Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard.
Publication
, Journal Article
Lockhart, SR; Ghannoum, MA; Alexander, BD
Published in: J Clin Microbiol
May 2017
Breakpoints are used to predict whether an antifungal agent will be clinically effective against a particular fungal isolate. They are based on a combination of MIC values, pharmacokinetic/pharmacodynamic values, and clinical outcome data. For many fungus-antifungal combinations, these data might never be available. For these combinations, epidemiological cutoff values (ECVs) provide a methodology for categorizing isolates as either wild type (WT) or non-WT. In this review, we define ECVs, explain how they are generated using the CLSI methodology in standard M57, and describe how they can be used in clinical practice.
Duke Scholars
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Published In
J Clin Microbiol
DOI
EISSN
1098-660X
Publication Date
May 2017
Volume
55
Issue
5
Start / End Page
1262 / 1268
Location
United States
Related Subject Headings
- Treatment Outcome
- Microbiology
- Microbial Sensitivity Tests
- Humans
- Drug Resistance, Fungal
- Cryptococcus neoformans
- Cryptococcosis
- Candidiasis
- Candida glabrata
- Antifungal Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Lockhart, S. R., Ghannoum, M. A., & Alexander, B. D. (2017). Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard. J Clin Microbiol, 55(5), 1262–1268. https://doi.org/10.1128/JCM.02416-16
Lockhart, Shawn R., Mahmoud A. Ghannoum, and Barbara D. Alexander. “Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard.” J Clin Microbiol 55, no. 5 (May 2017): 1262–68. https://doi.org/10.1128/JCM.02416-16.
Lockhart SR, Ghannoum MA, Alexander BD. Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard. J Clin Microbiol. 2017 May;55(5):1262–8.
Lockhart, Shawn R., et al. “Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard.” J Clin Microbiol, vol. 55, no. 5, May 2017, pp. 1262–68. Pubmed, doi:10.1128/JCM.02416-16.
Lockhart SR, Ghannoum MA, Alexander BD. Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard. J Clin Microbiol. 2017 May;55(5):1262–1268.
Published In
J Clin Microbiol
DOI
EISSN
1098-660X
Publication Date
May 2017
Volume
55
Issue
5
Start / End Page
1262 / 1268
Location
United States
Related Subject Headings
- Treatment Outcome
- Microbiology
- Microbial Sensitivity Tests
- Humans
- Drug Resistance, Fungal
- Cryptococcus neoformans
- Cryptococcosis
- Candidiasis
- Candida glabrata
- Antifungal Agents