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New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.

Publication ,  Journal Article
Liebscher, I; Ackley, B; Araç, D; Ariestanti, DM; Aust, G; Bae, B-I; Bista, BR; Bridges, JP; Duman, JG; Engel, FB; Giera, S; Goffinet, AM ...
Published in: Ann N Y Acad Sci
December 2014

The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGPCRs but one (GPR123) contain a GPCR autoproteolysis-inducing (GAIN) domain that mediates autoproteolytic cleavage at the GPCR autoproteolysis site motif to generate N- and a C-terminal fragments (NTF and CTF, respectively) during protein maturation. Subsequently, the NTF and CTF are associated noncovalently as a heterodimer at the plasma membrane. While the biological function of the GAIN domain-mediated autocleavage is not fully understood, mounting evidence suggests that the NTF and CTF possess distinct biological activities in addition to their function as a receptor unit. We discuss recent advances in understanding the biological functions, signaling mechanisms, and disease associations of the aGPCRs.

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Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

December 2014

Volume

1333

Issue

1

Start / End Page

43 / 64

Location

United States

Related Subject Headings

  • Synapses
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Neoplasms
  • Mutation
  • Humans
  • General Science & Technology
  • Developmental Disabilities
  • Cell Adhesion
  • Animals
 

Citation

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Liebscher, I., Ackley, B., Araç, D., Ariestanti, D. M., Aust, G., Bae, B.-I., … Piao, X. (2014). New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci, 1333(1), 43–64. https://doi.org/10.1111/nyas.12580
Liebscher, Ines, Brian Ackley, Demet Araç, Donna M. Ariestanti, Gabriela Aust, Byoung-il Bae, Bigyan R. Bista, et al. “New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.Ann N Y Acad Sci 1333, no. 1 (December 2014): 43–64. https://doi.org/10.1111/nyas.12580.
Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae B-I, et al. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec;1333(1):43–64.
Liebscher, Ines, et al. “New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.Ann N Y Acad Sci, vol. 1333, no. 1, Dec. 2014, pp. 43–64. Pubmed, doi:10.1111/nyas.12580.
Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae B-I, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin H-H, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 2014 Dec;1333(1):43–64.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

December 2014

Volume

1333

Issue

1

Start / End Page

43 / 64

Location

United States

Related Subject Headings

  • Synapses
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Neoplasms
  • Mutation
  • Humans
  • General Science & Technology
  • Developmental Disabilities
  • Cell Adhesion
  • Animals