Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.
Journal Article
Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl2. Interestingly, analogous reactions in the absence of ZnCl2 resulted in the formation of indole aminal products.
Full Text
Duke Authors
Cited Authors
- Ortiz, GX; Hemric, BN; Wang, Q
Published Date
- March 10, 2017
Published In
Volume / Issue
- 19 / 6
Start / End Page
- 1314 - 1317
PubMed ID
- 28281340
Electronic International Standard Serial Number (EISSN)
- 1523-7052
International Standard Serial Number (ISSN)
- 1523-7060
Digital Object Identifier (DOI)
- 10.1021/acs.orglett.7b00358
Language
- eng