Skip to main content
Journal cover image

DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study.

Publication ,  Journal Article
Lupo, PJ; Brown, AL; Arroyo, VM; Kamdar, KY; Belmont, JW; Scheurer, ME; Leisenring, WM; Gramatges, MM; Okcu, MF; Yasui, Y; Oeffinger, KC ...
Published in: Genes Chromosomes Cancer
January 2019

Because survivors of pediatric acute lymphoblastic leukemia (ALL) are more likely to be obese than unaffected contemporaries, we compared DNA methylation profiles between normal-weight and obese survivors at adiposity-associated CpG sites previously-reported by epigenome-wide association studies (EWAS) of body mass index (BMI) in the general population. We selected 96 ALL survivors from the Childhood Cancer Survivor Study: 48 obese and 48 normal weight. The Illumina HumanMethylation450 BeadChip was used to compare DNA methylation at 211 loci identified in EWAS of BMI in the general population. Thirty-nine loci were associated (false discovery rate <0.05) with obesity among survivors who only received chemotherapy (n = 49). No loci were significantly associated with obesity among CRT-exposed survivors (n = 47). Our results suggest that previously identified BMI-DNA methylation loci are associated with obesity in ALL survivors who were spared CRT, while no loci were significantly associated with obesity in survivors who received CRT.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Genes Chromosomes Cancer

DOI

EISSN

1098-2264

Publication Date

January 2019

Volume

58

Issue

1

Start / End Page

52 / 59

Location

United States

Related Subject Headings

  • Young Adult
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oncology & Carcinogenesis
  • Obesity
  • Neoplasm Proteins
  • Male
  • Humans
  • Female
  • DNA Methylation
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lupo, P. J., Brown, A. L., Arroyo, V. M., Kamdar, K. Y., Belmont, J. W., Scheurer, M. E., … Bhatia, S. (2019). DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Genes Chromosomes Cancer, 58(1), 52–59. https://doi.org/10.1002/gcc.22701
Lupo, Philip J., Austin L. Brown, Vidal M. Arroyo, Kala Y. Kamdar, John W. Belmont, Michael E. Scheurer, Wendy M. Leisenring, et al. “DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study.Genes Chromosomes Cancer 58, no. 1 (January 2019): 52–59. https://doi.org/10.1002/gcc.22701.
Lupo PJ, Brown AL, Arroyo VM, Kamdar KY, Belmont JW, Scheurer ME, et al. DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Genes Chromosomes Cancer. 2019 Jan;58(1):52–9.
Lupo, Philip J., et al. “DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study.Genes Chromosomes Cancer, vol. 58, no. 1, Jan. 2019, pp. 52–59. Pubmed, doi:10.1002/gcc.22701.
Lupo PJ, Brown AL, Arroyo VM, Kamdar KY, Belmont JW, Scheurer ME, Leisenring WM, Gramatges MM, Okcu MF, Yasui Y, Oeffinger KC, Robison LL, Armstrong GT, Bhatia S. DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. Genes Chromosomes Cancer. 2019 Jan;58(1):52–59.
Journal cover image

Published In

Genes Chromosomes Cancer

DOI

EISSN

1098-2264

Publication Date

January 2019

Volume

58

Issue

1

Start / End Page

52 / 59

Location

United States

Related Subject Headings

  • Young Adult
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oncology & Carcinogenesis
  • Obesity
  • Neoplasm Proteins
  • Male
  • Humans
  • Female
  • DNA Methylation
  • Child, Preschool