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Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer.

Publication ,  Journal Article
Yu, AF; Raikhelkar, J; Zabor, EC; Tonorezos, ES; Moskowitz, CS; Adsuar, R; Mara, E; Huie, K; Oeffinger, KC; Steingart, RM; Liu, JE
Published in: Biomed Res Int
2016

Two-dimensional speckle tracking echocardiography (2DSTE) provides a sensitive measure of left ventricular (LV) systolic function and may aid in the diagnosis of cardiotoxicity. 2DSTE was performed in a cross-sectional study of 134 patients (mean age: 31.4 ± 8.8 years; 55% male; mean time since diagnosis: 15.4 ± 9.4 years) previously treated with anthracyclines (mean cumulative dose: 320 ± 124 mg/m(2)), with (n = 52) or without (n = 82) mediastinal radiotherapy. The prevalence of LV systolic dysfunction, defined as fractional shortening < 27%, LV ejection fraction (LVEF) < 55%, and global longitudinal strain (GLS) ≤ 16%, was 5.2%, 6.0%, and 23.1%, respectively. Abnormal GLS was observed in 24 (18%) patients despite a normal LVEF. Indices of LV systolic function were similar regardless of anthracycline dose. However, GLS was worse (18.0 versus 19.0, p = 0.003) and prevalence of abnormal GLS was higher (36.5% versus 14.6%, p = 0.004) in patients treated with mediastinal radiotherapy. Mediastinal radiotherapy was associated with reduced GLS (p = 0.040) after adjusting for sex, age, and cumulative anthracycline dose. In adult survivors of childhood, adolescent, and young adult cancer, 2DSTE frequently detects LV systolic dysfunction despite a normal LVEF and may be useful for the long-term cardiac surveillance of adult cancer survivors.

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Published In

Biomed Res Int

DOI

EISSN

2314-6141

Publication Date

2016

Volume

2016

Start / End Page

9363951

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Systole
  • Survivors
  • Stroke Volume
  • Neoplasms
  • Male
  • Humans
  • Female
  • Echocardiography
 

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Yu, A. F., Raikhelkar, J., Zabor, E. C., Tonorezos, E. S., Moskowitz, C. S., Adsuar, R., … Liu, J. E. (2016). Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer. Biomed Res Int, 2016, 9363951. https://doi.org/10.1155/2016/9363951
Yu, Anthony F., Jayant Raikhelkar, Emily C. Zabor, Emily S. Tonorezos, Chaya S. Moskowitz, Roberto Adsuar, Elton Mara, et al. “Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer.Biomed Res Int 2016 (2016): 9363951. https://doi.org/10.1155/2016/9363951.
Yu AF, Raikhelkar J, Zabor EC, Tonorezos ES, Moskowitz CS, Adsuar R, Mara E, Huie K, Oeffinger KC, Steingart RM, Liu JE. Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer. Biomed Res Int. 2016;2016:9363951.

Published In

Biomed Res Int

DOI

EISSN

2314-6141

Publication Date

2016

Volume

2016

Start / End Page

9363951

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Dysfunction, Left
  • Systole
  • Survivors
  • Stroke Volume
  • Neoplasms
  • Male
  • Humans
  • Female
  • Echocardiography