Daunorubicin treatment in a refined experimental model of proliferative vitreoretinopathy.

Journal Article (Journal Article)

A condition similar to proliferative vitreoretinopathy (PVR) in man can be produced by injecting 25,000 homologous dermal fibroblasts into rabbit eyes following gas compression of the vitreous. Daunorubicin (15 nmol) was effective in preventing retinal detachment in this model when injected simultaneously with the fibroblasts or in two doses (10 nmol followed by 5 nmol 4 h later) on the 3rd day after fibroblast injection. A single dose of 15 nmol on the 3rd day was not effective in preventing retinal detachment. These results suggest that daunorubicin may be clinically useful in preventing PVR when given by injection both at the time of vitrectomy as well as later, when protein exudation and pigment clumps in the vitreous cavity herald the onset of PVR.

Full Text

Duke Authors

Cited Authors

  • Khawly, JA; Saloupis, P; Hatchell, DL; Machemer, R

Published Date

  • 1991

Published In

Volume / Issue

  • 229 / 5

Start / End Page

  • 464 - 467

PubMed ID

  • 1937080

International Standard Serial Number (ISSN)

  • 0721-832X

Digital Object Identifier (DOI)

  • 10.1007/BF00166311


  • eng

Conference Location

  • Germany