Overview
Kevin Oeffinger, MD, is a family physician, Professor in the Department of Medicine, and a member of the Duke Cancer Institute (DCI). He is founding Director of the DCI Center for Onco-Primary Care, and Co-Director of the DCI Supportive Care and Survivorship Center. He has a long-standing track record of NIH-supported research in cancer screening, early cancer detection, and survivorship. He has published in high impact journals, including the New England Journal of Medicine, Lancet, and JAMA. Dr. Oeffinger is the Duke PI for Pathfinder-2, a multicenter study supported by Grail that is evaluating the utility of Galleri, a multi-cancer early detection blood test (MCED).
Dr. Oeffinger has served in a leadership capacity in various cancer-focused and primary care-focused national committees and organizations, including the American Society of Clinical Oncology, the American Cancer Society, and the American Academy of Family Physicians. He is a past Associate Editor for the Journal of the National Cancer Institute. He is also a member of the Executive Committee for the long-standing NCI-supported Childhood Cancer Survivor Study.
The three-fold mission of the DCI Center for Onco-Primary Care are are to: (1) deliver evidence-based, patient-centered, personalized health care across the cancer continuum by enhancing the interface between cancer specialists and primary care clinicians; (2) conduct innovative research with cutting-edge technology that can be translated to the community setting; and (3) train and educate the next generation of clinicians and researchers to extend this mission.
Current Appointments & Affiliations
Recent Publications
Late complications of treatment for childhood pelvic sarcoma: A report from the Childhood Cancer Survivor Study (CCSS).
Journal Article J Pediatr Surg · March 30, 2026 OBJECTIVE: Evaluate late effects in survivors of childhood pelvic sarcoma by disease origin (bony vs. soft-tissue) and local control modality (bone surgery, pelvic organ resection, radiotherapy). METHODS: Among 5-year pediatric pelvic sarcoma survivors, we ... Full text Link to item CiteReply to: Methodologic Considerations for Subsequent Colorectal Cancer in Survivors of Childhood Cancer.
Journal Article J Clin Oncol · March 11, 2026 Full text Link to item CiteMortality after colorectal cancer among survivors of childhood cancer.
Journal Article J Natl Cancer Inst · March 1, 2026 Mortality after diagnosis of colorectal subsequent malignant neoplasms (CRC-SMN) among childhood cancer survivors is understudied. Using data from the Childhood Cancer Survivor Study (CCSS) and the Surveillance, Epidemiology, and End Results (SEER) program ... Full text Link to item CiteRecent Grants
Symptom Management and Transitioning to Engagement with Post-treatment Care for Adolescent and Young Adult Cancer Survivors (AYA STEPS)
ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2029PATHFINDER 2
Clinical TrialPrincipal Investigator · Awarded by GRAIL · 2022 - 2027Improving outcomes for women experiencing premature or early menopause after cancer: development and pilot testing of a novel intervention
ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2027View All Grants