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Barbara Dudley Alexander

Professor of Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
315 Trent Drive, Hanes House, Room 163A, Durham, NC 27710

Overview


Clinical research related to infectious complications of solid organ and bone marrow transplantation, with a particular interest in the treatment and rapid diagnosis of fungal disease. Training the next generation of Transplant Infectious Disease Physicians is a special focus of mine as the Principal Investigator of our Interdisciplinary T32 Training Program funded the NIH.

Current Appointments & Affiliations


Professor of Medicine · 2014 - Present Medicine, Infectious Diseases, Medicine
Professor of Pathology · 2014 - Present Pathology, Clinical Science Departments

Recent Publications


A change of heart: Limitations of National Healthcare Safety Network (NHSN) and Society of Thoracic Surgeons (STS) surveillance strategies in identifying surgical site infections after heart transplant surgery.

Journal Article Am J Infect Control · July 2025 Surgical site infections (SSI) surveillance after heart transplantation is critical for preventing SSI. We analyzed the accuracy of 3 SSI surveillance systems: National-Healthcare-Safety-Network (NHSN), Society-of-Thoracic-Surgeons (STS), and detailed manu ... Full text Link to item Cite

Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study.

Journal Article Lancet Infect Dis · June 17, 2025 BACKGROUND: Only a small number of antifungal therapies for invasive fungal disease (IFD) are currently available, and many pathogens are resistant to one or more of these therapies. Olorofim, the first orotomide antifungal agent to be developed, is active ... Full text Link to item Cite

Limited utility of Epstein-Barr virus (EBV) surveillance for predicting post-transplant lymphoproliferative disorders in adult EBV seropositive lung transplant recipients.

Journal Article J Clin Virol · February 2025 BACKGROUND: EBV DNAemia surveillance, with reduction of immunosuppression at certain viral load (VL) thresholds, is a common practice for mitigating progression from EBV DNAemia to post-transplant lymphoproliferative disorder (PTLD) in lung transplant reci ... Full text Link to item Cite
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Recent Grants


Novel Host-Response Biomarker Diagnostics for Invasive Aspergillosis

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2029

Tri-Institutional Molecular Mycology and Pathogenesis Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

UAB - Clinical and Applied Research Strategies for the Prevention and Control of Fungal Diseases

ResearchPrincipal Investigator · Awarded by University of Alabama at Birmingham · 2023 - 2028

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Education, Training & Certifications


East Carolina University · 1993 M.D.