Reduced cardiac selenium content in the acquired immunodeficiency syndrome.

Journal Article (Journal Article)

Selenium deficiency has been implicated in the pathogenesis of a dilated congestive cardiomyopathy in areas of China (Keshan disease) and in several patients on long-term total parenteral nutrition. Recently a clinically and pathologically similar cardiomyopathy has been described in AIDS. Since blood selenium levels are low in AIDS, we assayed cardiac selenium status by a spectrofluorometric method in eight AIDS patients at autopsy compared to nine age-matched, non-AIDS autopsy controls with histologically normal hearts. We found (mean +/- SD) a cardiac selenium level of 0.327 +/- 0.082 microgram/g dry weight in AIDS vs 0.534 +/- 0.184 microgram/g dry weight in controls (p less than 0.01; Student's t test). There were no significant differences between the groups for heart weight, serum CPK, or other laboratory parameters. No specific chest x-ray or electrocardiographic abnormalities were present. Histologically, all AIDS hearts were abnormal; mostly with mild degrees of muscle hypertrophy or fibrosis. Foci of myocytolysis and myocyte necrosis and fibrous replacement of myocytes and monocytic infiltration were present in two AIDS cases. We conclude that heart tissue in AIDS demonstrates a significant selenium deficit. These data provide a potential link between selenium deficiency and cardiomyopathy in AIDS.

Full Text

Duke Authors

Cited Authors

  • Dworkin, BM; Antonecchia, PP; Smith, F; Weiss, L; Davidian, M; Rubin, D; Rosenthal, WS

Published Date

  • 1989

Published In

Volume / Issue

  • 13 / 6

Start / End Page

  • 644 - 647

PubMed ID

  • 2614866

International Standard Serial Number (ISSN)

  • 0148-6071

Digital Object Identifier (DOI)

  • 10.1177/0148607189013006644


  • eng

Conference Location

  • United States