Kevin Charles Oeffinger

Journal Article J Geriatr Oncol · January 2026 INTRODUCTION: Due to the growth of the cancer survivor population, strategies to facilitate efficient delivery of survivorship care are critical to reduce the risk of adverse events associated with frailty. The objective of this study was to develop a risk ... Full text Link to item Cite

Self-collected vaginal specimens for human papillomavirus testing and guidance on screening exit: An update to the American Cancer Society cervical cancer screening guideline.

Journal Article CA Cancer J Clin · 2026 This update expands the 2020 American Cancer Society (ACS) cervical cancer screening guideline for average-risk women and individuals with a cervix who are at average risk, to include self-collection for human papillomavirus (HPV) testing and revised guida ... Full text Link to item Cite

Treatment exposure-based risk-stratification for care of survivors of childhood cancer: a report from the childhood cancer survivor study.

Conference J Natl Cancer Inst · December 1, 2025 BACKGROUND: Treatment exposure-based risk-stratification of long-term cancer survivors may help inform health care in survivorship clinics. We used the large, diverse population of the Childhood Cancer Survivor Study to test a modified, exposure-based stra ... Full text Link to item Cite

Psychosocial Health and Chronic Health Conditions Among Bereaved Siblings: A Report From the Childhood Cancer Survivor Study (CCSS).

Journal Article Pediatr Blood Cancer · December 2025 OBJECTIVE: To compare psychosocial health and chronic health conditions (CHCs) in bereaved and non-bereaved adult siblings impacted by childhood cancer and to identify predictors of emotional distress and health-related quality of life among bereaved sibli ... Full text Link to item Cite

Impact of an Electronic Patient-Reported Outcome-Informed Clinical Decision Support Tool on Clinical Discussions With Head and Neck Cancer Survivors: Findings From the HN-STAR Randomized Controlled Trial (WF-1805CD).

Journal Article JCO Oncol Pract · December 2025 PURPOSE: Post-treatment head and neck cancer (HNC) survivors experience multiple symptoms and behavioral health issues. We developed Head and Neck Survivorship Tool: Assessments and Recommendation (HN-STAR), a clinical decision support tool using electroni ... Full text Link to item Cite

LiveWell: Pilot Feasibility Trial of an Adapted Dialectical Behavioral Therapy Skills Training Protocol in Patients With Metastatic Non-Small Cell Lung Cancer.

Journal Article Psychooncology · December 2025 BACKGROUND: People living longer with metastatic non-small cell lung cancer (mNSCLC) experience heightened psychological distress and decrements in quality of life. Therefore, we developed LiveWell, an 8-session adapted dialectical behavioral therapy skill ... Full text Open Access Link to item Cite

What cancer patients may or may not be surprised to know about survivorship.

Journal Article Clin Adv Hematol Oncol · December 2025 The number of US cancer survivors has increased from fewer than 4 million in the 1970s to 18.1 million in 2022, with the increase reflecting advancements in screening, diagnosis, treatment, and supportive care. Despite these advancements, cancer remains th ... Link to item Cite

Assessing delivery of and attitudes toward a randomized intervention to increase mammography uptake among childhood cancer survivors: A report from the Childhood Cancer Survivor Study.

Journal Article J Psychosoc Oncol · November 19, 2025 OBJECTIVE: This study characterizes utilization of, and attitudes toward, a two-part intervention of (1) mailed materials, including educational laminated cards for patients and healthcare providers, and (2) telephone counseling, that aimed to increase scr ... Full text Link to item Cite

Late Morbidity and Mortality in Survivors of Childhood Ependymoma: A Report from the Childhood Cancer Survivor Study (CCSS).

Journal Article Cancers (Basel) · November 15, 2025 BACKGROUND/OBJECTIVES: Treatment of childhood ependymoma evolved from 1970 to 1999 by reducing radiation volumes and incorporating chemotherapy. The impact of these changes on long-term health outcomes remains unknown. In this report, we evaluated temporal ... Full text Link to item Cite

Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts.

Journal Article Cancer Epidemiol Biomarkers Prev · November 3, 2025 BACKGROUND: Dyslipidemia can occur as a long-term side effect of childhood cancer treatment. The difference in prevalence among children receiving comparable treatment suggests a role for genetic variation. We conducted the first genome-wide association st ... Full text Link to item Cite

Risk of Late-Onset Depression in Long-Term Survivors of Breast, Prostate, and Colorectal Cancer.

Journal Article JAMA Netw Open · November 3, 2025 IMPORTANCE: The prevalence of depression is higher in cancer survivors than in the general population. As the long-term cancer survivor population increases, it is increasingly important to understand risk factors for late-onset depression. OBJECTIVE: To i ... Full text Link to item Cite

Colorectal-Specific Radiation Dose and Chemotherapy Risk for Subsequent Colorectal Malignancies in Childhood Cancer Survivors: A Childhood Cancer Survivor Study (CCSS) Report.

Journal Article J Clin Oncol · November 2025 PURPOSE: Among childhood cancer survivors, we evaluated not previously explored relationships between colorectal subsequent malignant neoplasm (SMN) incidence and colorectum-specific radiation dose metrics currently used in radiation therapy (RT) planning ... Full text Link to item Cite

Impact of an ePRO-informed clinical decision support tool on clinical discussions during a follow-up visit for post-treatment head and neck cancer survivors: Results from the HN-STAR trial (WF-1805CD).

Journal Article JCO Oncology Practice · October 15, 2025 509Background: ASCO guidelines for care of post-treatment head and neck cancer (HNC) survivors recommend comprehensive management of late effects, comorbidities, health behaviors, and cancer risks. We developed HN-STAR: a clinical decision support tool bas ... Full text Cite

Health-related social needs and symptom burden among survivors of head and neck cancer in the HN-STAR trial (WF-1805CD).

Journal Article JCO Oncology Practice · October 14, 2025 540Background: Head and neck cancer survivors (HNCS) face high symptom burden and unmet health-related social needs (HRSN), yet few studies examine the co-occurrence of these issues. We investigated the association between HRSN and 4 commonly co-occurring ... Full text Cite

Predicting the 10-year risk of cardiomyopathy in long-term survivors of childhood cancer.

Journal Article Ann Oncol · October 2025 BACKGROUND: Considering the heightened risk of cancer treatment-related cardiomyopathy and cardiac death in long-term survivors of childhood cancer, we aimed to develop and validate a clinically applicable risk prediction model for cardiomyopathy. PATIENTS ... Full text Link to item Cite

Health Outcomes Beyond Age 50 Years in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · September 20, 2025 PURPOSE: There are limited data on the risk for mortality and health outcomes among the increasing population of older (age >50 years) survivors of childhood cancer during this later stage in life when there is an expected increase in aging-related morbidi ... Full text Link to item Cite

Chronic Health Conditions and Academic Achievement: A Childhood Cancer Survivor Study Report.

Journal Article JCO Oncol Pract · September 8, 2025 PURPOSE: To examine associations between special education, chronic health conditions (CHCs), and college graduation in survivors of childhood cancer and their siblings. METHODS: Childhood Cancer Survivor Study participants included 23,082 5-year survivors ... Full text Link to item Cite

Body Mass Index, Physical Activity, and Subsequent Neoplasm Risk Among Childhood Cancer Survivors.

Journal Article JAMA Oncol · August 1, 2025 IMPORTANCE: High body mass index (BMI) and low physical activity levels are risk factors for adult-onset cancers. Limited data exist on their relationship with subsequent neoplasms among childhood cancer survivors. OBJECTIVE: To evaluate associations betwe ... Full text Link to item Cite

Oncology, Primary Care, and Survivorship: Time for Onco-primary Care?

Journal Article JCO Oncol Pract · June 2025 Full text Link to item Cite

Cardiac Safety of Reduced Cardiotoxicity Surveillance During HER2-Targeted Therapy

Journal Article Jacc Cardiooncology · June 1, 2025 Background: Echocardiograms are recommended every 3 months to monitor for cancer therapy–related cardiac dysfunction (CTRCD) among patients treated with HER2-targeted therapy, despite increasing use of safer regimens associated with low CTRCD risk. Objecti ... Full text Cite

Accelerated Aging in Survivors of Childhood Cancer-Early Onset and Excess Risk of Chronic Conditions.

Journal Article JAMA Oncol · May 1, 2025 IMPORTANCE: The lifetime risk of aging-related diseases among survivors of childhood cancer, accelerated by cancer treatment exposures, is unknown. Understanding this risk can provide a more comprehensive assessment of long-term health across the lifespan ... Full text Link to item Cite

Trends in physical functioning in acute lymphoblastic leukemia and non-Hodgkin lymphoma survivors across three decades.

Journal Article J Cancer Surviv · April 2025 PURPOSE: The impact of changes in therapy for childhood acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) on the prevalence of physical performance limitations and participation restrictions among survivors is unknown. We aimed to describe ... Full text Link to item Cite

Treatment, toxicity, and mortality after subsequent breast cancer in female survivors of childhood cancer.

Journal Article Nat Commun · March 31, 2025 Childhood cancer survivors, particularly those who received chest radiotherapy, are at high risk for developing subsequent breast cancer. Minimizing long-term toxicity risks associated with additional radiotherapy and chemotherapy is a priority, but therap ... Full text Link to item Cite

Metabolic syndrome in childhood, adolescent, and young adult cancer survivors: recommendations for surveillance from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

Journal Article Eur J Endocrinol · March 27, 2025 OBJECTIVE: Survivors of childhood, adolescent, and young adult (CAYA) cancer have an increased risk of metabolic syndrome (MetS). MetS describes the clustering of cardiovascular risk factors including overweight or obesity, hypertension, (pre)diabetes, and ... Full text Link to item Cite

Obesity Predisposes Anthracycline-Treated Survivors of Childhood and Adolescent Cancers to Subclinical Cardiac Dysfunction.

Journal Article Pediatr Cardiol · February 2025 Anthracyclines are effective chemotherapeutics used in approximately 60% of pediatric cancer cases but have a well-documented risk of cardiotoxicity. Existing cardiotoxicity risk calculators do not include cardiovascular risk factors present at the time of ... Full text Link to item Cite

Unmet Reproductive Health Care Information Needs of Female Young Adult Survivors of Childhood Cancer: Oncology Providers' Perspectives.

Journal Article J Adolesc Young Adult Oncol · February 2025 This study aimed to characterize unmet reproductive health needs of female young adult survivors of childhood cancer (YASCC), as understood by oncology providers (N = 10) caring for this patient population. Providers completed brief online questionnaires a ... Full text Link to item Cite

Neurocognitive outcomes and functional independence in adult survivors of childhood medulloblastoma diagnosed over 3 decades.

Journal Article Neuro Oncol · January 12, 2025 BACKGROUND: Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown. METHODS: Adult sur ... Full text Link to item Cite

Prevalence of carotid ultrasound screening in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · January 1, 2025 INTRODUCTION: Many childhood cancer survivors are at risk for cardiovascular disease and stroke. The North American Children's Oncology Group long-term follow-up guidelines recommend carotid ultrasound in cancer survivors 10 years after neck radiation ther ... Full text Link to item Cite

Continuity and coordination of care for childhood cancer survivors with multiple chronic conditions: Results from the Childhood Cancer Survivor Study.

Journal Article Cancer · December 15, 2024 INTRODUCTION: Continuity and coordination-of-care for childhood cancer survivors with multiple chronic conditions are understudied but critical for appropriate follow-up care. METHODS: From April through June 2022, 800 Childhood Cancer Survivor Study parti ... Full text Link to item Cite

Long-term outcomes among survivors of childhood osteosarcoma: A report from the Childhood Cancer Survivor Study (CCSS)

Conference Pediatric Blood and Cancer · October 1, 2024 Purpose: Treatment strategies for osteosarcoma evolving between 1970 and 1999 improved 5-year survival and continue as standard of care today. This report evaluates the impact of these evolving therapies on long-term health outcomes. Methods: Five-year sur ... Full text Cite

Benign and malignant pulmonary parenchymal findings on chest CT among adult survivors of childhood and young adult cancer with a history of chest radiotherapy.

Journal Article J Cancer Surviv · October 2024 PURPOSE: Childhood and young adult cancer survivors exposed to chest radiotherapy are at increased risk of lung cancer. In other high-risk populations, lung cancer screening has been recommended. Data is lacking on prevalence of benign and malignant pulmon ... Full text Link to item Cite

Experiences of adult survivors of childhood cancer in a randomized cardiovascular health promotion trial: a qualitative report from the Childhood Cancer Survivor Study.

Journal Article J Cancer Surviv · October 2024 PURPOSE: To better understand preferences and attitudes that adult-aged survivors of childhood cancer have toward survivorship care plans (SCP) and related SCP-based counseling. METHODS: Semi-structured qualitative interviews were conducted with 20 survivo ... Full text Link to item Cite

Primary Care Use and 90-Day Mortality Among Older Adults Undergoing Cancer Surgery.

Journal Article JAMA Surg · October 1, 2024 IMPORTANCE: Multimorbidity and postoperative clinical decompensation are common among older surgical patients with cancer, highlighting the importance of primary care to optimize survival. Little is known about the association between primary care use and ... Full text Link to item Cite

Exercise and QUality Diet after Leukemia: A Randomized Weight Loss Trial among Adult Survivors of Childhood Leukemia in the Childhood Cancer Survivor Study.

Journal Article Cancer Epidemiol Biomarkers Prev · September 3, 2024 BACKGROUND: Obesity is prevalent in childhood cancer survivors and interacts with cancer treatments to potentiate risk for cardiovascular (CV) death. We tested a remote weight-loss intervention trial that was effective among adults with CV risk factors in ... Full text Link to item Cite

Risk of increased mortality in underweight survivors: A brief report from the Childhood Cancer Survivor Study.

Journal Article Pediatr Blood Cancer · August 2024 BACKGROUND: Approximately 1 in 10 adult survivors of childhood cancer is underweight. Although the consequences of being overweight or obese have been well described, outcomes among childhood cancer survivors who are underweight are unknown. OBJECTIVE: To ... Full text Link to item Cite

Adverse Childhood Experiences, Resilience, and Cardiovascular Disease in Adult Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

Journal Article Cancer Epidemiol Biomarkers Prev · August 1, 2024 BACKGROUND: The impact of adverse childhood experiences (ACE, e.g., abuse, neglect, and/or household dysfunction experienced before the age of 18) and resilience on risk for cardiovascular disease (CVD) has not previously been investigated in adult survivo ... Full text Link to item Cite

Risk factors for neurocognitive impairment, emotional distress, and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · June 15, 2024 BACKGROUND: Prevalence and risk of poor psychological outcomes following rhabdomyosarcoma (RMS) are not well-established. METHODS: Participants in this cross-sectional, case-control study (n = 713 survivors, 42.5% female; mean [SD] age, 30.5 [6.6] years; n ... Full text Link to item Cite

Improving symptom management for survivors of young adult cancer: rationale and study protocol for a pilot randomized controlled trial.

Journal Article Pilot Feasibility Stud · June 8, 2024 BACKGROUND: Young adult (YA) cancer survivors are a growing, yet underserved population who often face significant and long-lasting cancer-related physical (e.g., pain, fatigue) and emotional (e.g., psychological distress) symptoms. Post-treatment symptoms ... Full text Link to item Cite

Impact of risk-based therapy on late morbidity and mortality in neuroblastoma survivors: a report from the Childhood Cancer Survivor Study.

Journal Article J Natl Cancer Inst · June 7, 2024 BACKGROUND: Early efforts at risk-adapted therapy for neuroblastoma are predicted to result in differential late effects; the magnitude of these differences has not been well described. METHODS: Late mortality, subsequent malignant neoplasms (SMNs), and se ... Full text Link to item Cite

Chronic Health Conditions and Longitudinal Employment in Survivors of Childhood Cancer.

Journal Article JAMA Netw Open · May 1, 2024 IMPORTANCE: Employment is an important factor in quality of life and provides social and economic support. Longitudinal data on employment and associations with chronic health conditions for adult survivors of childhood cancer are lacking. OBJECTIVE: To ev ... Full text Link to item Cite

Temporal changes in treatment and late mortality and morbidity in adult survivors of childhood glioma: a report from the Childhood Cancer Survivor Study.

Journal Article Nat Cancer · April 2024 Pediatric glioma therapy has evolved to delay or eliminate radiation for low-grade tumors. This study examined these temporal changes in therapy with long-term outcomes in adult survivors of childhood glioma. Among 2,501 5-year survivors of glioma in the C ... Full text Link to item Cite

Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Journal Article Eclinicalmedicine · March 1, 2024 Childhood, adolescent, and young adult (CAYA) cancer survivors are at risk of pulmonary dysfunction. Current follow-up care guidelines are discordant. Therefore, the International Late Effects of Childhood Cancer Guideline Harmonization Group established a ... Full text Cite

Mechanisms of sleep disturbances in long-term cancer survivors: a childhood cancer survivor study report.

Journal Article JNCI Cancer Spectr · February 29, 2024 BACKGROUND: Sleep problems following childhood cancer treatment may persist into adulthood, exacerbating cancer-related late effects and putting survivors at risk for poor physical and psychosocial functioning. This study examines sleep in long-term surviv ... Full text Link to item Cite

The ENGAGE study: a 3-arm randomized hybrid type 1 effectiveness and implementation study of an in-home, collaborative PCP model of remote telegenetic services to increase uptake of cancer genetic services in childhood cancer survivors.

Journal Article BMC Health Serv Res · February 28, 2024 BACKGROUND: Germline cancer genetic testing has become a standard evidence-based practice, with established risk reduction and screening guidelines for genetic carriers. Access to genetic services is limited in many places, which leaves many genetic carrie ... Full text Link to item Cite

Mortality After Major Cardiovascular Events in Survivors of Childhood Cancer.

Journal Article J Am Coll Cardiol · February 27, 2024 BACKGROUND: Adult survivors of childhood cancer are at risk for cardiovascular events. OBJECTIVES: In this study, we sought to determine the risk for mortality after a major cardiovascular event among childhood cancer survivors compared with noncancer popu ... Full text Link to item Cite

Evolving therapies, neurocognitive outcomes, and functional independence in adult survivors of childhood glioma.

Journal Article J Natl Cancer Inst · February 8, 2024 BACKGROUND: Treatment of childhood glioma has evolved to reduce radiotherapy exposure with the goal of limiting late toxicity. However, the associations between treatment changes and neurocognition, and the contribution of neurocognition and chronic health ... Full text Link to item Cite

Health Care Access Barriers and Self-Reported Health Among Adolescent and Young Adult Cancer Survivors.

Journal Article J Adolesc Young Adult Oncol · February 2024 Purpose: Adolescents and young adult (AYA) cancer survivors (15-39 years at diagnosis) are at risk for treatment-related late effects but face barriers in accessing survivorship care. We examined the prevalence of five health care access (HCA) barriers: af ... Full text Link to item Cite

Neurologic morbidity and functional independence in adult survivors of childhood cancer.

Journal Article Ann Clin Transl Neurol · February 2024 OBJECTIVE: To examine associations between neurologic late effects and attainment of independence in adult survivors of childhood cancer treated with central nervous system (CNS)-directed therapies. METHODS: A total of 7881 survivors treated with cranial r ... Full text Link to item Cite

Managing Chronic Pain in Cancer Survivorship: Communication Challenges and Opportunities as Described by Cancer Survivors.

Journal Article Am J Hosp Palliat Care · January 2024 OBJECTIVES: Many cancer survivors experience chronic pain after completing curative-intent treatment. Based on available data, chronic pain may be undertreated in this context; however, little is known about cancer survivors' experiences with clinical mana ... Full text Link to item Cite

Assisted reproductive technology use and outcomes in childhood cancer survivors.

Journal Article Cancer · January 1, 2024 BACKGROUND: Treatment exposures for childhood cancer reduce ovarian reserve. However, the success of assisted reproductive technology (ART) among female survivors is not well established. METHODS: Five-year survivors of childhood cancer in the Childhood Ca ... Full text Link to item Cite

Screening for lung cancer: 2023 guideline update from the American Cancer Society.

Journal Article CA Cancer J Clin · 2024 Lung cancer is the leading cause of mortality and person-years of life lost from cancer among US men and women. Early detection has been shown to be associated with reduced lung cancer mortality. Our objective was to update the American Cancer Society (ACS ... Full text Link to item Cite

Rationale and design of a cardiac safety study for reduced cardiotoxicity surveillance during HER2-targeted therapy

Journal Article Cardio Oncology · December 1, 2023 Background: Echocardiograms are recommended every 3 months in patients receiving human epidermal growth factor 2 (HER2)-targeted therapy for surveillance of left ventricular ejection fraction (LVEF). Efforts to tailor treatment for HER2-positive breast can ... Full text Cite

Gene-Level Analysis of Anthracycline-Induced Cardiomyopathy in Cancer Survivors: A Report From COG-ALTE03N1, BMTSS, and CCSS.

Journal Article JACC CardioOncol · December 2023 BACKGROUND: Anthracyclines are highly effective in treating cancer, albeit with increased cardiomyopathy risk. Although risk is attributed to associations with single nucleotide polymorphisms (SNPs), multiple SNPs on a gene and their interactions remain un ... Full text Link to item Cite

Primary Care Utilization and Cardiovascular Screening in Adult Survivors of Childhood Cancer.

Journal Article JAMA Netw Open · December 1, 2023 IMPORTANCE: Cardiovascular disease is the leading noncancer cause of premature death among survivors of childhood cancer. Adult survivors of childhood cancer are largely managed by primary care practitioners (PCPs), and health care utilization patterns rel ... Full text Link to item Cite

Risk factors for overweight and obesity after childhood acute lymphoblastic leukemia in North America and Switzerland: A comparison of two cohort studies.

Conference Cancer Med · October 2023 BACKGROUND: After childhood acute lymphoblastic leukemia (ALL), sequelae include overweight and obesity, yet with conflicting evidence. We compared the prevalence of overweight and obesity between ≥5-year ALL survivors from the North American Childhood Can ... Full text Link to item Cite

Neurocognitive outcomes in adult survivors of neuroblastoma: A report from the Childhood Cancer Survivor Study.

Conference Cancer · September 15, 2023 BACKGROUND: Despite survival improvements, there is a paucity of data on neurocognitive outcomes in neuroblastoma survivors. This study addresses this literature gap. METHODS: Neurocognitive impairments in survivors were compared to sibling controls from t ... Full text Link to item Cite

Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer.

Journal Article Nat Med · September 2023 Anthracycline-based chemotherapy is associated with increased subsequent breast cancer (SBC) risk in female childhood cancer survivors, but the current evidence is insufficient to support early breast cancer screening recommendations for survivors treated ... Full text Link to item Cite

Improving Symptom Management for Survivors of Young Adult Cancer: Development of a Novel Intervention.

Journal Article J Adolesc Young Adult Oncol · August 2023 Purpose: Improved symptom management is a critical although unmet post-treatment need for young adult (YA) cancer survivors (aged 18-39 at diagnosis). This study aimed to develop and refine a behavioral symptom management intervention for YA survivors. Met ... Full text Link to item Cite

Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population.

Journal Article JACC CardioOncol · August 2023 BACKGROUND: It is unknown whether a history of childhood cancer modifies the established disparities in cardiovascular risk factors (CVRFs) observed in the general population. OBJECTIVES: We sought to determine if disparities in CVRFs by race/ethnicity are ... Full text Link to item Cite

Cardiac Substructure Radiation Dose and Risk of Late Cardiac Disease in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · August 1, 2023 PURPOSE: Radiation-associated cardiac disease is a major cause of morbidity/mortality among childhood cancer survivors. Radiation dose-response relationships for cardiac substructures and cardiac diseases remain unestablished. METHODS: Using the 25,481 5-y ... Full text Link to item Cite

Adolescent and Young Adult (AYA) Oncology, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · August 2023 This selection from the NCCN Guidelines for Adolescent and Young Adult (AYA) Oncology focuses on considerations for the comprehensive care of AYA patients with cancer. Compared with older adults with cancer, AYA patients have unique needs regarding treatme ... Full text Link to item Cite

Accumulation of Chronic Disease Among Survivors of Childhood Cancer Predicts Early Mortality.

Journal Article J Clin Oncol · July 10, 2023 PURPOSE: Cancer survivors develop cancer and treatment-related morbidities at younger than normal ages and are at risk for early mortality, suggestive of an aging phenotype. The Cumulative Illness Rating Scale for Geriatrics (CIRS-G) is specifically design ... Full text Link to item Cite

Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US.

Journal Article JAMA Netw Open · July 3, 2023 IMPORTANCE: Improvements in cancer outcomes have led to a need to better understand long-term oncologic and nononcologic outcomes and quantify cancer-specific vs noncancer-specific mortality risks among long-term survivors. OBJECTIVE: To assess absolute an ... Full text Link to item Cite

Initial Longitudinal Outcomes of Risk-Stratified Men in Their Forties Screened for Prostate Cancer Following Implementation of a Baseline Prostate-Specific Antigen.

Journal Article World J Mens Health · July 2023 PURPOSE: Prostate cancer (PCa) screening can lead to potential over-diagnosis/over-treatment of indolent cancers. There is a need to optimize practices to better risk-stratify patients. We examined initial longitudinal outcomes of mid-life men with an elev ... Full text Link to item Cite

Association of Circulating Cardiomyocyte Cell-Free DNA With Cancer Therapy-Related Cardiac Dysfunction in Patients Undergoing Treatment for ERBB2-Positive Breast Cancer.

Journal Article JAMA Cardiol · July 1, 2023 IMPORTANCE: Cancer therapy-related cardiac dysfunction (CTRCD) is a potentially serious cardiotoxicity of treatments for ERBB2-positive breast cancer (formerly HER2). Identifying early biomarkers of cardiotoxicity could facilitate an individualized approac ... Full text Link to item Cite

Informatics tools to implement late cardiovascular risk prediction modeling for population management of high-risk childhood cancer survivors.

Conference Pediatr Blood Cancer · June 7, 2023 BACKGROUND: Clinical informatics tools to integrate data from multiple sources have the potential to catalyze population health management of childhood cancer survivors at high risk for late heart failure through the implementation of previously validated ... Full text Link to item Cite

Adherence to cardiovascular disease risk factor medications among patients with cancer: a systematic review.

Journal Article J Cancer Surviv · June 2023 PURPOSE: The most common cause of mortality for many cancer survivors is cardiovascular disease (CVD). This requires a shift in thinking where control of CVD risk factor-related comorbidity is paramount. Our objective was to provide an understanding of adh ... Full text Link to item Cite

Cumulative burden of late, major surgical intervention in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study (CCSS) cohort.

Journal Article Lancet Oncol · June 2023 BACKGROUND: Multimodal cancer therapy places childhood cancer survivors at increased risk for chronic health conditions, subsequent malignancies, and premature mortality as they age. We aimed to estimate the cumulative burden of late (>5 years from cancer ... Full text Link to item Cite

Late Health Outcomes Among Survivors of Wilms Tumor Diagnosed Over Three Decades: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · May 10, 2023 PURPOSE: To evaluate long-term morbidity and mortality among unilateral, nonsyndromic Wilms tumor (WT) survivors according to conventional treatment regimens. METHODS: Cumulative incidence of late mortality (≥ 5 years from diagnosis) and chronic health con ... Full text Link to item Cite

Rural, Large Town, and Urban Differences in Optimal Subspecialty Follow-up and Survivorship Care Plan Documentation among Childhood Cancer Survivors.

Journal Article Cancer Epidemiol Biomarkers Prev · May 1, 2023 BACKGROUND: Children with cancer from rural and nonurban areas face unique challenges. Health equity for this population requires attention to geographic disparities in optimal survivorship-focused care. METHODS: The Oklahoma Childhood Cancer Survivor Coho ... Full text Link to item Cite

Late-onset Cognitive Impairment and Modifiable Risk Factors in Adult Childhood Cancer Survivors.

Journal Article JAMA Netw Open · May 1, 2023 IMPORTANCE: Long-term survivors of childhood cancer may be at elevated risk for new neurocognitive impairment and decline as they age into adulthood. OBJECTIVE: To determine whether aging adult childhood cancer survivors report more new-onset neurocognitiv ... Full text Link to item Cite

Specific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort.

Journal Article Lancet · April 29, 2023 BACKGROUND: 5-year survival after childhood cancer does not fully describe life-years lost due to childhood cancer because there are a large number of deaths occurring beyond 5-years (late mortality) related to cancer and cancer treatment. Specific causes ... Full text Link to item Cite

Development and Validation of a Prediction Model for Kidney Failure in Long-Term Survivors of Childhood Cancer.

Journal Article J Clin Oncol · April 20, 2023 PURPOSE: Kidney failure is a rare but serious late effect following treatment for childhood cancer. We developed a model using demographic and treatment characteristics to predict individual risk of kidney failure among 5-year survivors of childhood cancer ... Full text Link to item Cite

Modifiable patient-reported factors associated with cancer-screening knowledge and participation in a community-based health assessment.

Journal Article Am J Surg · April 2023 BACKGROUND: We sought to identify modifiable factors associated with cancer screening in a community-based health assessment. METHODS: 24 organizations at 47 community events in central North Carolina distributed a 91-item survey from April-December 2017. ... Full text Link to item Cite

Clinician Perspectives on Managing Chronic Pain After Curative-Intent Cancer Treatment.

Journal Article JCO Oncol Pract · April 2023 PURPOSE: Among cancer survivors who have completed curative-intent treatment, the high prevalence and adverse consequences of chronic pain are well documented. Yet, research on clinicians' experiences with and perspectives on managing chronic pain among ca ... Full text Link to item Cite

Emotional, behavioral, and physical health consequences of loneliness in young adult survivors of childhood cancer: Results from the Childhood Cancer Survivor Study.

Journal Article Cancer · April 1, 2023 BACKGROUND: Young adults in the general population are at risk of experiencing loneliness, which has been associated with physical and mental health morbidities. The prevalence and consequences of loneliness in young adult survivors of childhood cancer rem ... Full text Link to item Cite

Genome-Wide Association Study Identifies ROBO2 as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors.

Journal Article J Clin Oncol · March 20, 2023 PURPOSE: Interindividual variability in the dose-dependent association between anthracyclines and cardiomyopathy suggests a modifying role of genetic susceptibility. Few previous studies have examined gene-anthracycline interactions. We addressed this gap ... Full text Link to item Cite

Long-Term Morbidity and Mortality Among Survivors of Neuroblastoma Diagnosed During Infancy: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · March 10, 2023 PURPOSE: To describe the risk of late mortality, subsequent malignant neoplasms (SMNs), and chronic health conditions (CHCs) in survivors of neuroblastoma diagnosed in infancy by treatment era and exposures. METHODS: Among 5-year survivors of neuroblastoma ... Full text Link to item Cite

Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies.

Journal Article J Exp Med · March 6, 2023 Late cardiac toxicity is a potentially lethal complication of cancer therapy, yet the pathogenic mechanism remains largely unknown, and few treatment options exist. Here we report DNA-damaging agents such as radiation and anthracycline chemotherapies induc ... Full text Link to item Cite

What Are Risk Factors for and Outcomes of Late Amputation After Treatment for Lower Extremity Sarcoma: A Childhood Cancer Survivor Study Report.

Journal Article Clin Orthop Relat Res · March 1, 2023 BACKGROUND: Although pediatric lower extremity sarcoma once was routinely treated with amputation, multiagent chemotherapy as well as the evolution of tumor resection and reconstruction techniques have enabled the wide adoption of limb salvage surgery (LSS ... Full text Link to item Cite

Health Benefits and Cost-Effectiveness of Children's Oncology Group Breast Cancer Screening Guidelines for Chest-Irradiated Hodgkin Lymphoma Survivors.

Journal Article J Clin Oncol · February 10, 2023 PURPOSE: To evaluate the outcomes and cost-effectiveness of the Children's Oncology Group Guideline recommendation for breast cancer (BC) screening using mammography (MAM) and breast magnetic resonance imaging (MRI) in female chest-irradiated childhood Hod ... Full text Link to item Cite

Chronic conditions, late mortality, and health status after childhood AML: a Childhood Cancer Survivor Study report.

Journal Article Blood · January 5, 2023 Five-year survival following childhood acute myeloid leukemia (AML) has increased following improvements in treatment and supportive care. Long-term health outcomes are unknown. To address this, cumulative incidence of late mortality and grades 3 to 5 chro ... Full text Link to item Cite

Concurrent prescribing of opioids with other sedating medications after cancer diagnosis: a population-level analysis.

Journal Article Support Care Cancer · December 2022 PURPOSE: Cancer is a major reason for concurrent prescription of opioids with other sedating medications-particularly benzodiazepines and gabapentinoids-yet population-based assessments of the extent and predictors of concurrent prescribing among clinicall ... Full text Link to item Cite

Association of Changes in Cancer Therapy Over 3 Decades With Risk of Subsequent Breast Cancer Among Female Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study (CCSS).

Journal Article JAMA Oncol · October 13, 2022 IMPORTANCE: Breast cancer is the most common invasive subsequent malignant disease in childhood cancer survivors, though limited data exist on changes in breast cancer rates as primary cancer treatments have evolved. OBJECTIVE: To quantify the association ... Full text Link to item Cite

Symptom Communication Preferences and Communication Barriers for Young Adult Cancer Survivors and Their Health Care Providers.

Journal Article J Adolesc Young Adult Oncol · October 2022 Purpose: Effective communication between young adult (YA; aged 18-39 years) cancer survivors and their health care providers is critical for managing post-treatment symptoms. Yet, little is known about YAs' and providers' preferences for and barriers to sy ... Full text Link to item Cite

CLL-517 Hypertension as an Adverse Event of Ibrutinib: Does Age Matter?

Journal Article Clin Lymphoma Myeloma Leuk · October 2022 CONTEXT: Ibrutinib and other Bruton-tyrosine kinase inhibitors (BTKi) have transformed treatment of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and improved overall survival. However, cardiovascular and other non-CLL progression rel ... Full text Link to item Cite

Genome-Wide Association Study of Pregnancy in Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study.

Journal Article Cancer Epidemiol Biomarkers Prev · September 2, 2022 BACKGROUND: Gonadotoxic treatment-related infertility has a significant impact on quality of life in childhood cancer survivors. Genome-wide association analyses to delineate the risk of infertility in childhood cancer survivors have not been previously re ... Full text Link to item Cite

Cardiovascular risk factors, radiation therapy, and myocardial infarction among lymphoma survivors.

Journal Article Acta Oncol · September 2022 BACKGROUND: Mediastinal radiation is associated with increased risk of myocardial infarction (MI) among non-Hodgkin lymphoma (NHL) survivors. OBJECTIVE: To evaluate how preexisting cardiovascular risk factors (CVRFs) modify the association of mediastinal r ... Full text Link to item Cite

A Novel Locus on 6p21.2 for Cancer Treatment-Induced Cardiac Dysfunction Among Childhood Cancer Survivors.

Journal Article J Natl Cancer Inst · August 8, 2022 BACKGROUND: Adult survivors of childhood cancer are at increased risk of cardiac late effects. METHODS: Using whole-genome sequencing data from 1870 survivors of European ancestry in the St. Jude Lifetime Cohort (SJLIFE) study, genetic variants were examin ... Full text Link to item Cite

Development and Validation of Models to Predict Poor Health-Related Quality of Life Among Adult Survivors of Childhood Cancer.

Journal Article JAMA Netw Open · August 1, 2022 IMPORTANCE: Risk prediction models are important to identify survivors of childhood cancer who are at risk of experiencing poor health-related quality of life (HRQOL) as they age. OBJECTIVE: To develop and validate prediction models for a decline in HRQOL ... Full text Link to item Cite

Underdiagnosis and Undertreatment of Modifiable Cardiovascular Risk Factors Among Survivors of Childhood Cancer.

Journal Article J Am Heart Assoc · June 21, 2022 Background Determine the prevalence and predictors associated with underdiagnosis and undertreatment of modifiable cardiovascular disease (CVD) risk factors (hypertension, dyslipidemia, glucose intolerance/diabetes) among adult survivors of childhood cance ... Full text Link to item Cite

Cardiometabolic Comorbidities in Cancer Survivors: JACC: CardioOncology State-of-the-Art Review.

Journal Article JACC CardioOncol · June 2022 There are nearly 17 million cancer survivors in the United States, including those who are currently receiving cancer therapy with curative intent and expected to be long-term survivors, as well as those with chronic cancers such as metastatic disease or c ... Full text Open Access Link to item Cite

Implementing a mHealth intervention to increase colorectal cancer screening among high-risk cancer survivors treated with radiotherapy in the Childhood Cancer Survivor Study (CCSS).

Journal Article BMC Health Serv Res · May 23, 2022 BACKGROUND: Cancer survivors treated with any dose of radiation to the abdomen, pelvis, spine, or total body irradiation (TBI) are at increased risk for developing colorectal cancer (CRC) compared to the general population. Since earlier detection of CRC i ... Full text Link to item Cite

Modifiable risk factors for neurocognitive and psychosocial problems after Hodgkin lymphoma.

Journal Article Blood · May 19, 2022 Long-term survivors of childhood Hodgkin lymphoma (HL) experience a high burden of chronic health morbidities. Correlates of neurocognitive and psychosocial morbidity have not been well established. A total of 1760 survivors of HL (mean ± SD age, 37.5 ± 6. ... Full text Link to item Cite

Long-term care for people treated for cancer during childhood and adolescence.

Journal Article Lancet · April 16, 2022 Worldwide advances in treatment and supportive care for children and adolescents with cancer have resulted in a increasing population of survivors growing into adulthood. Yet, this population is at very high risk of late occurring health problems, includin ... Full text Link to item Cite

Opioid Prescribing and Use Among Cancer Survivors: A Mapping Review of Observational and Intervention Studies.

Journal Article J Pain Symptom Manage · April 2022 CONTEXT: Recent years show a sharp increase in research on opioid use among cancer survivors, but evidence syntheses are lacking, leaving knowledge gaps. Corresponding research needs are unclear. OBJECTIVES: To provide an evidence synthesis. METHODS: We se ... Full text Link to item Cite

How to Treat Breast Cancer After Childhood Cancer: Management of Oncologic and Cardiovascular Concerns

Journal Article Jacc Cardiooncology · March 1, 2022 Full text Cite

Breast Cancer Screening Among Childhood Cancer Survivors Treated Without Chest Radiation: Clinical Benefits and Cost-Effectiveness.

Journal Article J Natl Cancer Inst · February 7, 2022 BACKGROUND: Early initiation of breast cancer screening is recommended for high-risk women, including survivors of childhood cancer treated with chest radiation. Recent studies suggest that female survivors of childhood leukemia or sarcoma treated without ... Full text Link to item Cite

Cost-Sharing and Out-of-Pocket Cost for Women Who Received MRI for Breast Cancer Screening.

Journal Article J Natl Cancer Inst · February 7, 2022 BACKGROUND: The financial protection of the prevention provision of the Affordable Care Act (ACA) doesn't apply to breast MRI but only to mammography for breast cancer screening. The purpose of the study is to examine the financial burden among women who r ... Full text Link to item Cite

Subsequent malignant neoplasms in the Childhood Cancer Survivor Study: Occurrence of cancer types in which human papillomavirus is an established etiologic risk factor.

Journal Article Cancer · January 15, 2022 BACKGROUND: Human papillomavirus (HPV)-associated subsequent malignant neoplasms (SMNHPV ) in childhood cancer survivors are poorly understood. METHODS: The cumulative risk of SMNHPV was assessed among 24,363 Childhood Cancer Survivor Study participants. S ... Full text Link to item Cite

Impact of Risk-Stratified Therapy on Health Status in Survivors of Childhood Acute Lymphoblastic Leukemia: A Report from the Childhood Cancer Survivor Study.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2022 BACKGROUND: Prior studies have identified that survivors of childhood acute lymphoblastic leukemia (ALL) report poor health status. It is unknown how risk-stratified therapy impacts the health status of ALL survivors. METHODS: We estimated and compared the ... Full text Link to item Cite

Functional Outcomes and Social Attainment in Asian/Pacific Islander Childhood Cancer Survivors in the United States: A Report from the Childhood Cancer Survivor Study.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2021 BACKGROUND: Given the relatively small population of Asians or Pacific Islanders (API) in the United States, studies describing long-term outcomes in API survivors of childhood cancer are limited. This study compared functional outcomes between API versus ... Full text Link to item Cite

Low-touch, team-based care for co-morbidity management in cancer patients: the ONE TEAM randomized controlled trial.

Journal Article BMC Fam Pract · November 18, 2021 BACKGROUND: As treatments for cancer have improved, more people are surviving cancer. However, compared to people without a history of cancer, cancer survivors are more likely to die of cardiovascular disease (CVD). Increased risk for CVD-related mortality ... Full text Link to item Cite

Predictors of Chronic Opioid Use: A Population-Level Analysis of North Carolina Cancer Survivors Using Multi-Payer Claims.

Journal Article J Natl Cancer Inst · November 2, 2021 BACKGROUND: No population-based studies have examined chronic opioid use among cancer survivors who are diverse with respect to diagnosis, age group, and insurance status. METHODS: We conducted a retrospective cohort study using North Carolina cancer regis ... Full text Link to item Cite

Clinical and genetic risk factors for radiation-associated ototoxicity: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.

Journal Article Cancer · November 1, 2021 BACKGROUND: Cranial radiation therapy (CRT) is associated with ototoxicity, which manifests as hearing loss and tinnitus. The authors sought to identify clinical determinants and genetic risk factors for ototoxicity among adult survivors of pediatric cance ... Full text Link to item Cite

Impact of Cardiac Substructure Dosimetry on Late Cardiac Risk: A Report From the Childhood Cancer Survivor Study (CCSS).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Prior estimates of radiation (RT)-associated cardiac disease risk in childhood cancer survivors are based on estimates of RT dose to the entire heart. We aimed to evaluate whether cardiac substructure RT dosimetry improves esti ... Full text Cite

Radiation therapy related cardiac disease risk in childhood cancer survivors: Updated dosimetry analysis from the Childhood Cancer Survivor Study.

Journal Article Radiother Oncol · October 2021 BACKGROUND AND PURPOSE: We previously evaluated late cardiac disease in long-term survivors in the Childhood Cancer Survivor Study (CCSS) based on heart radiation therapy (RT) doses estimated from an age-scaled phantom with a simple atlas-based heart model ... Full text Link to item Cite

Leveraging Clinical Informatics Tools to Extract Cumulative Anthracycline Exposure, Measure Cardiovascular Outcomes, and Assess Guideline Adherence for Children With Cancer.

Journal Article JCO Clin Cancer Inform · October 2021 PURPOSE: Cardiovascular disease is a significant cause of late morbidity and mortality in survivors of childhood cancer. Clinical informatics tools could enhance provider adherence to echocardiogram guidelines for early detection of late-onset cardiomyopat ... Full text Link to item Cite

Development and Validation of a Breast Cancer Risk Prediction Model for Childhood Cancer Survivors Treated With Chest Radiation: A Report From the Childhood Cancer Survivor Study and the Dutch Hodgkin Late Effects and LATER Cohorts.

Journal Article J Clin Oncol · September 20, 2021 PURPOSE: Women treated with chest radiation for childhood cancer have one of the highest risks of breast cancer. Models producing personalized breast cancer risk estimates applicable to this population do not exist. We sought to develop and validate a brea ... Full text Link to item Cite

Material, behavioral, and psychological financial hardship among survivors of childhood cancer in the Childhood Cancer Survivor Study.

Journal Article Cancer · September 1, 2021 BACKGROUND: Medical financial burden includes material, behavioral, and psychological hardship and has been underinvestigated among adult survivors of childhood cancer. METHODS: A survey from 698 survivors and 210 siblings from the Childhood Cancer Survivo ... Full text Link to item Cite

Late-onset kidney failure in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Journal Article Eur J Cancer · September 2021 BACKGROUND: The incidence of and risk factors for late-onset kidney failure among survivors over the very long term remains understudied. MATERIALS AND METHODS: A total of 25,530 childhood cancer survivors (median follow-up 22.3 years, interquartile range ... Full text Link to item Cite

Esophageal disease among childhood cancer survivors-A report from the Childhood Cancer Survivors Study.

Journal Article Pediatr Blood Cancer · August 2021 There is limited information addressing the occurrence of esophageal strictures among the growing population of survivors of childhood cancer. Using the Childhood Cancer Survivor Study, we analyzed data from 17,121 5-year survivors and 3400 siblings to det ... Full text Link to item Cite

The Head and Neck Survivorship Tool (HN-STAR) Trial (WF-1805CD): A protocol for a cluster-randomized, hybrid effectiveness-implementation, pragmatic trial to improve the follow-up care of head and neck cancer survivors.

Journal Article Contemp Clin Trials · August 2021 Survivors of head and neck cancer (HNC) can have multiple health concerns. To facilitate their care, we developed and pilot-tested a clinical informatics intervention, HN-STAR. HN-STAR elicits concerns online from HNC survivors prior to a routine oncology ... Full text Link to item Cite

Longitudinal Evaluation of Neuromuscular Dysfunction in Long-term Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2021 BACKGROUND: Children treated for cancer are at risk for neuromuscular dysfunction, but data are limited regarding prevalence, longitudinal patterns, and long-term impact. METHODS: Longitudinal surveys from 25,583 childhood cancer survivors ≥5 years from di ... Full text Link to item Cite

Impact of Risk-Adapted Therapy for Pediatric Hodgkin Lymphoma on Risk of Long-Term Morbidity: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · July 10, 2021 PURPOSE: To determine the incidence of serious chronic health conditions among survivors of pediatric Hodgkin lymphoma (HL), compare by era of therapy and by selected cancer therapies, and provide estimates of risks associated with contemporary therapy. ME ... Full text Link to item Cite

Integration of cancer registry and electronic health record data to construct a childhood cancer survivorship cohort, facilitate risk stratification for late effects, and assess appropriate follow-up care.

Journal Article Pediatr Blood Cancer · June 2021 BACKGROUND: This retrospective study harnessed an institutional cancer registry to construct a childhood cancer survivorship cohort, integrate electronic health record (EHR) and geospatial data to stratify survivors based on late-effect risk, analyze follo ... Full text Link to item Cite

Hodgkin Lymphoma Survivors: We Need to Do Better.

Journal Article J Natl Cancer Inst · June 1, 2021 Full text Link to item Cite

Sex-Specific Associations Between Chemotherapy, Chronic Conditions, and Neurocognitive Impairment in Acute Lymphoblastic Leukemia Survivors: A Report From the Childhood Cancer Survivor Study.

Journal Article J Natl Cancer Inst · May 4, 2021 BACKGROUND: The purpose was to examine associations between treatment and chronic health conditions with neurocognitive impairment survivors of acute lymphoblastic leukemia (ALL) treated with chemotherapy only. METHODS: This cross-sectional study included ... Full text Link to item Cite

A Comparison of Late Mortality Among Survivors of Childhood Cancer in the United States and United Kingdom.

Journal Article J Natl Cancer Inst · May 4, 2021 BACKGROUND: It is unclear whether late-effect risks among childhood cancer survivors vary internationally. We compared late mortality in the North American Childhood Cancer Survivor Study (CCSS) and British Childhood Cancer Survivor Study (BCCSS). METHODS: ... Full text Link to item Cite

Surveillance for subsequent neoplasms of the CNS for childhood, adolescent, and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

Journal Article Lancet Oncol · May 2021 Exposure to cranial radiotherapy is associated with an increased risk of subsequent CNS neoplasms among childhood, adolescent, and young adult (CAYA) cancer survivors. Surveillance for subsequent neoplasms can translate into early diagnoses and interventio ... Full text Link to item Cite

Outcomes and Costs for Women After Breast Cancer: Preparing for Improved Survivorship of Medicare Beneficiaries.

Journal Article JCO Oncol Pract · April 2021 PURPOSE: Increasing health care costs, longer life expectancy, improved breast cancer (BC) survival, and higher levels of complex comorbidities have important implications for future Medicare expenditures. METHODS: Data from the SEER program linked to Medi ... Full text Link to item Cite

General cancer screening practices among adult survivors of retinoblastoma: Results from the Retinoblastoma Survivor Study.

Journal Article Pediatr Blood Cancer · April 2021 We assessed breast, cervical, and colorectal cancer screening practices in adult retinoblastoma (Rb) survivors and non-Rb controls. We found that most Rb survivors adhered to general population cancer screening recommendations. Rates did not differ among R ... Full text Link to item Cite

Psychological, educational, and social late effects in adolescent survivors of Wilms tumor: A report from the Childhood Cancer Survivor Study.

Journal Article Psychooncology · March 2021 OBJECTIVE: To delineate the impact of treatment exposures and chronic health conditions on psychological, educational, and social outcomes in adolescent survivors of Wilms tumor. METHODS: Parent reports from the Childhood Cancer Survivor Study were analyze ... Full text Link to item Cite

Genetic variation in the body mass index of adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.

Journal Article Cancer · January 15, 2021 BACKGROUND: Treatment characteristics such as cranial radiation therapy (CRT) do not fully explain adiposity risk in childhood acute lymphoblastic leukemia (ALL) survivors. This study was aimed at characterizing genetic variation related to adult body mass ... Full text Link to item Cite

Implementation and Impact of a Risk-Stratified Prostate Cancer Screening Algorithm as a Clinical Decision Support Tool in a Primary Care Network.

Conference J Gen Intern Med · January 2021 BACKGROUND: Implementation methods of risk-stratified cancer screening guidance throughout a health care system remains understudied. OBJECTIVE: Conduct a preliminary analysis of the implementation of a risk-stratified prostate cancer screening algorithm i ... Full text Link to item Cite

Personalized Cancer Follow-Up Care Pathways: A Delphi Consensus of Research Priorities.

Journal Article J Natl Cancer Inst · December 14, 2020 Development of personalized, stratified follow-up care pathways where care intensity and setting vary with needs could improve cancer survivor outcomes and efficiency of health-care delivery. Advancing such an approach in the United States requires identif ... Full text Link to item Cite

Updated Breast Cancer Surveillance Recommendations for Female Survivors of Childhood, Adolescent, and Young Adult Cancer From the International Guideline Harmonization Group.

Journal Article J Clin Oncol · December 10, 2020 PURPOSE: As new evidence is available, the International Late Effects of Childhood Cancer Guideline Harmonization Group has updated breast cancer surveillance recommendations for female survivors of childhood, adolescent, and young adult cancer. METHODS: W ... Full text Link to item Cite

The Future of Childhood Cancer Survivorship: Challenges and Opportunities for Continued Progress.

Journal Article Pediatr Clin North Am · December 2020 As treatment evolves and the population who survive childhood cancer ages and increases in number, researchers must use novel approaches to prevent, identify and mitigate adverse effects of treatment. Future priorities include collaborative efforts to pool ... Full text Link to item Cite

Cost-Effectiveness of the International Late Effects of Childhood Cancer Guideline Harmonization Group Screening Guidelines to Prevent Heart Failure in Survivors of Childhood Cancer.

Journal Article J Clin Oncol · November 20, 2020 PURPOSE: Survivors of childhood cancer treated with anthracyclines and/or chest-directed radiation are at increased risk for heart failure (HF). The International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) recommends risk-based s ... Full text Link to item Cite

Late morbidity and mortality in adult survivors of childhood glioma with neurofibromatosis type 1: report from the Childhood Cancer Survivor Study.

Journal Article Genet Med · November 2020 PURPOSE: Neurofibromatosis type 1 (NF1) is associated with tumor predisposition and nonmalignant health conditions. Whether survivors of childhood cancer with NF1 are at increased risk for poor long-term health outcomes is unknown. METHODS: One hundred for ... Full text Link to item Cite

Recommendations for Long-Term Follow-up of Adults with Heritable Retinoblastoma.

Journal Article Ophthalmology · November 2020 PURPOSE: To generate recommendations for long-term follow-up of adult survivors of heritable retinoblastoma. DESIGN: We convened a meeting of providers from retinoblastoma centers around the world to review the state of the science and to evaluate the publ ... Full text Link to item Cite

The Importance of Cancer Screening.

Journal Article Med Clin North Am · November 2020 The burden of cancer in the United States is substantial, providing important opportunity and obligation for primary care clinicians to promote cancer prevention and early detection. Without a system of organized screening to support reminders and follow-u ... Full text Link to item Cite

Cancer Screening in Primary Care: So Much Progress, So Much Left to Do.

Journal Article Med Clin North Am · November 2020 Full text Link to item Cite

Reduced Morbidity and Mortality in Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · October 10, 2020 PURPOSE: Risk-stratified therapy, which modifies treatment on the basis of clinical and biologic features, has improved 5-year overall survival of childhood acute lymphoblastic leukemia (ALL) to 90%, but its impact on long-term toxicity remains unknown. ME ... Full text Link to item Cite

Utilization of clinical genetic counseling among childhood and young adult cancer survivors in a registry trial.

Journal Article J Community Genet · October 2020 We describe utilization of clinical genetic services among survivors of childhood and young adult cancer after participation in a genetic registry. Clinical genetic counselors flagged 162 out of 1069 pedigrees (15.2%) as suggestive of inheritable cancer su ... Full text Link to item Cite

Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society.

Journal Article CA Cancer J Clin · September 2020 The American Cancer Society (ACS) recommends that individuals with a cervix initiate cervical cancer screening at age 25 years and undergo primary human papillomavirus (HPV) testing every 5 years through age 65 years (preferred); if primary HPV testing is ... Full text Link to item Cite

Clinical Benefits, Harms, and Cost-Effectiveness of Breast Cancer Screening for Survivors of Childhood Cancer Treated With Chest Radiation : A Comparative Modeling Study.

Journal Article Ann Intern Med · September 1, 2020 BACKGROUND: Surveillance with annual mammography and breast magnetic resonance imaging (MRI) is recommended for female survivors of childhood cancer treated with chest radiation, yet benefits, harms, and costs are uncertain. OBJECTIVE: To compare the benef ... Full text Link to item Cite

Follow-Up Care for Breast and Colorectal Cancer Across the Globe: Survey Findings From 27 Countries.

Journal Article JCO Glob Oncol · September 2020 PURPOSE: The purpose of this study was to describe follow-up care for breast and colorectal cancer survivors in countries with varying levels of resources and highlight challenges regarding posttreatment survivorship care. METHODS: We surveyed one key stak ... Full text Link to item Cite

The Durham Initiative for Stomach Health (DISH): a pilot community-based Helicobacter pylori education and screening study.

Journal Article BMC Gastroenterol · August 6, 2020 BACKGROUND: Approximately 15% of all cancers are due to infection. The bacteria Helicobacter pylori is the single leading carcinogenic infectious agent and the main cause of stomach cancer. Prevalence of H. pylori, and, correspondingly, stomach cancer inci ... Full text Link to item Cite

Technology-enabled activation of skin cancer screening for hematopoietic cell transplantation survivors and their primary care providers (TEACH).

Journal Article BMC Cancer · August 3, 2020 BACKGROUND: Hematopoietic cell transplantation (HCT) is a curative option for a growing number of patients with hematologic diseases and malignancies. However, HCT-related factors, such as total body irradiation used for conditioning, graft-versus-host dis ... Full text Link to item Cite

Communicating cardiovascular risk to high-risk cancer survivors: a mixed-methods pilot study of a statin risk communication tool.

Journal Article J Cancer Surviv · August 2020 PURPOSE: Childhood, adolescent, and young adult cancer survivors treated with radiation therapy (RT) may be unaware of their high cardiovascular disease (CVD) risk or how to mitigate it. Tools are needed to improve understanding. We developed and pilot-tes ... Full text Link to item Cite

Whole-body magnetic resonance imaging as surveillance for subsequent malignancies in preadolescent, adolescent, and young adult survivors of germline retinoblastoma: An update.

Journal Article Pediatr Blood Cancer · July 2020 BACKGROUND: Germline retinoblastoma (Rb) survivors are at lifelong risk for developing subsequent malignancies (SMNs). Optimal surveillance modalities are needed to detect SMN at an early stage in this high-risk cohort. We investigated the use of rapid who ... Full text Link to item Cite

Incidence of and risk factors for late cholecystectomy in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Eur J Cancer · July 2020 BACKGROUND: Gallbladder disease and need for cholecystectomy are common and significant contributors to patient morbidity and healthcare costs. Childhood cancer survivors are at elevated risk for developing cholelithiasis. However, their incidence of and r ... Full text Link to item Cite

Consistent Physical Activity and Future Neurocognitive Problems in Adult Survivors of Childhood Cancers: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · June 20, 2020 PURPOSE: To investigate longitudinal associations between physical activity (PA) and neurocognitive problems in adult survivors of childhood cancer. METHODS: A total of 12,123 5-year survivors diagnosed between 1970 and 1999 (median [range] age at diagnosi ... Full text Link to item Cite

Longitudinal pain and pain interference in long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · June 15, 2020 BACKGROUND: The objective of this study was to characterize the prevalence and risk of pain, pain interference, and recurrent pain in adult survivors of childhood cancer in comparison with siblings. METHODS: This study analyzed longitudinal data from survi ... Full text Link to item Cite

Impact of enucleation on adult retinoblastoma survivors' quality of life: A qualitative study of survivors' perspectives.

Journal Article Palliat Support Care · June 2020 OBJECTIVES: Retinoblastoma is the most common primary intraocular tumor of childhood with >95% survival rates in the US. Traditional therapy for retinoblastoma often included enucleation (removal of the eye). While much is known about the visual, physical, ... Full text Link to item Cite

Cardiotoxicity Surveillance and Risk of Heart Failure During HER2 Targeted Therapy.

Journal Article JACC CardioOncol · June 2020 BACKGROUND: Guidelines recommend left ventricular ejection fraction (LVEF) assessments every 3 months for cardiotoxicity monitoring during human epidermal growth factor receptor 2 (HER2) targeted therapy. Evidence in support of this practice is lacking. OB ... Full text Link to item Cite

Adherence to Surveillance for Second Malignant Neoplasms and Cardiac Dysfunction in Childhood Cancer Survivors: A Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · May 20, 2020 PURPOSE: To evaluate childhood cancer survivors' adherence to surveillance protocols for late effects of treatment and to determine the factors affecting adherence. METHODS: Between 2014 and 2016, 11,337 survivors and 2,146 siblings in the Childhood Cancer ... Full text Link to item Cite

Radiation Dose and Volume to the Pancreas and Subsequent Risk of Diabetes Mellitus: A Report from the Childhood Cancer Survivor Study.

Journal Article J Natl Cancer Inst · May 1, 2020 BACKGROUND: Childhood cancer survivors exposed to abdominal radiation (abdRT) are at increased risk for diabetes mellitus, but the association between risk and radiation dose and volume is unclear. METHODS: Participants included 20 762 5-year survivors of ... Full text Link to item Cite

Why palliative care is the answer to the serious illness question in payment reform.

Journal Article Am J Manag Care · April 2020 Full text Link to item Cite

Traditional Cardiovascular Risk Factors and Individual Prediction of Cardiovascular Events in Childhood Cancer Survivors.

Journal Article J Natl Cancer Inst · March 1, 2020 BACKGROUND: Childhood cancer survivors have an increased risk of heart failure, ischemic heart disease, and stroke. They may benefit from prediction models that account for cardiotoxic cancer treatment exposures combined with information on traditional car ... Full text Link to item Cite

Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study.

Journal Article Cancer · March 1, 2020 BACKGROUND: Poor socioeconomic and health-related quality of life (HRQOL) outcomes in survivors of childhood cancer can lead to distress and overall negatively impact the lives of these individuals. The current report has highlighted the impact of stroke a ... Full text Link to item Cite

Life Expectancy of Adult Survivors of Childhood Cancer Over 3 Decades.

Journal Article JAMA Oncol · March 1, 2020 IMPORTANCE: Advances in childhood and adolescent cancer treatment have been associated with increased rates of cure during the past 3 decades; however, improvement in adult life expectancy for these individuals has not yet been reported. OBJECTIVES: To pro ... Full text Link to item Cite

Long-term Cardiopulmonary Consequences of Treatment-Induced Cardiotoxicity in Survivors of ERBB2-Positive Breast Cancer.

Journal Article JAMA Cardiol · March 1, 2020 IMPORTANCE: Trastuzumab improves outcomes in patients with ERBB2-positive (formerly HER2) breast cancer but is associated with treatment-induced cardiotoxicity, most commonly manifest by an asymptomatic decline in left ventricular ejection fraction (LVEF). ... Full text Link to item Cite

Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study.

Journal Article Lancet Oncol · March 2020 BACKGROUND: Treatment outcomes among survivors of cancer diagnosed during adolescence and early young adulthood have not been characterised independently of survivors of cancers diagnosed during childhood. We aimed to describe chronic health conditions and ... Full text Link to item Cite

Predicting acute ovarian failure in female survivors of childhood cancer: a cohort study in the Childhood Cancer Survivor Study (CCSS) and the St Jude Lifetime Cohort (SJLIFE).

Journal Article Lancet Oncol · March 2020 BACKGROUND: Cancer treatment can cause gonadal impairment. Acute ovarian failure is defined as the permanent loss of ovarian function within 5 years of cancer diagnosis. We aimed to develop and validate risk prediction tools to provide accurate clinical gu ... Full text Link to item Cite

Barriers and facilitators of risk-based health care for adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · February 1, 2020 BACKGROUND: Optimal risk-based survivor health care includes surveillance for late effects and education targeted at reducing or preventing risky health behaviors. Understanding the reasons for a lack of risk-based follow-up care is essential. METHODS: Adu ... Full text Link to item Cite

Communicating health information and improving coordination with primary care (CHIIP): Rationale and design of a randomized cardiovascular health promotion trial for adult survivors of childhood cancer.

Journal Article Contemp Clin Trials · February 2020 BACKGROUND: Long-term survival for children diagnosed with cancer exceeds 80%. Notably, premature cardiovascular disease has become the leading non-cancer cause of late mortality among these survivors. METHODS/DESIGN: This randomized controlled trial (RCT; ... Full text Link to item Cite

Comparison of Radiation Dose Reconstruction Methods to Investigate Late Adverse Effects of Radiotherapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

Journal Article Radiat Res · February 2020 Quantification of radiation dose to normal tissue during radiotherapy is critical for assessing risk for radiotherapy-related late effects, including subsequent neoplasms (SNs). Case-control studies of SNs typically reconstruct absorbed radiation dose to t ... Full text Link to item Cite

Prevalence and Predictors of Frailty in Childhood Cancer Survivors and Siblings: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · January 20, 2020 PURPOSE: To estimate the prevalence of frailty among childhood cancer survivors and to determine the direct and indirect effects of treatment exposures, lifestyle factors, and severe, disabling, and life-threatening chronic condition on frailty. METHODS: C ... Full text Link to item Cite

Major cardiac events for adult survivors of childhood cancer diagnosed between 1970 and 1999: report from the Childhood Cancer Survivor Study cohort.

Journal Article BMJ · January 15, 2020 OBJECTIVE: To investigate the impact of modifications to contemporary cancer protocols, which minimize exposures to cardiotoxic treatments and preserve long term health, on serious cardiac outcomes among adult survivors of childhood cancer. DESIGN: Retrosp ... Full text Link to item Cite

Association of Breast Cancer Risk After Childhood Cancer With Radiation Dose to the Breast and Anthracycline Use: A Report From the Childhood Cancer Survivor Study.

Journal Article JAMA Pediatr · December 1, 2019 IMPORTANCE: Chest irradiation for childhood cancer is associated with increases in breast cancer risk. Growing evidence suggests that anthracyclines increase this risk, but the outcome of combined anthracycline use and radiotherapy has not been studied. OB ... Full text Link to item Cite

Cardiovascular Prevention Strategies in Breast Cancer

Journal Article Jacc Cardiooncology · December 1, 2019 Full text Cite

Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity.

Journal Article J Clin Endocrinol Metab · November 1, 2019 CONTEXT: Childhood cancer survivors experience chronic health conditions that impact health-related quality of life (HRQOL) and participation in optimal physical activity. OBJECTIVE: The study aimed to determine independent effects of endocrine and metabol ... Full text Link to item Cite

Late-onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · November 1, 2019 BACKGROUND: The prevalence and associated psychosocial morbidity of late-onset anorectal disease after surgery and radiotherapy for the treatment of childhood cancer are not known. METHODS: A total of 25,530 survivors diagnosed between 1970 and 1999 (media ... Full text Link to item Cite

Cost-Effectiveness of Colonoscopy-Based Colorectal Cancer Screening in Childhood Cancer Survivors.

Journal Article J Natl Cancer Inst · November 1, 2019 BACKGROUND: Childhood cancer survivors (CCS) are at increased risk of developing colorectal cancer (CRC) compared to the general population, especially those previously exposed to abdominal or pelvic radiation therapy (APRT). However, the benefits and cost ... Full text Link to item Cite

Late Health Outcomes After Contemporary Lymphome Malin de Burkitt Therapy for Mature B-Cell Non-Hodgkin Lymphoma: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · October 1, 2019 PURPOSE: The widely used, risk-based Lymphome Malin de Burkitt (LMB) chemotherapy regimen has improved survival rates for children with mature B-cell non-Hodgkin lymphoma (NHL); however, associated late effects remain understudied. We assessed late health ... Full text Link to item Cite

Solid organ transplantation after treatment for childhood cancer: a retrospective cohort analysis from the Childhood Cancer Survivor Study.

Journal Article Lancet Oncol · October 2019 BACKGROUND: Serious chronic medical conditions occur in childhood cancer survivors. We aimed to investigate incidence of and risk factors for end-organ damage resulting in registration on a waiting list for or receiving a solid organ transplantation and 5- ... Full text Link to item Cite

Impact of exercise on psychological burden in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · September 1, 2019 BACKGROUND: Childhood cancer survivors are at risk for adverse psychological outcomes. Whether exercise can attenuate this risk is unknown. METHODS: In total, 6199 participants in the Childhood Cancer Survivor Study (median age, 34.3 years [range, 22.0-54. ... Full text Link to item Cite

Childhood Leukemia, Late Effects, and a Person-centric Model of Follow-up.

Journal Article J Natl Cancer Inst · September 1, 2019 Full text Link to item Cite

Promoting Breast Cancer Surveillance: The EMPOWER Study, a Randomized Clinical Trial in the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · August 20, 2019 PURPOSE: The aim of the current study was to increase the uptake of screening mammography among high-risk women who were treated for a childhood cancer with chest radiotherapy. PATIENTS AND METHODS: Two hundred four female survivors in the Childhood Cancer ... Full text Link to item Cite

Mortality After Breast Cancer Among Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Conference J Clin Oncol · August 20, 2019 PURPOSE: Female survivors of childhood cancer have a high risk of subsequent breast cancer. We describe the ensuing risk for mortality and additional breast cancers. PATIENTS AND METHODS: Female participants in the Childhood Cancer Survivor Study, a cohort ... Full text Link to item Cite

Automated Breast Density Measurements From Chest Computed Tomography Scans.

Journal Article J Med Syst · June 22, 2019 To develop an automated method for quantifying percent breast density from chest computed tomography (CT) scans. A naïve Bayesian classifier based on gray-level intensities and spatial relationships was developed on CT scans from 10 patients diagnosed with ... Full text Link to item Cite

Derivation of Anthracycline and Anthraquinone Equivalence Ratios to Doxorubicin for Late-Onset Cardiotoxicity.

Journal Article JAMA Oncol · June 1, 2019 IMPORTANCE: Anthracyclines are part of many effective pediatric cancer treatment protocols. Most pediatric oncology treatment groups assume that the hematologic toxicity of anthracycline agents is equivalent to their cardiotoxicity; for example, Children's ... Full text Link to item Cite

Oncologists' Attitudes and Practice of Addressing Diet, Physical Activity, and Weight Management With Patients With Cancer: Findings of an ASCO Survey of the Oncology Workforce.

Journal Article J Oncol Pract · June 2019 PURPOSE: Obesity and related factors have been linked to cancer risk and outcomes, but little information exists with regard to oncologists' attention to these issues as a part of clinical care. METHODS: Oncology providers actively caring for patients with ... Full text Link to item Cite

Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement From the American Heart Association.

Journal Article Circulation · May 21, 2019 Cardiovascular disease is a competing cause of death in patients with cancer with early-stage disease. This elevated cardiovascular disease risk is thought to derive from both the direct effects of cancer therapies and the accumulation of risk factors such ... Full text Link to item Cite

Therapy-Related Cardiac Risk in Childhood Cancer Survivors: An Analysis of the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · May 1, 2019 PURPOSE: The impacts of radiotherapy dose and exposed cardiac volume, select chemotherapeutic agents, and age at exposure on risk for late-onset cardiac disease in survivors of childhood cancer remain unresolved. PATIENTS AND METHODS: We determined the rat ... Full text Link to item Cite

Sleep, emotional distress, and physical health in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Psychooncology · April 2019 OBJECTIVE: Sleep disorders are associated with psychological and physical health, although reports in long-term survivors of childhood cancer are limited. We characterized the prevalence and risk factors for behaviors consistent with sleep disorders in sur ... Full text Link to item Cite

Assessment of Early Radiation-Induced Changes in Left Ventricular Function by Myocardial Strain Imaging After Breast Radiation Therapy.

Journal Article J Am Soc Echocardiogr · April 2019 BACKGROUND: Radiation therapy (RT)-induced cardiotoxicity is among the concerning sequelae of breast cancer (BCA) treatment, particularly in HER2-positive BCA patients who receive anthracyclines and trastuzumab-based therapy. The aim of this study was to a ... Full text Link to item Cite

Late Morbidity and Mortality Among Medulloblastoma Survivors Diagnosed Across Three Decades: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · March 20, 2019 PURPOSE: Treatment of medulloblastoma has evolved from surgery and radiotherapy to contemporary multimodal regimens. However, the impact on long-term health outcomes remains unknown. METHODS: Cumulative incidence of late mortality (5 or more years from dia ... Full text Link to item Cite

Advanced Practice Providers and Survivorship Care: They Can Deliver.

Journal Article J Oncol Pract · March 2019 INTRODUCTION: As the number of cancer survivors grows, new models of survivorship care are being implemented, but there is limited evaluation to date. This retrospective review assesses the concordance of care provided to adult-onset cancer survivors by ad ... Full text Link to item Cite

Automating Treatment Summary Development Using Electronic Billing Information: A Pilot Study of Survivors of Head and Neck Cancer.

Journal Article J Oncol Pract · January 2019 PURPOSE: Although the provision of a treatment summary (TS) is a quality indicator in oncology, routine delivery of TSs remains challenging. Automatic TS generation could facilitate use, but data on accuracy are lacking in complex cancers such as head and ... Full text Link to item Cite

DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study.

Journal Article Genes Chromosomes Cancer · January 2019 Because survivors of pediatric acute lymphoblastic leukemia (ALL) are more likely to be obese than unaffected contemporaries, we compared DNA methylation profiles between normal-weight and obese survivors at adiposity-associated CpG sites previously-report ... Full text Link to item Cite

Long-term health and social function in adult survivors of paediatric astrocytoma: A report from the Childhood Cancer Survivor Study.

Journal Article Eur J Cancer · January 2019 BACKGROUND: Although paediatric astrocytoma has an excellent 5-year survival rate, survivors remain at risk for morbidity and late mortality. This study aimed to estimate the risk of late mortality, chronic conditions, poor health status and social impairm ... Full text Link to item Cite

Care coordination for complex cancer survivors in an integrated safety-net system: a study protocol.

Journal Article BMC Cancer · December 4, 2018 BACKGROUND: The growing numbers of cancer survivors challenge delivery of high-quality survivorship care by healthcare systems. Innovative ways to improve care coordination for patients with cancer and multiple chronic conditions ("complex cancer survivors ... Full text Link to item Cite

Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970-99: a report from the Childhood Cancer Survivor Study cohort.

Journal Article Lancet Oncol · December 2018 BACKGROUND: Treatments for childhood cancer have evolved over the past 50 years, with the goal of maximising the proportion of patients who achieve long-term survival, while minimising the adverse effects of therapy. We aimed to assess incidence patterns o ... Full text Link to item Cite

Incorporating Multiple Perspectives Into the Development of an Electronic Survivorship Platform for Head and Neck Cancer.

Journal Article JCO Clin Cancer Inform · December 2018 PURPOSE: To improve the care of survivors of head and neck cancer, we developed the Head and Neck Survivorship Tool: Assessment and Recommendations (HN-STAR). HN-STAR is an electronic platform that incorporates patient-reported outcomes into a clinical dec ... Full text Link to item Cite

Second cancers

Chapter · November 16, 2018 Cite

Cancer survivorship

Chapter · November 16, 2018 Cite

Insulin and glucose homeostasis in childhood cancer survivors treated with abdominal radiation: A pilot study.

Journal Article Pediatr Blood Cancer · November 2018 BACKGROUND: Childhood cancer survivors exposed to abdominal radiation (abdRT) are at increased risk for both insulin-dependent and non-insulin-dependent diabetes. We sought to clarify the pathophysiology of diabetes after abdRT by performing dynamic studie ... Full text Link to item Cite

Primary care perspective and implementation of a multidisciplinary, institutional prostate cancer screening algorithm embedded in the electronic health record.

Journal Article Urol Oncol · November 2018 PURPOSE: In response to controversy regarding prostate cancer (CaP) screening recommendations, a consolidated Duke Cancer Institute (DCI) multidisciplinary algorithm for CaP screening was developed and implemented. We conducted an online survey within the ... Full text Link to item Cite

Long-term risk of venous thromboembolism in survivors of childhood cancer: A report from the childhood cancer survivor study

Journal Article Journal of Clinical Oncology · November 1, 2018 Purpose To estimate the incidence of late-occurring venous thromboembolism (VTE) among survivors of childhood cancer and to identify risk factors for VTE to facilitate diagnosis and prevention. Methods The Childhood Cancer Survivor Study is a multi-institu ... Full text Cite

Long-term survivors of childhood cancer: cure and care-the Erice Statement (2006) revised after 10 years (2016).

Journal Article J Cancer Surviv · October 2018 PURPOSE: The number of persons who have successfully completed treatment for a cancer diagnosed during childhood and who have entered adulthood is increasing over time, and former patients will become aging citizens. METHODS: Ten years ago, an expert panel ... Full text Link to item Cite

Insurance, chronic health conditions, and utilization of primary and specialty outpatient services: a Childhood Cancer Survivor Study report.

Journal Article J Cancer Surviv · October 2018 PURPOSE: Survivors of childhood cancer require life-long outpatient healthcare, which may be impacted by health insurance. This study sought to understand survivors' utilization of outpatient healthcare provider services. METHODS: The study examined cross- ... Full text Link to item Cite

Association of Exercise With Mortality in Adult Survivors of Childhood Cancer.

Journal Article JAMA Oncol · October 1, 2018 IMPORTANCE: Adult survivors of childhood cancer are at excess risk for mortality compared with the general population. Whether exercise attenuates this risk is not known. OBJECTIVE: To examine the association between vigorous exercise and change in exercis ... Full text Link to item Cite

Li-Fraumeni Syndrome-related Malignancies Involving the Genitourinary Tract: Review of a Single-institution Experience.

Journal Article Urology · September 2018 OBJECTIVE: To report a case of pelvic angiosarcoma in a 27-year-old man with Li-Fraumeni Syndrome (LFS) and evaluate the presentation and timeline of genitourinary (GU) tract involvement in LFS patients. METHODS: We retrospectively identified 39 LFS patien ... Full text Link to item Cite

Predicting Cardiovascular Disease Among Testicular Cancer Survivors After Modern Cisplatin-based Chemotherapy: Application of the Framingham Risk Score.

Journal Article Clin Genitourin Cancer · August 2018 BACKGROUND: Testicular cancer survivors (TCSs) are at increased risk of cardiovascular disease (CVD) after cisplatin-based chemotherapy (CBCT). Identifying at-risk survivors would allow early intervention, but risk prediction tools such as the Framingham R ... Full text Link to item Cite

Development and Validation of a Clinical Score for Cardiovascular Risk Stratification of Long-Term Childhood Cancer Survivors.

Journal Article Oncologist · August 2018 BACKGROUND: Long-term childhood cancer survivors (CCS) are at increased risk of adverse cardiovascular events; however, there is a paucity of risk-stratification tools to identify those at higher-than-normal risk. SUBJECTS, MATERIALS, AND METHODS: This was ... Full text Link to item Cite

Long-term psychological and educational outcomes for survivors of neuroblastoma: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · August 1, 2018 BACKGROUND: Neuroblastoma survivors may be at elevated risk for psychological impairments because of their young age at diagnosis and neurotoxic treatment, but this is not well described. METHODS: A total of 859 ≥5-year survivors of neuroblastoma younger t ... Full text Link to item Cite

Models of Care for Survivors of Childhood Cancer From Across the Globe: Advancing Survivorship Care in the Next Decade.

Journal Article J Clin Oncol · July 20, 2018 With improvements in cancer treatment and supportive care, a growing population of survivors of childhood cancer at risk for significant and potentially life-threatening late effects has been identified. To provide a current snapshot of the models of care ... Full text Link to item Cite

Risk, Risk Factors, and Surveillance of Subsequent Malignant Neoplasms in Survivors of Childhood Cancer: A Review.

Journal Article J Clin Oncol · July 20, 2018 Subsequent malignant neoplasms (SMNs) in childhood cancer survivors cause substantial morbidity and mortality. This review summarizes recent literature on SMN epidemiology, risk factors, surveillance, and interventions. Survivors of childhood cancer experi ... Full text Link to item Cite

Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society.

Journal Article CA Cancer J Clin · July 2018 In the United States, colorectal cancer (CRC) is the fourth most common cancer diagnosed among adults and the second leading cause of death from cancer. For this guideline update, the American Cancer Society (ACS) used an existing systematic evidence revie ... Full text Link to item Cite

Vision-Targeted Health-Related Quality of Life in Adult Survivors of Retinoblastoma.

Journal Article JAMA Ophthalmol · June 1, 2018 IMPORTANCE: Retinoblastoma survivors are at risk for adverse oculo-visual outcomes. Limited data are available regarding long-term vision-targeted health-related quality of life (HRQoL) of adult retinoblastoma survivors. OBJECTIVE: To examine vision-target ... Full text Link to item Cite

Late Infection-Related Mortality in Asplenic Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Conference J Clin Oncol · June 1, 2018 Purpose Infection-related outcomes associated with asplenia or impaired splenic function in survivors of childhood cancer remains understudied. Methods Late infection-related mortality was evaluated in 20,026 5-year survivors of childhood cancer (diagnosed ... Full text Link to item Cite

Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy.

Journal Article Children (Basel) · May 4, 2018 The ototoxic effects of radiotherapy have been poorly characterized. We examined adult survivors of childhood cancer who were treated with radiotherapy, which included the head, before the age of 22 years and between 1952 and 2016. Those who received plati ... Full text Link to item Cite

"Job Lock" Among Long-term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Journal Article JAMA Oncol · May 1, 2018 IMPORTANCE: Childhood cancer survivors may be reluctant to make changes in their employment because of access to health insurance. OBJECTIVE: To examine the prevalence of "job lock" (staying at a job to keep work-related health insurance) in a sample drawn ... Full text Link to item Cite

Chronic Health Conditions and Neurocognitive Function in Aging Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

Journal Article J Natl Cancer Inst · April 1, 2018 BACKGROUND: Neurocognitive impairment in survivors of childhood cancer may be associated with direct neurotoxicity, as well as indirect effects of systemic health complications. We evaluated associations among treatment exposures, chronic health conditions ... Full text Link to item Cite

Paediatrics: Addressing the health burden of childhood cancer survivors - improvements are needed.

Journal Article Nat Rev Clin Oncol · March 2018 Full text Link to item Cite

Factors associated with physical activity among adolescent and young adult survivors of early childhood cancer: A report from the childhood cancer survivor study (CCSS).

Journal Article Psychooncology · February 2018 OBJECTIVE: To evaluate concurrent and longitudinal associations between psychosocial functioning and physical activity in adolescent and young adult survivors of early childhood cancer. METHODS: Adolescent survivors of early childhood cancer (diagnosed bef ... Full text Link to item Cite

Long-term sequelae in survivors of childhood leukemia with Down syndrome: A childhood cancer survivor study report.

Journal Article Cancer · February 1, 2018 BACKGROUND: Children with Down syndrome (DS) are at increased risk of developing acute leukemia and are more prone to acute toxicities. We studied the incidence and severity of chronic health conditions among survivors of childhood leukemia with DS compare ... Full text Link to item Cite

Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium.

Journal Article Cancer Treat Rev · February 2018 Radiation exposure to the thyroid gland during treatment of childhood, adolescent and young adult cancer (CAYAC) may cause differentiated thyroid cancer (DTC). Surveillance recommendations for DTC vary considerably, causing uncertainty about optimum screen ... Full text Link to item Cite

Longitudinal assessment of late-onset neurologic conditions in survivors of childhood central nervous system tumors: a Childhood Cancer Survivor Study report.

Journal Article Neuro Oncol · January 10, 2018 BACKGROUND: Survivors of childhood central nervous system (CNS) tumors experience high rates of treatment-related neurologic sequelae. Whether survivors continue to be at increased risk for new events as they age is unknown. METHODS: Adverse neurologic hea ... Full text Link to item Cite

Prediction of Ischemic Heart Disease and Stroke in Survivors of Childhood Cancer.

Journal Article J Clin Oncol · January 1, 2018 Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year survivors of childhood cancer. Patients and Methods Participants in the Childhood Cancer Survivor Study (CCSS; n = 13,060) were observed through age 50 years for the ... Full text Link to item Cite

Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · January 2018 This selection from the NCCN Guidelines for Adolescent and Young Adult (AYA) Oncology focuses on treatment and management considerations for AYA patients with cancer. Compared with older adults with cancer, AYA patients have unique needs regarding treatmen ... Full text Link to item Cite

Health maintenance and screening in cancer survivors

Chapter · January 1, 2018 Cite

Reducing the global cancer burden among young adults.

Journal Article Lancet Oncol · December 2017 Full text Link to item Cite

Preexisting Cardiovascular Risk and Subsequent Heart Failure Among Non-Hodgkin Lymphoma Survivors.

Journal Article J Clin Oncol · December 1, 2017 Purpose The use of anthracycline chemotherapy is associated with heart failure (HF) among survivors of non-Hodgkin lymphoma (NHL). We aimed to understand the contribution of preexisting cardiovascular risk factors to HF risk among NHL survivors. Methods Us ... Full text Link to item Cite

Risk stratification of childhood cancer survivors necessary for evidence-based clinical long-term follow-up.

Journal Article Br J Cancer · November 21, 2017 BACKGROUND: Reorganisation of clinical follow-up care in England was proposed by the National Cancer Survivorship Initiative (NCSI), based on cancer type and treatment, ranging from Level 1 (supported self-management) to Level 3 (consultant-led care). The ... Full text Link to item Cite

Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study.

Journal Article J Clin Oncol · November 10, 2017 Purpose Survivors of childhood cancer treated with cranial radiation therapy are at risk for subsequent CNS tumors. However, significant interindividual variability in risk suggests a role for genetic susceptibility and provides an opportunity to identify ... Full text Link to item Cite

Morbidity and mortality after treatment of Ewing sarcoma: A single-institution experience.

Journal Article Pediatr Blood Cancer · November 2017 BACKGROUND: Children, adolescents, and young adults treated for Ewing sarcoma (ES) are at risk for disease-related and treatment-related complications. We aimed to describe early and late overall mortality, cause-specific mortality, and key adverse health ... Full text Link to item Cite

Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer.

Journal Article J Natl Cancer Inst · November 1, 2017 BACKGROUND: Childhood cancer survivors treated with chest-directed radiotherapy have substantially elevated risk for developing breast cancer. Although genetic susceptibility to breast cancer in the general population is well studied, large-scale evaluatio ... Full text Link to item Cite

Cardiac safety of non-anthracycline trastuzumab-based therapy for HER2-positive breast cancer.

Journal Article Breast Cancer Res Treat · November 2017 PURPOSE: Trastuzumab improves overall survival for women with HER2-positive breast cancer but is associated with cardiotoxicity, especially when administered after anthracyclines. Use of non-anthracycline trastuzumab-based regimens is rising, particularly ... Full text Link to item Cite

Financial Burden in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · October 20, 2017 Purpose Survivors of childhood cancer may experience financial burden as a result of health care costs, particularly because these patients often require long-term medical care. We sought to evaluate the prevalence of financial burden and identify associat ... Full text Link to item Cite

Reply to Second malignancies in Ewing sarcoma survivors.

Journal Article Cancer · October 15, 2017 Full text Link to item Cite

Radiation-associated breast cancer and gonadal hormone exposure: a report from the Childhood Cancer Survivor Study.

Journal Article Br J Cancer · July 11, 2017 BACKGROUND: The relationship between hormone exposure and breast cancer risk in women treated with chest radiotherapy for childhood cancer is uncertain. METHODS: Participants included 1108 females from the Childhood Cancer Survivor Study who were diagnosed ... Full text Link to item Cite

Longitudinal follow-up of adult survivors of Ewing sarcoma: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · July 1, 2017 BACKGROUND: Ewing sarcoma survivors (ESSs) are at increased risk for treatment-related complications. The incidence of treatment-related morbidity and late mortality with aging is unknown. METHODS: This study reports survival probabilities, estimated with ... Full text Link to item Cite

Screening for thyroid cancer in survivors of childhood and young adult cancer treated with neck radiation.

Journal Article J Cancer Surviv · June 2017 BACKGROUND: The optimal method of screening for thyroid cancer in survivors of childhood and young adult cancer exposed to neck radiation remains controversial. Outcome data for a physical exam-based screening approach are lacking. METHODS: We conducted a ... Full text Link to item Cite

LGG-17. IMPACT OF STROKE AND STROKE RECURRENCE ON LATE MORTALITY AS WELL AS PSYCHOLOGICAL AND SOCIOECONOMIC OUTCOMES IN CHILDHOOD CANCER SURVIVORS

Conference Neuro-Oncology · June 2017 Full text Cite

Cardiac Safety of Dual Anti-HER2 Therapy in the Neoadjuvant Setting for Treatment of HER2-Positive Breast Cancer.

Journal Article Oncologist · June 2017 BACKGROUND: Trastuzumab and pertuzumab are approved for the neoadjuvant treatment of human epidermal growth receptor 2 (HER2)-positive breast cancer, but cardiac safety data is limited. We report the cardiac safety of dose-dense doxorubicin and cyclophosph ... Full text Link to item Cite

Morbidity and Mortality Associated With Meningioma After Cranial Radiotherapy: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · May 10, 2017 Purpose Little is known about neurologic morbidity attributable to cranial radiotherapy (CRT) -associated meningiomas. Materials and Methods From 4,221 survivors exposed to CRT in the Childhood Cancer Survivor Study, a diagnosis of meningioma and onset of ... Full text Link to item Cite

Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study.

Journal Article Neuro Oncol · May 1, 2017 BACKGROUND: Medulloblastoma is the most common malignant childhood brain tumor, although long-term risks for chronic neurologic health and psychosocial functioning in aging adult survivors are incompletely characterized. METHODS: The Childhood Cancer Survi ... Full text Link to item Cite

Hepatocellular adenoma among adult survivors of childhood and young adult cancer.

Journal Article Pediatr Blood Cancer · April 2017 Hepatocellular adenoma (HCA) is a rare benign epithelial neoplasm with potential for hemorrhage, rupture, or malignant transformation. Reported annual incidence of HCA is approximately 1/1,000,000. We identified 12 cases of HCA among adults with a history ... Full text Link to item Cite

Adenomatous Lesions Among Adult Survivors of Childhood and Young Adult Cancer

Conference Gastroenterology · April 2017 Full text Cite

Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline.

Journal Article J Clin Oncol · March 10, 2017 Purpose Cardiac dysfunction is a serious adverse effect of certain cancer-directed therapies that can interfere with the efficacy of treatment, decrease quality of life, or impact the actual survival of the patient with cancer. The purpose of this effort w ... Full text Link to item Cite

Cardiovascular Risk Factors in Survivors of Childhood Hematopoietic Cell Transplantation Treated with Total Body Irradiation: A Longitudinal Analysis.

Journal Article Biol Blood Marrow Transplant · March 2017 Hematopoietic cell transplantation (HCT) survivors treated with total body irradiation (TBI) are known to be at increased risk for the development of cardiovascular risk factors (CVRFs). We sought to characterize the incidence of CVRFs in a TBI-exposed sur ... Full text Link to item Cite

Effect of Population Socioeconomic and Health System Factors on Medical Care of Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study.

Journal Article J Adolesc Young Adult Oncol · March 2017 PURPOSE: To determine the independent contribution of population socioeconomic and health system factors on childhood cancer survivors' medical care and screening. METHODS: 7899 childhood cancer survivors in the United States and Canada enrolled in the Chi ... Full text Link to item Cite

Impact of chronic disease on emotional distress in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · February 1, 2017 BACKGROUND: The current study was performed to examine associations between childhood cancer therapies, chronic health conditions, and symptoms of emotional distress in adult survivors of childhood cancer. METHODS: Participants included 5021 adult survivor ... Full text Link to item Cite

Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors.

Journal Article Ann Intern Med · January 17, 2017 BACKGROUND: The effect of temporal changes in cancer therapy on health status among childhood cancer survivors has not been evaluated. OBJECTIVE: To compare proportions of self-reported adverse health status outcomes among childhood cancer survivors across ... Full text Link to item Cite

Health-related Quality of Life (HR-QOL) and Chronic Health Conditions in Survivors of Childhood Acute Myeloid Leukemia (AML) with Down Syndrome (DS): A Report From the Children's Oncology Group.

Journal Article J Pediatr Hematol Oncol · January 2017 Survival rates for children with Down syndrome (DS) and acute myeloid leukemia (AML) are high; however, little is known regarding the health-related quality of life (HR-QOL) of these survivors. Individuals who survived ≥5 years following diagnosis of child ... Full text Link to item Cite

Survivorship Care

Chapter · January 1, 2017 With the aging of the general population and as a result of advances in prevention, screening, and treatment for cancer, the number of adult cancer survivors in the United States is anticipated to reach 20 million by the year 2026. Attention to the healthc ... Full text Cite

Risk and impact of pulmonary complications in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · December 1, 2016 BACKGROUND: Pulmonary complications after cancer therapy are varied. This study describes pulmonary outcomes among childhood cancer survivors and evaluates their impact on daily activities. METHODS: The incidence of pulmonary outcomes (asthma, chronic coug ... Full text Link to item Cite

Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium.

Journal Article J Clin Oncol · October 1, 2016 PURPOSE: Female survivors of childhood, adolescent, and young adult (CAYA) cancer who were treated with alkylating agents and/or radiation, with potential exposure of the ovaries, have an increased risk of premature ovarian insufficiency (POI). Clinical pr ... Full text Link to item Cite

A head and neck cancer intervention for use in survivorship clinics: A protocol for a feasibility study

Journal Article Pilot and Feasibility Studies · September 23, 2016 Background: Head and neck cancer survivors commonly experience severe long-term toxicities, late-occurring symptoms, and significant risks of the second primary malignancy and comorbid illnesses. With multiple simultaneous health issues, these complex canc ... Full text Cite

Endocrine Abnormalities in Aging Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · September 20, 2016 PURPOSE: The development of endocrinopathies in survivors of childhood cancer as they age remains understudied. We characterized endocrine outcomes in aging survivors from the Childhood Cancer Survivor Study on the basis of therapeutic exposures. PATIENTS ... Full text Link to item Cite

Chronic Conditions and Utility-Based Health-Related Quality of Life in Adult Childhood Cancer Survivors.

Journal Article J Natl Cancer Inst · September 2016 Health utility, a summary measure of quality of life, has not been previously used to compare outcomes among childhood cancer survivors and individuals without a cancer history. We estimated health utility (0, death; 1, perfect health) using the Short Form ... Full text Link to item Cite

Patterns and predictors of clustered risky health behaviors among adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Cancer · September 1, 2016 BACKGROUND: Health complications related to childhood cancer may be influenced by risky health behaviors (RHBs), particularly when RHBs co-occur. To the authors' knowledge, only limited information is available describing how RHBs cluster among survivors o ... Full text Link to item Cite

Childhood cancer survivorship research in minority populations: A position paper from the Childhood Cancer Survivor Study.

Journal Article Cancer · August 1, 2016 By the middle of this century, racial/ethnic minority populations will collectively constitute 50% of the US population. This temporal shift in the racial/ethnic composition of the US population demands a close look at the race/ethnicity-specific burden of ... Full text Link to item Cite

Abstract 2691: Genome-wide association study identifies two susceptibility loci that modify radiation-related risk for breast cancer after childhood cancer: A report from the Childhood Cancer Survivor Study and St. Jude Lifetime Cohort

Conference Cancer Research · July 15, 2016 AbstractBackground: Childhood cancer survivors treated with chest radiotherapy have substantially elevated risk for developing breast cancer. Although numerous breast cancer susceptibility variants have been ... Full text Cite

Late effects in patients with Fanconi anemia following allogeneic hematopoietic stem cell transplantation from alternative donors.

Journal Article Bone Marrow Transplant · July 2016 Hematopoietic stem cell transplantation (HSCT) is curative for hematological manifestations of Fanconi anemia (FA). We performed a retrospective analysis of 22 patients with FA and aplastic anemia, myelodysplastic syndrome or acute myelogenous leukemia who ... Full text Open Access Link to item Cite

Controversies in Breast Cancer Screening Strategies.

Conference J Natl Compr Canc Netw · May 2016 A panel discussion on controversies in breast cancer screening held recently at the NCCN 21st Annual Conference included only a few controversies. Representatives of the U.S. Preventive Services Task Force, American Cancer Society, and NCCN disagreed prima ... Full text Link to item Cite

Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort.

Journal Article Lancet Oncol · May 2016 BACKGROUND: The effect of many contemporary chemotherapeutic drugs on pregnancy and livebirth is not well established. We aimed to establish the effects of these drugs on pregnancy in male and female survivors of childhood cancer not exposed to pelvic or c ... Full text Link to item Cite

Incorrect Data in 2 Tables

Journal Article JAMA · April 5, 2016 Full text Open Access Cite

Clinical Breast Examination and Breast Cancer Screening Guideline--Reply.

Journal Article JAMA · April 5, 2016 Full text Link to item Cite

Health behaviors, quality of life, and psychosocial health among survivors of adolescent and young adult cancers.

Journal Article J Cancer Surviv · April 2016 PURPOSE: Survivors of adolescent and young adult (AYA) cancer may engage in unhealthy lifestyles (e.g., smoking), potentially heightening their risk for long-term health problems. We assessed health behaviors and constructs including quality of life (QOL) ... Full text Link to item Cite

Breast Cancer Risk in Childhood Cancer Survivors Without a History of Chest Radiotherapy: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · March 20, 2016 PURPOSE: Little is known about the breast cancer risk among childhood cancer survivors who did not receive chest radiotherapy. We sought to determine the magnitude of risk and associated risk factors for breast cancer among these women. PATIENTS AND METHOD ... Full text Link to item Cite

CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study.

Journal Article J Clin Oncol · March 10, 2016 PURPOSE: Interindividual variability in the dose-dependent association between anthracyclines and cardiomyopathy suggests that genetic susceptibility could play a role. The current study uses an agnostic approach to identify genetic variants that could mod ... Full text Link to item Cite

Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer.

Conference N Engl J Med · March 3, 2016 BACKGROUND: Among patients in whom childhood cancer was diagnosed in the 1970s and 1980s, 18% of those who survived for 5 years died within the subsequent 25 years. In recent decades, cancer treatments have been modified with the goal of reducing life-thre ... Full text Link to item Cite

Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study.

Journal Article Cancer · March 1, 2016 BACKGROUND: Limited data are available regarding long-term morbidity in adult survivors of retinoblastoma (Rb). METHODS: The Retinoblastoma Survivor Study is a retrospective cohort of adult survivors of Rb diagnosed between 1932 and 1994. Participants comp ... Full text Link to item Cite

Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update from the American Cancer Society

Journal Article Obstetrical and Gynecological Survey · March 1, 2016 Full text Cite

Tobacco Use Among Siblings of Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study.

Journal Article Pediatr Blood Cancer · February 2016 BACKGROUND: Having a brother or sister with childhood cancer may influence health behaviors during adulthood. The aim of this study was to compare tobacco use in siblings of survivors with peers and to identify factors associated with sibling tobacco use. ... Full text Link to item Cite

Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer.

Journal Article Biomed Res Int · 2016 Two-dimensional speckle tracking echocardiography (2DSTE) provides a sensitive measure of left ventricular (LV) systolic function and may aid in the diagnosis of cardiotoxicity. 2DSTE was performed in a cross-sectional study of 134 patients (mean age: 31.4 ... Full text Link to item Cite

Specialty care for adult survivors of childhood cancer.

Journal Article Cancer · December 15, 2015 Full text Link to item Cite

Enhancing Health Care of Survivors of Childhood Cancer With Tailored Education.

Journal Article J Clin Oncol · November 20, 2015 Full text Link to item Cite

Longitudinal smoking patterns in survivors of childhood cancer: An update from the Childhood Cancer Survivor Study.

Journal Article Cancer · November 15, 2015 BACKGROUND: Survivors of pediatric cancer have elevated risks of mortality and morbidity. Many late adverse effects associated with cancer treatment (eg, second cancers and cardiac and pulmonary disease) are also associated with cigarette smoking, and this ... Full text Link to item Cite

Equivalence Ratio for Daunorubicin to Doxorubicin in Relation to Late Heart Failure in Survivors of Childhood Cancer.

Journal Article J Clin Oncol · November 10, 2015 PURPOSE: Cumulative anthracycline dose is one of the strongest predictors of heart failure (HF) after cancer treatment. However, the differential risk for cardiotoxicity between daunorubicin and doxorubicin has not been rigorously evaluated among survivors ... Full text Link to item Cite

Breast cancer following spinal irradiation for a childhood cancer: A report from the Childhood Cancer Survivor Study.

Journal Article Radiother Oncol · November 2015 It has been suggested that pediatric patients treated with spinal irradiation may have an elevated risk of breast cancer. Among a cohort of 363 long-term survivors of a pediatric central nervous system tumor or leukemia treated with spinal irradiation, the ... Full text Link to item Cite

Psychosocial Outcomes in Adult Survivors of Retinoblastoma.

Journal Article J Clin Oncol · November 1, 2015 PURPOSE: Survival rates for individuals diagnosed with retinoblastoma (RB) exceed 95% in the United States; however, little is known about the long-term psychosocial outcomes of these survivors. PATIENTS AND METHODS: Adult RB survivors, diagnosed from 1932 ... Full text Link to item Cite

Health care utilization, lifestyle, and emotional factors and mammography practices in the Childhood Cancer Survivor Study.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2015 BACKGROUND: Women with a history of chest radiotherapy have an increased risk of breast cancer; however, many do not undergo annual recommended screening mammography. We sought to characterize the relationship between mammography and potentially modifiable ... Full text Link to item Cite

Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society.

Journal Article JAMA · October 20, 2015 IMPORTANCE: Breast cancer is a leading cause of premature mortality among US women. Early detection has been shown to be associated with reduced breast cancer morbidity and mortality. OBJECTIVE: To update the American Cancer Society (ACS) 2003 breast cance ... Full text Link to item Cite

Intestinal Obstruction in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · September 10, 2015 PURPOSE: For adult survivors of childhood cancer, knowledge about the long-term risk of intestinal obstruction from surgery, chemotherapy, and radiotherapy is limited. METHODS: Intestinal obstruction requiring surgery (IOS) occurring 5 or more years after ... Full text Link to item Cite

Identifying Predictors of Longitudinal Decline in the Level of Medical Care Received by Adult Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

Journal Article Health Serv Res · August 2015 OBJECTIVES: Characterize longitudinal changes in the use of medical care in adult survivors of childhood cancer. DATA SOURCES: The Childhood Cancer Survivor Study, a retrospective cohort study of 5+ year survivors of childhood cancer. STUDY DESIGN: Medical ... Full text Link to item Cite

Screening and management of adverse endocrine outcomes in adult survivors of childhood and adolescent cancer.

Journal Article Lancet Diabetes Endocrinol · July 2015 5 year survival for childhood and adolescent cancer in developed countries is now in excess of 80% and the number of survivors of cancer continues to increase worldwide. After completion of therapy, many of these survivors will face a lifelong risk of endo ... Full text Link to item Cite

TOBACCO USE BEHAVIORS AMONG SIBLINGS OF CHILDHOOD CANCER SURVIVORS: A REPORT FROM THE CHILDHOOD CANCER SURVIVOR STUDY

Conference PEDIATRIC BLOOD & CANCER · June 1, 2015 Link to item Cite

Supplemental security income and social security disability insurance coverage among long-term childhood cancer survivors.

Journal Article J Natl Cancer Inst · June 2015 Supplemental security income (SSI) and social security disability insurance (DI) are federal programs that provide disability benefits. We report on SSI/DI enrollment in a random sample of adult, long-term survivors of childhood cancer (n = 698) vs a compa ... Full text Link to item Cite

Predictors of colorectal cancer surveillance among survivors of childhood cancer treated with radiation: a report from the Childhood Cancer Survivor Study.

Journal Article Cancer · June 1, 2015 BACKGROUND: Childhood cancer survivors treated with radiotherapy to a field including the colon or rectum have an elevated risk of developing radiation-induced colorectal cancer (CRC). The Children's Oncology Group recommends colonoscopy every 5 years begi ... Full text Link to item Cite

Late morbidity and mortality in patients with Hodgkin's lymphoma treated during adulthood.

Journal Article J Natl Cancer Inst · April 2015 BACKGROUND: Survivors of Hodgkin's lymphoma (HL) treated as adults are at risk for late effects of therapy. However, the burden of late morbidity and mortality among adults treated for HL remains incompletely characterized. METHODS: Vital status and, for d ... Full text Link to item Cite

Survivors of childhood cancer in the United States: prevalence and burden of morbidity.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2015 BACKGROUND: No studies have estimated the population-level burden of morbidity in individuals diagnosed with cancer as children (ages 0-19 years). We updated prevalence estimates of childhood cancer survivors as of 2011 and burden of morbidity in this popu ... Full text Link to item Cite

Are we ready to predict late effects? A systematic review of clinically useful prediction models.

Journal Article Eur J Cancer · April 2015 BACKGROUND: After completing treatment for cancer, survivors may experience late effects: consequences of treatment that persist or arise after a latent period. PURPOSE: To identify and describe all models that predict the risk of late effects and could be ... Full text Link to item Cite

Individual prediction of heart failure among childhood cancer survivors.

Journal Article J Clin Oncol · February 10, 2015 PURPOSE: To create clinically useful models that incorporate readily available demographic and cancer treatment characteristics to predict individual risk of heart failure among 5-year survivors of childhood cancer. PATIENTS AND METHODS: Survivors in the C ... Full text Link to item Cite

Age-dependent changes in health status in the Childhood Cancer Survivor cohort.

Journal Article J Clin Oncol · February 10, 2015 PURPOSE: To compare age-dependent changes in health status among childhood cancer survivors and a sibling cohort. METHODS: Adult survivors of childhood cancer and siblings, all participants of the Childhood Cancer Survivor Study, completed three surveys as ... Full text Link to item Cite

Identifying and addressing the needs of adolescents and young adults with cancer: summary of an Institute of Medicine workshop.

Journal Article Oncologist · February 2015 Cancer is the leading disease-related cause of death in adolescents and young adults (AYAs). This population faces many short- and long-term health and psychosocial consequences of cancer diagnosis and treatment, but many programs for cancer treatment, sur ... Full text Link to item Cite

Second cancers

Chapter · January 7, 2015 Cite

Cancer survivorship

Chapter · January 7, 2015 Cite

Lifestyle, distress, and pregnancy outcomes in the Childhood Cancer Survivor Study cohort.

Journal Article Am J Obstet Gynecol · January 2015 OBJECTIVE: To evaluate associations between prepregnancy lifestyle factors, psychologic distress and adverse pregnancy outcomes among female survivors of childhood cancer. STUDY DESIGN: We examined pregnancies of 1192 female participants from the Childhood ... Full text Link to item Cite

American Cancer Society Colorectal Cancer Survivorship Care Guidelines.

Journal Article CA Cancer J Clin · 2015 Colorectal cancer (CRC) is the third most common cancer and third leading cause of cancer death in both men and women and second leading cause of cancer death when men and women are combined in the United States (US). Almost two-thirds of CRC survivors are ... Full text Link to item Cite

Increasing cardiomyopathy screening in at-risk adult survivors of pediatric malignancies: a randomized controlled trial.

Journal Article J Clin Oncol · December 10, 2014 PURPOSE: To determine whether the addition of advanced-practice nurse (APN) telephone counseling to a printed survivorship care plan (SCP) significantly increases the proportion of at-risk survivors who complete cardiomyopathy screening. PATIENTS AND METHO ... Full text Link to item Cite

LONG TERM FOLLOW UP OF EWING SARCOMA PATIENTS: THE MEMORIAL SLOAN KETTERING EXPERIENCE

Conference PEDIATRIC BLOOD & CANCER · December 1, 2014 Link to item Cite

Exercise and risk of major cardiovascular events in adult survivors of childhood hodgkin lymphoma: a report from the childhood cancer survivor study.

Journal Article J Clin Oncol · November 10, 2014 PURPOSE: Survivors of Hodgkin lymphoma (HL) are at increased risk of treatment-related cardiovascular (CV) events; whether exercise modifies this risk is unknown. METHODS: Survivors of HL (n = 1,187; median age, 31.2 years) completed a questionnaire evalua ... Full text Link to item Cite

Risk of Testicular Cancer Following Childhood Cancer Testicular Radiation

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Predicting adverse health outcomes in long-term survivors of a childhood cancer

Journal Article Children · September 1, 2014 More than 80% of children and young adults diagnosed with invasive cancer will survive five or more years beyond their cancer diagnosis. This population has an increased risk for serious illness-and treatment-related morbidity and premature mortality. A nu ... Full text Cite

Decline in physical activity level in the Childhood Cancer Survivor Study cohort.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2014 BACKGROUND: We aimed to identify demographic and health-related predictors of declining physical activity levels over a four-year period among participants in the Childhood Cancer Survivor Study. METHODS: Analyses included 7,287 ≥5-year childhood cancer su ... Full text Link to item Cite

Whole-body magnetic resonance imaging (WB-MRI) as surveillance for subsequent malignancies in survivors of hereditary retinoblastoma: a pilot study.

Journal Article Pediatr Blood Cancer · August 2014 BACKGROUND: Individuals with hereditary retinoblastoma (RB) are at very high risk of developing subsequent malignant neoplasms (SMNs) of which osteosarcoma (OS) is one of the most common. We hypothesized that annual surveillance using whole-body magnetic r ... Full text Link to item Cite

Breast cancer after chest radiation therapy for childhood cancer.

Journal Article J Clin Oncol · July 20, 2014 PURPOSE: The risk of breast cancer is high in women treated for a childhood cancer with chest irradiation. We sought to examine variations in risk resulting from irradiation field and radiation dose. PATIENTS AND METHODS: We evaluated cumulative breast can ... Full text Link to item Cite

Colorectal cancer survivors' needs and preferences for survivorship information.

Journal Article J Oncol Pract · July 2014 PURPOSE: Before developing a survivorship care plan (SCP) that colorectal cancer (CRC) survivors will value, understanding the informational needs of CRC survivors is critical. METHODS: We surveyed survivors treated for nonmetastatic CRC at two hospitals i ... Full text Link to item Cite

Risk of late effects of treatment in children newly diagnosed with standard-risk acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study cohort.

Journal Article Lancet Oncol · July 2014 BACKGROUND: Treatment of patients with paediatric acute lymphoblastic leukaemia has evolved such that the risk of late effects in survivors treated in accordance with contemporary protocols could be different from that noted in those treated decades ago. W ... Full text Link to item Cite

Childhood cancer, endocrine disorders, and cohort studies.

Journal Article Lancet · June 7, 2014 Full text Link to item Cite

DNA methylation and body-mass index: a genome-wide analysis.

Journal Article Lancet · June 7, 2014 BACKGROUND: Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although associations between several genetic variants and body-mass index (BMI) have been identified, little is known ... Full text Link to item Cite

Pain in cancer survivors.

Journal Article J Clin Oncol · June 1, 2014 Pain is a common problem in cancer survivors, especially in the first few years after treatment. In the longer term, approximately 5% to 10% of survivors have chronic severe pain that interferes with functioning. The prevalence is much higher in certain su ... Full text Link to item Cite

Exercise and risk of major cardiovascular events in adult survivors of childhood Hodgkin lymphoma: A report from the Childhood Cancer Survivor Study (CCSS).

Conference Journal of Clinical Oncology · May 20, 2014 Full text Cite

Cost-effectiveness of screening for asymptomatic left ventricular dysfunction in childhood cancer survivors.

Journal Article Ann Intern Med · May 20, 2014 Full text Link to item Cite

Causes of death in long-term survivors of head and neck cancer.

Journal Article Cancer · May 15, 2014 BACKGROUND: Survivors of head and neck squamous cell carcinoma (HNSCC) face excess mortality from multiple causes. METHODS: We used the population-based Surveillance, Epidemiology, and End Results (SEER) cancer registry data to evaluate the causes of death ... Full text Link to item Cite

Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor study.

Journal Article J Clin Oncol · April 20, 2014 PURPOSE: The first generation of childhood cancer survivors is now aging into their fourth and fifth decades of life, yet health risks across the aging spectrum are not well established. METHODS: Analyses included 14,359 5-year survivors from the Childhood ... Full text Link to item Cite

LATE CARDIAC ABNORMALITIES IN ADULT SURVIVORS OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA: A CARDIAC MRI STUDY

Conference Journal of the American College of Cardiology · April 2014 Full text Cite

Health conditions and quality of life in survivors of childhood acute myeloid leukemia comparing post remission chemotherapy to BMT: a report from the children's oncology group.

Journal Article Pediatr Blood Cancer · April 2014 BACKGROUND: Therapy for childhood acute myeloid leukemia (AML) has historically included chemotherapy with or without autologous bone marrow transplant (autoBMT) or allogeneic hematopoietic stem cell transplantation (alloBMT). We sought to compare health-r ... Full text Link to item Cite

Survivorship care plans: is there buy-in from community oncology providers?

Journal Article Cancer · March 1, 2014 BACKGROUND: The Institute of Medicine recommended that survivors of cancer and their primary care providers receive survivorship care plans (SCPs) to summarize cancer treatment and plan ongoing care. However, the use of SCPs remains limited. METHODS: Oncol ... Full text Link to item Cite

General internists' preferences and knowledge about the care of adult survivors of childhood cancer: a cross-sectional survey.

Journal Article Ann Intern Med · January 7, 2014 BACKGROUND: Adult childhood cancer survivors (CCSs) are at high risk for illness and premature death. Little is known about the physicians who provide their routine medical care. OBJECTIVE: To determine general internists' self-reported attitudes and knowl ... Full text Link to item Cite

Adolescent and young adult oncology, version 2.2014.

Journal Article J Natl Compr Canc Netw · January 2014 The NCCN Guidelines Insights on Adolescent and Young Adult (AYA) Oncology discuss the fertility and endocrine issues that are relevant to the management of AYA patients with cancer. Fertility preservation should be an essential part in the treatment of AYA ... Full text Link to item Cite

Models of cancer survivorship health care: moving forward.

Journal Article Am Soc Clin Oncol Educ Book · 2014 The population of cancer survivors in the United States and worldwide is rapidly increasing. Many survivors will develop health conditions as a direct or indirect consequence of their cancer therapy. Thus, models to deliver high-quality care for cancer sur ... Full text Link to item Cite

Solid tumor second primary neoplasms: who is at risk, what can we do?

Journal Article Semin Oncol · December 2013 Eighteen percent of incident malignancies in the United States are a second (or subsequent) cancer. Second primary neoplasms (SPNs), particularly solid tumors, are a major cause of mortality and serious morbidity among cancer survivors successfully cured o ... Full text Link to item Cite

Introduction: The science of survivorship: moving from risk to risk reduction.

Journal Article Semin Oncol · December 2013 Full text Link to item Cite

Recommendations for breast cancer surveillance for female survivors of childhood, adolescent, and young adult cancer given chest radiation: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

Journal Article Lancet Oncol · December 2013 Female survivors of childhood, adolescent, and young adult (CAYA) cancer who were given radiation to fields that include breast tissue (ie, chest radiation) have an increased risk of breast cancer. Clinical practice guidelines are essential to ensure that ... Full text Link to item Cite

Long-term cardiac safety and outcomes of dose-dense doxorubicin and cyclophosphamide followed by paclitaxel and trastuzumab with and without lapatinib in patients with early breast cancer.

Conference Cancer · November 15, 2013 BACKGROUND: The authors have previously reported 2 consecutive phase 2 trials in patients with early breast cancer that overexpresses human epidermal growth factor receptor 2 (HER2) to assess the feasibility of incorporating anti-HER2 therapies into dose-d ... Full text Link to item Cite

Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association.

Journal Article Circulation · October 22, 2013 Full text Link to item Cite

Modifiable risk factors and major cardiac events among adult survivors of childhood cancer.

Journal Article J Clin Oncol · October 10, 2013 PURPOSE: To evaluate the relative contribution of modifiable cardiovascular risk factors on the development of major cardiac events in aging adult survivors of childhood cancer. PATIENTS AND METHODS: Among 10,724 5-year survivors (median age, 33.7 years) a ... Full text Link to item Cite

LONG-TERM SEQUELAE IN SURVIVORS OF CHILDHOOD LEUKEMIA WITH DOWN SYNDROME: A MATCHED COHORT STUDY FROM THE CHILDHOOD CANCER SURVIVOR STUDY

Conference PEDIATRIC BLOOD & CANCER · September 1, 2013 Link to item Cite

LOWER DOSES OF CHEST RADIATION TO LARGE FIELDS MAY INCREASE BREAST CANCER RISK AMONG FEMALE CANCER SURVIVORS: A REPORT FROM THE CHILDHOOD CANCER SURVIVOR STUDY

Conference PEDIATRIC BLOOD & CANCER · September 1, 2013 Link to item Cite

Developing international consensus for late effects screening and guidance.

Journal Article Curr Opin Support Palliat Care · September 2013 PURPOSE OF REVIEW: Long-term follow-up (LTFU) of childhood cancer survivors is important in view of their high frequency of chronic medical problems, many of which may be serious, disabling or life-threatening. Several LTFU guidelines for the care of survi ... Full text Link to item Cite

Family physician preferences and knowledge gaps regarding the care of adolescent and young adult survivors of childhood cancer.

Journal Article J Cancer Surviv · September 2013 PURPOSE: Childhood cancer survivors are at risk for long-term morbidity and early mortality. Since most adult and some adolescent survivors of childhood cancer will receive their long-term care from a primary care physician, we sought to determine family p ... Full text Link to item Cite

Reduced cardiorespiratory fitness in adult survivors of childhood acute lymphoblastic leukemia.

Journal Article Pediatr Blood Cancer · August 2013 BACKGROUND: Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at increased cardiovascular risk. Studies of factors including treatment exposures that may modify risk of low cardiorespiratory fitness in this population have been limited. P ... Full text Link to item Cite

Survivor typologies predict medical surveillance participation: the childhood cancer survivor study.

Journal Article Psychooncology · July 2013 BACKGROUND: Adult survivors of childhood cancer adhere poorly to recommended medical surveillance. We sought to identify modifiable factors that contribute to non-adherence. METHODS: Latent class analysis categorized survivors (ages 18-52 years) at risk of ... Full text Link to item Cite

Long-term medical outcomes in survivors of extra-ocular retinoblastoma: the Memorial Sloan-Kettering Cancer Center (MSKCC) experience.

Journal Article Pediatr Blood Cancer · April 2013 BACKGROUND: Data on long-term outcomes of survivors of extra-ocular retinoblastoma are lacking. The authors sought to provide the first report characterizing long-term outcomes among survivors of extra-ocular retinoblastoma. PROCEDURE: Retrospective analys ... Full text Link to item Cite

A worldwide collaboration to harmonize guidelines for the long-term follow-up of childhood and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group.

Journal Article Pediatr Blood Cancer · April 2013 Childhood and young adult cancer survivors should receive optimum care to reduce the consequences of late effects and improve quality of life. We can facilitate achieving this goal by international collaboration in guideline development. In 2010, the Inter ... Full text Link to item Cite

Predictors of Colorectal Cancer Surveillance among Radiation-treated Survivors of Childhood Cancer

Conference Cancer Epidemiology, Biomarkers & Prevention · March 1, 2013 AbstractPurpose: To identify predictors of adherence to colorectal cancer (CRC) surveillance guidelines among survivors of childhood cancer who received ≥30 Gy radiotherapy to the abdomen, pelvis, or spine, ... Full text Cite

LABOR FORCE TRANSITIONS IN THE CHILDHOOD CANCER SURVIVOR STUDY

Conference ANNALS OF BEHAVIORAL MEDICINE · March 1, 2013 Link to item Cite

American Cancer Society lung cancer screening guidelines.

Journal Article CA: a cancer journal for clinicians · March 1, 2013 Findings from the National Cancer Institute's National Lung Screening Trial established that lung cancer mortality in specific high-risk groups can be reduced by annual screening with low-dose computed tomography. These findings indicate that the adoption ... Open Access Cite

American Society of Clinical Oncology statement: achieving high-quality cancer survivorship care.

Journal Article J Clin Oncol · February 10, 2013 Full text Link to item Cite

Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia.

Journal Article Cancer Causes Control · February 2013 PURPOSE: Determine the relationship between diet and metabolic abnormalities among adult survivors of childhood acute lymphoblastic leukemia (ALL). METHODS: We surveyed 117 adult survivors of childhood ALL using the Harvard Food Frequency Questionnaire. Ph ... Full text Link to item Cite

American Cancer Society lung cancer screening guidelines.

Journal Article CA Cancer J Clin · 2013 Findings from the National Cancer Institute's National Lung Screening Trial established that lung cancer mortality in specific high-risk groups can be reduced by annual screening with low-dose computed tomography. These findings indicate that the adoption ... Full text Link to item Cite

Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia.

Journal Article J Lipid Res · December 2012 Survivors of childhood acute lymphoblastic leukemia (ALL) have an increased risk of cardiovascular disease. Small density lipoproteins are atherogenic but have not been studied in this population. We conducted a cross-sectional analysis of 110 ALL survivor ... Full text Link to item Cite

Clear cell sarcoma of the gastrointestinal tract after very low-dose therapeutic radiation therapy: a case report.

Journal Article J Pediatr Surg · October 2012 Childhood cancer survivors are at risk for developing second malignant neoplasms. Very-low-dose therapeutic radiation therapy (RT) may be used to treat infants with Stage 4S neuroblastoma. We report a case of a patient who subsequently developed clear cell ... Full text Link to item Cite

Abdominal radiation and diabetes: one more piece in the puzzle.

Journal Article Lancet Oncol · October 2012 Full text Link to item Cite

Cancer survivors and the patient-centered medical home

Journal Article Translational Behavioral Medicine · September 1, 2012 Survivor care plans have been described as useful tools for enhancing the quality of follow-up care that cancer survivors receive after their active treatment has been completed. The relative success of current survivor care plan models is strongly depende ... Full text Cite

Adolescent and young adult oncology. Clinical practice guidelines in oncology.

Journal Article J Natl Compr Canc Netw · September 2012 Cancer is the leading cause of death among the adolescent and young adult (AYA) population, excluding homicide, suicide, or unintentional injury. AYA patients should be managed by a multidisciplinary team of health care professionals who are well-versed in ... Full text Link to item Cite

Hospitalization rates among survivors of childhood cancer in the Childhood Cancer Survivor Study cohort.

Journal Article Pediatr Blood Cancer · July 15, 2012 BACKGROUND: Chronic health conditions are common among long-term childhood cancer survivors, but hospitalization rates have not been reported. The objective of this study was to determine overall and cause-specific hospitalization rates among survivors of ... Full text Link to item Cite

Cancer prevention and screening practices of siblings of childhood cancer survivors: a report from the Childhood Cancer Survivor Study.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2012 BACKGROUND: To compare the skin and breast/cervical cancer prevention/screening practices of adult siblings of childhood cancer survivors with controls and to identify modifying factors for these practices. METHODS: Cross-sectional, self-report data from 2 ... Full text Link to item Cite

Summaries for patients. Increased risk for gastrointestinal cancer in childhood cancer survivors.

Journal Article Ann Intern Med · June 5, 2012 Full text Link to item Cite

Secondary gastrointestinal cancer in childhood cancer survivors: a cohort study.

Journal Article Ann Intern Med · June 5, 2012 BACKGROUND: Childhood cancer survivors develop gastrointestinal cancer more frequently and at a younger age than the general population, but the risk factors have not been well-characterized. OBJECTIVE: To determine the risk and associated risk factors for ... Full text Link to item Cite

Response to a treatment summary and care plan among adult survivors of pediatric and young adult cancer

Journal Article Journal of Oncology Practice · May 1, 2012 Purpose: Survivors of pediatric and young adult cancer are at increased risk for treatment-related problems. Yet, few survivors receive risk-based care. The treatment summary and care plan are recommended to improve understanding of cancer treatment, poten ... Full text Cite

Survivor profiles predict health behavior intent: the Childhood Cancer Survivor Study.

Journal Article Psychooncology · May 2012 OBJECTIVES: To determine whether unique groups of adult childhood cancer survivors could be defined on the basis of modifiable cognitive, affective, and motivation indicators. Secondary objectives were to examine to what extent group membership co-varied w ... Full text Link to item Cite

Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.

Journal Article J Clin Oncol · May 1, 2012 PURPOSE: Carbonyl reductases (CBRs) catalyze reduction of anthracyclines to cardiotoxic alcohol metabolites. Polymorphisms in CBR1 and CBR3 influence synthesis of these metabolites. We examined whether single nucleotide polymorphisms in CBR1 (CBR1 1096G>A) ... Full text Link to item Cite

THE SURVIVOR PROGRAM TO EMPOWER ACTION IN CARE (SPEAC): PRE-PILOT TESTING

Conference ANNALS OF BEHAVIORAL MEDICINE · April 1, 2012 Link to item Cite

SUPERIORITY OF 2D MYOCARDIAL STRAIN IMAGING IN THE DETECTION OF LATE-ONSET TREATMENT RELATED CARDIAC TOXICITY IN ASYMPTOMATIC ADULT SURVIVORS OF CHILDHOOD CANCER

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 27, 2012 Link to item Cite

Physical activity among adult survivors of childhood lower-extremity sarcoma.

Journal Article J Cancer Surviv · March 2012 INTRODUCTION: Adult survivors of childhood lower-extremity sarcoma are largely physically inactive, a behavior which potentially compounds their health burden. Altering this behavior requires understanding those factors that contribute to their physical in ... Full text Link to item Cite

Risk factors for obesity in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · January 20, 2012 PURPOSE: Many Childhood Cancer Survivor Study (CCSS) participants are at increased risk for obesity. The etiology of their obesity is likely multifactorial but not well understood. PATIENTS AND METHODS: We evaluated the potential contribution of demographi ... Full text Link to item Cite

Adult cancer survivors discuss follow-up in primary care: 'not what i want, but maybe what i need'.

Journal Article Ann Fam Med · 2012 BACKGROUND Nearly one-third of office visits for cancer are handled by primary care physicians. Yet, few studies examine patient perspectives on these physicians' roles in their cancer follow-up care or their care preferences. METHODS We explored survivor ... Full text Link to item Cite

Primary care providers' needs and preferences for information about colorectal cancer survivorship care.

Journal Article J Am Board Fam Med · 2012 BACKGROUND: The Institute of Medicine (IOM) proposed that cancer survivors and their primary care providers (PCPs) should receive survivorship care plans to inform ongoing care. We aimed to determine PCPs' preferences for the content of survivorship care p ... Full text Link to item Cite

Survivorship care plans in research and practice.

Journal Article CA Cancer J Clin · 2012 The Institute of Medicine (IOM) recommends the use of survivorship care plans (SCPs) for all cancer survivors. Developing useful SCPs requires understanding what survivors and their providers need and how SCPs can be implemented in practice. Published stud ... Full text Link to item Cite

Adipokines, body fatness, and insulin resistance among survivors of childhood leukemia.

Journal Article Pediatr Blood Cancer · January 2012 BACKGROUND: Following our previous reports of an increased prevalence of insulin resistance and adiposity among acute lymphoblastic leukemia (ALL) survivors, particularly women treated with cranial radiotherapy (CRT), we aimed to (1) assess the relationshi ... Full text Link to item Cite

Obesity following childhood cancer: Mechanisms and consequences

Chapter · January 1, 2012 Due to advances in the treatment of pediatric cancer, the population of adult survivors has increased dramatically. Many survivors face a significant threat of becoming overweight, obese, and insulin resistant. In this chapter, we present four case vignett ... Full text Cite

Childhood cancer survivorship educational resources in North American pediatric hematology/oncology fellowship training programs: a survey study.

Journal Article Pediatr Blood Cancer · December 15, 2011 BACKGROUND: Childhood cancer survivors require life-long care by clinicians with an understanding of the specific risks arising from the prior cancer and its therapy. We surveyed North American pediatric hematology/oncology training programs to evaluate th ... Full text Link to item Cite

Twenty-five year follow-up of childhood Wilms tumor: a report from the Childhood Cancer Survivor Study.

Journal Article Pediatr Blood Cancer · December 15, 2011 BACKGROUND: Treatment cures over 90% of children with Wilms tumor (WT) who subsequently risk late morbidity and mortality. This study describes the 25-year outcomes of 5-year WT survivors in the Childhood Cancer Survivor Study (CCSS). PROCEDURE: The CCSS, ... Full text Link to item Cite

LONGITUDINAL CHANGES IN HEALTH STATUS OF THE CHILDHOOD CANCER SURVIVOR COHORT

Conference PEDIATRIC BLOOD & CANCER · November 1, 2011 Link to item Cite

Methods to assess adverse health-related outcomes in cancer survivors.

Journal Article Cancer Epidemiol Biomarkers Prev · October 2011 Designing a study focused on adverse health-related outcomes among cancer survivors is complex. Similarly, reading and interpreting the findings of a survivorship-focused study requires an appreciation of the complexities of study design, potential biases, ... Full text Link to item Cite

Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS).

Journal Article Blood · August 4, 2011 HSCT is being increasingly offered as a curative option for children with hematologic malignancies. Although survival has improved, the long-term morbidity ascribed to the HSCT procedure is not known. We compared the risk of chronic health conditions and a ... Full text Link to item Cite

Occupational outcomes of adult childhood cancer survivors: A report from the childhood cancer survivor study.

Journal Article Cancer · July 1, 2011 BACKGROUND: The authors examined whether survivors from the Childhood Cancer Survivor Study were less likely to be in higher-skill occupations than a sibling comparison and whether certain survivors were at higher risk for lower-skill jobs. METHODS: The au ... Full text Link to item Cite

Physician preferences and knowledge gaps regarding the care of childhood cancer survivors: A survey of the American Academy of Family Physicians (AAFP).

Conference Journal of Clinical Oncology · May 20, 2011 Full text Cite

Cardiorespiratory fitness in adult survivors of childhood acute lymphoblastic leukemia (ALL).

Conference Journal of Clinical Oncology · May 20, 2011 Full text Cite

Survivorship care plans for colorectal cancer survivors: What do primary care providers want and need?

Conference Journal of Clinical Oncology · May 20, 2011 Full text Cite

Impact of traditional cardiovascular disease risk factors on long-term cardiovascular outcome in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Conference Journal of Clinical Oncology · May 20, 2011 Full text Cite

The cancer is over, now what?: Understanding risk, changing outcomes.

Journal Article Cancer · May 15, 2011 About 26,000 adolescents and young adults ages 15 to 29 years are diagnosed with invasive cancer each year. Although >80% will survive beyond 5 years from their cancer diagnosis, many will develop serious morbidity or die prematurely secondary to health pr ... Full text Link to item Cite

Research challenges in adolescent and young adult cancer survivor research.

Journal Article Cancer · May 15, 2011 Every year in Canada and the United States, about 26,000 adolescent and young adults (AYA) between ages 15 and 29 years are diagnosed with cancer. Although the majority of AYA cancer patients will survive their primary cancer, many will develop serious hea ... Full text Link to item Cite

Survivors of childhood cancer have increased risk of gastrointestinal complications later in life.

Journal Article Gastroenterology · May 2011 BACKGROUND & AIMS: Children who receive cancer therapy experience numerous acute gastrointestinal (GI) toxicities. However, the long-term GI consequences have not been extensively studied. We evaluated the incidence of long-term GI outcomes and identified ... Full text Link to item Cite

Impact of insurance type on survivor-focused and general preventive health care utilization in adult survivors of childhood cancer: the Childhood Cancer Survivor Study (CCSS).

Journal Article Cancer · May 1, 2011 BACKGROUND: Lack of health insurance is a key barrier to accessing care for chronic conditions and cancer screening. The influence of insurance type (private, public, none) on survivor-focused and general preventive health care in adult survivors of childh ... Full text Link to item Cite

Increasing rates of breast cancer and cardiac surveillance among high-risk survivors of childhood Hodgkin lymphoma following a mailed, one-page survivorship care plan.

Journal Article Pediatr Blood Cancer · May 2011 BACKGROUND: Hodgkin lymphoma (HL) survivors face substantially elevated risks of breast cancer and cardiovascular disease. They and their physicians are often unaware of these risks and surveillance recommendations. PROCEDURE: A prospective one-arm study w ... Full text Link to item Cite

LATE CARDIAC ABNORMALITIES AFTER ANTHRACYCLINE THERAPY IN ASYMPTOMATIC ADULT SURVIVORS OF CHILDHOOD CANCER: LONG-TERM FOLLOW-UP STUDY FROM THE MEMORIAL SLOAN-KETTERING CANCER CENTER

Conference Journal of the American College of Cardiology · April 2011 Full text Cite

Screening breast MR imaging in women with a history of chest irradiation.

Journal Article Radiology · April 2011 PURPOSE: To assess the utility of screening magnetic resonance (MR) imaging in detecting otherwise occult breast cancers in women with a history of radiation therapy to the chest. MATERIALS AND METHODS: This HIPAA-compliant study was approved by the author ... Full text Link to item Cite

Physical therapy and chiropractic use among childhood cancer survivors with chronic disease: impact on health-related quality of life.

Journal Article J Cancer Surviv · March 2011 INTRODUCTION: The use of rehabilitation services to address musculoskeletal, neurological and cardiovascular late effects among childhood cancer survivors could improve physical function and health-related quality-of-life (HRQL). We describe physical thera ... Full text Link to item Cite

LATE GASTROINTESTINAL SEQUELAE IN SURVIVORS OF CHILDHOOD CANCER: A REPORT FROM THE CHILDHOOD CANCER SURVIVOR STUDY

Conference PEDIATRIC BLOOD & CANCER · November 1, 2010 Link to item Cite

Unemployment among adult survivors of childhood cancer: a report from the childhood cancer survivor study.

Journal Article Med Care · November 2010 BACKGROUND: Adult childhood cancer survivors report high levels of unemployment, although it is unknown whether this is because of health or employability limitations. OBJECTIVES: We examined 2 employment outcomes from 2003 in the Childhood Cancer Survivor ... Full text Link to item Cite

Screening and surveillance for second malignant neoplasms in adult survivors of childhood cancer: a report from the childhood cancer survivor study.

Journal Article Ann Intern Med · October 5, 2010 BACKGROUND: Survivors of childhood cancer may develop a second malignant neoplasm during adulthood and therefore require regular surveillance. OBJECTIVE: To examine adherence to population cancer screening guidelines by survivors at average risk for a seco ... Full text Link to item Cite

Inconsistent mammography perceptions and practices among women at risk of breast cancer following a pediatric malignancy: a report from the Childhood Cancer Survivor Study.

Journal Article Cancer Causes Control · October 2010 Women treated with chest radiation for a pediatric cancer have low mammography screening rates despite their high risk for breast cancer. This study characterized the relationship between perceptions of mammography and screening practices. A cross-sectiona ... Full text Link to item Cite

Long-term survivors of childhood Ewing sarcoma: report from the childhood cancer survivor study.

Journal Article J Natl Cancer Inst · August 18, 2010 BACKGROUND: The survival of Ewing sarcoma (ES) patients has improved since the 1970s but is associated with considerable future health risks. METHODS: The study population consisted of long-term (> or =5-year) survivors of childhood ES diagnosed before age ... Full text Link to item Cite

Testicular cancer survivorship: research strategies and recommendations.

Journal Article J Natl Cancer Inst · August 4, 2010 Testicular cancer represents the most curable solid tumor, with a 10-year survival rate of more than 95%. Given the young average age at diagnosis, it is estimated that effective treatment approaches, in particular, platinum-based chemotherapy, have result ... Full text Link to item Cite

Gastrointestinal malignancies as a subsequent malignant neoplasm in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

Conference Journal of Clinical Oncology · May 20, 2010 Full text Cite

Chronic medical conditions, health status, and health care practices at 25 years in 5-year survivors of Wilms tumor: A report from the Childhood Cancer Survivor Study.

Conference Journal of Clinical Oncology · May 20, 2010 Full text Cite

Anthracycline-related cardiomyopathy in childhood cancer survivors and association with polymorphisms in the carbonyl reductase genes: A Children's Oncology Group study.

Conference Journal of Clinical Oncology · May 20, 2010 Full text Cite

Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer.

Journal Article Ann Intern Med · April 6, 2010 BACKGROUND: Women treated with therapeutic chest radiation may develop breast cancer. PURPOSE: To summarize breast cancer risk and breast cancer surveillance in women after chest radiation for pediatric or young adult cancer. DATA SOURCES: Studies from MED ... Full text Link to item Cite

Knowledge of hepatitis C virus screening in long-term pediatric cancer survivors: a report from the Childhood Cancer Survivor Study.

Journal Article Cancer · February 15, 2010 BACKGROUND: Pediatric cancer survivors who were treated before routine hepatitis C virus (HCV) screening of blood donors in 1992 have an elevated risk of transfusion-acquired HCV. METHODS: To assess long-term pediatric cancer survivors' knowledge of HCV te ... Full text Link to item Cite

Challenges after curative treatment for childhood cancer and long-term follow up of survivors.

Journal Article Hematol Oncol Clin North Am · February 2010 Childhood cancer survivors are at increased risk of serious morbidity, premature mortality, and diminished health status. Proactive and anticipatory risk-based health care of survivors and healthy lifestyles can reduce these risks. In this article, the aut ... Full text Link to item Cite

Cardiovascular risk factors in adult survivors of pediatric cancer--a report from the childhood cancer survivor study.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2010 BACKGROUND: Childhood cancer survivors are at higher risk of morbidity and mortality from cardiovascular disease compared with the general population. METHODS: Eight thousand five hundred ninety-nine survivors (52% male) and 2,936 siblings (46% male) from ... Full text Link to item Cite

Survey of long-term follow-up programs in the United States for survivors of childhood brain tumors.

Journal Article Pediatr Blood Cancer · December 15, 2009 INTRODUCTION: Despite recognition that childhood brain tumor survivors often suffer multiple late effects following therapy, little is known regarding the long-term follow-up (LTFU) programs for these patients. METHODS: A 16-question survey was mailed to m ... Full text Link to item Cite

Survivorship: childhood cancer survivors.

Journal Article Prim Care · December 2009 Late effects of therapy for childhood cancer are frequent and serious. Fortunately, many late effects are also modifiable. Proactive and anticipatory risk-based care can reduce the frequency and severity of treatment-related morbidity. The primary care cli ... Full text Link to item Cite

Second primary cancers in survivors of childhood cancer.

Journal Article Lancet · October 31, 2009 Full text Link to item Cite

Missed Opportunities: Breast Cancer Surveillance and Pediatric Cancer Survivors

Journal Article Breast Diseases · September 17, 2009 Full text Cite

Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot study.

Journal Article Bone Marrow Transplant · September 2009 Impairment of glucose metabolism (in particular insulin resistance and type 2 diabetes mellitus) has been reported in patients who have undergone hematopoietic SCT (HSCT) during childhood, especially those treated with TBI. This pilot study was conducted t ... Full text Link to item Cite

Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: a report for the childhood cancer survivor study.

Journal Article Arch Intern Med · August 10, 2009 BACKGROUND: Childhood cancer survivors are at increased risk of morbidity and mortality. To further characterize this risk, this study aimed to compare the prevalence of diabetes mellitus (DM) in childhood cancer survivors and their siblings. METHODS: Part ... Full text Link to item Cite

Insulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia.

Journal Article J Clin Oncol · August 1, 2009 PURPOSE: To determine the prevalence of insulin resistance and other risk factors for cardiovascular disease (CVD) in young adult survivors of childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: In this cross-sectional evaluation of 118 sur ... Full text Link to item Cite

Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer

Journal Article Obstetrical and Gynecological Survey · July 1, 2009 Full text Cite

Cancer screening in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS)

Conference JOURNAL OF CLINICAL ONCOLOGY · June 20, 2009 Link to item Cite

Late mortality and morbidity of patients with Hodgkin lymphoma treated in adulthood

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2009 Link to item Cite

Cancer screening in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS)

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2009 Link to item Cite

High-risk populations identified in Childhood Cancer Survivor Study investigations: implications for risk-based surveillance.

Journal Article J Clin Oncol · May 10, 2009 Childhood cancer survivors often experience complications related to cancer and its treatment that may adversely affect quality of life and increase the risk of premature death. The purpose of this manuscript is to review how data derived from Childhood Ca ... Full text Link to item Cite

Chronic disease in the Childhood Cancer Survivor Study cohort: a review of published findings.

Journal Article J Clin Oncol · May 10, 2009 Full text Link to item Cite

Health behaviors, medical care, and interventions to promote healthy living in the Childhood Cancer Survivor Study cohort.

Journal Article J Clin Oncol · May 10, 2009 Childhood cancer survivors are at risk for medical and psychosocial late effects as a result of their cancer and its therapy. Promotion of healthy lifestyle behaviors and provision of regular risk-based medical care and surveillance may modify the evolutio ... Full text Link to item Cite

Medical care in adult survivors of childhood cancer: Data from the Childhood Cancer Survivor Study (CCSS)

Journal Article American Journal of Hematology Oncology · May 1, 2009 Many adult survivors of childhood cancer do not receive regular medical care focused on the long-term risks arising from their prior therapy. A minority of at-risk survivors undergo surveillance for cardiac dysfunction and secondary breast cancers. Survivo ... Cite

Predictors of inactive lifestyle among adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Journal Article Cancer · May 1, 2009 BACKGROUND: : Participation in physical activity is important for childhood cancer survivors, because inactivity may compound cancer/treatment-related late effects. However, some survivors may have difficulty participating in physical activity, and these i ... Full text Link to item Cite

Medical screening participation in the childhood cancer survivor study.

Conference Arch Intern Med · March 9, 2009 BACKGROUND: Despite their risk for serious late sequelae, survivors of childhood cancer do not adhere to recommended medical screening guidelines. We identified treatment, survivor, physician, and contextual factors that may influence survivor adherence to ... Full text Link to item Cite

Assessment of selection bias in clinic-based populations of childhood cancer survivors: a report from the childhood cancer survivor study.

Journal Article Pediatr Blood Cancer · March 2009 BACKGROUND: It is not known to what extent prevalence estimates of late effects among childhood cancer survivors derived from clinic based samples represent the actual estimates that would be derived if the entire population of childhood cancer survivors w ... Full text Link to item Cite

Promoting physical activity in childhood cancer survivors: results from the Childhood Cancer Survivor Study.

Journal Article Cancer · February 1, 2009 BACKGROUND: Although physical activity may modify the late effects of childhood cancer treatment, from 20% to 52% of adult survivors are sedentary. The authors of this report sought to identify modifiable factors that influence survivors' participation in ... Full text Link to item Cite

Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer.

Journal Article JAMA · January 28, 2009 CONTEXT: Women treated with chest radiation for a pediatric malignancy have a significantly increased risk of breast cancer at a young age and are recommended to have an annual screening mammogram starting at age 25 years or 8 years after radiation, whiche ... Full text Link to item Cite

Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · October 1, 2008 PURPOSE: We examined the rate of increase in the body mass index (BMI; kg/m(2)) after final height attainment in survivors of acute lymphoblastic leukemia (ALL) and a noncancer comparison group. METHODS: Childhood Cancer Survivor Study (CCSS) is a retrospe ... Full text Link to item Cite

Medical care in long-term survivors of childhood cancer: a report from the childhood cancer survivor study.

Journal Article J Clin Oncol · September 20, 2008 PURPOSE: To evaluate whether childhood cancer survivors receive regular medical care focused on the specific morbidities that can arise from their therapy. PATIENTS AND METHODS: We conducted a cross-sectional survey of health care use in 8,522 participants ... Full text Link to item Cite

Coronary artery disease after radiation therapy for Hodgkin's lymphoma: coronary CT angiography findings and calcium scores in nine asymptomatic patients.

Journal Article AJR Am J Roentgenol · July 2008 OBJECTIVE: Long-term survivors of Hodgkin's lymphoma treated with radiation therapy have an increased incidence of coronary artery disease. The purpose of this study is to describe the coronary CT angiography findings and calcium scores of asymptomatic pat ... Full text Link to item Cite

Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.

Journal Article Blood · June 15, 2008 Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for late effects of cancer therapy. Five-year ALL survivors (< 21 years at diagnosis; n = 5760 eligible, 4151 participants), diagnosed from 1970 to 1986 were compared with the general po ... Full text Link to item Cite

Psychosocial functioning in survivors of Hodgkin lymphoma (HL) treated during adulthood

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2008 Link to item Cite

Survey of long-term follow-up programs in the United States for adult survivors of childhood brain tumors

Conference Journal of Clinical Oncology · May 20, 2008 Full text Cite

Prevalence of late morbidity in survivors of Hodgkin’s lymphoma (HL) treated during adulthood

Conference Journal of Clinical Oncology · May 20, 2008 Full text Cite

Health-related quality of life (HR-QOL) and chronic health conditions (CHC) in survivors of childhood acute myelogenous leukemia (AML)

Conference Journal of Clinical Oncology · May 20, 2008 Full text Cite

Follow-up of childhood cancer survivors: The role of the primary care physician

Journal Article Consultant · May 1, 2008 As the cure rates for childhood cancer have increased, the number of adult survivors of childhood cancer has grown. These adult survivors have unique health problems, many of which do not become apparent until 20 or 30 years after treatment for cancer. Neu ... Cite

A risk-based approach to the care of survivors of childhood cancer: 3 Case studies

Journal Article Consultant · May 1, 2008 Cite

Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia: a report from the Childhood Cancer Survivor Study.

Journal Article Cancer · May 1, 2008 BACKGROUND: Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML). METHODS: This analysis included 272 5-year AML survivors who participated ... Full text Link to item Cite

Imaging of late complications from mantle field radiation in lymphoma patients.

Journal Article Radiol Clin North Am · March 2008 Hodgkin lymphoma is one of the most curable cancers because of its sensitivity to both radiation and several chemotherapy agents. Radical radiotherapy alone provided curative therapy for patients who had Hodgkin lymphoma as early as six decades ago. Yet, t ... Full text Link to item Cite

Shared care of adult survivors of childhood cancers.

Journal Article Lancet Oncol · March 2008 Full text Link to item Cite

Are survivors of acute lymphoblastic leukemia (ALL) at increased risk of cardiovascular disease?

Journal Article Pediatr Blood Cancer · February 2008 Through a variety of different mechanisms, it appears that survivors of childhood acute lymphoblastic leukemia have an increased prevalence of several cardiovascular risk factors and thus are at increased risk for developing cardiovascular disease. The aim ... Full text Link to item Cite

Challenges after curative treatment for childhood cancer and long-term follow up of survivors.

Journal Article Pediatr Clin North Am · February 2008 Childhood cancer survivors are at increased risk of serious morbidity, premature mortality, and diminished health status. Proactive and anticipatory risk-based health care of survivors and healthy lifestyles can reduce these risks. In this article, the aut ... Full text Link to item Cite

Survivorship after childhood, adolescent, and young adult cancer.

Journal Article Cancer J · 2008 Survivors of pediatric and young adult cancers face lifetime risks associated with their cancer therapy, with a significant proportion at risk for serious morbidity and premature mortality. This growing population has complex healthcare needs. In this arti ... Full text Link to item Cite

Screening adult survivors of childhood cancer with the distress thermometer: a comparison with the SCL-90-R.

Journal Article Psychooncology · November 2007 As the number of cancer survivors continues to grow, identification of brief, valid psychological screening measures will be a critical step in providing them with appropriate psychosocial care. The distress thermometer (DT) is a one-item distress screenin ... Full text Link to item Cite

Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia.

Journal Article J Clin Endocrinol Metab · October 2007 CONTEXT: Survivors of childhood acute lymphoblastic leukemia (ALL) become obese, and are at increased risk for morbidity and mortality post therapy. OBJECTIVE: We determined the association of cranial radiotherapy (CRT) and/or sex with levels of total, reg ... Full text Link to item Cite

Prevalence of symptoms, medical conditions post diagnosis, physical functioning and communication with doctors among adult non-Hodgkin lymphoma survivors

Conference PSYCHO-ONCOLOGY · September 1, 2007 Link to item Cite

Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study.

Journal Article Cancer Epidemiol Biomarkers Prev · July 2007 PURPOSE: To determine if adult survivors of childhood acute lymphoblastic leukemia (ALL) are less active (and more inactive) than the general population and to identify modifying factors. PATIENTS AND METHODS: Physical activity was assessed by self-report ... Full text Link to item Cite

Childhood cancer survivors, late effects, and a new model for understanding survivorship.

Journal Article JAMA · June 27, 2007 Full text Link to item Cite

Risk of stroke among long-term survivors of childhood brain tumors: A report from the childhood cancer survivor study

Conference NEURO-ONCOLOGY · April 1, 2007 Link to item Cite

Follow-up care in cancer survivors: Newsletters cannot do it alone - A report from the childhood cancer survivor study

Conference PSYCHO-ONCOLOGY · March 1, 2007 Link to item Cite

Dr. Oeffinger and colleagues reply [12]

Journal Article New England Journal of Medicine · January 11, 2007 Cite

Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · November 20, 2006 PURPOSE: This report examines the incidence of and risk factors for strokes that occur in > or = 5-year survivors of childhood leukemia and brain tumors. PATIENTS AND METHODS: The rate of first occurrence of self-reported late-occurring strokes was determi ... Full text Link to item Cite

Models for delivering survivorship care.

Journal Article J Clin Oncol · November 10, 2006 Survivors of adult cancer face lifetime health risks that are dependent on their cancer, cancer treatment exposures, comorbid health conditions, genetic predispositions, and lifestyle behaviors. Content, intensity, and frequency of health care that address ... Full text Link to item Cite

Chronic health conditions in adult survivors of childhood cancer.

Journal Article N Engl J Med · October 12, 2006 BACKGROUND: Only a few small studies have assessed the long-term morbidity that follows the treatment of childhood cancer. We determined the incidence and severity of chronic health conditions in adult survivors. METHODS: The Childhood Cancer Survivor Stud ... Full text Link to item Cite

Comprehensive long-term follow-up programs for pediatric cancer survivors.

Journal Article Cancer · August 15, 2006 BACKGROUND: The objective of this study was to provide a detailed description of comprehensive long-term follow-up (LTFU) programs for pediatric cancer survivors. METHODS: Program directors from 24 comprehensive LTFU programs in the U.S. and Canada complet ... Full text Link to item Cite

Advocacy skills training for young adult cancer survivors: the Young Adult Survivors Conference at Camp Māk-a-Dream.

Journal Article Support Care Cancer · July 2006 GOALS OF THE WORK: This manuscript reports on the design, implementation, and evaluation of the Young Adult Survivor Conference (YASC)-a 4-day retreat designed to provide an educational and support experience for cancer survivors diagnosed as children, ado ... Full text Link to item Cite

Incidence and clinical relevance of abnormal complete blood counts in long-term survivors of childhood cancer.

Journal Article Cancer · April 1, 2006 BACKGROUND: The purpose of the study was to determine the incidence and clinical significance of abnormal complete blood counts (CBCs) obtained during follow-up of childhood cancer survivors. METHODS: A retrospective cohort study was conducted on 193 survi ... Full text Link to item Cite

In reply [2]

Journal Article Journal of Clinical Oncology · March 20, 2006 Full text Cite

Advocacy skills training for young adult cancer survivors: The Young Adult Survivors Conference (YASC) at Camp Make-a-Dream

Conference PSYCHO-ONCOLOGY · February 1, 2006 Link to item Cite

Barriers to follow-up care of survivors in the United States and the United Kingdom.

Journal Article Pediatr Blood Cancer · February 2006 Survivors of pediatric cancer face an increased risk of morbidity, mortality, and diminished quality of life associated with their previous cancer therapy. Because these risks are often modifiable, periodic lifetime medical follow-up is recommended for all ... Full text Link to item Cite

The impact of psychosocial factors on access to care in adult minority survivors of childhood cancer: A childhood cancer survivor study.

Conference JOURNAL OF INVESTIGATIVE MEDICINE · January 1, 2006 Link to item Cite

Obesity in pediatric oncology.

Journal Article Pediatr Blood Cancer · December 2005 Today's obesity pandemic began in the United States, spread to Western Europe and other developed regions, and is emerging in developing countries. Its influences on outcomes of childhood cancer are unknown. A recent Children's Oncology Group symposium con ... Full text Link to item Cite

Limitations on physical performance and daily activities among long-term survivors of childhood cancer.

Journal Article Ann Intern Med · November 1, 2005 BACKGROUND: Survivors of childhood cancer may experience important disease- and treatment-related late effects, including functional limitations. OBJECTIVE: This study evaluated performance limitations and restricted abilities to participate in personal ca ... Full text Link to item Cite

Stroke as a late treatment effect of Hodgkin's Disease: a report from the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · September 20, 2005 PURPOSE: The objectives of this report are to examine the incidence of and risk factors for stroke among childhood Hodgkin's disease (HD) survivors. PATIENTS AND METHODS: The Childhood Cancer Survivor Study is a multi-institutional cohort study of more tha ... Full text Link to item Cite

Minority adult survivors of childhood cancer: a comparison of long-term outcomes, health care utilization, and health-related behaviors from the childhood cancer survivor study.

Journal Article J Clin Oncol · September 20, 2005 PURPOSE: To determine the influence of race/ethnicity on outcomes in the Childhood Cancer Survivor Study (CCSS). PATIENTS AND METHODS: Of CCSS adult survivors in the United States, 443 (4.9%) were black, 503 (5.6%) were Hispanic and 7,821 (86.6%) were whit ... Full text Link to item Cite

Body mass index in long-term adult survivors of childhood cancer: a report of the Childhood Cancer Survivor Study.

Journal Article Cancer · April 15, 2005 BACKGROUND: The goals of the current study were to determine the distribution of body mass index (BMI) of survivors of common pediatric malignancies and to identify factors associated with abnormal BMI. METHODS: The Childhood Cancer Survivor Study (CCSS) i ... Full text Link to item Cite

Care of cancer survivors.

Journal Article Am Fam Physician · February 15, 2005 Cancer survivors are at increased risk for recurrence of their original malignancy; development of second primary malignancies; and medical, developmental, and psychologic problems resulting from cancer therapy, genetic predisposition to cancer, and other ... Link to item Cite

Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing Discipline.

Journal Article J Clin Oncol · December 15, 2004 The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers are risk-based, exposure-related clinical practice guidelines intended to promote earlier detection of and intervention for complic ... Full text Link to item Cite

Screening for therapy-related second cancers.

Conference CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION · November 1, 2004 Link to item Cite

Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · September 1, 2004 PURPOSE: Overweight (body mass index [BMI] 25 to 29 kg/m2) and obesity (BMI > or = 30 kg/m2) frequently follow treatment for childhood acute lymphoblastic leukemia (ALL). Recent studies suggest that risk is most apparent in females treated with cranial rad ... Full text Link to item Cite

Improving health care for adult survivors of childhood cancer: recommendations from a delphi panel of health policy experts.

Journal Article Health Policy · August 2004 OBJECTIVES: To identify barriers to, models of care for, and initiatives to improve health care of adult survivors of childhood cancer. METHODS: Seventeen health care policy experts were asked to respond to the three objectives through a three-iterative De ... Full text Link to item Cite

Health status, medical care, preventive screening, and risk behaviors in adult survivors of cancer diagnosed during adolescence: A report from the Childhood Cancer Survivor Study (CCSS).

Conference JOURNAL OF CLINICAL ONCOLOGY · July 15, 2004 Link to item Cite

Psychological outcomes in long-term survivors of childhood brain cancer: a report from the childhood cancer survivor study.

Journal Article J Clin Oncol · March 15, 2004 PURPOSE: To evaluate and compare psychological outcomes in long-term survivors of pediatric brain cancer and siblings of childhood cancer survivors, and to identify significant correlates of psychological distress. METHODS: One thousand one hundred one adu ... Full text Link to item Cite

Health care for childhood cancer survivors: insights and perspectives from a Delphi panel of young adult survivors of childhood cancer.

Journal Article Cancer · February 15, 2004 BACKGROUND: Most children diagnosed with cancer are surviving into adulthood but are not receiving adequate or appropriate follow-up health care. However, to the authors' knowledge, there is little literature published to date exploring potential barriers ... Full text Link to item Cite

The cancer screening practices of adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Journal Article Cancer · February 1, 2004 BACKGROUND: The current study characterized the self-reported cancer screening practices of adult survivors of childhood cancer. METHODS: A cohort of 9434 long-term survivors of childhood cancer and a comparison group of 2667 siblings completed a 289-item ... Full text Link to item Cite

An examination of the dental utilization practices of adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Journal Article J Public Health Dent · 2004 OBJECTIVES: This study characterized the self-reported dental utilization practice of long-term survivors of childhood cancer, a group at increased risk for treatment-induced dental abnormalities. METHODS: 9,434 survivors and a comparison group of 3,858 si ... Full text Link to item Cite

Health care of young adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Journal Article Ann Fam Med · 2004 BACKGROUND: We wanted to determine the type of outpatient medical care reported by young adult survivors of childhood cancer and to examine factors associated with limited medical care. METHODS: We analyzed data from 9,434 adult childhood cancer survivors ... Full text Link to item Cite

Long-term complications following childhood and adolescent cancer: foundations for providing risk-based health care for survivors.

Journal Article CA Cancer J Clin · 2004 Survivors of childhood and adolescent cancer are one of the higher risk populations seen by health care professionals. The curative therapy administered for the cancer also affects growing and developing tissues. Following chemotherapy, radiation therapy, ... Full text Link to item Cite

US perspective

Chapter · January 1, 2004 Late effects or health problems secondary to previous treatment with chemotherapy or radiation are common. As many as two-thirds of survivors of childhood cancer will experience a late effect secondary to their previous cancer treatment.1-4 Commonly, survi ... Cite

Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

Journal Article JAMA · September 24, 2003 CONTEXT: Adult survivors of childhood cancer are at risk for medical and psychosocial sequelae that may adversely affect their health status. OBJECTIVES: To compare the health status of adult survivors of childhood cancer and siblings and to identify facto ... Full text Link to item Cite

Thyroid nodules and survivors of Hodgkin's disease.

Journal Article Am Fam Physician · September 15, 2003 Link to item Cite

Obesity in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.

Journal Article J Clin Oncol · April 1, 2003 PURPOSE: To determine whether adult survivors (>or= 18 years of age) of childhood acute lymphoblastic leukemia (ALL) are at increased risk for obesity and to assess patient and treatment variables that influence risk. PATIENTS AND METHODS: A retrospective ... Full text Link to item Cite

Longitudinal risk-based health care for adult survivors of childhood cancer.

Journal Article Curr Probl Cancer · 2003 Full text Link to item Cite

Survey methodology for the uninitiated.

Journal Article J Fam Pract · June 2002 Mailed, self-administered questionnaires are a common data collection method used in family practice research. However, little guidance exists in the medical literature about survey methodology specifically designed for family practitioners. As a result, p ... Link to item Cite

Cardiovascular risk factors in young adult survivors of childhood acute lymphoblastic leukemia.

Journal Article J Pediatr Hematol Oncol · October 2001 PURPOSE: To assess cardiovascular risk factors (CVRF) in young adult survivors of childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: Twenty-six subjects (median age, 20.9 years; median interval since completion of therapy, 13.3 years) were ... Full text Link to item Cite

Providing primary care for long-term survivors of childhood acute lymphoblastic leukemia.

Journal Article J Fam Pract · December 2000 Primary care physicians will be providing longitudinal health care for long-term survivors of childhood acute lymphoblastic leukemia (ALL) with increasing frequency. Late effects (sequelae) secondary to treatment with radiation or chemotherapeutic agents a ... Link to item Cite

Childhood cancer survivors and primary care physicians.

Journal Article J Fam Pract · August 2000 Link to item Cite

Grading of late effects in young adult survivors of childhood cancer followed in an ambulatory adult setting.

Journal Article Cancer · April 1, 2000 BACKGROUND: The objective of the current study was to describe a multidisciplinary transition program for following young adult survivors of childhood cancer in an adult-based ambulatory medical setting and to report the late effects with grades of toxicit ... Link to item Cite

Antibiotics for acute bronchitis.

Journal Article J Fam Pract · December 1998 Link to item Cite

Programs for adult survivors of childhood cancer.

Journal Article J Clin Oncol · August 1998 PURPOSE: The potential for late effects of treatment necessitates long-term monitoring of adult survivors of childhood cancer. The purpose of this study was to determine how institutions follow up young adult survivors of pediatric malignancy. Specifically ... Full text Link to item Cite

Treatment of acute bronchitis in adults. A national survey of family physicians.

Journal Article J Fam Pract · June 1998 BACKGROUND: The purpose of this study was to determine how family physicians in the United States treat acute bronchitis in an otherwise healthy adult. METHODS: A 33-item questionnaire on the diagnosis and treatment of acute bronchitis was mailed to a rand ... Link to item Cite

Diagnosis of acute bronchitis in adults: a national survey of family physicians.

Journal Article J Fam Pract · November 1997 BACKGROUND: The purpose of this study was to determine how family physicians in the United States diagnose acute bronchitis in otherwise healthy adults. METHODS: A 33-item questionnaire on the diagnosis and treatment of acute bronchitis was mailed to a ran ... Link to item Cite

Support and rewards for scholarly activity in family medicine: a national survey.

Journal Article Fam Med · 1997 BACKGROUND AND OBJECTIVES: This survey examined how time is allotted for family medicine faculty to pursue scholarly activities and how these activities are rewarded. METHODS: A survey was sent to all directors of family practice residency programs (n = 37 ... Link to item Cite

Antiphospholipid syndrome.

Journal Article J Fam Pract · June 1994 The antiphospholipid syndrome is an illness characterized by recurrent venous or arterial thrombosis, recurrent fetal loss, and thrombocytopenia. It is diagnosed by the presence of antiphospholipid antibodies, such as anticardiolipin antibody or lupus anti ... Link to item Cite

Scurvy: more than historical relevance.

Journal Article Am Fam Physician · September 15, 1993 The clinical description of scurvy is well recorded in the history of medicine. Yet, because scurvy is relatively uncommon in industrially developed countries, it is often underdiagnosed, and unnecessary tests are performed. The result of a prolonged defic ... Link to item Cite

The effect of patient education on pediatric immunization rates.

Journal Article J Fam Pract · September 1992 BACKGROUND: Over the last decade, the immunization rate among preschool children has decreased, especially in the lower socioeconomic population. During this period, reports of outbreaks of immunizable diseases, especially pertussis and measles, have corre ... Link to item Cite

Developing on outpatient care syllabus for a third-year clerkship in family medicine.

Journal Article Fam Med · 1991 Selecting and evaluating student reading resources are important steps in preparing for a clerkship, but a literature review yields little information about these processes. The following brief report outlines the method used to produce the outpatient care ... Link to item Cite

The effect of phencyclidine on dopamine metabolism in the mouse brain.

Journal Article Life Sci · January 26, 1981 Full text Link to item Cite