Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor.
Journal Article (Journal Article)
Matrix Gla protein (MGP) is a mineral binding extra-cellular matrix protein which is thought to be a key inhibitor of tissue and vascular calcification. It is known to be upregulated in areas of extracellular calcification possibly to limit further harmful calcification. In this study we have demonstrated that extracellular ionic calcium (high levels of which induce calcification) is a key signal for MGP regulation and that this effect is mediated by a G protein mediated cation-sensing mechanism, functionally related to, but molecularly distinct from the calcium-sensing receptor. We therefore propose that this novel cation sensing mechanism may play a homeostatic role in preventing pathological calcification.
Full Text
Duke Authors
Cited Authors
- Farzaneh-Far, A; Proudfoot, D; Weissberg, PL; Shanahan, CM
Published Date
- November 2, 2000
Published In
Volume / Issue
- 277 / 3
Start / End Page
- 736 - 740
PubMed ID
- 11062022
International Standard Serial Number (ISSN)
- 0006-291X
Digital Object Identifier (DOI)
- 10.1006/bbrc.2000.3747
Language
- eng
Conference Location
- United States