Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.

Journal Article (Journal Article)

Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl2 . Interestingly, analogous reactions in the absence of ZnCl2 resulted in the formation of indole aminal products.

Full Text

Duke Authors

Cited Authors

  • Ortiz, GX; Hemric, BN; Wang, Q

Published Date

  • March 10, 2017

Published In

Volume / Issue

  • 19 / 6

Start / End Page

  • 1314 - 1317

PubMed ID

  • 28281340

Pubmed Central ID

  • PMC5685508

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/acs.orglett.7b00358

Language

  • eng