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Impact of Visual Impairment and Eye diseases on Mortality: the Singapore Malay Eye Study (SiMES).

Publication ,  Journal Article
Siantar, RG; Cheng, C-Y; Gemmy Cheung, CM; Lamoureux, EL; Ong, PG; Chow, KY; Mitchell, P; Aung, T; Wong, T-Y; Cheung, CY
Published in: Sci Rep
November 9, 2015

We investigated the relationship of visual impairment (VI) and age-related eye diseases with mortality in a prospective, population-based cohort study of 3,280 Malay adults aged 40-80 years between 2004-2006. Participants underwent a full ophthalmic examination and standardized lens and fundus photographic grading. Visual acuity was measured using logMAR chart. VI was defined as presenting (PVA) and best-corrected (BCVA) visual acuity worse than 0.30 logMAR in the better-seeing eye. Participants were linked with mortality records until 2012. During follow-up (median 7.24 years), 398 (12.2%) persons died. In Cox proportional-hazards models adjusting for relevant factors, participants with VI (PVA) had higher all-cause mortality (hazard ratio[HR], 1.57; 95% confidence interval[CI], 1.25-1.96) and cardiovascular (CVD) mortality (HR 1.75; 95% CI, 1.24-2.49) than participants without. Diabetic retinopathy (DR) was associated with increased all-cause (HR 1.70; 95% CI, 1.25-2.36) and CVD mortality (HR 1.57; 95% CI, 1.05-2.43). Retinal vein occlusion (RVO) was associated with increased CVD mortality (HR 3.14; 95% CI, 1.26-7.73). No significant associations were observed between cataract, glaucoma and age-related macular degeneration with mortality. We conclude that persons with VI were more likely to die than persons without. DR and RVO are markers of CVD mortality.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

November 9, 2015

Volume

5

Start / End Page

16304

Location

England

Related Subject Headings

  • Visual Acuity
  • Vision Disorders
  • Singapore
  • Risk Factors
  • Proportional Hazards Models
  • Population Surveillance
  • Mortality
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Siantar, R. G., Cheng, C.-Y., Gemmy Cheung, C. M., Lamoureux, E. L., Ong, P. G., Chow, K. Y., … Cheung, C. Y. (2015). Impact of Visual Impairment and Eye diseases on Mortality: the Singapore Malay Eye Study (SiMES). Sci Rep, 5, 16304. https://doi.org/10.1038/srep16304
Siantar, Rosalynn Grace, Ching-Yu Cheng, Chui Ming Gemmy Cheung, Ecosse L. Lamoureux, Peng Guan Ong, Khuan Yew Chow, Paul Mitchell, Tin Aung, Tien-Yin Wong, and Carol Y. Cheung. “Impact of Visual Impairment and Eye diseases on Mortality: the Singapore Malay Eye Study (SiMES).Sci Rep 5 (November 9, 2015): 16304. https://doi.org/10.1038/srep16304.
Siantar RG, Cheng C-Y, Gemmy Cheung CM, Lamoureux EL, Ong PG, Chow KY, et al. Impact of Visual Impairment and Eye diseases on Mortality: the Singapore Malay Eye Study (SiMES). Sci Rep. 2015 Nov 9;5:16304.
Siantar, Rosalynn Grace, et al. “Impact of Visual Impairment and Eye diseases on Mortality: the Singapore Malay Eye Study (SiMES).Sci Rep, vol. 5, Nov. 2015, p. 16304. Pubmed, doi:10.1038/srep16304.
Siantar RG, Cheng C-Y, Gemmy Cheung CM, Lamoureux EL, Ong PG, Chow KY, Mitchell P, Aung T, Wong T-Y, Cheung CY. Impact of Visual Impairment and Eye diseases on Mortality: the Singapore Malay Eye Study (SiMES). Sci Rep. 2015 Nov 9;5:16304.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

November 9, 2015

Volume

5

Start / End Page

16304

Location

England

Related Subject Headings

  • Visual Acuity
  • Vision Disorders
  • Singapore
  • Risk Factors
  • Proportional Hazards Models
  • Population Surveillance
  • Mortality
  • Middle Aged
  • Male
  • Humans