Biology of vascular calcification in renal disease.

Journal Article (Journal Article;Review)

The high rates of atherosclerotic vascular disease in patients with end-stage renal disease (ESRD) cannot be fully explained by the excess of traditional risk factors. Interest has therefore arisen in the possible role of vascular calcification, which is increased in these patients and may effect plaque stability and have detrimental hemodynamic consequences. Considerable evidence has accumulated recently pointing to the regulated nature of the calcification process. The initiation of calcium crystal formation appears to require the presence of small membrane bound vesicles released by living or apoptotic cells. The cellular release, content and phagocytosis of these vesicles appear to be important regulatory pathways in vascular calcification. Better understanding of these mechanisms may have therapeutic potential in reducing the adverse cardiovascular event rates in patients with (ESRD).

Full Text

Duke Authors

Cited Authors

  • Farzaneh-Far, A; Shanahan, CM

Published Date

  • 2005

Published In

Volume / Issue

  • 101 / 4

Start / End Page

  • e134 - e138

PubMed ID

  • 16113585

Pubmed Central ID

  • 16113585

Electronic International Standard Serial Number (EISSN)

  • 1660-2129

Digital Object Identifier (DOI)

  • 10.1159/000087578

Language

  • eng

Conference Location

  • Switzerland