Guidelines for the welfare and use of animals in cancer research.

Journal Article (Journal Article)

Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.

Full Text

Duke Authors

Cited Authors

  • Workman, P; Aboagye, EO; Balkwill, F; Balmain, A; Bruder, G; Chaplin, DJ; Double, JA; Everitt, J; Farningham, DAH; Glennie, MJ; Kelland, LR; Robinson, V; Stratford, IJ; Tozer, GM; Watson, S; Wedge, SR; Eccles, SA; Committee of the National Cancer Research Institute,

Published Date

  • May 25, 2010

Published In

Volume / Issue

  • 102 / 11

Start / End Page

  • 1555 - 1577

PubMed ID

  • 20502460

Pubmed Central ID

  • PMC2883160

Electronic International Standard Serial Number (EISSN)

  • 1532-1827

Digital Object Identifier (DOI)

  • 10.1038/sj.bjc.6605642


  • eng

Conference Location

  • England