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Barbara Dudley Alexander

Professor of Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
315 Trent Drive, Hanes House, Room 163A, Durham, NC 27710

Overview


Clinical research related to infectious complications of solid organ and bone marrow transplantation, with a particular interest in the treatment and rapid diagnosis of fungal disease. Training the next generation of Transplant Infectious Disease Physicians is a special focus of mine as the Principal Investigator of our Interdisciplinary T32 Training Program funded the NIH.

Current Appointments & Affiliations


Professor of Medicine · 2014 - Present Medicine, Infectious Diseases, Medicine
Professor of Pathology · 2014 - Present Pathology, Clinical Science Departments

Recent Publications


Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study.

Journal Article Lancet Infect Dis · November 2025 BACKGROUND: Only a small number of antifungal therapies for invasive fungal disease (IFD) are currently available, and many pathogens are resistant to one or more of these therapies. Olorofim, the first orotomide antifungal agent to be developed, is active ... Full text Link to item Cite

Assessing blood culture appropriateness in solid organ transplant recipients: a diagnostic stewardship approach.

Journal Article Infect Control Hosp Epidemiol · September 29, 2025 OBJECTIVE: Diagnostic stewardship of blood culture utilization is important to mitigate the risks associated with unnecessary culturing. Although blood culture algorithms have been studied previously, there is a lack of data on their application among soli ... Full text Link to item Cite

Healthcare Resource Utilization, Treatment Costs, and Mortality in Patients with Malignancies or Transplantation Who Develop Invasive Aspergillosis.

Journal Article J Fungi (Basel) · September 6, 2025 Objectives: Invasive aspergillosis (IA) poses significant risks to patients with malignancies or transplantation; however, estimates of burden-of-illness in patients with IA are sparse. We sought to assess in-hospital and outpatient healthcare resource uti ... Full text Link to item Cite
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Recent Grants


Novel Host-Response Biomarker Diagnostics for Invasive Aspergillosis

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2029

Tri-Institutional Molecular Mycology and Pathogenesis Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

UAB - Clinical and Applied Research Strategies for the Prevention and Control of Fungal Diseases

ResearchPrincipal Investigator · Awarded by University of Alabama at Birmingham · 2023 - 2028

View All Grants

Education, Training & Certifications


East Carolina University · 1993 M.D.