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Biology of vascular calcification in renal disease.

Publication ,  Journal Article
Farzaneh-Far, A; Shanahan, CM
Published in: Nephron Exp Nephrol
2005

The high rates of atherosclerotic vascular disease in patients with end-stage renal disease (ESRD) cannot be fully explained by the excess of traditional risk factors. Interest has therefore arisen in the possible role of vascular calcification, which is increased in these patients and may effect plaque stability and have detrimental hemodynamic consequences. Considerable evidence has accumulated recently pointing to the regulated nature of the calcification process. The initiation of calcium crystal formation appears to require the presence of small membrane bound vesicles released by living or apoptotic cells. The cellular release, content and phagocytosis of these vesicles appear to be important regulatory pathways in vascular calcification. Better understanding of these mechanisms may have therapeutic potential in reducing the adverse cardiovascular event rates in patients with (ESRD).

Duke Scholars

Published In

Nephron Exp Nephrol

DOI

EISSN

1660-2129

Publication Date

2005

Volume

101

Issue

4

Start / End Page

e134 / e138

Location

Switzerland

Related Subject Headings

  • Urology & Nephrology
  • Risk Factors
  • Phosphates
  • Phagocytosis
  • Muscle, Smooth, Vascular
  • Matrix Gla Protein
  • Kidney Failure, Chronic
  • Humans
  • Hemodynamics
  • Extracellular Matrix Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Farzaneh-Far, A., & Shanahan, C. M. (2005). Biology of vascular calcification in renal disease. Nephron Exp Nephrol, 101(4), e134–e138. https://doi.org/10.1159/000087578
Farzaneh-Far, Afshin, and Catherine M. Shanahan. “Biology of vascular calcification in renal disease.Nephron Exp Nephrol 101, no. 4 (2005): e134–38. https://doi.org/10.1159/000087578.
Farzaneh-Far A, Shanahan CM. Biology of vascular calcification in renal disease. Nephron Exp Nephrol. 2005;101(4):e134–8.
Farzaneh-Far, Afshin, and Catherine M. Shanahan. “Biology of vascular calcification in renal disease.Nephron Exp Nephrol, vol. 101, no. 4, 2005, pp. e134–38. Pubmed, doi:10.1159/000087578.
Farzaneh-Far A, Shanahan CM. Biology of vascular calcification in renal disease. Nephron Exp Nephrol. 2005;101(4):e134–e138.
Journal cover image

Published In

Nephron Exp Nephrol

DOI

EISSN

1660-2129

Publication Date

2005

Volume

101

Issue

4

Start / End Page

e134 / e138

Location

Switzerland

Related Subject Headings

  • Urology & Nephrology
  • Risk Factors
  • Phosphates
  • Phagocytosis
  • Muscle, Smooth, Vascular
  • Matrix Gla Protein
  • Kidney Failure, Chronic
  • Humans
  • Hemodynamics
  • Extracellular Matrix Proteins