NIH conference. HIV vaccine development: a progress report.


Journal Article (Review)

The development of a safe, effective preventive vaccine for human immunodeficiency virus (HIV) infection remains an area of vigorous research. Several highly innovative vaccine candidates are being developed, and more than 13 vaccine candidates have been tested in human phase I or II trials. All have produced antibody and several have produced modest neutralizing titers, but to date no reproducible evidence has suggested prolonged, high-titer neutralization across a diversity of HIV strains. Furthermore, only the live recombinant vector approaches have produced some evidence of cytotoxic T-cell responses. The principal obstacle to progress is the lack of definitive information on what constitutes a protective immune response. There is no animal model for HIV-induced disease. Hence, the identification of the correlates of immunity and more useful animal models is among the highest priorities for HIV vaccine research. Large-scale efficacy trials raise daunting scientific, ethical, and resource issues. Nonetheless, preparation in such trials is underway in order to be in a position to evaluate the most promising vaccine candidate.

Full Text

Duke Authors

Cited Authors

  • Hoth, DF; Bolognesi, DP; Corey, L; Vermund, SH

Published Date

  • October 15, 1994

Published In

Volume / Issue

  • 121 / 8

Start / End Page

  • 603 - 611

PubMed ID

  • 8085693

Pubmed Central ID

  • 8085693

International Standard Serial Number (ISSN)

  • 0003-4819

Digital Object Identifier (DOI)

  • 10.7326/0003-4819-121-8-199410150-00008


  • eng

Conference Location

  • United States