Uterine leiomyoma in the Eker rat: a unique model for important diseases of women.
Publication
, Journal Article
Walker, CL; Hunter, D; Everitt, JI
Published in: Genes Chromosomes Cancer
December 2003
Eker rats carry a defect in the Tsc-2 tumor suppressor gene and female Eker rats develop uterine leiomyoma with a high frequency. The presentation, response to hormones and molecular alterations in these mesenchymal smooth muscle tumors, closely resembles their cognate human disease. Female rats and tumor-derived cell lines from Eker rat leiomyomas (ELT lines) have been developed as an in vivo/in vitro model system for preclinical studies to identify novel therapeutic agents for this disease and for studying disease pathogenesis. In addition to serving as a model for uterine leiomyoma, Eker rats have proven valuable for studying lymphangioleiomyomatosis, a related proliferative smooth muscle disease of women.
Duke Scholars
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Published In
Genes Chromosomes Cancer
DOI
ISSN
1045-2257
Publication Date
December 2003
Volume
38
Issue
4
Start / End Page
349 / 356
Location
United States
Related Subject Headings
- Uterine Neoplasms
- Rats, Mutant Strains
- Rats, Long-Evans
- Rats
- Oncology & Carcinogenesis
- Male
- Lymphangioleiomyomatosis
- Leiomyoma
- Humans
- Female
Citation
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MLA
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Walker, C. L., Hunter, D., & Everitt, J. I. (2003). Uterine leiomyoma in the Eker rat: a unique model for important diseases of women. Genes Chromosomes Cancer, 38(4), 349–356. https://doi.org/10.1002/gcc.10281
Walker, Cheryl Lyn, Deborah Hunter, and Jeffery I. Everitt. “Uterine leiomyoma in the Eker rat: a unique model for important diseases of women.” Genes Chromosomes Cancer 38, no. 4 (December 2003): 349–56. https://doi.org/10.1002/gcc.10281.
Walker CL, Hunter D, Everitt JI. Uterine leiomyoma in the Eker rat: a unique model for important diseases of women. Genes Chromosomes Cancer. 2003 Dec;38(4):349–56.
Walker, Cheryl Lyn, et al. “Uterine leiomyoma in the Eker rat: a unique model for important diseases of women.” Genes Chromosomes Cancer, vol. 38, no. 4, Dec. 2003, pp. 349–56. Pubmed, doi:10.1002/gcc.10281.
Walker CL, Hunter D, Everitt JI. Uterine leiomyoma in the Eker rat: a unique model for important diseases of women. Genes Chromosomes Cancer. 2003 Dec;38(4):349–356.
Published In
Genes Chromosomes Cancer
DOI
ISSN
1045-2257
Publication Date
December 2003
Volume
38
Issue
4
Start / End Page
349 / 356
Location
United States
Related Subject Headings
- Uterine Neoplasms
- Rats, Mutant Strains
- Rats, Long-Evans
- Rats
- Oncology & Carcinogenesis
- Male
- Lymphangioleiomyomatosis
- Leiomyoma
- Humans
- Female