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Kevin Charles Oeffinger

Professor of Medicine
Medicine, Medical Oncology
Box 2714 DUMC, Durham, NC 27705
2424 Erwin Dr, Suite 601, Duke Cancer Institute, Durham, NC 27705

Overview


Kevin Oeffinger, MD, is a family physician, Professor in the Department of Medicine, and a member of the Duke Cancer Institute (DCI). He is founding Director of the DCI Center for Onco-Primary Care, and Co-Director of the DCI Supportive Care and Survivorship Center. He has a long-standing track record of NIH-supported research in cancer screening, early cancer detection, and survivorship. He has published in high impact journals, including the New England Journal of Medicine, Lancet, and JAMA. Dr. Oeffinger is the Duke PI for Pathfinder-2, a multicenter study supported by Grail that is evaluating the utility of Galleri, a multi-cancer early detection blood test (MCED).

Dr. Oeffinger has served in a leadership capacity in various cancer-focused and primary care-focused national committees and organizations, including the American Society of Clinical Oncology, the American Cancer Society, and the American Academy of Family Physicians. He is a past Associate Editor for the Journal of the National Cancer Institute. He is also a member of the Executive Committee for the long-standing NCI-supported Childhood Cancer Survivor Study.

The three-fold mission of the DCI Center for Onco-Primary Care are are to: (1) deliver evidence-based, patient-centered, personalized health care across the cancer continuum by enhancing the interface between cancer specialists and primary care clinicians; (2) conduct innovative research with cutting-edge technology that can be translated to the community setting; and (3) train and educate the next generation of clinicians and researchers to extend this mission. 

Current Appointments & Affiliations


Professor of Medicine · 2018 - Present Medicine, Medical Oncology, Medicine
Professor in the Department of Family Medicine and Community Health · 2018 - Present Family Medicine and Community Health, Clinical Science Departments
Professor in Population Health Sciences · 2020 - Present Population Health Sciences, Basic Science Departments
Member of the Duke Cancer Institute · 2017 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published May 16, 2025
Duke Program Helps Young Adults Move Forward After Cancer

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Recent Publications


Benefits, Harms, and Burden of Colorectal Cancer Screening Among Childhood Cancer Survivors Previously Treated With Abdominopelvic Radiation.

Journal Article J Clin Oncol · February 2026 PURPOSE: Childhood cancer survivors treated with abdominopelvic radiation (RT) are at increased risk of colorectal cancer (CRC), yet adherence to Children's Oncology Group screening guidelines remains low. Estimating the benefits, burdens, and costs of all ... Full text Link to item Cite

Cardiovascular risk in long-term survivors of breast, prostate, colon, and rectal cancer.

Journal Article J Natl Cancer Inst · January 1, 2026 BACKGROUND: Cardiovascular disease (CVD) is the leading cause of noncancer mortality in long-term cancer survivors. Population-level assessment of cancer-related exposures is limited with respect to long-term cardiovascular risk in older survivors who have ... Full text Link to item Cite

Personalized risk assessment of frailty in long-term cancer survivors.

Journal Article J Geriatr Oncol · January 2026 INTRODUCTION: Due to the growth of the cancer survivor population, strategies to facilitate efficient delivery of survivorship care are critical to reduce the risk of adverse events associated with frailty. The objective of this study was to develop a risk ... Full text Link to item Cite
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Recent Grants


PATHFINDER 2

Clinical TrialPrincipal Investigator · Awarded by GRAIL · 2022 - 2027

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Education, Training & Certifications


University of Texas Health Science Center San Antonio · 1984 M.D.