Coronary blood flow in chronic insulin-dependent diabetic dogs.

Journal Article

Diabetic patients appear to be at an increased risk for perioperative morbidity and mortality following coronary artery bypass grafting. Many have suggested that microangiopathy is a primary cause. Using radionuclide labelled microspheres, we measured the perfusion of the subendocardium, midmyocardium, subepicardium, and the subendocardium/subepicardium ratio in alloxan-induced diabetic and normal dogs. We found no statistical difference in the myocardial perfusion of dogs made diabetic for five months when compared to normal dogs. By using repeated measures two-factor analysis of variance-regression model, changing blood glucose levels had no effect on coronary blood flow in either the diabetic or normal dogs.

Full Text

Duke Authors

Cited Authors

  • Small, KW; Stefansson, E; Hatchell, DL

Published Date

  • October 1989

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • 275 - 282

PubMed ID

  • 2629449

Pubmed Central ID

  • 2629449

International Standard Serial Number (ISSN)

  • 0001-5563

Digital Object Identifier (DOI)

  • 10.1007/BF02624638


  • eng

Conference Location

  • Italy