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Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity.

Publication ,  Journal Article
Pradhan, KR; Chen, Y; Moustoufi-Moab, S; Krull, K; Oeffinger, KC; Sklar, C; Armstrong, GT; Ness, KK; Robison, L; Yasui, Y; Nathan, PC
Published in: J Clin Endocrinol Metab
November 1, 2019

CONTEXT: Childhood cancer survivors experience chronic health conditions that impact health-related quality of life (HRQOL) and participation in optimal physical activity. OBJECTIVE: The study aimed to determine independent effects of endocrine and metabolic disorders on HRQOL and physical activity. DESIGN, SETTING, AND PATIENTS: Retrospective cohort with longitudinal follow-up of survivors of childhood cancer enrolled in the North American Childhood Cancer Survivor Study. MAIN OUTCOME MEASURES: Medical Outcomes Short Form-36 estimated HRQOL, and participation in physical activity was dichotomized as meeting or not meeting recommendations from the Centers for Disease Control and Prevention. Log binomial regression evaluated the association of each endocrine/metabolic disorder with HRQOL scales and physical activity. RESULTS: Of 7287 survivors, with a median age of 32 years (range, 18 to 54 years) at their last follow-up survey, 4884 (67%) reported one or more endocrine/metabolic disorders. Survivors with either disorder were significantly more likely to be male, older, have received radiation treatment, and have experienced other chronic health conditions. After controlling for covariates, survivors with any endocrine/metabolic disorder were more likely to report poor physical function risk ratio (RR, 1.25; 95% CI, 1.05 to 1.48), increased bodily pain (RR, 1.27; 95% CI, 1.12 to 1.44), poor general health (RR, 1.49; 95% CI, 1.32 to 1.68), and lower vitality (RR, 1.21; 95% CI, 1.09 to 1.34) compared with survivors without. The likelihood of meeting recommended physical activity was lower among survivors with growth disorders (RR, 0.90; 95% CI, 0.83 to 0.97), osteoporosis (RR, 0.87; 95% CI, 0.76 to 0.99), and overweight/obesity (RR, 0.92; 95% CI, 0.88 to 0.96). CONCLUSION: Endocrine and metabolic disorders are independently associated with poor HRQOL and suboptimal physical activity among childhood cancer survivors.

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Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

November 1, 2019

Volume

104

Issue

11

Start / End Page

5183 / 5194

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Quality of Life
  • Neoplasms
  • Metabolic Diseases
  • Male
  • Longitudinal Studies
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Pradhan, K. R., Chen, Y., Moustoufi-Moab, S., Krull, K., Oeffinger, K. C., Sklar, C., … Nathan, P. C. (2019). Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity. J Clin Endocrinol Metab, 104(11), 5183–5194. https://doi.org/10.1210/jc.2019-00627
Pradhan, Kamnesh R., Yan Chen, Sogol Moustoufi-Moab, Kevin Krull, Kevin C. Oeffinger, Charles Sklar, Gregory T. Armstrong, et al. “Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity.J Clin Endocrinol Metab 104, no. 11 (November 1, 2019): 5183–94. https://doi.org/10.1210/jc.2019-00627.
Pradhan KR, Chen Y, Moustoufi-Moab S, Krull K, Oeffinger KC, Sklar C, et al. Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5183–94.
Pradhan, Kamnesh R., et al. “Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity.J Clin Endocrinol Metab, vol. 104, no. 11, Nov. 2019, pp. 5183–94. Pubmed, doi:10.1210/jc.2019-00627.
Pradhan KR, Chen Y, Moustoufi-Moab S, Krull K, Oeffinger KC, Sklar C, Armstrong GT, Ness KK, Robison L, Yasui Y, Nathan PC. Endocrine and Metabolic Disorders in Survivors of Childhood Cancers and Health-Related Quality of Life and Physical Activity. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5183–5194.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

November 1, 2019

Volume

104

Issue

11

Start / End Page

5183 / 5194

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Quality of Life
  • Neoplasms
  • Metabolic Diseases
  • Male
  • Longitudinal Studies
  • Humans
  • Follow-Up Studies
  • Female