Skip to main content

SU-C-9A-06: The Impact of CT Image Used for Attenuation Correction in 4D-PET.

Publication ,  Journal Article
Cui, Y; Bowsher, J; Yan, S; Cai, J; Das, S; Yin, F
Published in: Med Phys
June 2014

PURPOSE: To evaluate the appropriateness of using 3D non-gated CT image for attenuation correction (AC) in a 4D-PET (gated PET) imaging protocol used in radiotherapy treatment planning simulation. METHODS: The 4D-PET imaging protocol in a Siemens PET/CT simulator (Biograph mCT, Siemens Medical Solutions, Hoffman Estates, IL) was evaluated. CIRS Dynamic Thorax Phantom (CIRS Inc., Norfolk, VA) with a moving glass sphere (8 mL) in the middle of its thorax portion was used in the experiments. The glass was filled with (18) F-FDG and was in a longitudinal motion derived from a real patient breathing pattern. Varian RPM system (Varian Medical Systems, Palo Alto, CA) was used for respiratory gating. Both phase-gating and amplitude-gating methods were tested. The clinical imaging protocol was modified to use three different CT images for AC in 4D-PET reconstruction: first is to use a single-phase CT image to mimic actual clinical protocol (single-CT-PET); second is to use the average intensity projection CT (AveIP-CT) derived from 4D-CT scanning (AveIP-CT-PET); third is to use 4D-CT image to do the phase-matched AC (phase-matching- PET). Maximum SUV (SUVmax) and volume of the moving target (glass sphere) with threshold of 40% SUVmax were calculated for comparison between 4D-PET images derived with different AC methods. RESULTS: The SUVmax varied 7.3%±6.9% over the breathing cycle in single-CT-PET, compared to 2.5%±2.8% in AveIP-CT-PET and 1.3%±1.2% in phasematching PET. The SUVmax in single-CT-PET differed by up to 15% from those in phase-matching-PET. The target volumes measured from single- CT-PET images also presented variations up to 10% among different phases of 4D PET in both phase-gating and amplitude-gating experiments. CONCLUSION: Attenuation correction using non-gated CT in 4D-PET imaging is not optimal process for quantitative analysis. Clinical 4D-PET imaging protocols should consider phase-matched 4D-CT image if available to achieve better accuracy.

Duke Scholars

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2014

Volume

41

Issue

6

Start / End Page

105

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cui, Y., Bowsher, J., Yan, S., Cai, J., Das, S., & Yin, F. (2014). SU-C-9A-06: The Impact of CT Image Used for Attenuation Correction in 4D-PET. Med Phys, 41(6), 105. https://doi.org/10.1118/1.4887847
Cui, Y., J. Bowsher, S. Yan, J. Cai, S. Das, and F. Yin. “SU-C-9A-06: The Impact of CT Image Used for Attenuation Correction in 4D-PET.Med Phys 41, no. 6 (June 2014): 105. https://doi.org/10.1118/1.4887847.
Cui Y, Bowsher J, Yan S, Cai J, Das S, Yin F. SU-C-9A-06: The Impact of CT Image Used for Attenuation Correction in 4D-PET. Med Phys. 2014 Jun;41(6):105.
Cui, Y., et al. “SU-C-9A-06: The Impact of CT Image Used for Attenuation Correction in 4D-PET.Med Phys, vol. 41, no. 6, June 2014, p. 105. Pubmed, doi:10.1118/1.4887847.
Cui Y, Bowsher J, Yan S, Cai J, Das S, Yin F. SU-C-9A-06: The Impact of CT Image Used for Attenuation Correction in 4D-PET. Med Phys. 2014 Jun;41(6):105.

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2014

Volume

41

Issue

6

Start / End Page

105

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences