Marie Davidian

My interests include hierarchial nonlinear random effects models for longitudinal data, methods for handling covariate measuement error and missing data in regression and random effects models, design and analysis clinical trials, analysis of survival data, causal inference, and general biostatistics.

Current Appointments & Affiliations

Adjunct Professor of Biostatistics & Bioinformatics · 2022 - Present Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics

Recent Publications

Independent Increments and Group Sequential Tests.

Journal Article Stat Med · November 2025 Widely used methods and software for group sequential tests of a null hypothesis of no treatment difference that allow for early stopping of a clinical trial depend primarily on the fact that sequentially-computed test statistics have the independent incre ... Full text Link to item Cite

Bayesian adaptive randomization in the I-SPY2.2 sequential multiple assignment randomized trial

Preprint · May 21, 2025 Link to item Cite

Datopotamab-deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial.

Journal Article Nat Med · December 2024 Sequential adaptive trial designs can help accomplish the goals of personalized medicine, optimizing outcomes and avoiding unnecessary toxicity. Here we describe the results of incorporating a promising antibody-drug conjugate, datopotamab-deruxtecan (Dato ... Full text Link to item Cite

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Education, Training & Certifications

University of North Carolina, Chapel Hill · 1987 Ph.D.