Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.
Publication
, Journal Article
Ortiz, GX; Hemric, BN; Wang, Q
Published in: Organic letters
March 2017
Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl2. Interestingly, analogous reactions in the absence of ZnCl2 resulted in the formation of indole aminal products.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
March 2017
Volume
19
Issue
6
Start / End Page
1314 / 1317
Related Subject Headings
- Zinc Compounds
- Stereoisomerism
- Organic Chemistry
- Indoles
- Chlorides
- Catalysis
- Benzenesulfonates
- Amines
- Amides
- 34 Chemical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Ortiz, G. X., Hemric, B. N., & Wang, Q. (2017). Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides. Organic Letters, 19(6), 1314–1317. https://doi.org/10.1021/acs.orglett.7b00358
Ortiz, Gerardo X., Brett N. Hemric, and Qiu Wang. “Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.” Organic Letters 19, no. 6 (March 2017): 1314–17. https://doi.org/10.1021/acs.orglett.7b00358.
Ortiz GX, Hemric BN, Wang Q. Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides. Organic letters. 2017 Mar;19(6):1314–7.
Ortiz, Gerardo X., et al. “Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides.” Organic Letters, vol. 19, no. 6, Mar. 2017, pp. 1314–17. Epmc, doi:10.1021/acs.orglett.7b00358.
Ortiz GX, Hemric BN, Wang Q. Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides. Organic letters. 2017 Mar;19(6):1314–1317.
Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
March 2017
Volume
19
Issue
6
Start / End Page
1314 / 1317
Related Subject Headings
- Zinc Compounds
- Stereoisomerism
- Organic Chemistry
- Indoles
- Chlorides
- Catalysis
- Benzenesulfonates
- Amines
- Amides
- 34 Chemical sciences