Ocular Surface Epithelial Atypia Mimicking Squamous Neoplasia in Association With Ulcerative Colitis.

Journal Article (Journal Article)

PURPOSE: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC). METHODS: Case report. RESULTS: A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia. Shortly after treatment of the second eye, the patient was diagnosed with UC. Residual disease improved dramatically in response to systemic corticosteroids. CONCLUSIONS: Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.

Full Text

Duke Authors

Cited Authors

  • Ong, SS; Walter, SD; Chen, X; Vora, GK; Daluvoy, M; Proia, AD; Mruthyunjaya, P

Published Date

  • April 2017

Published In

Volume / Issue

  • 36 / 4

Start / End Page

  • 502 - 505

PubMed ID

  • 28129293

Electronic International Standard Serial Number (EISSN)

  • 1536-4798

Digital Object Identifier (DOI)

  • 10.1097/ICO.0000000000001144


  • eng

Conference Location

  • United States