Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo.
Journal Article (Journal Article)
The effects of acute intraocular pressure (IOP) on the reduction/oxidation ratio of cytochrome a, a3 were measured from intact cat optic nerve by microfiber reflection spectrophotometry. This enabled the real-time analysis of optic nerve-head oxidative metabolism following IOP or mean arterial pressure (MAP) changes. Findings included: (1) cytochrome a, a3 became more reduced and relative blood volume decreased at lower perfusion pressures, even at IOP of less than 20 mm Hg; (2) metabolic inhibition began at variable perfusion pressures but invariably progressed as perfusion pressure declined; and (3) increased IOP or decreased MAP caused metabolic inhibition. These findings demonstrate that: (1) optic nerve metabolic dysfunction is possible at low IOPs; (2) lowering IOP can reverse metabolic dysfunction; (3) the metabolic response is dependent on IOP and/or MAP changes; and (4) the metabolic inhibition is related to optic nerve ischemia.
Full Text
Duke Authors
Cited Authors
- Novack, RL; Stefánsson, E; Hatchell, DL
Published Date
- 1990
Published In
Volume / Issue
- 228 / 2
Start / End Page
- 128 - 133
PubMed ID
- 2159940
International Standard Serial Number (ISSN)
- 0721-832X
Digital Object Identifier (DOI)
- 10.1007/BF00935721
Language
- eng
Conference Location
- Germany