Immune Thrombocytopenia Treated with High-Dose Intravenous Gamma Globulin and Corticosteroids in Two Patients with Wiskott-Aldrich Syndrome


Journal Article

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disorder characterized by thrombocytopenia, atopic dermatitis, and susceptibility to recurrent infections. The thrombocytopenia, due to an intrinsic platelet defect, is only rarely complicated by immune thrombocytopenia (ITP). We report two patients with WAS in whom ITP complicated their thrombocytopenia. In addition, immune neutropenia accompanied the ITP in one patient. Whereas administration of high-dose intravenous gamma globulin (IGIV) alone did not ameliorate the ITP, corticosteroids did improve the ITP and immune neutropenia. High-dose IGIV appeared to be synergistic with corticosteroids and thus have a steroid-sparing effect. © 1988, Mary Ann Liebert, Inc. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Mings, R; Knutsen, AP; Williams, LW; Buckley, RH; Warren, RW

Published Date

  • January 1, 1988

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 191 - 197

Electronic International Standard Serial Number (EISSN)

  • 1557-7767

International Standard Serial Number (ISSN)

  • 0883-1874

Digital Object Identifier (DOI)

  • 10.1089/pai.1988.2.191

Citation Source

  • Scopus