Quality of Care and Outcomes Research, and Council on Epidemiology and Prevention. (2015). Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation, 131(19), 1715–1736. https://doi.org/10.1161/CIR.0000000000000211
Fox, Caroline S., Jennifer L. Hall, Donna K. Arnett, Euan A. Ashley, Christian Delles, Mary B. Engler, Mason W. Freeman, et al. “Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.Circulation 131, no. 19 (May 12, 2015): 1715–36. https://doi.org/10.1161/CIR.0000000000000211.
Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, et al. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation. 2015 May 12;131(19):1715–36.
Fox, Caroline S., et al. “Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.Circulation, vol. 131, no. 19, May 2015, pp. 1715–36. Pubmed, doi:10.1161/CIR.0000000000000211.
Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O’Donnell CJ, Rich SS, Terzic A, American Heart Association Council on Functional Genomics and Translational Biology, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Quality of Care and Outcomes Research, and Council on Epidemiology and Prevention. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation. 2015 May 12;131(19):1715–1736.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

May 12, 2015

Volume

131

Issue

19

Start / End Page

1715 / 1736

Location

United States

Related Subject Headings

  • United States
  • Translational Research, Biomedical
  • Molecular Targeted Therapy
  • Mice
  • Induced Pluripotent Stem Cells
  • Hyperlipoproteinemia Type II
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Human Genome Project
  • Genomics