Possible cellular and molecular mechanisms for asbestos carcinogenicity.

Journal Article (Journal Article;Review)

Asbestos fibers may exert their carcinogenic effects on mesothelial cells and bronchial epithelial cells by direct and indirect mechanisms. Direct effects can occur following the physical interaction of fibers with target cells or by the generation of free radicals from the fiber surface; indirect effects, following the interaction of fibers with inflammatory cells can result in the production of cellular mediators such as cytokines and various reactive oxygen species. As a result, target cells may be induced to proliferate and/or sustain genetic alterations, which lead to tumor development.

Full Text

Duke Authors

Cited Authors

  • Walker, C; Everitt, J; Barrett, JC

Published Date

  • 1992

Published In

Volume / Issue

  • 21 / 2

Start / End Page

  • 253 - 273

PubMed ID

  • 1536158

International Standard Serial Number (ISSN)

  • 0271-3586

Digital Object Identifier (DOI)

  • 10.1002/ajim.4700210214


  • eng

Conference Location

  • United States