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Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.

Publication ,  Journal Article
Recio, L; Everitt, J
Published in: Comp Med
October 2001

There has been increasing interest in the use of selected genetically modified (GM) mouse models for the testing of chemicals to determine their carcinogenic potential. GM mouse models are believed to be useful tools that offer mechanistically relevant insights for understanding and predicting the human response to chemical exposure. They have been proposed as alternatives to the traditional 2-year mouse oncogenicity bioassay. In this overview we will review the GM mouse models that have been proposed as bioassay alternatives and present some of the key laboratory animal science challenges that need to be considered when using these unique animals.

Duke Scholars

Published In

Comp Med

ISSN

1532-0820

Publication Date

October 2001

Volume

51

Issue

5

Start / End Page

399 / 405

Location

United States

Related Subject Headings

  • Xeroderma Pigmentosum Group A Protein
  • Xenobiotics
  • Veterinary Sciences
  • Mice, Transgenic
  • Mice, Mutant Strains
  • Mice, Knockout
  • Mice
  • Humans
  • Genotype
  • Genetic Engineering
 

Published In

Comp Med

ISSN

1532-0820

Publication Date

October 2001

Volume

51

Issue

5

Start / End Page

399 / 405

Location

United States

Related Subject Headings

  • Xeroderma Pigmentosum Group A Protein
  • Xenobiotics
  • Veterinary Sciences
  • Mice, Transgenic
  • Mice, Mutant Strains
  • Mice, Knockout
  • Mice
  • Humans
  • Genotype
  • Genetic Engineering