Reduced effects of age on dopamine D2 receptor levels in physically active adults.

Journal Article (Journal Article)

Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.

Full Text

Duke Authors

Cited Authors

  • Dang, LC; Castrellon, JJ; Perkins, SF; Le, NT; Cowan, RL; Zald, DH; Samanez-Larkin, GR

Published Date

  • March 2017

Published In

Volume / Issue

  • 148 /

Start / End Page

  • 123 - 129

PubMed ID

  • 28089678

Pubmed Central ID

  • PMC5344739

Electronic International Standard Serial Number (EISSN)

  • 1095-9572

International Standard Serial Number (ISSN)

  • 1053-8119

Digital Object Identifier (DOI)

  • 10.1016/j.neuroimage.2017.01.018


  • eng