Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.
Journal Article
Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl2 . Interestingly, analogous reactions in the absence of ZnCl2 resulted in the formation of indole aminal products.
Full Text
Duke Authors
Cited Authors
- Ortiz, GX; Hemric, BN; Wang, Q
Published Date
- March 10, 2017
Published In
Volume / Issue
- 19 / 6
Start / End Page
- 1314 - 1317
PubMed ID
- 28281340
Pubmed Central ID
- 28281340
Electronic International Standard Serial Number (EISSN)
- 1523-7052
International Standard Serial Number (ISSN)
- 1523-7060
Digital Object Identifier (DOI)
- 10.1021/acs.orglett.7b00358
Language
- eng