Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.
Publication
, Journal Article
Recio, L; Everitt, J
Published in: Comp Med
October 2001
There has been increasing interest in the use of selected genetically modified (GM) mouse models for the testing of chemicals to determine their carcinogenic potential. GM mouse models are believed to be useful tools that offer mechanistically relevant insights for understanding and predicting the human response to chemical exposure. They have been proposed as alternatives to the traditional 2-year mouse oncogenicity bioassay. In this overview we will review the GM mouse models that have been proposed as bioassay alternatives and present some of the key laboratory animal science challenges that need to be considered when using these unique animals.
Duke Scholars
Published In
Comp Med
ISSN
1532-0820
Publication Date
October 2001
Volume
51
Issue
5
Start / End Page
399 / 405
Location
United States
Related Subject Headings
- Xeroderma Pigmentosum Group A Protein
- Xenobiotics
- Veterinary Sciences
- Mice, Transgenic
- Mice, Mutant Strains
- Mice, Knockout
- Mice
- Humans
- Genotype
- Genetic Engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Recio, L., & Everitt, J. (2001). Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist. Comp Med, 51(5), 399–405.
Recio, L., and J. Everitt. “Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.” Comp Med 51, no. 5 (October 2001): 399–405.
Recio L, Everitt J. Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist. Comp Med. 2001 Oct;51(5):399–405.
Recio, L., and J. Everitt. “Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.” Comp Med, vol. 51, no. 5, Oct. 2001, pp. 399–405.
Recio L, Everitt J. Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist. Comp Med. 2001 Oct;51(5):399–405.
Published In
Comp Med
ISSN
1532-0820
Publication Date
October 2001
Volume
51
Issue
5
Start / End Page
399 / 405
Location
United States
Related Subject Headings
- Xeroderma Pigmentosum Group A Protein
- Xenobiotics
- Veterinary Sciences
- Mice, Transgenic
- Mice, Mutant Strains
- Mice, Knockout
- Mice
- Humans
- Genotype
- Genetic Engineering