Uterine leiomyoma in the Eker rat: a unique model for important diseases of women.
Journal Article (Journal Article;Review)
Eker rats carry a defect in the Tsc-2 tumor suppressor gene and female Eker rats develop uterine leiomyoma with a high frequency. The presentation, response to hormones and molecular alterations in these mesenchymal smooth muscle tumors, closely resembles their cognate human disease. Female rats and tumor-derived cell lines from Eker rat leiomyomas (ELT lines) have been developed as an in vivo/in vitro model system for preclinical studies to identify novel therapeutic agents for this disease and for studying disease pathogenesis. In addition to serving as a model for uterine leiomyoma, Eker rats have proven valuable for studying lymphangioleiomyomatosis, a related proliferative smooth muscle disease of women.
- Walker, CL; Hunter, D; Everitt, JI
- December 2003
Volume / Issue
- 38 / 4
Start / End Page
- 349 - 356
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States