Reduced effects of age on dopamine D2 receptor levels in physically active adults.
Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.
Dang, LC; Castrellon, JJ; Perkins, SF; Le, NT; Cowan, RL; Zald, DH; Samanez-Larkin, GR
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