
Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor.
Publication
, Journal Article
Farzaneh-Far, A; Proudfoot, D; Weissberg, PL; Shanahan, CM
Published in: Biochem Biophys Res Commun
November 2, 2000
Matrix Gla protein (MGP) is a mineral binding extra-cellular matrix protein which is thought to be a key inhibitor of tissue and vascular calcification. It is known to be upregulated in areas of extracellular calcification possibly to limit further harmful calcification. In this study we have demonstrated that extracellular ionic calcium (high levels of which induce calcification) is a key signal for MGP regulation and that this effect is mediated by a G protein mediated cation-sensing mechanism, functionally related to, but molecularly distinct from the calcium-sensing receptor. We therefore propose that this novel cation sensing mechanism may play a homeostatic role in preventing pathological calcification.
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Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
November 2, 2000
Volume
277
Issue
3
Start / End Page
736 / 740
Location
United States
Related Subject Headings
- Virulence Factors, Bordetella
- Transcription, Genetic
- Receptors, Cell Surface
- Receptors, Calcium-Sensing
- Rats, Wistar
- Rats
- Muscle, Smooth, Vascular
- Matrix Gla Protein
- Extracellular Matrix Proteins
- Cells, Cultured
Citation
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NLM
Farzaneh-Far, A., Proudfoot, D., Weissberg, P. L., & Shanahan, C. M. (2000). Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor. Biochem Biophys Res Commun, 277(3), 736–740. https://doi.org/10.1006/bbrc.2000.3747
Farzaneh-Far, A., D. Proudfoot, P. L. Weissberg, and C. M. Shanahan. “Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor.” Biochem Biophys Res Commun 277, no. 3 (November 2, 2000): 736–40. https://doi.org/10.1006/bbrc.2000.3747.
Farzaneh-Far A, Proudfoot D, Weissberg PL, Shanahan CM. Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor. Biochem Biophys Res Commun. 2000 Nov 2;277(3):736–40.
Farzaneh-Far, A., et al. “Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor.” Biochem Biophys Res Commun, vol. 277, no. 3, Nov. 2000, pp. 736–40. Pubmed, doi:10.1006/bbrc.2000.3747.
Farzaneh-Far A, Proudfoot D, Weissberg PL, Shanahan CM. Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor. Biochem Biophys Res Commun. 2000 Nov 2;277(3):736–740.

Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
November 2, 2000
Volume
277
Issue
3
Start / End Page
736 / 740
Location
United States
Related Subject Headings
- Virulence Factors, Bordetella
- Transcription, Genetic
- Receptors, Cell Surface
- Receptors, Calcium-Sensing
- Rats, Wistar
- Rats
- Muscle, Smooth, Vascular
- Matrix Gla Protein
- Extracellular Matrix Proteins
- Cells, Cultured