Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus.

Journal Article (Clinical Trial;Journal Article)

Many studies have shown that patients infected with hepatitis C virus (HCV) of genotype 2 have better response to interferon (IFN)-alpha treatment than genotype 1 patients; however, the mechanisms responsible for this difference are not understood. In this study, viral dynamics during high-dose IFN induction treatment were compared between the genotypes. Patients in each group received 10 MU of IFN-alpha2b for 14 days, and HCV RNA levels were frequently determined. Nonlinear fitting, both individually for each patient and using a mixed-effects approach, of the viral kinetic data to a mathematical model of the IFN effect on HCV infection was performed. The antiviral effectiveness of IFN in blocking virus production, the free virion clearance rate, and the HCV-infected cell death rate were all significantly higher for genotype 2 patients than for genotype 1 patients. Thus, the better response rate of patients infected with HCV genotype 2 is multifactorial. This is the first finding of a difference in viral dynamics between subtypes of the same virus and demonstrates the importance of subtype-specific virus-host-drug interactions.

Full Text

Duke Authors

Cited Authors

  • Neumann, AU; Lam, NP; Dahari, H; Davidian, M; Wiley, TE; Mika, BP; Perelson, AS; Layden, TJ

Published Date

  • July 2000

Published In

Volume / Issue

  • 182 / 1

Start / End Page

  • 28 - 35

PubMed ID

  • 10882578

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/315661

Language

  • eng

Conference Location

  • United States