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Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.

Publication ,  Journal Article
Ross, JA; Oeffinger, KC; Davies, SM; Mertens, AC; Langer, EK; Kiffmeyer, WR; Sklar, CA; Stovall, M; Yasui, Y; Robison, LL
Published in: J Clin Oncol
September 1, 2004

PURPOSE: Overweight (body mass index [BMI] 25 to 29 kg/m2) and obesity (BMI > or = 30 kg/m2) frequently follow treatment for childhood acute lymphoblastic leukemia (ALL). Recent studies suggest that risk is most apparent in females treated with cranial radiation at a younger age. Because radiation at a young age may affect the hypothalamus causing leptin receptor insensitivity, we hypothesized that a polymorphism in the leptin receptor (LEPR) gene, Gln223Arg, might influence susceptibility to obesity in survivors of childhood ALL. PATIENTS AND METHODS: We genotyped 600 non-Hispanic white adult ALL survivors enrolled onto the Childhood Cancer Survivor Study. BMI was compared between those with two copies of the Arg allele to those who had at least one copy of the Gln allele. RESULTS: Female survivors with BMI > or = 25 kg/m2 were more likely Arg homozygous than those with BMI less than 25 kg/m2 (24% v 12%; P =.007). This difference was not observed in males. Moreover, among females treated with > or = 20 Gy cranial radiation, Arg/Arg individuals had six times higher odds of having BMI > or = 25 kg/m2 (95% CI, 2.1 to 22.0) than those with a Gln allele (P =.04 for interaction). CONCLUSION LEPR polymorphism may influence obesity in female survivors of childhood ALL, particularly those exposed to cranial radiation. Because obesity is associated with increased morbidity and mortality in later life, identification of children at high risk might allow for early targeted interventions.

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Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

September 1, 2004

Volume

22

Issue

17

Start / End Page

3558 / 3562

Location

United States

Related Subject Headings

  • Sex Factors
  • Receptors, Leptin
  • Receptors, Cell Surface
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oncology & Carcinogenesis
  • Obesity
  • Male
  • Humans
  • Genotype
  • Genetic Variation
 

Citation

APA
Chicago
ICMJE
MLA
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Ross, J. A., Oeffinger, K. C., Davies, S. M., Mertens, A. C., Langer, E. K., Kiffmeyer, W. R., … Robison, L. L. (2004). Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. J Clin Oncol, 22(17), 3558–3562. https://doi.org/10.1200/JCO.2004.11.152
Ross, Julie A., Kevin C. Oeffinger, Stella M. Davies, Ann C. Mertens, Erica K. Langer, William R. Kiffmeyer, Charles A. Sklar, Marilyn Stovall, Yutaka Yasui, and Leslie L. Robison. “Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.J Clin Oncol 22, no. 17 (September 1, 2004): 3558–62. https://doi.org/10.1200/JCO.2004.11.152.
Ross JA, Oeffinger KC, Davies SM, Mertens AC, Langer EK, Kiffmeyer WR, et al. Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2004 Sep 1;22(17):3558–62.
Ross, Julie A., et al. “Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.J Clin Oncol, vol. 22, no. 17, Sept. 2004, pp. 3558–62. Pubmed, doi:10.1200/JCO.2004.11.152.
Ross JA, Oeffinger KC, Davies SM, Mertens AC, Langer EK, Kiffmeyer WR, Sklar CA, Stovall M, Yasui Y, Robison LL. Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2004 Sep 1;22(17):3558–3562.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

September 1, 2004

Volume

22

Issue

17

Start / End Page

3558 / 3562

Location

United States

Related Subject Headings

  • Sex Factors
  • Receptors, Leptin
  • Receptors, Cell Surface
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oncology & Carcinogenesis
  • Obesity
  • Male
  • Humans
  • Genotype
  • Genetic Variation