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Vasodilator action of pentoxifylline on microcirculation of rat cremaster muscle.

Publication ,  Journal Article
Sonkin, PL; Chen, LE; Seaber, AV; Hatchell, DL
Published in: Angiology
June 1992

Pentoxifylline improves microvascular blood flow in conditions of vascular insufficiency. The clinical benefits of pentoxifylline have been attributed to its effects on the cellular elements of whole blood, although a few studies suggest it may also be a vasodilator. The purpose of this study was to determine whether pentoxifylline has a vasodilator effect on the luminal diameter of small arteries preconstricted with norepinephrine and on resting small arteries in the rat cremaster muscle. Intravital videomicroscopy was used in order to observe directly the vasodilator capacity of topically applied pentoxifylline. The results reveal that pentoxifylline (100 microM and more) can significantly dilate small arteries preconstricted with norepinephrine. Pentoxifylline had no effect on the diameter of resting small arteries. These results suggest that vasodilation may play a role in the ability of pentoxifylline to improve arterial blood flow.

Duke Scholars

Published In

Angiology

DOI

ISSN

0003-3197

Publication Date

June 1992

Volume

43

Issue

6

Start / End Page

462 / 469

Location

United States

Related Subject Headings

  • Vasodilation
  • Vasoconstriction
  • Testis
  • Rats, Inbred Strains
  • Rats
  • Pentoxifylline
  • Norepinephrine
  • Muscles
  • Microcirculation
  • Male
 

Citation

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Chicago
ICMJE
MLA
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Sonkin, P. L., Chen, L. E., Seaber, A. V., & Hatchell, D. L. (1992). Vasodilator action of pentoxifylline on microcirculation of rat cremaster muscle. Angiology, 43(6), 462–469. https://doi.org/10.1177/000331979204300602
Sonkin, P. L., L. E. Chen, A. V. Seaber, and D. L. Hatchell. “Vasodilator action of pentoxifylline on microcirculation of rat cremaster muscle.Angiology 43, no. 6 (June 1992): 462–69. https://doi.org/10.1177/000331979204300602.
Sonkin PL, Chen LE, Seaber AV, Hatchell DL. Vasodilator action of pentoxifylline on microcirculation of rat cremaster muscle. Angiology. 1992 Jun;43(6):462–9.
Sonkin, P. L., et al. “Vasodilator action of pentoxifylline on microcirculation of rat cremaster muscle.Angiology, vol. 43, no. 6, June 1992, pp. 462–69. Pubmed, doi:10.1177/000331979204300602.
Sonkin PL, Chen LE, Seaber AV, Hatchell DL. Vasodilator action of pentoxifylline on microcirculation of rat cremaster muscle. Angiology. 1992 Jun;43(6):462–469.
Journal cover image

Published In

Angiology

DOI

ISSN

0003-3197

Publication Date

June 1992

Volume

43

Issue

6

Start / End Page

462 / 469

Location

United States

Related Subject Headings

  • Vasodilation
  • Vasoconstriction
  • Testis
  • Rats, Inbred Strains
  • Rats
  • Pentoxifylline
  • Norepinephrine
  • Muscles
  • Microcirculation
  • Male