Morphological, chemical, and antigenic organization of mammalian C-type viruses.
Journal Article (Journal Article)
New features in the architecture of mammalian type C viruses, in particular knoblike surface projections and hexagonally arranged subunits on the core shell could be demonstrated by electron microscopy, taking advantage of newly developed preparation techniques. As examples, murine leukemia viruses (MuLVs) and newly isolated porcine and bovine C viruses are presented. The major proteins of a MuLV were isolated and partially characterized in chemical terms and with respect to their serological and other biological activities, such as interfering and hemagglutinating (HA) capacity. Most of the characterized proteins could be localized in particular substructures of the virion either by selective removal or isolation of electron microscopically identifiable constituents. The information obtained allowed the design of a more detailed model of mammalian C viruses. Special attention was devoted to the further characterization of interspecies antigens of mammalian C viruses. Different antigenic determinants were revealed. Their distribution allows further subgrouping of mammalian C viruses.
Full Text
Duke Authors
Cited Authors
- Schäfer, W; Demsey, A; Frank, H; Hunsmann, G; Lange, J; Moennig, V; Pister, L; Bolognesi, DP; Green, RW; Luftig, RB; Shaper, J; Hüper, G
Published Date
- 1975
Published In
Start / End Page
- 497 - 515
PubMed ID
- 51634
Pubmed Central ID
- 51634
International Standard Serial Number (ISSN)
- 0067-7957
Digital Object Identifier (DOI)
- 10.1159/000397568
Language
- eng
Conference Location
- Switzerland