Impact of Visual Impairment and Eye diseases on Mortality: the Singapore Malay Eye Study (SiMES).

Journal Article (Journal Article)

We investigated the relationship of visual impairment (VI) and age-related eye diseases with mortality in a prospective, population-based cohort study of 3,280 Malay adults aged 40-80 years between 2004-2006. Participants underwent a full ophthalmic examination and standardized lens and fundus photographic grading. Visual acuity was measured using logMAR chart. VI was defined as presenting (PVA) and best-corrected (BCVA) visual acuity worse than 0.30 logMAR in the better-seeing eye. Participants were linked with mortality records until 2012. During follow-up (median 7.24 years), 398 (12.2%) persons died. In Cox proportional-hazards models adjusting for relevant factors, participants with VI (PVA) had higher all-cause mortality (hazard ratio[HR], 1.57; 95% confidence interval[CI], 1.25-1.96) and cardiovascular (CVD) mortality (HR 1.75; 95% CI, 1.24-2.49) than participants without. Diabetic retinopathy (DR) was associated with increased all-cause (HR 1.70; 95% CI, 1.25-2.36) and CVD mortality (HR 1.57; 95% CI, 1.05-2.43). Retinal vein occlusion (RVO) was associated with increased CVD mortality (HR 3.14; 95% CI, 1.26-7.73). No significant associations were observed between cataract, glaucoma and age-related macular degeneration with mortality. We conclude that persons with VI were more likely to die than persons without. DR and RVO are markers of CVD mortality.

Full Text

Duke Authors

Cited Authors

  • Siantar, RG; Cheng, C-Y; Gemmy Cheung, CM; Lamoureux, EL; Ong, PG; Chow, KY; Mitchell, P; Aung, T; Wong, T-Y; Cheung, CY

Published Date

  • November 9, 2015

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 16304 -

PubMed ID

  • 26549406

Pubmed Central ID

  • PMC4637872

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/srep16304


  • eng

Conference Location

  • England