Reduced effects of age on dopamine D2 receptor levels in physically active adults.
Published
Journal Article
Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.
Full Text
Duke Authors
Cited Authors
- Dang, LC; Castrellon, JJ; Perkins, SF; Le, NT; Cowan, RL; Zald, DH; Samanez-Larkin, GR
Published Date
- March 2017
Published In
Volume / Issue
- 148 /
Start / End Page
- 123 - 129
PubMed ID
- 28089678
Pubmed Central ID
- 28089678
Electronic International Standard Serial Number (EISSN)
- 1095-9572
International Standard Serial Number (ISSN)
- 1053-8119
Digital Object Identifier (DOI)
- 10.1016/j.neuroimage.2017.01.018
Language
- eng