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Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study.

Publication ,  Journal Article
King, AA; Seidel, K; Di, C; Leisenring, WM; Perkins, SM; Krull, KR; Sklar, CA; Green, DM; Armstrong, GT; Zeltzer, LK; Wells, E; Stovall, M ...
Published in: Neuro Oncol
May 1, 2017

BACKGROUND: Medulloblastoma is the most common malignant childhood brain tumor, although long-term risks for chronic neurologic health and psychosocial functioning in aging adult survivors are incompletely characterized. METHODS: The Childhood Cancer Survivor Study (CCSS) includes 380 five-year survivors of medulloblastoma/primitive neuroectodermal tumor (PNET; median age at follow-up: 30 y, interquartile range 24-36) and sibling comparison (n = 4031). Cumulative incidence of neurologic health conditions was reported. Cox regression models provided hazard ratios (HRs) and 95% CIs. Cross-sectional outcomes were assessed using generalized linear models. RESULTS: Compared with siblings, survivors were at increased risk of late-onset hearing loss (HR: 36.0, 95% CI: 23.6-54.9), stroke (HR: 33.9, 95% CI: 17.8-64.7), seizure (HR: 12.8, 95% CI: 9.0-18.1), poor balance (HR: 10.4, 95% CI: 6.7-15.9), tinnitus (HR: 4.8, 95% CI: 3.5-6.8), and cataracts (HR: 31.8, 95% CI: 16.7-60.5). Temporal/frontal lobe radiotherapy of 50 Gy or more increased risk for hearing loss (HR: 1.9, 95% CI: 1.1-1.3), seizure (HR: 2.1, 95% CI: 1.1-3.9), stroke (HR: 3.5, 95% CI: 1.3-9.1), and tinnitus (HR: 2.0, 95% CI: 1.0-3.9). Survivors were less likely than siblings to earn a college degree (relative risk [RR]: 0.49, 95% CI: 0.39-0.60), marry (RR: 0.35, 95% CI: 0.29-0.42), and live independently (RR: 0.58, 95% CI: 0.52-0.66). CONCLUSIONS: Adult survivors of childhood medulloblastoma/PNET demonstrate pronounced risk for hearing impairment, stroke, lower educational attainment, and social independence. Interventions to support survivors should be a high priority.

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Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

May 1, 2017

Volume

19

Issue

5

Start / End Page

689 / 698

Location

England

Related Subject Headings

  • Young Adult
  • Survival Rate
  • Stress, Psychological
  • Retrospective Studies
  • Radiotherapy
  • Prospective Studies
  • Prognosis
  • Oncology & Carcinogenesis
  • Neuroectodermal Tumors, Primitive
  • Nervous System Diseases
 

Citation

APA
Chicago
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MLA
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King, A. A., Seidel, K., Di, C., Leisenring, W. M., Perkins, S. M., Krull, K. R., … Packer, R. J. (2017). Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study. Neuro Oncol, 19(5), 689–698. https://doi.org/10.1093/neuonc/now242
King, Allison A., Kristy Seidel, Chongzhi Di, Wendy M. Leisenring, Stephanie Mabry Perkins, Kevin R. Krull, Charles A. Sklar, et al. “Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study.Neuro Oncol 19, no. 5 (May 1, 2017): 689–98. https://doi.org/10.1093/neuonc/now242.
King AA, Seidel K, Di C, Leisenring WM, Perkins SM, Krull KR, et al. Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study. Neuro Oncol. 2017 May 1;19(5):689–98.
King, Allison A., et al. “Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study.Neuro Oncol, vol. 19, no. 5, May 2017, pp. 689–98. Pubmed, doi:10.1093/neuonc/now242.
King AA, Seidel K, Di C, Leisenring WM, Perkins SM, Krull KR, Sklar CA, Green DM, Armstrong GT, Zeltzer LK, Wells E, Stovall M, Ullrich NJ, Oeffinger KC, Robison LL, Packer RJ. Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study. Neuro Oncol. 2017 May 1;19(5):689–698.
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

May 1, 2017

Volume

19

Issue

5

Start / End Page

689 / 698

Location

England

Related Subject Headings

  • Young Adult
  • Survival Rate
  • Stress, Psychological
  • Retrospective Studies
  • Radiotherapy
  • Prospective Studies
  • Prognosis
  • Oncology & Carcinogenesis
  • Neuroectodermal Tumors, Primitive
  • Nervous System Diseases