Current Appointments & Affiliations
James B. Duke Distinguished Professor Emeritus of Medicine
·
2002 - Present
Surgery, Surgical Sciences,
Surgery
Professor Emeritus of Surgery
·
2002 - Present
Surgery, Surgical Sciences,
Surgery
Recent Publications
Vaccine strategies for AIDS
Chapter · November 1, 2024 Full text CiteRecombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.
Journal Article Lancet Child Adolesc Health · July 2023 BACKGROUND: Outcomes of recurrent paediatric high-grade glioma are poor, with a median overall survival of less than 6 months. Viral immunotherapy, such as the polio-rhinovirus chimera lerapolturev, is a novel approach for treatment of recurrent paediatric ... Full text Link to item CiteVery low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.
Journal Article Nat Commun · January 13, 2021 Several immunotherapy clinical trials in recurrent glioblastoma have reported long-term survival benefits in 10-20% of patients. Here we perform genomic analysis of tumor tissue from recurrent WHO grade IV glioblastoma patients acquired prior to immunother ... Full text Open Access Link to item CiteRecent Grants
Utilizing Nucleic Acid Binding Polymers to Ameliorate Inflammation-driven Metastatic Progression in Breast Cancer
FellowshipMentor · Awarded by National Institutes of Health · 2018 - 2021Host Virus Interactions During Acute Infection
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1999Viral Control And Immune Reconstitution In Hiv Infection
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1996 - 1999View All Grants
Education, Training & Certifications
Duke University ·
1967
Ph.D.