Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.

Journal Article (Journal Article;Review)

There has been increasing interest in the use of selected genetically modified (GM) mouse models for the testing of chemicals to determine their carcinogenic potential. GM mouse models are believed to be useful tools that offer mechanistically relevant insights for understanding and predicting the human response to chemical exposure. They have been proposed as alternatives to the traditional 2-year mouse oncogenicity bioassay. In this overview we will review the GM mouse models that have been proposed as bioassay alternatives and present some of the key laboratory animal science challenges that need to be considered when using these unique animals.

Full Text

Duke Authors

Cited Authors

  • Recio, L; Everitt, J

Published Date

  • October 1, 2001

Published In

Volume / Issue

  • 51 / 5

Start / End Page

  • 399 - 405

PubMed ID

  • 11924798

International Standard Serial Number (ISSN)

  • 1532-0820


  • eng

Conference Location

  • United States