Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.

Journal Article

Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl2. Interestingly, analogous reactions in the absence of ZnCl2 resulted in the formation of indole aminal products.

Full Text

Duke Authors

Cited Authors

  • Ortiz, GX; Hemric, BN; Wang, Q

Published Date

  • March 10, 2017

Published In

Volume / Issue

  • 19 / 6

Start / End Page

  • 1314 - 1317

PubMed ID

  • 28281340

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/acs.orglett.7b00358

Language

  • eng