Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.

Journal Article (Journal Article)

Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl₂ . Interestingly, analogous reactions in the absence of ZnCl₂ resulted in the formation of indole aminal products.

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Duke Authors

Wang, Qiu

Cited Authors

Ortiz, GX; Hemric, BN; Wang, Q

Published Date

March 10, 2017

Published In

Organic Letters

Volume / Issue

19 / 6

Start / End Page

1314 - 1317

PubMed ID

28281340

Pubmed Central ID

PMC5685508

Electronic International Standard Serial Number (EISSN)

1523-7052

International Standard Serial Number (ISSN)

1523-7060

Digital Object Identifier (DOI)

10.1021/acs.orglett.7b00358

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