Solid tumor second primary neoplasms: who is at risk, what can we do?

Journal Article (Journal Article;Review)

Eighteen percent of incident malignancies in the United States are a second (or subsequent) cancer. Second primary neoplasms (SPNs), particularly solid tumors, are a major cause of mortality and serious morbidity among cancer survivors successfully cured of their first cancer. Multiple etiologies may lead to a cancer survivor subsequently being diagnosed with an SPN, including radiotherapy for the first cancer, unhealthy lifestyle behaviors, genetic factors, aging, or an interaction between any of these factors. In this article, we discuss these factors and synthesize this information for use in clinical practice, including preventive strategies and screening recommendations for SPNs.

Full Text

Duke Authors

Cited Authors

  • Oeffinger, KC; Baxi, SS; Novetsky Friedman, D; Moskowitz, CS

Published Date

  • December 2013

Published In

Volume / Issue

  • 40 / 6

Start / End Page

  • 676 - 689

PubMed ID

  • 24331190

Pubmed Central ID

  • PMC3921623

Electronic International Standard Serial Number (EISSN)

  • 1532-8708

Digital Object Identifier (DOI)

  • 10.1053/j.seminoncol.2013.09.012


  • eng

Conference Location

  • United States