Uterine leiomyoma in the Eker rat: a unique model for important diseases of women.

Journal Article (Journal Article;Review)

Eker rats carry a defect in the Tsc-2 tumor suppressor gene and female Eker rats develop uterine leiomyoma with a high frequency. The presentation, response to hormones and molecular alterations in these mesenchymal smooth muscle tumors, closely resembles their cognate human disease. Female rats and tumor-derived cell lines from Eker rat leiomyomas (ELT lines) have been developed as an in vivo/in vitro model system for preclinical studies to identify novel therapeutic agents for this disease and for studying disease pathogenesis. In addition to serving as a model for uterine leiomyoma, Eker rats have proven valuable for studying lymphangioleiomyomatosis, a related proliferative smooth muscle disease of women.

Full Text

Duke Authors

Cited Authors

  • Walker, CL; Hunter, D; Everitt, JI

Published Date

  • December 2003

Published In

Volume / Issue

  • 38 / 4

Start / End Page

  • 349 - 356

PubMed ID

  • 14566855

International Standard Serial Number (ISSN)

  • 1045-2257

Digital Object Identifier (DOI)

  • 10.1002/gcc.10281


  • eng

Conference Location

  • United States