Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor.

Journal Article (Journal Article)

Matrix Gla protein (MGP) is a mineral binding extra-cellular matrix protein which is thought to be a key inhibitor of tissue and vascular calcification. It is known to be upregulated in areas of extracellular calcification possibly to limit further harmful calcification. In this study we have demonstrated that extracellular ionic calcium (high levels of which induce calcification) is a key signal for MGP regulation and that this effect is mediated by a G protein mediated cation-sensing mechanism, functionally related to, but molecularly distinct from the calcium-sensing receptor. We therefore propose that this novel cation sensing mechanism may play a homeostatic role in preventing pathological calcification.

Full Text

Duke Authors

Cited Authors

  • Farzaneh-Far, A; Proudfoot, D; Weissberg, PL; Shanahan, CM

Published Date

  • November 2, 2000

Published In

Volume / Issue

  • 277 / 3

Start / End Page

  • 736 - 740

PubMed ID

  • 11062022

Pubmed Central ID

  • 11062022

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1006/bbrc.2000.3747

Language

  • eng

Conference Location

  • United States