Possible cellular and molecular mechanisms for asbestos carcinogenicity.
Publication
, Journal Article
Walker, C; Everitt, J; Barrett, JC
Published in: Am J Ind Med
1992
Asbestos fibers may exert their carcinogenic effects on mesothelial cells and bronchial epithelial cells by direct and indirect mechanisms. Direct effects can occur following the physical interaction of fibers with target cells or by the generation of free radicals from the fiber surface; indirect effects, following the interaction of fibers with inflammatory cells can result in the production of cellular mediators such as cytokines and various reactive oxygen species. As a result, target cells may be induced to proliferate and/or sustain genetic alterations, which lead to tumor development.
Duke Scholars
Published In
Am J Ind Med
DOI
ISSN
0271-3586
Publication Date
1992
Volume
21
Issue
2
Start / End Page
253 / 273
Location
United States
Related Subject Headings
- Smoking
- Rats
- Oxidants
- Mutation
- Mesothelioma
- Mesocricetus
- Humans
- Growth Substances
- Environmental & Occupational Health
- Cricetinae
Citation
APA
Chicago
ICMJE
MLA
NLM
Walker, C., Everitt, J., & Barrett, J. C. (1992). Possible cellular and molecular mechanisms for asbestos carcinogenicity. Am J Ind Med, 21(2), 253–273. https://doi.org/10.1002/ajim.4700210214
Walker, C., J. Everitt, and J. C. Barrett. “Possible cellular and molecular mechanisms for asbestos carcinogenicity.” Am J Ind Med 21, no. 2 (1992): 253–73. https://doi.org/10.1002/ajim.4700210214.
Walker C, Everitt J, Barrett JC. Possible cellular and molecular mechanisms for asbestos carcinogenicity. Am J Ind Med. 1992;21(2):253–73.
Walker, C., et al. “Possible cellular and molecular mechanisms for asbestos carcinogenicity.” Am J Ind Med, vol. 21, no. 2, 1992, pp. 253–73. Pubmed, doi:10.1002/ajim.4700210214.
Walker C, Everitt J, Barrett JC. Possible cellular and molecular mechanisms for asbestos carcinogenicity. Am J Ind Med. 1992;21(2):253–273.
Published In
Am J Ind Med
DOI
ISSN
0271-3586
Publication Date
1992
Volume
21
Issue
2
Start / End Page
253 / 273
Location
United States
Related Subject Headings
- Smoking
- Rats
- Oxidants
- Mutation
- Mesothelioma
- Mesocricetus
- Humans
- Growth Substances
- Environmental & Occupational Health
- Cricetinae